AutismKB 2.0

Annotation Detail for TFAM


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Basic Information Top
Gene Symbol:TFAM ( MtTF1,TCF6,TCF6L1,TCF6L2,TCF6L3,mtTFA )
Gene Full Name: transcription factor A, mitochondrial
Band: 10q21.1
Quick LinksEntrez ID:7019; OMIM: 600438; Uniprot ID:TFAM_HUMAN; ENSEMBL ID: ENSG00000108064; HGNC ID: 11741
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
Pathway IDPathway Name
Transcription
No data
No data
Pathway IDPathway Name
500587Mitochondrial transcription initiation
Related Diseases/Disorders Top
No data
No data
Desease Name
Alzheimer's disease
NEUROLOGICAL
Alzheimer's disease Parkinson's disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C095284 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]decreases reaction|increases expression 17179207
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TFAM mRNAaffects expression 21346803
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]decreases reaction|increases expression 17179207
C005975 3,4-dihydroxyphenylethanol 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of TFAM mRNA]decreases expression|decreases reaction 20938484
C516138 (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]decreases reaction|increases expression 17438283
D000171 Acrolein 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in decreased expression of TFAM mRNA]decreases expression|decreases reaction 20938484
D000171 Acrolein Acrolein results in decreased expression of TFAM mRNAdecreases expression 20938484
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TFAM mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TFAM mRNAincreases expression 19150397
C459604 candoxin candoxin results in decreased expression of TFAM mRNAdecreases expression 16309724
D002248 Carbon Monoxide Carbon Monoxide results in increased expression of TFAM mRNAincreases expression 17179207
D002248 Carbon Monoxide Carbon Monoxide results in increased expression of TFAM proteinincreases expression 17179207
D002248 Carbon Monoxide 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]decreases reaction|increases expression 17179207
D002248 Carbon Monoxide 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]decreases reaction|increases expression 17179207
D002248 Carbon Monoxide Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]affects binding|increases reaction 17179207
D002248 Carbon Monoxide Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]affects binding|increases reaction 17179207
D002248 Carbon Monoxide Carbon Monoxide results in increased expression of TFAM proteinincreases expression 17179207
D002248 Carbon Monoxide CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]affects binding|decreases reaction|increases reaction 17179207
D002976 Clenbuterol Clenbuterol results in increased expression of TFAM mRNAincreases expression 17446185
D016047 Zalcitabine Zalcitabine affects the expression of TFAM proteinaffects expression 7849699
D004610 Ellagic Acid Ellagic Acid results in decreased expression of TFAM mRNAdecreases expression 12002526
D004958 Estradiol [Estradiol co-treated with Norepinephrine] results in decreased expression of TFAM mRNAaffects cotreatment|decreases expression 16954335
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TFAM mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TFAM mRNAincreases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of TFAM mRNAincreases expression 18035473
D005632 Fructose Fructose results in increased expression of TFAM proteinincreases expression 11934685
D017313 Fenretinide Fenretinide affects the expression of TFAM mRNAaffects expression 16570282
C006552 kaempferol kaempferol results in increased expression of TFAM mRNAincreases expression 17327447
D009638 Norepinephrine [Estradiol co-treated with Norepinephrine] results in decreased expression of TFAM mRNAaffects cotreatment|decreases expression 16954335
D009638 Norepinephrine [Progesterone co-treated with Norepinephrine] results in increased expression of TFAM mRNAaffects cotreatment|increases expression 16954335
C006253 pirinixic acid pirinixic acid results in increased expression of TFAM mRNAincreases expression 18301758
D011374 Progesterone [Progesterone co-treated with Norepinephrine] results in increased expression of TFAM mRNAaffects cotreatment|increases expression 16954335
D011374 Progesterone Progesterone results in increased expression of TFAM mRNAincreases expression 16954335
C059514 resveratrol resveratrol results in decreased expression of TFAM mRNAdecreases expression 12002526
C059514 resveratrol (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]decreases reaction|increases expression 17438283
C059514 resveratrol resveratrol results in increased expression of TFAM mRNAincreases expression 17438283
D012643 Selenium NRF1 protein promotes the reaction [Selenium results in increased expression of TFAM mRNA]increases expression|increases reaction 17936198
D012643 Selenium Selenium results in increased expression of TFAM mRNAincreases expression 17936198
C017947 sodium arsenite sodium arsenite results in increased expression of TFAM mRNAincreases expression 12016162
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TFAM mRNAdecreases expression 17101203
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TFAM mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TFAM mRNAincreases expression 16960034
