AutismKB 2.0

Annotation Detail for ACTC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACTC1 ( ACTC,ASD5,CMD1R,CMH11,LVNC4 )
Gene Full Name: actin, alpha, cardiac muscle 1
Band: 15q14
Quick LinksEntrez ID:70; OMIM: 102540; Uniprot ID:ACTC_HUMAN; ENSEMBL ID: ENSG00000159251; HGNC ID: 143
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
No data
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Cardiac diseases
H00294Dilated cardiomyopathy (DCM)
H00292Hypertrophic cardiomyopathy (HCM)
Desease IDDesease Name
1832Congenital abnormality
1975Congenital heart disease
1849Myopathies, Nemaline
No data
No data
Desease Name
Cardiomyopathy, familial hypertrophic, 11
Cardiomyopathy, dilated, 1R
Left ventricular noncompaction 4
Atrial septal defect 5
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in increased expression of ACTC1 mRNAincreases expression 17327690
D000082 Acetaminophen Acetaminophen affects the expression of ACTC1 mRNAaffects expression 17562736
D000171 Acrolein Acrolein affects the metabolism of ACTC1 proteinaffects metabolic processing 17921335
C095105 bexarotene bexarotene results in increased expression of ACTC1 mRNAincreases expression 16648578
C487049 BXL628 BXL628 results in decreased expression of ACTC1 mRNAdecreases expression 16003237
D002330 Carmustine Carmustine results in decreased expression of ACTC1 mRNAdecreases expression 15980968
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTC1 mRNAaffects cotreatment|decreases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTC1 mRNA]affects cotreatment|decreases expression|increases reaction 16054899
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ACTC1 mRNAaffects expression 17555576
D005492 Folic Acid Folic Acid affects the expression of ACTC1 mRNAaffects expression 17320366
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTC1 mRNAaffects cotreatment|decreases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTC1 mRNA]affects cotreatment|decreases expression|increases reaction 16054899
D008713 Methimazole Methimazole results in increased expression of ACTC1 mRNAincreases expression 17403546
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of ACTC1 mRNA]decreases expression|decreases reaction 19615344
C091888 monoisoamyl-2,3-dimercaptosuccinate monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of ACTC1 mRNAdecreases expression 19615344
C029938 nickel sulfate nickel sulfate results in decreased expression of ACTC1 mRNAdecreases expression 16100012
D010126 Ozone Ozone results in decreased expression of ACTC1 mRNAdecreases expression 12763052
C494474 perchlorate perchlorate results in increased expression of ACTC1 mRNAincreases expression 17403546
C006253 pirinixic acid pirinixic acid results in increased expression of ACTC1 mRNAincreases expression 17951219
D011441 Propylthiouracil Propylthiouracil results in increased expression of ACTC1 mRNAincreases expression 17403546
D011794 Quercetin Quercetin results in increased expression of ACTC1 proteinincreases expression 18095365
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTC1 mRNAaffects cotreatment|decreases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTC1 mRNA]affects cotreatment|decreases expression|increases reaction 16054899
C017947 sodium arsenite monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of ACTC1 mRNA]decreases expression|decreases reaction 19615344
C017947 sodium arsenite sodium arsenite results in decreased expression of ACTC1 mRNAdecreases expression 19615344
D013629 Tamoxifen Tamoxifen affects the expression of ACTC1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ACTC1 mRNA]affects cotreatment|decreases expression|increases reaction 16054899
D015032 Zinc Zinc results in decreased expression of ACTC1 mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of ACTC1 mRNAdecreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6811752688 14514962 15322242
MESH:D000138 Acidosis Zinc Sulfate 4.737265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D000169 Acrodermatitis Zinc 5.2316889938 17190629 17202136
MESH:D058186 Acute Kidney Injury Folic Acid 4.1717003819 16595132 16316344
MESH:D055371 Acute Lung Injury Acrolein 14.4820525806 21297076
MESH:D055371 Acute Lung Injury nickel sulfate 14.4819131640 12718980 11954676 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 14.4818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7714692618
MESH:D000236 Adenoma Folic Acid 3.7016963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7317306315 16712894
MESH:D000544 Alzheimer Disease Acrolein 12.2014715435 17570602 15207723
MESH:D000544 Alzheimer Disease Folic Acid 12.2017116317
MESH:D000544 Alzheimer Disease Ozone 12.2015513908
MESH:D000544 Alzheimer Disease rosiglitazone 12.2019621015
MESH:D000544 Alzheimer Disease Zinc 12.2016580781 16325427 17119284 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0817084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.7316916123
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D000860 Anoxia Zinc Sulfate 4.857265320
