AutismKB 2.0

Annotation Detail for TCN2


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Basic Information Top
Gene Symbol:TCN2 ( D22S676,D22S750,II,TC,TC II,TC-2,TC2,TCII )
Gene Full Name: transcobalamin II
Band: 22q12.2
Quick LinksEntrez ID:6948; OMIM: 613441; Uniprot ID:TCO2_HUMAN; ENSEMBL ID: ENSG00000185339; HGNC ID: 11653
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
homocysteine
Alzheimer's disease
spontaneous abortion
NEUROLOGICAL
METABOLIC
methylmalonic acid
holotranscobalamin
vitamin B12
oxidative stress
No data
Desease Name
Transcobalamin II deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of TCN2 mRNAaffects expression 19414516
D000082 Acetaminophen Acetaminophen affects the expression of TCN2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TCN2 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TCN2 mRNAaffects expression 17484886
D003907 Dexamethasone Dexamethasone results in decreased expression of TCN2 mRNAdecreases expression 12732289
D004041 Dietary Fats Dietary Fats results in decreased expression of TCN2 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TCN2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TCN2 mRNAincreases expression 16174780
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCN2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TCN2 mRNAdecreases expression 16174780
C008493 methylselenic acid methylselenic acid results in increased expression of TCN2 mRNAincreases expression 18548127
C041786 palm oil palm oil results in decreased expression of TCN2 mRNAdecreases expression 18042831
C017947 sodium arsenite sodium arsenite affects the expression of TCN2 mRNAaffects expression 19590694
D013629 Tamoxifen Tamoxifen affects the expression of TCN2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TCN2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TCN2 mRNAincreases expression 17942748
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.939612607
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma marker/mechanism 17389618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0417306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.5417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5415885639
MESH:D001321 Autistic Disorder marker/mechanism 16917939
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Tamoxifen 1.8319487384 16818667 19011961 20135344 16873071 15668708 21138602 19066611 20859285 17893378 16273361 18425577 17049068 18815881 19084267 19142967 19288272 20065188 17440819 17242785 19200415 19103187 17261762 19155303 21152245 18629630 20390343 19221464 19410462 18984771 19289846 18351453 18855134 19244106 16202921 20544844 20005174 18821012 19059307 19115204 19189210 11161223 18997820 15565566 19189212
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816050911 16011737 10355542 16097048 16192424 16124888 16227642 15700767 15721981 3786805 15673190 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.663084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6618788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6615276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6616924424
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4018572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0420056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9315861022 17681005 11677210 17110522 16105132 17333356 16919318
MESH:D002971 Cleft Lip marker/mechanism 16470748
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15340226 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5015824018
MESH:D015179 Colorectal Neoplasms marker/mechanism 17389618
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6417728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6415322242 10048152 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.5112438553
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D003967 Diarrhea Dexamethasone 3.797237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2514725611 11461765 12153990 18071297 14550746 17906064 11739529 19085960 16781746 19370779 15619225 2444490 11529661 16227642 10663392 11834606 11743745 19164858 12540782 16081117 18713872 19923254 19739265 11287661 16393943 12392966 10774834 14986274 17562736 16485898 12705907 16109766 12958197 15968718 19420014 12594235 16177239 11421492 10915739 17522070 19416960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.259327722 7179309 15998439 10915739 4309450 21278145 3732212 2869522 11566570 6884620 17522070 19085960 15968718 16227642 19336974 10092053 7120509 16177239 6623471 15027814 3786805 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.4411462148
MESH:D004362 Drug Toxicity Zidovudine 8.4415040536
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004485 Eczema Dexamethasone 4.5512438553
MESH:D004487 Edema Dexamethasone 7.1519703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1020544844 17893378 16202921 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.5919224547 12631006 16239168 12795759 15959796 16045604 17595544 61145
MESH:D005234 Fatty Liver Dietary Fats 25.5918296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.5915345470
MESH:D005234 Fatty Liver Tamoxifen 25.5919224547 14986274
MESH:D005234 Fatty Liver Zidovudine 25.5918299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 15.3918705752
MESH:D005355 Fibrosis Dietary Fats 15.3918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3920067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.8012579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.097520565
