AutismKB 2.0

Annotation Detail for BUB1


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Basic Information Top
Gene Symbol:BUB1 ( BUB1A,BUB1L,hBUB1 )
Gene Full Name: budding uninhibited by benzimidazoles 1 homolog (yeast)
Band: 2q13
Quick LinksEntrez ID:699; OMIM: 602452; Uniprot ID:BUB1_HUMAN; ENSEMBL ID: ENSG00000169679; HGNC ID: 1148
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04110Cell cycle
hsa04114Oocyte meiosis
Related Diseases/Disorders Top
Desease IDDesease Name
1934Cancer
2164Barrett's esophagus
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in decreased expression of BUB1 mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of BUB1 proteinaffects expression 20106945
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of BUB1 mRNAincreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of BUB1 mRNA]decreases reaction|increases expression 12205029
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of BUB1 mRNAaffects cotreatment|increases expression 17639512
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BUB1 mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BUB1 mRNAdecreases expression 17942131
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BUB1 mRNAdecreases expression 20018196
19150397
20382639
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of BUB1 mRNAdecreases expression 17942131
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of BUB1 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of BUB1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of BUB1 mRNAdecreases expression 17942131
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of BUB1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of BUB1 mRNA]decreases reaction|increases expression 17854601
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of BUB1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BUB1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of BUB1 mRNAdecreases expression 16709241
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of BUB1 mRNAaffects cotreatment|increases expression 16996129
D019833 Genistein Genistein affects the expression of BUB1 mRNAaffects expression 18847459
C051890 irinotecan irinotecan metabolite results in decreased expression of BUB1 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of BUB1 mRNAdecreases expression 15956246
D008294 Malathion Malathion results in decreased expression of BUB1 mRNAdecreases expression 16079077
D008345 Manganese Manganese results in decreased expression of BUB1 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of BUB1 mRNAdecreases expression 17175027
D008628 Mercury Mercury results in increased expression of BUB1 mRNAincreases expression 16823088
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of BUB1 mRNAincreases expression 20713471
D015741 Metribolone Metribolone results in increased expression of BUB1 mRNAincreases expression 19318562
D010126 Ozone TTPA protein affects the reaction [Ozone results in increased expression of BUB1 mRNA]affects reaction|increases expression 19555225
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of BUB1 mRNAincreases expression 17560707
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of BUB1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of BUB1 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BUB1 mRNAaffects binding|decreases expression|increases activity 19710929
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of BUB1 mRNAaffects cotreatment|increases expression 17639512
C059514 resveratrol resveratrol results in decreased expression of BUB1 mRNAdecreases expression 15767336
D013629 Tamoxifen Tamoxifen results in increased expression of BUB1 mRNAincreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BUB1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BUB1 mRNAincreases expression 19465110
D014635 Valproic Acid Valproic Acid results in increased expression of BUB1 mRNAincreases expression 19101580
D014747 Vinblastine BUB1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of BUB1 mRNAaffects cotreatment|increases expression 16996129
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018