MESH:D001161 Arteriosclerosis Acrolein 9.7515014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7511256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.0317659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0315885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 5.0017854713 16373670
MESH:D001249 Asthma Zinc 5.0017085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8015336622
MESH:D050197 Atherosclerosis Acrolein 3.8816037261 16126721 17363696
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001327 Autoimmune Diseases Quercetin 4.2419761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.4519483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 14.4519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.4512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001930 Brain Injuries Zinc 4.5217109824
MESH:D001932 Brain Neoplasms Carmustine 4.2416187019
MESH:D001943 Breast Neoplasms bexarotene 2.3116818667 16344269
MESH:D001943 Breast Neoplasms Folic Acid 2.3116777985
MESH:D001943 Breast Neoplasms Quercetin 2.3118628248
MESH:D001943 Breast Neoplasms Tamoxifen 2.3119487384 20859285 15565566 17242785 19189210 19066611 21138602 19288272 19189212 20065188 17049068 19289846 18855134 17261762 17893378 21152245 20544844 19200415 19221464 18821012 19084267 18997820 18351453 20005174 19115204 18984771 18815881 16818667 17440819 20390343 16873071 18425577 19410462 19244106 19011961 20135344 15668708 19142967 16202921 19059307 11161223 19155303 18629630 16273361 19103187
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5418417511 14754758 15516495 19059883 18315731 17626835 16777450
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002105 Cadmium Poisoning Quercetin 5.3716962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.353084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.3512508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.3517306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.3516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1716247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7817234771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7418572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.7416543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4617572228
MESH:D006332 Cardiomegaly Quercetin 6.4919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4916120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
OMIM:192600 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1 marker/mechanism
OMIM:612098 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 11 marker/mechanism
MESH:D002318 Cardiovascular Diseases Folic Acid 7.4316755160
MESH:D002318 Cardiovascular Diseases Zinc 7.4316936243
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.8720056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3217110522 16919318 15861022 17681005 11677210 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 7.3219176532
MESH:D002971 Cleft Lip Folic Acid 3.8921254359
MESH:D002972 Cleft Palate Folic Acid 5.8621254359 8946559
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8615340226 16354765 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 3.8915824018
MESH:D003110 Colonic Neoplasms Quercetin 3.8919440933 17191121 17148506 19056647 15741050 11134977 16640504
MESH:D015179 Colorectal Neoplasms Acrolein 3.6317597105
MESH:D015179 Colorectal Neoplasms Folic Acid 3.6317116713 16963246 17245555 16985020 17087956
MESH:D015179 Colorectal Neoplasms Quercetin 3.6318095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.7917728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 3.7919302082
MESH:D003556 Cystitis Acrolein 5.2212161096
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.8112438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.8111298694 16823706 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003920 Diabetes Mellitus rosiglitazone 9.1017446233
MESH:D003920 Diabetes Mellitus Zinc 9.1016479319
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5919496084
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 7.0416886840
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.0412642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0417107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3319279558
MESH:D003967 Diarrhea Dexamethasone 3.537237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.3911743745 19420014 11461765 12153990 17906064 12540782 16177239 14550746 19739265 15619225 11739529 10774834 16781746 10663392 14725611 12392966 19085960 11529661 12705907 12594235 11287661 16393943 10915739 11421492 19416960 11834606 18713872 17522070 15968718 16485898 18071297 17562736 16227642 19923254 14986274 12958197 16109766 19164858 2444490 16081117 19370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004485 Eczema Dexamethasone 4.2912438553
MESH:D004487 Edema Dexamethasone 15.1919703484
MESH:D004487 Edema pirinixic acid 15.1912083418
MESH:D004487 Edema rosiglitazone 15.1912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.1912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3919031437
MESH:D016889 Endometrial Neoplasms Folic Acid 7.4017301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.4016202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8710568697 9294722
