AutismKB 2.0

Annotation Detail for DYNLT1


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Basic Information Top
Gene Symbol:DYNLT1 ( CW-1,MGC111571,TCTEL1,tctex-1 )
Gene Full Name: dynein, light chain, Tctex-type 1
Band: 6q25.3
Quick LinksEntrez ID:6993; OMIM: 601554; Uniprot ID:DYLT1_HUMAN; ENSEMBL ID: ENSG00000146425; HGNC ID: 11697
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
200114Lissencephaly gene (LIS1) in neuronal migration and development
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DYNLT1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DYNLT1 mRNAaffects expression 16483693
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DYNLT1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of DYNLT1 mRNA]decreases reaction|increases expression 17942915
C017947 sodium arsenite sodium arsenite results in increased expression of DYNLT1 mRNAincreases expression 20308225
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DYNLT1 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000236 Adenoma Diethylnitrosamine 3.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.9216434500 19061943 17162532 19052882 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.9216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5116712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.803084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.803581430 16288022 19335982 19919837 18494052 20214788 20432363 16878318 18056438 17978847 16698587 18978308 16681979 18788625 18691550 17173139 17162532 18506893 16540662 19539802 20101231 17055752 20007298 19208518 19383236 16569478 19107877 19171122 19822196 16502159 20524982 16328049 18665156 19701751 10737359 16830150 21159647 16935385 19418558 18393292 20512989 20514400 16779866 20727157 18971187 10672840 19394651 17138121 19052882 17761372 11831363 20935162 18210153 16807293 18785209 20084675 17428255 19519916 3084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.8017306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.562727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.5620056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.4319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.4316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215340226 15668235 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6312705907 2444490 12958197 17562736 14725611 11739529 16781746 12540782 11834606 11529661 16227642 10915739 17522070 14550746 11421492 19420014 16109766 11743745 19085960 19370779 19416960 19923254 18071297 17906064 11461765 19164858 14986274 12153990 16081117 15619225 16177239 16485898 12392966 16393943 15968718 19739265 10774834 11287661 18713872 10663392 12594235
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Diethylnitrosamine 3.5621071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.2112646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 5.4418785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4412878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Acetaminophen 6.5815629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.5820008137
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9919638242 18407596 18665156 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 4.1519014921 16610002 19460945 11587558 12969438 19784758 12587719 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0719427195 10737359 15885732 18644402 20501860 18754104 20118626 19812893 18978307 20405173 16942905 19256749 21047994 9163691 20434301 20492335 19850985 21071580 19833225 2862719 19551842 21167192 19255062 21278145 19073162 19642983 2422723 12112319 20583210 19294768 19090486 15175105 19254457 12771043 19996281 18977376 20137499 19690152 20101389 19499222 19426721 18648771 19638242 20452335
MESH:D008113 Liver Neoplasms sodium arsenite 8.0715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4518253720 18308698 19004024 16267830 18093689 18079962 17174075 9362446 21159647 19539802 19519916 19009564 18282651 16842330 19126423 18775883 3124819 17942915 17854601 18544905 2563599 18164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5620512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 3.5619931552 15276417 17306315 17077188 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.683581430 9029167
MESH:D009369 Neoplasms sodium arsenite 2.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.2218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.2220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5217306315 15276417
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5216540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.882563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms sodium arsenite 6.0719524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.257505956
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6217306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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