AutismKB 2.0

Annotation Detail for TCF12


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Basic Information Top
Gene Symbol:TCF12 ( HEB,HTF4,HsT17266,bHLHb20 )
Gene Full Name: transcription factor 12
Band: 15q21.3
Quick LinksEntrez ID:6938; OMIM: 600480; Uniprot ID:HTF4_HUMAN; ENSEMBL ID: ENSG00000140262; HGNC ID: 11623
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TCF12 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TCF12 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in increased expression of TCF12 mRNAincreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TCF12 mRNAdecreases expression 20106945
20064835
D002117 Calcitriol Calcitriol results in decreased expression of TCF12 mRNAdecreases expression 12875902
C472511 dimethylarsinous acid dimethylarsinous acid results in decreased expression of TCF12 mRNAdecreases expression 16507463
D004610 Ellagic Acid Ellagic Acid results in increased expression of TCF12 mRNAincreases expression 12002526
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TCF12 mRNAaffects cotreatment|increases expression 17183730
C027185 indirubin indirubin results in decreased expression of TCF12 mRNAdecreases expression 15056799
C051890 irinotecan irinotecan analog results in decreased expression of TCF12 mRNAdecreases expression 18927307
D008727 Methotrexate TCF12 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of TCF12 mRNAdecreases expression 17616710
C059514 resveratrol resveratrol results in increased expression of TCF12 mRNAincreases expression 12002526
D012643 Selenium Selenium results in decreased expression of TCF12 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite affects the expression of TCF12 mRNAaffects expression 19590694
C017947 sodium arsenite sodium arsenite results in decreased expression of TCF12 mRNAdecreases expression 16507463
C017947 sodium arsenite sodium arsenite results in increased expression of TCF12 mRNAincreases expression 12016162
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TCF12 mRNAdecreases expression 15056799
D014212 Tretinoin Tretinoin results in decreased expression of TCF12 mRNAdecreases expression 12875902
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TCF12 mRNAaffects cotreatment|increases expression 17183730
C047426 venlafaxine venlafaxine results in decreased expression of TCF12 mRNAdecreases expression 16341940
C025643 vinclozolin vinclozolin results in decreased expression of TCF12 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 13.8112039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.8115322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.818875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8419490988
MESH:D058186 Acute Kidney Injury resveratrol 3.7716538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 6.636695378
MESH:D000236 Adenoma resveratrol 6.6315688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000544 Alzheimer Disease resveratrol 2.5516183991 16162502
MESH:D000550 Amblyopia Valproic Acid 5.1517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.6217497229
MESH:D001008 Anxiety Disorders vinclozolin 8.6219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001169 Arthritis, Experimental resveratrol 7.3317115116
MESH:D001169 Arthritis, Experimental Tretinoin 7.3316412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.8017286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8016292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D050197 Atherosclerosis resveratrol 3.2216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 19232924 18316065 18177632 17507914 18396377 18775368 16609825 20603192 18558336 18985861 18940202 17688650 17157402 19460635
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0320046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6616197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.838888407
MESH:D002545 Brain Ischemia resveratrol 4.2017600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9220146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 2.9211237771
MESH:D001943 Breast Neoplasms Methotrexate 2.9216978400
MESH:D001943 Breast Neoplasms resveratrol 2.9216393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.723084413
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.7216227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7217306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.721917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5116675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.0720419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 14.0711237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 14.0716227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.0718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.0716096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.4115458977
MESH:D002386 Cataract Acetaminophen 7.0510977129
MESH:D002386 Cataract Tretinoin 7.0517460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.546135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5419524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6412621046 16354765 15340226 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis resveratrol 15.5416474422
MESH:D003092 Colitis Selenium 15.5417936198
MESH:D003092 Colitis Tretinoin 15.5417035595
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6220423518
MESH:D003110 Colonic Neoplasms irinotecan 3.9917287894 17725105
MESH:D003110 Colonic Neoplasms resveratrol 3.9916338953
MESH:D015179 Colorectal Neoplasms irinotecan 2.7916303861 17159606 18509181 16391804 18259882 15273666 17454858
MESH:D015179 Colorectal Neoplasms resveratrol 2.7916550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.6916507316
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.369562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.369142499 10589399 16925845 17551590 9211117 9664655 9224671 8800419 9125849 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.368888407 16575769 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.2514966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.1619747007
MESH:D003866 Depressive Disorder venlafaxine 4.7620305041
MESH:D003882 Dermatomyositis Methotrexate 5.0420191521
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6916873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.8916286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.7321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.7311834606 19370779 16109766 10663392 17522070 11739529 19420014 16485898 15968718 11287661 19085960 19164858 12958197 12392966 16177239 18071297 10774834 11529661 11421492 12594235 16227642 11743745 17906064 10915739 14986274 16393943 15619225 12705907 16081117 12153990 12540782 19416960 16781746 19923254 2444490 18713872 17562736 14550746 19739265 11461765 14725611
MESH:D056486 Drug-Induced Liver Injury Selenium 11.7315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.731733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D004421 Dystonia Valproic Acid 3.961851702
MESH:D004487 Edema resveratrol 6.598985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.1115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.1117872969
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.949294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7617923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.073659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.516426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.983659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver Valproic Acid 3.2219224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0418558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3320067830
MESH:D005355 Fibrosis Tretinoin 8.3317994277
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2216417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005909 Glioblastoma Tretinoin 2.9517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.0616518429
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.829664655 14991402
MESH:D006333 Heart Failure Selenium 3.0217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8116120746 12621046 15340226
MESH:D006561 Herpes Simplex resveratrol 4.0916876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D019584 Hot Flashes venlafaxine 5.4514716179
MESH:D006849 Hydrocephalus Valproic Acid 4.7817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9616354765 8697196 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.3916870215
MESH:D006930 Hyperalgesia Tretinoin 7.3916870215
MESH:D006937 Hypercholesterolemia resveratrol 3.9217188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006949 Hyperlipidemias resveratrol 3.9416873680
MESH:D006968 Hypersensitivity, Delayed indirubin 5.8511275354
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5416612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2217488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5617600658
