AutismKB 2.0

Annotation Detail for TDO2


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Basic Information Top
Gene Symbol:TDO2 ( TDO,TPH2,TRPO )
Gene Full Name: tryptophan 2,3-dioxygenase
Band: 4q32.1
Quick LinksEntrez ID:6999; OMIM: 191070; Uniprot ID:T23O_HUMAN; ENSEMBL ID: ENSG00000151790; HGNC ID: 11708
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
NADSYN-PWYNAD biosynthesis II (from tryptophan)
PWY-5651tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
TRYPTOPHAN-DEGRADATION-1tryptophan degradation III (eukaryotic)
Pathway IDPathway Name
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
bipolar disorder
PSYCH
schizophrenia
speech perception in dyslexia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TDO2 mRNAaffects expression 17366322
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TDO2 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of TDO2 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TDO2 mRNAaffects expression 16483693
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of TDO2 mRNAincreases expression 19925653
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene affects the expression of TDO2 mRNAaffects expression 18539377
D012721 Carbaryl Carbaryl results in decreased activity of TDO2 proteindecreases activity 2547861
D012721 Carbaryl Carbaryl results in decreased activity of TDO2 proteindecreases activity 2119399
D016572 Cyclosporine Cyclosporine results in decreased expression of TDO2 mRNAdecreases expression 20106945
D002945 Cisplatin Cisplatin results in increased expression of TDO2 mRNAincreases expression 15471895
15464296
D004041 Dietary Fats Dietary Fats results in decreased expression of TDO2 mRNAdecreases expression 15238619
D004117 Dimethoate Dimethoate results in decreased activity of TDO2 proteindecreases activity 2547861
D004298 Dopamine [Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopaminedecreases abundance|decreases activity 16952380
D004298 Dopamine [Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopaminedecreases abundance|decreases activity 16952380
D004958 Estradiol Estradiol results in decreased expression of TDO2 mRNAdecreases expression 20106945
D000431 Ethanol Ethanol results in decreased expression of TDO2 mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TDO2 mRNAaffects cotreatment|increases expression 17942748
C056933 fumonisin B1 fumonisin B1 results in decreased expression of TDO2 mRNAdecreases expression 16221962
D006418 Heme Heme promotes the reaction [pyridine results in increased activity of TDO2 protein]increases activity|increases reaction 10413312
D012701 Serotonin [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonindecreases activity|increases abundance 16952380
D012701 Serotonin [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonindecreases activity|increases abundance 16952380
D008550 Melatonin [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonindecreases activity|increases abundance 16952380
D026023 Permethrin Permethrin results in decreased activity of TDO2 proteindecreases activity 2547861
C006253 pirinixic acid pirinixic acid results in increased expression of TDO2 mRNAincreases expression 18445702
D011374 Progesterone Progesterone results in increased expression of TDO2 mRNAincreases expression 18070364
C023666 pyridine Heme promotes the reaction [pyridine results in increased activity of TDO2 protein]increases activity|increases reaction 10413312
C009250 sevoflurane sevoflurane affects the expression of TDO2 mRNAaffects expression 15967596
D013467 Sulindac Sulindac results in decreased activity of TDO2 proteindecreases activity 16952380
D013467 Sulindac [Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopaminedecreases abundance|decreases activity 16952380
D013467 Sulindac [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonindecreases activity|increases abundance 16952380
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TDO2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TDO2 mRNAaffects cotreatment|increases expression 17942748
D014046 Tolmetin Tolmetin results in decreased activity of TDO2 proteindecreases activity 16952380
D014046 Tolmetin [Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopaminedecreases abundance|decreases activity 16952380
D014046 Tolmetin [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonindecreases activity|increases abundance 16952380
D014046 Tolmetin [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonindecreases activity|increases abundance 16952380
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.2914745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.7718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 9.7718287403
MESH:D000138 Acidosis Ethanol 9.7711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D058186 Acute Kidney Injury Cisplatin 13.7512690470 17670903 15814532
MESH:D058186 Acute Kidney Injury Sulindac 13.757897758
MESH:D058186 Acute Kidney Injury Tolmetin 13.756375363
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Cisplatin 9.7817638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 9.7811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7814692618
MESH:D000230 Adenocarcinoma Sulindac 9.7811910360
MESH:D000236 Adenoma Melatonin 7.2017195641