MESH:D004938 Esophageal Neoplasms Zinc 2.8216543248
MESH:D017889 Exfoliation Syndrome Folic Acid 5.3216504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.5015345470
MESH:D005234 Fatty Liver pirinixic acid 17.5019236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 17.5019196556
MESH:D005234 Fatty Liver Tamoxifen 17.5019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Quercetin 8.2019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.2020067830
MESH:D005756 Gastritis Acetaminophen 18.1216983495
MESH:D005756 Gastritis Folic Acid 18.1217171786
MESH:D005756 Gastritis Zinc 18.1217241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5116452187
MESH:D005901 Glaucoma Folic Acid 4.9216504073
MESH:D005909 Glioblastoma Carmustine 7.2316187019
MESH:D005909 Glioblastoma Quercetin 7.2319804834
MESH:D005910 Glioma Quercetin 2.9917643826
MESH:D006042 Goiter perchlorate 5.1418801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006130 Growth Disorders Zinc 3.8517217573
MESH:D006330 Heart Defects, Congenital Folic Acid 6.5716524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.8020558911
MESH:D006333 Heart Failure Zinc 6.8017162251
MESH:D006335 Heart Injuries Zinc 5.6017074742
MESH:D006344 Heart Septal Defects, Atrial marker/mechanism
MESH:D016481 Helicobacter Infections Zinc 4.3717241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006527 Hepatolenticular Degeneration Zinc 10.7517276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.7517063115
MESH:D006529 Hepatomegaly pirinixic acid 7.7019176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7015340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.017520565
MESH:D006679 HIV Seropositivity Folic Acid 5.3217209195
MESH:D006689 Hodgkin Disease sodium arsenite 3.0112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8718606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.4316870215
MESH:D006930 Hyperalgesia rosiglitazone 7.4312083418
MESH:D006943 Hyperglycemia pirinixic acid 8.7420558911
MESH:D006943 Hyperglycemia Quercetin 8.7418262572 11834736
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.3516755160 16397167 16433478 16395265 16865747
MESH:D006973 Hypertension Dexamethasone 8.3117042910
MESH:D006973 Hypertension Quercetin 8.3118356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3118670907 18850075
MESH:D006980 Hyperthyroidism Methimazole 5.4514678291
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.317265320
MESH:D007037 Hypothyroidism Methimazole 11.3818031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.388137927 18031379
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.2718306037
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2617937319
MESH:D007248 Infertility, Male sodium arsenite 6.2612646999 15346721
MESH:D007249 Inflammation Dexamethasone 11.2711099482 8960868
MESH:D007249 Inflammation rosiglitazone 11.2712083418
MESH:D007249 Inflammation Tamoxifen 11.2719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2712878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.3416624496
MESH:D007333 Insulin Resistance pirinixic acid 7.1316306350
MESH:D007333 Insulin Resistance rosiglitazone 7.1316306350
MESH:D007511 Ischemia Zinc 4.4616584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.2718306037
MESH:D007627 Keloid Quercetin 4.7817086741
MESH:D007674 Kidney Diseases Acetaminophen 18.0512587719 15629191
MESH:D007674 Kidney Diseases Acrolein 18.0512488133
MESH:D007674 Kidney Diseases Quercetin 18.0516962696
MESH:D007674 Kidney Diseases sodium arsenite 18.0520008137
MESH:D007674 Kidney Diseases Zinc 18.0516960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.2616518626
MESH:D007680 Kidney Neoplasms Tamoxifen 2.9118625569
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.1215237267
MESH:D007938 Leukemia Quercetin 3.0717468513
MESH:D008064 Lipidoses Tamoxifen 3.0317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.4616718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.4612741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.4615980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4612878042
MESH:D008107 Liver Diseases Acetaminophen 4.1016611625 12587719 12969438 16610002 19014921 19784758 11587558 19460945
MESH:D008107 Liver Diseases Folic Acid 4.1016877991
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0817185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 13.5420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 13.5418980244
MESH:D008113 Liver Neoplasms sodium arsenite 13.5415276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 13.5416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.5416984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 5.5719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5712151625
MESH:D008171 Lung Diseases Acrolein 11.8511504702
MESH:D008171 Lung Diseases Ozone 11.858266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 11.8519095001
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms bexarotene 10.3817849452
MESH:D008175 Lung Neoplasms Dexamethasone 10.3815824018 11195469
MESH:D008175 Lung Neoplasms Ozone 10.387614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 10.3816280456
MESH:D008175 Lung Neoplasms sodium arsenite 10.3815276417 16712894 17077188 19931552 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 10.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3819555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2917718048
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9811161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 13.4619196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 13.4616827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.4611731420 19196723 14580682 16827153 19196722
MESH:D008325 Mammary Neoplasms, Experimental Zinc 13.4612773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.3819453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5216832597
MESH:D008545 Melanoma Carmustine 5.0412393984
MESH:D008545 Melanoma sodium arsenite 5.0416487513 19082730
MESH:D008545 Melanoma Tamoxifen 5.0412393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.4119513568
MESH:D008546 Melanoma, Experimental Acrolein 10.4110803710
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2317261469
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D009101 Multiple Myeloma Dexamethasone 3.3815867202 16118317 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.449809623
MESH:D009203 Myocardial Infarction pirinixic acid 5.4919151258
MESH:D009203 Myocardial Infarction Quercetin 5.4919595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0016411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.0019207477
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Acrolein 11.2317329238
MESH:D009369 Neoplasms pirinixic acid 11.2317405874
MESH:D009369 Neoplasms Quercetin 11.2315185748
MESH:D009369 Neoplasms sodium arsenite 11.2311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5020056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.3619196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.3619189210 19196722 19200415
MESH:D009393 Nephritis Acrolein 6.1112653641
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0514600291
MESH:D009436 Neural Tube Defects Folic Acid 7.2717438019
MESH:D009436 Neural Tube Defects sodium arsenite 7.2712854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1518514411
MESH:D019636 Neurodegenerative Diseases Acrolein 8.1511342003
MESH:D020078 Neurogenic Inflammation Quercetin 4.2017929310
MESH:D009503 Neutropenia Folic Acid 4.3416322990
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0619495926
MESH:D010051 Ovarian Neoplasms Quercetin 4.8519005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8515276417 17306315
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.7916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010300 Parkinson Disease Acrolein 3.5317690948
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D010787 Photosensitivity Disorders Acrolein 5.5711550810
MESH:D011014 Pneumonia Ozone 4.2218929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Quercetin 3.8319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4521297632
MESH:D011225 Pre-Eclampsia Zinc 4.0417114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211222880 11118676 11896295 11399792
MESH:D011470 Prostatic Hyperplasia BXL628 6.3515572423 16957418
MESH:D011471 Prostatic Neoplasms Quercetin 2.1514715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1516039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1515067354
MESH:D011471 Prostatic Neoplasms Zinc 2.1516700911 16606632 12429649 16517595
MESH:D011537 Pruritus Ethinyl Estradiol 3.1416919318 15861022
MESH:D012030 Refractive Errors marker/mechanism 20835239
MESH:D051437 Renal Insufficiency Acrolein 10.2412732208
MESH:D051437 Renal Insufficiency Folic Acid 10.2415728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8618379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012162 Retinal Degeneration Zinc 4.0016584753
MESH:D012554 Schistosomiasis japonica Quercetin 5.3716862918
MESH:D012559 Schizophrenia Folic Acid 2.8716641680
MESH:D012871 Skin Diseases Folic Acid 3.2118709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.3319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3216361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6612854658
MESH:D013272 Stomach Diseases Dexamethasone 4.1515472012
MESH:D013274 Stomach Neoplasms Folic Acid 2.6917171786
MESH:D013276 Stomach Ulcer Dexamethasone 3.3415138204
MESH:D020521 Stroke Acrolein 8.8316269634
MESH:D020521 Stroke Folic Acid 8.8316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.5515710170
MESH:D014062 Tongue Neoplasms Zinc 4.2516543248
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.0016720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.0016452187 16712894 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.0017572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6211813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014605 Uveitis Dexamethasone 4.641336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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