AutismKB 2.0

Annotation Detail for TCF21


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Basic Information Top
Gene Symbol:TCF21 ( POD1,bHLHa23 )
Gene Full Name: transcription factor 21
Band: 6q23.2
Quick LinksEntrez ID:6943; OMIM: 603306; Uniprot ID:TCF21_HUMAN; ENSEMBL ID: ENSG00000118526; HGNC ID: 11632
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TCF21 mRNAincreases expression 19933214
C105260 4-tert-octylphenol 4-tert-octylphenol results in decreased expression of TCF21 mRNAdecreases expression 17011747
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of TCF21 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TCF21 mRNAaffects expression 16483693
D002330 Carmustine Carmustine results in decreased expression of TCF21 mRNAdecreases expression 15980968
D003345 Corticosterone Corticosterone results in increased expression of TCF21 mRNAincreases expression 15755911
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of TCF21 mRNAdecreases expression 15289156
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of TCF21 mRNAdecreases expression 17011747
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of TCF21 mRNAincreases expression 17011747
D004958 Estradiol Estradiol results in decreased expression of TCF21 mRNAdecreases expression 15289156
D019833 Genistein Genistein results in decreased expression of TCF21 mRNAdecreases expression 15289156
C011890 kojic acid kojic acid results in decreased expression of TCF21 mRNAdecreases expression 16595896
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TCF21 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TCF21 mRNAdecreases expression 19482888
D010795 Phthalic Acids Phthalic Acids results in increased expression of TCF21 mRNAincreases expression 15728792
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TCF21 mRNAincreases expression 18691609
19933214
C025643 vinclozolin vinclozolin affects the expression of TCF21 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of TCF21 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000230 Adenocarcinoma Estradiol 4.5111473722
MESH:D000230 Adenocarcinoma Genistein 4.5111473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.3617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3616835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4020106747
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9717129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 1.9712948864 19861407 16675129 17261762 17018787 14630087 18497071 17289903
MESH:D001943 Breast Neoplasms Genistein 1.9717200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.6815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.686705139 20007298 17173139 1701930 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8118566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 15340226 15668235 8697196 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D003324 Coronary Artery Disease marker/mechanism 21378990
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 11.5912952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 11.5914966744
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.1716402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.1716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.7216804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 12.7219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 12.7211473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.973922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6916002989 16513791 16611131 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0316452187
MESH:D005909 Glioblastoma Carmustine 7.6616187019
MESH:D005909 Glioblastoma Genistein 7.6616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6616080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Phenobarbital 8.6816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6816120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 8697196 16959395 15340226 18606429
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5114722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.6516002989
MESH:D007246 Infertility Diethylstilbestrol 4.4215036965
MESH:D007248 Infertility, Male vinclozolin 3.0716467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.3116624496
MESH:D007333 Insulin Resistance Estradiol 3.0016627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Estradiol 6.2115618244
MESH:D007674 Kidney Diseases Vitamin E 6.2112488133
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.6916762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 7.6915610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1317184923
MESH:D007938 Leukemia Genistein 3.0517468513 18980019
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9221047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0116169303
MESH:D008107 Liver Diseases Phenobarbital 2.1819363144
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.5715890375 16712894
MESH:D008113 Liver Neoplasms Phenobarbital 7.5721047994 15975961 19073162 19482888 8742319 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental kojic acid 10.0918544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.091399818 6150874 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0912151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3211062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2315166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6116002989
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 10.3212807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.3212929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6517141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009369 Neoplasms Diethylstilbestrol 2.7915313581
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 24.0311399458
MESH:D009421 Nervous System Malformations Estradiol 24.0316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.0316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.0314600291
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.9519401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9519005980
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7416977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.672563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.7817184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.7811399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.7818042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0917136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0915256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0915084515
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures Phenobarbital 2.7316876388 11442880 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.8116002989 16709447
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.091399818
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.7916452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0816175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1316690809 15809267
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5116002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36387
    • No data
    Releated disease ID Related disease Name
    PA444818Lung Neoplasms
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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