MESH:D000236 Adenoma Sulindac 7.2010223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2016835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4211535846 11874996 16460482 15623613 19003578 17611924 12394442
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1115451040 15451039
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D000853 Anophthalmos Ethanol 4.6115513904
MESH:D001008 Anxiety Disorders Ethanol 3.8411141031
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6220041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 9.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.7519698954 18651412
MESH:D001321 Autistic Disorder marker/mechanism 14755447
MESH:D001321 Autistic Disorder Acetaminophen 2.4518445737
MESH:D001321 Autistic Disorder Melatonin 2.4516897403 16919138
MESH:D001321 Autistic Disorder Serotonin 2.4519221690 17157402 15132762 18062943 18361446 18405062 8570775
MESH:D001778 Blood Coagulation Disorders Amiodarone 14.2119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.2119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6714601052
MESH:D001913 Bowen's Disease Sulindac 5.1411207687
MESH:D001919 Bradycardia Serotonin 5.268112388
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 4.0515665606 15380490 15845082
MESH:D001943 Breast Neoplasms Cisplatin 2.8619526202 18382427
MESH:D001943 Breast Neoplasms Dietary Fats 2.8620435547
MESH:D001943 Breast Neoplasms Estradiol 2.8616675129 17289903 19861407 18497071 14630087 12948864 17261762 17018787
MESH:D001943 Breast Neoplasms Progesterone 2.8616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Sulindac 2.8616642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8620435547
MESH:D002056 Burns Ethanol 4.4416374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002252 Carbon Tetrachloride Poisoning Melatonin 5.1115700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.953084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.9521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 10.9517982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.9516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.9515289165 18788625 15763234
MESH:D006528 Carcinoma, Hepatocellular pyridine 10.9510696769
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9612023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.7618337622 17066447 6189445
MESH:D006332 Cardiomegaly Ethanol 6.4619332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4616120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8215710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8718974383
MESH:D002386 Cataract Acetaminophen 2.4610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1018566989
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.0921254450
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Cyclosporine 12.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4517333356 17110522 16919318 16105132 17681005 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 12.4519176532
MESH:D021081 Chronobiology Disorders Serotonin 6.4817157402
MESH:D002971 Cleft Lip Ethanol 3.4815513904
MESH:D002972 Cleft Palate Ethanol 5.6615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.668697196 15340226 15668235 16354765 12621046
MESH:D003110 Colonic Neoplasms Sulindac 2.8912458338 12902858
MESH:D015179 Colorectal Neoplasms Cisplatin 2.9215273666
MESH:D015179 Colorectal Neoplasms Sulindac 2.9211076880 10666051 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8715451040 11198716 15513904 15451039 19302082 11873399 10194807
MESH:D019465 Craniofacial Abnormalities Permethrin 3.8719861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8710048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact Permethrin 4.8014617103
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.9812861449 17621415
MESH:D003967 Diarrhea Serotonin 4.5710446763 11488427 8112388
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.3511739529 16485898 12153990 16081117 12594235 19164858 19739265 16227642 11743745 2444490 12705907 16177239 10774834 17562736 18071297 19085960 19420014 11834606 12540782 19370779 10915739 12958197 19416960 17522070 10663392 14986274 15619225 14725611 18713872 16109766 11461765 11421492 17906064 16393943 14550746 15968718 12392966 16781746 11529661 19923254 11287661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.3515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.3511566570
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 11.3516221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Cisplatin 7.6712231392 15033597 19839026 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6711462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3018367378
MESH:D004487 Edema pirinixic acid 10.4912083418
MESH:D004487 Edema Serotonin 10.4918841975
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.3617692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.8511473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 14.2916134523
MESH:D004715 Endometriosis Sulindac 14.2915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.299294722 10568697
MESH:D004938 Esophageal Neoplasms Cisplatin 7.1916785472 15173087 17638652 16481741 15464296
MESH:D004938 Esophageal Neoplasms Ethanol 7.1916704527
MESH:D004938 Esophageal Neoplasms Sulindac 7.1912235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver Amiodarone 28.2514986274
