Gene Symbol:	TF ( DKFZp781D0156,PRO1557,PRO2086 )
Gene Full Name:	transferrin
Band:	3q22.1
Quick Links	Entrez ID:7018; OMIM: 190000; Uniprot ID:TRFE_HUMAN; ENSEMBL ID: ENSG00000091513; HGNC ID: 11740
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
200172	HIF-1-alpha transcription factor network
200041	EPHB forward signaling

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene results in decreased expression of TF mRNA	decreases expression	16917068
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of TF protein	decreases activity	19238537
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane results in decreased expression of TF mRNA	decreases expression	16192472
C497286	3,4',5-trimethoxystilbene	3,4',5-trimethoxystilbene analog inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TF protein	affects expression	20106945
C061621	alpha-naphthyl isocyanate	alpha-naphthyl isocyanate affects the expression of TF protein	affects expression	16099942
D000535	Aluminum	Aluminum binds to TF protein	affects binding	12627980
D000535	Aluminum	TF protein binds to Aluminum	affects binding	11193083
D000535	Aluminum	TF protein binds to [Aluminum co-treated with Iron]	affects binding\|affects cotreatment	11193083
D000535	Aluminum	TF protein binds to and results in increased uptake of Aluminum	affects binding\|increases uptake	10978387
D000535	Aluminum	[TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein	affects binding\|decreases secretion\|increases uptake	10978387
D000535	Aluminum	TF protein binds to Aluminum	affects binding	15149824
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of TF mRNA	affects cotreatment\|decreases expression	17639512
D016589	Astemizole	Astemizole results in decreased expression of TF mRNA	decreases expression	20221588
D001280	Atrazine	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of TF mRNA	affects cotreatment\|increases expression	16532367
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TF mRNA	increases expression	20440473
C095105	bexarotene	bexarotene results in increased expression of TF mRNA	increases expression	16648578
C032036	bromobenzene	bromobenzene results in decreased expression of TF mRNA	decreases expression	12628495
D002104	Cadmium	Cadmium results in increased expression of TF mRNA	increases expression	20067845
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of TF mRNA	increases expression	11566570
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of TF mRNA	affects expression	15963342
D003345	Corticosterone	Corticosterone results in increased expression of TF mRNA	increases expression	15755911
D003474	Curcumin	Curcumin results in increased expression of TF mRNA	increases expression	15713895
D016572	Cyclosporine	Cyclosporine results in decreased expression of TF mRNA	decreases expression	20106945
D003907	Dexamethasone	Dexamethasone results in increased expression of TF protein	increases expression	15965953
C004717	diacetylmonoxime	diacetylmonoxime results in decreased uptake of TF protein	decreases uptake	16563724
D002945	Cisplatin	Cisplatin binds to TF protein	affects binding	16773208
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of TF mRNA	decreases expression	20360939
D004237	Diuron	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of TF mRNA	affects cotreatment\|increases expression	16532367
D004958	Estradiol	Estradiol results in decreased expression of TF mRNA	decreases expression	11254367
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TF mRNA	decreases expression	17108234
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TF mRNA	increases expression	12655037 17351261
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TF mRNA	decreases expression	17157075
C000499	ferric oxide	ferric oxide results in increased expression of TF mRNA	increases expression	16428268
C049051	ferric pyrophosphate	[ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein	affects cotreatment\|increases expression	16772442
D005708	Gallium	Gallium analog binds to TF protein	affects binding	16938349
D005708	Gallium	[TF protein binds to Gallium] which binds to TFRC protein	affects binding	16988841
D005708	Gallium	TF protein results in increased uptake of Gallium	increases uptake	16988841
D018684	Glycine Agents	Glycine Agents results in increased expression of TF mRNA	increases expression	16532367
D017127	Glycosylation End Products, Advanced	Glycosylation End Products, Advanced results in increased expression of and results in increased activity of TF protein	increases activity\|increases expression	16872585
D017127	Glycosylation End Products, Advanced	Glycosylation End Products, Advanced results in increased expression of TF mRNA	increases expression	16872585
D017127	Glycosylation End Products, Advanced	phenylmethylpyrazolone inhibits the reaction [Glycosylation End Products, Advanced results in increased expression of and results in increased activity of TF protein]	decreases reaction\|increases activity\|increases expression	16872585