MESH:D007248 Infertility, Male sodium arsenite 6.6515346721 12646999
MESH:D007248 Infertility, Male vinclozolin 6.6516467254
MESH:D007249 Inflammation resveratrol 4.9216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9212878042 12200463
MESH:D007251 Influenza, Human resveratrol 10.8116624496
MESH:D007251 Influenza, Human Selenium 10.8116624496
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6617551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 5.7912587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 5.7920008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.8016518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9016705839
MESH:D007805 Language Development Disorders Methotrexate 5.029562676
MESH:D007938 Leukemia Tretinoin 2.7317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8319850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8317596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.5716087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5719035177 16891316 17107899 15748426 16140955 16823087 9834237 16331271 17712046 17301526 17339181 19225113 19642359 17294898 17217047 12679006 17506722 16788101 17368321 16935935 19029980 19075265 16766008 17649720 17361223
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008103 Liver Cirrhosis Methotrexate 3.6514986274
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.2818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6119014921 12969438 19460945 19784758 11587558 16611625 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7717185352 16871587
MESH:D017114 Liver Failure, Acute venlafaxine 9.7719857765
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.897678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.8920195826 21137059
MESH:D008113 Liver Neoplasms resveratrol 13.8919073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 13.8915276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.556135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5512151625
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 11.1918516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 11.1917228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3120464547 18569708 20135361 18816296 6695378 17053015 20869020 20064080 18520028
MESH:D008175 Lung Neoplasms sodium arsenite 3.3116712894 15276417 17077188 19931552 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3111884234 19555203
MESH:D008223 Lymphoma Methotrexate 3.8917352296
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2117088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8014749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1615688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.0311606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0315318939
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma resveratrol 5.0717992120
MESH:D008545 Melanoma sodium arsenite 5.0719082730 16487513
MESH:D008545 Melanoma Tretinoin 5.0716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D001523 Mental Disorders venlafaxine 4.7716856516
MESH:D008654 Mesothelioma Selenium 2.7615107826
MESH:D008659 Metabolic Diseases resveratrol 4.2917112576
MESH:D008881 Migraine Disorders Valproic Acid 7.9118765137 18803445
MESH:D008881 Migraine Disorders venlafaxine 7.9118803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D052016 Mucositis irinotecan 12.3117159606
MESH:D052016 Mucositis Methotrexate 12.3117488658
MESH:D009101 Multiple Myeloma resveratrol 3.4016490592 16267019 17164350 17049120 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7817962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.948888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2317596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.2317596541
MESH:D009203 Myocardial Infarction resveratrol 2.9916317513 17015251 17188708 17125593 16525036 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.7717125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7712213967
MESH:D009205 Myocarditis resveratrol 4.6717322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.787678174 18551238
MESH:D009362 Neoplasm Metastasis irinotecan 3.1418259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0111141357
MESH:D009369 Neoplasms sodium arsenite 8.0111559025
MESH:D009369 Neoplasms Tretinoin 8.0116946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 8.948985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.9420056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2214600291
MESH:D009421 Nervous System Malformations Tretinoin 9.229125849
MESH:D009436 Neural Tube Defects sodium arsenite 11.8212854658
MESH:D009436 Neural Tube Defects Tretinoin 11.829142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.828888407 16359493
MESH:D009447 Neuroblastoma irinotecan 3.438761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1118514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.1117652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.648761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.3117929310
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 5.5817503984
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3516049721
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1717513867
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.7917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7916936753
MESH:D010146 Pain Acetaminophen 6.3416870215
MESH:D010146 Pain Tretinoin 6.3416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4315976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010954 Plasmacytoma Selenium 4.8115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 22.5616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 22.5611896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 22.5620603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 22.5618042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8518220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6915572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1112479363 18247401 16644109 15754350 16289102
MESH:D011471 Prostatic Neoplasms resveratrol 2.1116731767 17675339 17718901 17636462 15767336 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1116039940
MESH:D011472 Prostatitis vinclozolin 4.8518629315
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.4612752131 11422049
MESH:D011565 Psoriasis Methotrexate 3.4017410198
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D051437 Renal Insufficiency Methotrexate 4.6217352296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5016325855
MESH:D015427 Reperfusion Injury resveratrol 3.2317058453 16314181 17520802 15827377 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5816283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0615737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7418551238
MESH:D012640 Seizures Valproic Acid 5.7414763951 16876388 3137016 11044598 17978042 1511512 15475178 11738929
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.4910029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 17.4915837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 17.4919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.4916192470
MESH:D012878 Skin Neoplasms Tretinoin 17.4916467112
MESH:D016135 Spinal Dysraphism sodium arsenite 9.3112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.3119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.362093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 3.3615723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.3617261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4016321402
MESH:D013576 Syndactyly Methotrexate 4.959562676
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.8615864552
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9616026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 9.6516227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.6516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1517262798
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.443119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.0916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.0917053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.0917306315 11723127 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.568888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.4317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.4311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.4316129372
MESH:D014594 Uterine Neoplasms resveratrol 4.0517044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2117488730
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
Pathway ID Pathway Name
REACT:21303 Myogenesis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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