MESH:D015658 HIV Infections Zidovudine 3.5320032539 11141242 11363243 17358032 11698656
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Dexamethasone 5.3517042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8217937319
MESH:D007248 Infertility, Male sodium arsenite 6.8215346721 12646999
MESH:D007249 Inflammation Dexamethasone 12.318960868 11099482
MESH:D007249 Inflammation Dietary Fats 12.3120412841
MESH:D007249 Inflammation Tamoxifen 12.3119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.3112200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1511836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1115629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.1120008137
MESH:D007680 Kidney Neoplasms Tamoxifen 7.9118625569
MESH:D007680 Kidney Neoplasms Zidovudine 7.9112579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4920370541
MESH:D008064 Lipidoses Tamoxifen 3.2117567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7717334410 16943688 16221502 11903743 16239168 17157831 17174718 11408273 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0417900296 12958196 14716496 18395914 15370692 15338365 16097048 17761835 12445418 16638106 15893842 18376398 18263696 13678700 15876570 18251166 17565644 17714472 12609069 12632512 18395095 18412020 18472094 17922224 14748882 12546737 12649538 17631135 18420326 15818738 15931870 18210741 18418968 17640975 15123356 17708605 17481882 17766677 16136751 15673190 18054572 17805973 14716833 15730626 16011737 16248980 12667390 16192424 15959796 12898905 17976157 17557913 17525996 18187930 12586293 12632514 18277467 15650968 18156304 15925388 20821823 14724832 16116963 18279442 10355542 17944888 16027843 17721639 14512876 18705752 12666154 14620537 15362042 11481614 18472332 18006644 16015684 18339082 18481824 18429990 15052691 12389079 18205269 18166357 17823541 17698563 16033810 15996030 12445421 15057751 17869086 18317297 12741479
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.0416718785
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0412878042
MESH:D008107 Liver Diseases Acetaminophen 3.9616611625 19784758 11587558 19014921 12587719 12969438 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9615830285 16246199 16964402 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.9419294768
MESH:D008113 Liver Neoplasms sodium arsenite 10.9415276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 10.9416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9212151625
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms Dexamethasone 6.7015824018 11195469
MESH:D008175 Lung Neoplasms sodium arsenite 6.7015276417 19931552 17077188 17306315 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 6.7018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7011884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 6.7018800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6711731420 19196722 19196723 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma sodium arsenite 3.3616487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.3619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.9717358032
MESH:D009101 Multiple Myeloma Dexamethasone 3.5615744524 15867202 16118317
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.589809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms sodium arsenite 2.5311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1912854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity Dietary Fats 2.3017217161 18457598 16723640 18674790 21332399 20132043 19632207 11836018 20518802
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4615276417 17306315
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5921297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6416205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6416039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.1018379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012878 Skin Neoplasms sodium arsenite 5.7118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013272 Stomach Diseases Dexamethasone 4.4415472012
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013276 Stomach Ulcer Dexamethasone 3.5715138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
OMIM:275350 TRANSCOBALAMIN II DEFICIENCY marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2111723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.218653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8411813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Dexamethasone 4.951336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.8612579204
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
Pathway ID Pathway Name
KEGG:04977 Vitamin digestion and absorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36404
    • No data
    Releated disease ID Related disease Name
    PA446975Neurotoxicity Syndromes
    Releated drug ID Related drug Name
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00115 - Liver-Stomach Concentrate with Intrinsic Factor Antianemic Agents;Essential Vitamin;Vitamins (Vitamin B Complex)
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00200 substrate Vege 1 Daily Caplet Nutritional Supplement;Anti-anemic Agents;Vitamin B Complex;Hematinics

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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