D017127	Glycosylation End Products, Advanced	phenylmethylpyrazolone inhibits the reaction [Glycosylation End Products, Advanced results in increased expression of TF mRNA]	decreases reaction\|increases expression	16872585
D006220	Haloperidol	Haloperidol results in decreased expression of TF mRNA	decreases expression	17177202
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of TF mRNA	increases expression	15159207
C113661	imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)	imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) binds to TF protein	affects binding	16773208
D007455	Iodine	[ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein	affects cotreatment\|increases expression	16772442
D007501	Iron	[CP protein co-treated with TF protein] results in increased export of Iron	affects cotreatment\|increases export	16806171
D007501	Iron	CP protein promotes the reaction [TF protein binds to Iron]	affects binding\|increases reaction	16806171
D007501	Iron	TF protein results in increased export of Iron	increases export	16806171
D007501	Iron	Iron binds to TF protein	affects binding	16631400
D007501	Iron	Iron binds to TF protein	affects binding	16564538 17266333 16793765
D007501	Iron	[Iron binds to TF protein] which binds to TFRC protein	affects binding	16564538
D007501	Iron	TF protein binds to [Aluminum co-treated with Iron]	affects binding\|affects cotreatment	11193083
D007501	Iron	TF protein binds to and affects the transport of Iron	affects binding\|affects transport	17327678
D007501	Iron	TF protein binds to Iron	affects binding	15214510
D007501	Iron	TF protein results in increased uptake of Iron	increases uptake	16988841
D007501	Iron	Iron binds to TF protein	affects binding	16631400
D007501	Iron	Iron binds to TF protein	affects binding	16631400
C028904	isoproturon	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of TF mRNA	affects cotreatment\|increases expression	16532367
D008070	Lipopolysaccharides	3,4',5-trimethoxystilbene analog inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
D008070	Lipopolysaccharides	Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
D008070	Lipopolysaccharides	rhapontigenin analog inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
D008345	Manganese	Manganese results in increased uptake of TF protein	increases uptake	17469137
C470148	nilestriol	nilestriol results in decreased expression of TF protein	decreases expression	12934402
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of TF mRNA	decreases expression	1359698
C025589	ochratoxin A	ochratoxin A results in increased expression of TF mRNA	increases expression	16251485
D019319	Okadaic Acid	Okadaic Acid results in decreased uptake of TF protein	decreases uptake	16563724
D010126	Ozone	Ozone results in decreased expression of TF mRNA	decreases expression	16716893
D010634	Phenobarbital	Phenobarbital results in increased expression of TF mRNA	increases expression	12082028
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone inhibits the reaction [Glycosylation End Products, Advanced results in increased expression of and results in increased activity of TF protein]	decreases reaction\|increases activity\|increases expression	16872585
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone inhibits the reaction [Glycosylation End Products, Advanced results in increased expression of TF mRNA]	decreases reaction\|increases expression	16872585
C006253	pirinixic acid	pirinixic acid affects the expression of TF protein	affects expression	16099942
C030984	pyrene	pyrene results in decreased expression of TF mRNA	decreases expression	15963578
C030984	pyrene	pyrene results in increased expression of TF mRNA	increases expression	15963578
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of TF mRNA	affects cotreatment\|decreases expression	17639512
D011794	Quercetin	Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
C431126	rhapontigenin	rhapontigenin analog inhibits the reaction [Lipopolysaccharides results in increased activity of TF protein]	decreases reaction\|increases activity	16507316
C017947	sodium arsenite	sodium arsenite affects the expression of TF mRNA	affects expression	17450228
D013629	Tamoxifen	Tamoxifen results in increased expression of TF mRNA	increases expression	17157075
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TF mRNA	decreases expression	15703262
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TF mRNA	increases expression	16267337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TF mRNA	decreases expression	16497791
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TF mRNA	increases expression	15644576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of TF protein	increases expression	16497791
D014501	Uranium	Uranium binds to and results in decreased stability of TF protein	affects binding\|decreases stability	17266333
D014638	Vanadates	Vanadates results in decreased uptake of TF protein	decreases uptake	16563724
D015032	Zinc	Zinc binds to TF protein	affects binding	17034863

Pathway ID	Pathway Name
REACT:604	Hemostasis
KEGG:04978	Mineral absorption
KEGG:03040	Spliceosome
REACT:15518	Transmembrane transport of small molecules

