AutismKB 2.0

Annotation Detail for TEF


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Basic Information Top
Gene Symbol:TEF ( KIAA1655 )
Gene Full Name: thyrotrophic embryonic factor
Band: 22q13.2
Quick LinksEntrez ID:7008; OMIM: 188595; Uniprot ID:TEF_HUMAN; ENSEMBL ID: ENSG00000167074; HGNC ID: 11722
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TEF mRNAdecreases expression 19933214
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TEF mRNAincreases expression 16788091
C111855 6-formylindolo(3,2-b)carbazole 6-formylindolo(3,2-b)carbazole results in increased expression of TEF mRNAincreases expression 19799885
D000638 Amiodarone Amiodarone results in increased expression of TEF mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TEF mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TEF mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TEF mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of TEF mRNAdecreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TEF mRNAdecreases expression 17606305
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TEF mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TEF mRNAaffects cotreatment|increases expression 17942748
D010634 Phenobarbital Phenobarbital results in increased expression of TEF mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TEF mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of TEF mRNAincreases expression 17426115
C025299 polyphenols polyphenols results in decreased expression of TEF mRNAdecreases expression 16293270
C009250 sevoflurane sevoflurane affects the expression of TEF mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TEF mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TEF mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of TEF mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5711752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma beta-Naphthoflavone 6.9819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 25.6118056438 16434500 17620307 17162532 19052882 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 25.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 25.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 25.6116835633
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8520041841 18057881 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.9419698954 18651412
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 22.4419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 22.4419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 22.4412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 22.4416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8316873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6516502159 17173139 16830150 17978847 21159647 11831363 10737359 17761372 16878318 20524982 20727157 19052882 16698587 19539802 20512989 19171122 17428255 19701751 20514400 19519916 16779866 18393292 16328049 3084413 18494052 19394651 18665156 19208518 18971187 16288022 18056438 16807293 16935385 18210153 20432363 20084675 19383236 17138121 20101231 18785209 18788625 18506893 20935162 18691550 17055752 19822196 19107877 20214788 19919837 16569478 19335982 3581430 20007298 16540662 10672840 19418558 17162532 18978308 16681979
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6517173139 6705139 1701930 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.651917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3016051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9115710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1718974383
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.8921159647 7505956 2727394 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8817333356 16919318 17110522 17681005 15861022 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 7.8819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315340226 8697196 15668235 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms polyphenols 2.6816293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4616925845 9224671 9211117 14991402 9125849 9142499 9664655 17551590 10589399 8800419
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.1515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1519107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.1519370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.973922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.979664655 16938888
MESH:D005234 Fatty Liver Amiodarone 19.2414986274
MESH:D005234 Fatty Liver Diethylnitrosamine 19.2421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.2415345470
MESH:D005234 Fatty Liver pirinixic acid 19.2419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8620067830
MESH:D005355 Fibrosis Tretinoin 8.8617994277
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6214991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Amiodarone 21.3215265979
MESH:D006529 Hepatomegaly Phenobarbital 21.3216109766
MESH:D006529 Hepatomegaly pirinixic acid 21.3218467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.3215340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.939751232 8137927
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.5917991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Diethylnitrosamine 8.5218785209
MESH:D007249 Inflammation polyphenols 8.5216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1217551590 15992940
MESH:D007859 Learning Disorders sevoflurane 4.8419212262
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1919075265 17107899 19035177 16766008 19225113 17217047 19029980 15748426 17294898 16140955 17649720 16331271 17301526 17712046 12679006 17368321 16823087 17339181 16788101 17506722 9834237 16891316 16935935 17361223 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008064 Lipidoses Amiodarone 3.5517567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7418665156 18522880 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7421047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4316248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7217034775
MESH:D008107 Liver Diseases Phenobarbital 6.7219363144
MESH:D008107 Liver Diseases polyphenols 6.7216698588
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.4519389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.4519499222 20101389 20137499 19427195 15175105 19090486 20405173 18978307 19426721 20583210 21278145 20501860 18644402 18977376 18754104 19073162 19812893 19833225 20492335 19254457 20452335 19551842 10737359 20118626 19638242 15885732 12771043 2422723 12112319 21047994 19690152 19256749 21167192 21071580 19642983 9163691 19294768 19996281 16942905 19255062 19850985 20434301 18648771 2862719
MESH:D008113 Liver Neoplasms Phenobarbital 14.4519482888 8742319 19812893 21047994 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.4520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4516984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.4118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.419362446 18775883 16842330 18164116 18282651 18079962 19519916 17942915 19539802 18253720 18093689 18544905 21159647 19126423 19004024 16267830 18308698 19009564 17174075 17854601 2563599 3124819
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.416150874 17172636 2563599 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6217391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5818516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2720512841 6695378 20970405 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2719555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008569 Memory Disorders sevoflurane 4.8119212262
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009181 Mycoses Amiodarone 5.0012754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009369 Neoplasms Tretinoin 4.9916594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3616936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.7216540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.7216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.252563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11118676 11399792 11222880
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8712832656 11597910 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616283617 16116481
MESH:D012640 Seizures Phenobarbital 2.734039156 11442880 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1718724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4318456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4317261132
MESH:D013276 Stomach Ulcer Amiodarone 3.3718087811
MESH:D013610 Tachycardia Amiodarone 4.3511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2519225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.3517997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Amiodarone 12.3819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.3812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.227505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.221399818
MESH:D013964 Thyroid Neoplasms Tretinoin 12.2217045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.9319584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D016171 Torsades de Pointes Amiodarone 4.2711989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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