MESH:D005234 Fatty Liver Cyclosporine 28.2519224547
MESH:D005234 Fatty Liver Dietary Fats 28.2518296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Ethanol 28.2519236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.2515345470
MESH:D005234 Fatty Liver pirinixic acid 28.2519236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4517920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0915513904 16946407 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.2714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.9219069698
MESH:D005355 Fibrosis Cyclosporine 13.5212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.5218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5220067830
MESH:D005756 Gastritis Acetaminophen 10.4216983495
MESH:D005756 Gastritis Ethanol 10.4215046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8111910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.5815102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.1219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2515464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly Amiodarone 19.0115265979
MESH:D006529 Hepatomegaly fumonisin B1 19.0116221962
MESH:D006529 Hepatomegaly pirinixic acid 19.0118467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.0112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006689 Hodgkin Disease Cisplatin 3.4216200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8316959395 16354765 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 7.2616870215
MESH:D006930 Hyperalgesia Ethanol 7.2618783367
MESH:D006937 Hypercholesterolemia Amiodarone 8.548137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.5421332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4221332399
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3217604070
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D007022 Hypotension Dopamine 4.826740701
MESH:D007037 Hypothyroidism Amiodarone 4.3117991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3517937319
MESH:D007249 Inflammation Dietary Fats 18.5920412841
MESH:D007249 Inflammation Heme 18.5912649161
MESH:D007249 Inflammation Progesterone 18.5915869954
MESH:D007249 Inflammation Sulindac 18.593291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.5912878042 12200463
MESH:D007249 Inflammation Tolmetin 18.593291741
MESH:D007299 Insect Bites and Stings Permethrin 5.6112971516 12749493 15189238
MESH:D007333 Insulin Resistance Dietary Fats 11.5111836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.5116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.5116306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.4512628509 10223192 12663524 12351151 12584176 10213222
MESH:D007417 Intestinal Polyps Sulindac 4.7911245490 12394442
MESH:D007569 Jaw Abnormalities Ethanol 9.4915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9315464296
MESH:D007674 Kidney Diseases Acetaminophen 13.4515629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 13.4512649298 19839026 15190930 18289764 12231392
MESH:D007674 Kidney Diseases Cyclosporine 13.458314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.4515618244
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 11.6715610895
MESH:D007680 Kidney Neoplasms pyridine 11.6710696769
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5811231351
MESH:D007859 Learning Disorders Ethanol 9.3615451040
MESH:D007859 Learning Disorders sevoflurane 9.3619212262
MESH:D007938 Leukemia Permethrin 4.0312937054
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6717676605
MESH:D008064 Lipidoses Amiodarone 3.3615342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.4618296743
MESH:D008103 Liver Cirrhosis Ethanol 6.4615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8918295389
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0912468960
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.4718166357
MESH:D008106 Liver Cirrhosis, Experimental Melatonin 6.4715925388 15298665 16703270
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4712878042
MESH:D008107 Liver Diseases Acetaminophen 4.0612969438 11587558 16611625 16610002 19460945 12587719 19784758 19014921
MESH:D008107 Liver Diseases Sulindac 4.0614986274 16867024
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4417347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0517185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.079163691 18177683 15890375 2125692
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 10.0718177683
MESH:D008113 Liver Neoplasms pirinixic acid 10.0720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.0716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.388603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4211989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.2412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2718516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2314755239
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 8.2311246140 19359593 16337739 19925653 18597497 11696405 15390079
MESH:D008175 Lung Neoplasms Cisplatin 8.236189445 11798837 17225452
MESH:D008175 Lung Neoplasms Melatonin 8.2317195641
MESH:D008175 Lung Neoplasms Sulindac 8.2319359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2319555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Melatonin 3.8516373423