Drugbank ID	Action	Drug Name	Description
DB01370	-	Aluminium
DB02737	-	Oxalate Ion	Reducing Agents
DB03965	-	Fucose

Drugbank ID	Action	Drug Name	Description
DB00893	substrate	Omni 2000tab	Anti-anemic Agents;Iron Supplement
DB01294	-	Watkins Settelz	Antidiarrheals
DB05260	substrate	Gallium nitrate	Antineoplastic Agents

Desease Name
HEMATOLOGICAL
CARDIOVASCULAR
serum markers of iron status
Alzheimer's disease
cardiac death myocardial infarct
NEUROLOGICAL

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms		Tamoxifen	3.95	14745880
MESH:D000014	Abnormalities, Drug-Induced		Phenobarbital	6.38	6195326
MESH:D000014	Abnormalities, Drug-Induced		Tetrachlorodibenzodioxin	6.38	15322242 11752688 14514962
MESH:D000152	Acne Vulgaris		Ethinyl Estradiol	3.35	17505938
MESH:D000169	Acrodermatitis		Zinc	4.82	16889938 17202136 17190629
MESH:D058186	Acute Kidney Injury		Cisplatin	7.15	17670903 15814532 12690470
MESH:D058186	Acute Kidney Injury		resveratrol	7.15	16538975
MESH:D055371	Acute Lung Injury		Lipopolysaccharides	7.26	18653653 11850527
MESH:D055371	Acute Lung Injury		pirinixic acid	7.26	18653653
MESH:D000230	Adenocarcinoma		Benzo(a)pyrene	8.60	20464547 20127859
MESH:D000230	Adenocarcinoma		Cisplatin	8.60	17638652 11798837
MESH:D000230	Adenocarcinoma		Estradiol	8.60	11473722
MESH:D000230	Adenocarcinoma		Ethinyl Estradiol	8.60	14692618
MESH:D000236	Adenoma		Benzo(a)pyrene	9.08	6695378
MESH:D000236	Adenoma		Diethylnitrosamine	9.08	10737359 6695378
MESH:D000236	Adenoma		resveratrol	9.08	15688382
MESH:D018248	Adenoma, Liver Cell		Diethylnitrosamine	20.09	18056438 17620307 17162532 16434500 19061943 19052882
MESH:D018248	Adenoma, Liver Cell		Phenobarbital	20.09	17620307
MESH:D018248	Adenoma, Liver Cell		pirinixic acid	20.09	16434500
MESH:D018248	Adenoma, Liver Cell		Tetrachlorodibenzodioxin	20.09	16835633
MESH:D000310	Adrenal Gland Neoplasms		sodium arsenite	4.10	15276417
MESH:D018246	Adrenocortical Adenoma		sodium arsenite	4.31	17306315 16712894
MESH:D000382	Agricultural Workers' Diseases		Atrazine	3.66	11874814
MESH:D019973	Alcohol-Related Disorders		Curcumin	4.49	17887948
MESH:D019896	alpha 1-Antitrypsin Deficiency		Iron	5.07	16640825
MESH:D000544	Alzheimer Disease	marker/mechanism			17192785
MESH:D000544	Alzheimer Disease		Aluminum	13.63	10721010 17662457
MESH:D000544	Alzheimer Disease		Curcumin	13.63	15590663
MESH:D000544	Alzheimer Disease		Iron	13.63	16640825 16563566
MESH:D000544	Alzheimer Disease		Ozone	13.63	15513908
MESH:D000544	Alzheimer Disease		resveratrol	13.63	16162502 16183991
MESH:D000544	Alzheimer Disease		Zinc	13.63	16410023 17119284 16325427 16580781
MESH:D000740	Anemia		Iron	7.24	16566752 16434484
MESH:D000740	Anemia		Tetrachlorodibenzodioxin	7.24	11748828
MESH:D000743	Anemia, Hemolytic		Quercetin	3.72	17084956
MESH:C536357	Anemia, hypochromic microcytic	marker/mechanism			11110675
MESH:D018798	Anemia, Iron-Deficiency	marker/mechanism
MESH:D018798	Anemia, Iron-Deficiency		ferric pyrophosphate	9.39	16881929
MESH:D018798	Anemia, Iron-Deficiency		Iron	9.39	16569441 17147795 17163184 17375513 17162259
MESH:D000755	Anemia, Sickle Cell		Zinc	4.35	16916123

AutismKB 2.0

Annotation Detail for TF

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics