AutismKB 2.0

Annotation Detail for TEC


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Basic Information Top
Gene Symbol:TEC ( MGC126760,MGC126762,PSCTK4 )
Gene Full Name: tec protein tyrosine kinase
Band: 4p12-p11
Quick LinksEntrez ID:7006; OMIM: 600583; Uniprot ID:TEC_HUMAN; ENSEMBL ID: ENSG00000135605; HGNC ID: 11719
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200157EPO signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TEC mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TEC mRNAincreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TEC mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of TEC mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TEC mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TEC mRNAaffects cotreatment|increases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TEC mRNAaffects cotreatment|increases expression 20360939
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TEC mRNAaffects cotreatment|increases expression 17183730
C029938 nickel sulfate nickel sulfate results in decreased expression of TEC mRNAdecreases expression 16100012
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of TEC mRNAaffects expression 17651324
C006253 pirinixic acid pirinixic acid results in increased expression of TEC mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TEC mRNAdecreases expression 19933214
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TEC mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7014514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury nickel sulfate 9.4412718980 11954676 16100012 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 9.4418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.823712494
MESH:D000236 Adenoma Diethylnitrosamine 6.8210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.9917620307 19061943 17162532 19052882 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.9916835633
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517688650 15238991 17507914 18775368 20603192 17157402 18316065 16609825 19232924 18396377 18177632 18985861 19460635 18940202 18558336
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1117594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.657296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.653084413 19919837 16807293 20514400 20512989 16502159 11831363 16569478 20524982 18971187 3581430 20214788 20101231 16878318 18785209 16328049 17162532 19418558 17138121 18691550 20084675 19052882 18506893 20727157 21159647 19208518 16698587 10672840 19171122 18056438 20007298 16681979 19519916 10737359 18393292 18665156 16830150 16935385 19335982 18210153 19822196 18788625 19701751 20432363 18494052 17055752 16288022 16540662 16779866 19539802 19394651 20935162 17761372 17978847 18978308 17173139 19107877 19383236 17428255
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.516135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.517505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.5121159647 7505956 2727394 17174075
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.049022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.0419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15340226 15668235 12621046 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.508888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.498970840 12868966 11298694 2524372 11906362 18759878 14531868 8156756
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.4911298694 16823706 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.579328219 6679447 8291058 7440962 18692083 16192314 6482804 18648102 11289319 9022650 1440618 9653073 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5711529661 12594235 11461765 16227642 14550746 15619225 14725611 16109766 11743745 14986274 12540782 17522070 18713872 2444490 19416960 17562736 10663392 11421492 11739529 19739265 16781746 11287661 12153990 16081117 10774834 19420014 16393943 19370779 12958197 19085960 15968718 17906064 12392966 18071297 16177239 12705907 10915739 16485898 19923254 11834606 19164858
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.5720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.571733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.263659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.667562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5921071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 13.5920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.5914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2318558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6116120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 16354765 16959395 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007249 Inflammation Diethylnitrosamine 5.0318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6610783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3915629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.3915369732
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.596582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0416766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8719638242 18407596 18665156 20032147 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 3.9711587558 19784758 16610002 16611625 12587719 12969438 19014921 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.917678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.9119551842 9163691 20501860 19833225 20118626 2862719 2422723 18644402 18977376 19638242 19254457 21278145 20101389 19642983 18754104 21047994 18648771 21071580 15175105 21167192 19294768 20405173 18978307 19427195 19090486 12112319 19812893 20137499 19499222 19073162 20583210 15885732 19426721 10737359 19996281 19255062 16942905 20452335 20492335 19256749 12771043 19850985 20434301 19690152
MESH:D008113 Liver Neoplasms pirinixic acid 10.9120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.516135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.511399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5119539802 18079962 2563599 18308698 19009564 18775883 17174075 3124819 19004024 16842330 19519916 18164116 16267830 18282651 18093689 18544905 17942915 19126423 17854601 9362446 18253720 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5112151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2820970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2518803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.803581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.803581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.436679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.4316359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.144026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8611118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.8620603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.6712752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1218551238
MESH:D012640 Seizures Valproic Acid 6.1211044598 14763951 15475178 16876388 17978042 11738929 3137016 1511512
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.333712494 1399818 7505956 6582329 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.337505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.118074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36436
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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