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 9.351500032
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.3516891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.3511408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008545 Melanoma Cisplatin 3.7117023156 11135225 16248763 16809738 17761969 18505091 12883367 12374674 16432458 18176117 15577323 18332650 12393984
MESH:D008545 Melanoma Sulindac 3.7116642371
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008569 Memory Disorders Ethanol 9.3015451040 18411066
MESH:D008569 Memory Disorders sevoflurane 9.3019212262
MESH:D008654 Mesothelioma Cisplatin 3.1617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009181 Mycoses Amiodarone 4.6912754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D009336 Necrosis Melatonin 5.2512195237
MESH:D009369 Neoplasms Cisplatin 4.7616773208
MESH:D009369 Neoplasms pirinixic acid 4.7617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009395 Nephritis, Interstitial Cisplatin 10.7015464296
MESH:D009395 Nephritis, Interstitial Tolmetin 10.706375363
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.7916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7914600291
MESH:D009447 Neuroblastoma Cisplatin 3.348761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.4518514411
MESH:D019636 Neurodegenerative Diseases Sulindac 13.4516850258 17266991
MESH:D019636 Neurodegenerative Diseases Tolmetin 13.4516850258 17266991
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.498761367
MESH:D009765 Obesity Dietary Fats 4.2518674790 21332399 19632207 17217161 20132043 11836018 20518802 18457598 16723640
MESH:D009765 Obesity pirinixic acid 4.2520558911
MESH:D010051 Ovarian Neoplasms Cisplatin 7.5715464296 6897625 17225452 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 7.5719401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.5716525653 17393432
MESH:D010146 Pain Acetaminophen 10.6616870215
MESH:D010146 Pain Sulindac 10.663291741
MESH:D010146 Pain Tolmetin 10.663291741
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.4319003803
MESH:D010190 Pancreatic Neoplasms Ethanol 8.4312384795
MESH:D010190 Pancreatic Neoplasms Sulindac 8.4311504793 16820089
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D020734 Parkinsonian Disorders Melatonin 4.8515574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1115464296
MESH:D010538 Peritonitis Melatonin 5.1115707874
MESH:D010997 Pleural Neoplasms Cisplatin 5.1317638057
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.9511893704
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1416740699
MESH:D011507 Proteinuria Tolmetin 5.776375363
MESH:D011537 Pruritus Ethinyl Estradiol 3.1016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7711597910 12490602 12832656
MESH:D051437 Renal Insufficiency Cisplatin 4.2015464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2314601052
MESH:D012640 Seizures Ethanol 3.039754883
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8718724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9516192470
MESH:D012893 Sleep Disorders Melatonin 5.2518182647 16897403 16919138
MESH:D020178 Sleep Disorders, Circadian Rhythm Melatonin 6.4218078449 19452292
MESH:D007319 Sleep Initiation and Maintenance Disorders Melatonin 5.0418078449
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1315464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0715862959 16503802
MESH:D013274 Stomach Neoplasms Cisplatin 2.7617522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Ethanol 2.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 11.2118087811
MESH:D013276 Stomach Ulcer Ethanol 11.2116755016 17918041 9211565 9562338 11906479 17189318
MESH:D013276 Stomach Ulcer Melatonin 11.2111523592 12500499 16150113
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.079754883
MESH:D013610 Tachycardia Amiodarone 4.0911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9919225199
MESH:D013736 Testicular Neoplasms Cisplatin 4.4315464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Amiodarone 11.3419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.3412697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.6519584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D016171 Torsades de Pointes Amiodarone 3.9811989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 2.8712973940 15464296 17225452
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.0216803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0014692618
MESH:D014594 Uterine Neoplasms Sulindac 9.0018645019
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4015577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014839 Vomiting Cisplatin 4.5111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Dietary Fats 3.5616723640
MESH:D014947 Wounds and Injuries Heme 5.1212649161
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00380 Tryptophan metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36427
    • No data
    No data
    Releated drug ID Related drug Name
    PA10090l-glutamine
    PA448055l-alanine
    PA10323l-tryptophan
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00150 - L-Tryptophan Dietary supplement;Micronutrient;Essential Amino Acids;Antidepressive Agents, Second-Generation
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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