D014501 Uranium Uranium affects the expression of TFAM mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of TFAM mRNAaffects expression 15672453
D015215 Zidovudine Zidovudine results in increased expression of TFAM mRNAincreases expression 10535663
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5911752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.579612607
MESH:D058186 Acute Kidney Injury resveratrol 3.6216538975
MESH:D055371 Acute Lung Injury Acrolein 8.4821297076 20525806
MESH:D055371 Acute Lung Injury pirinixic acid 8.4818653653
MESH:D000230 Adenocarcinoma Estradiol 6.7411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7414692618
MESH:D000230 Adenocarcinoma Fenretinide 6.7410697514
MESH:D000236 Adenoma resveratrol 3.1715688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6417306315 16712894
MESH:D000544 Alzheimer Disease marker/mechanism 17192785
MESH:D000544 Alzheimer Disease Acrolein 4.4817570602 14715435 15207723
MESH:D000544 Alzheimer Disease resveratrol 4.4816162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D001161 Arteriosclerosis Acrolein 9.4615014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8315885639
MESH:D001169 Arthritis, Experimental resveratrol 6.8317115116
MESH:D050197 Atherosclerosis Acrolein 6.6417363696 16037261 16126721
MESH:D050197 Atherosclerosis resveratrol 6.6417967414 16873680
MESH:D001321 Autistic Disorder Norepinephrine 3.398570775
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 4.0015665606 15380490 15845082
MESH:D002545 Brain Ischemia resveratrol 4.0217600658
MESH:D001932 Brain Neoplasms Fenretinide 4.1316187019
MESH:D001943 Breast Neoplasms Estradiol 2.8417261762 17018787 16675129 17289903 14630087 19861407 12948864 18497071
MESH:D001943 Breast Neoplasms Fenretinide 2.8416601279
MESH:D001943 Breast Neoplasms kaempferol 2.8416756079
MESH:D001943 Breast Neoplasms Progesterone 2.8417614352 16175315 15562024
MESH:D001943 Breast Neoplasms resveratrol 2.8417651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.4116705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.4116924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.4117159502 16270382
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.4119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.4115276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3316675471
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 7.2516274795
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.2516227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.2518572023
MESH:D006332 Cardiomegaly Norepinephrine 6.7111179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7116120746 18850075 18670907
MESH:D009202 Cardiomyopathies Zalcitabine 4.5410591146
MESH:D002318 Cardiovascular Diseases kaempferol 7.3216756079
MESH:D002318 Cardiovascular Diseases resveratrol 7.3215458977
MESH:D002375 Catalepsy Norepinephrine 5.278216760
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.1620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.1618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.1620056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.2116154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1011677210 17681005 16105132 17110522 15861022 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 7.1019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9916354765 12621046 8697196 15340226 15668235
MESH:D003092 Colitis Carbon Monoxide 14.8116365149
MESH:D003092 Colitis resveratrol 14.8116474422
MESH:D003092 Colitis Selenium 14.8117936198
MESH:D003110 Colonic Neoplasms resveratrol 2.4116338953
MESH:D015179 Colorectal Neoplasms Acrolein 3.5817597105
MESH:D015179 Colorectal Neoplasms Fenretinide 3.5817273769
MESH:D015179 Colorectal Neoplasms resveratrol 3.5816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8414669216 17141729
MESH:D003327 Coronary Disease Fructose 8.2318504504
MESH:D003327 Coronary Disease resveratrol 8.2316507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7618551238
MESH:D003556 Cystitis Acrolein 5.1312161096
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003921 Diabetes Mellitus, Experimental Fructose 8.1318603373
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.1316873680
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.4318603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2919279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.2916286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 5.7218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 5.7215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.8411462148
MESH:D004362 Drug Toxicity Zalcitabine 12.847515130
MESH:D004362 Drug Toxicity Zidovudine 12.8415040536
MESH:D004487 Edema pirinixic acid 10.0812083418
MESH:D004487 Edema resveratrol 10.088985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6416714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.9317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 13.9317872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.8118566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1710568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5917923197
MESH:D004827 Epilepsy Norepinephrine 4.16821787
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.2015345470
MESH:D005234 Fatty Liver Fructose 22.2019196556 18395287 18641190
MESH:D005234 Fatty Liver pirinixic acid 22.2019236843 20131406
MESH:D005234 Fatty Liver Zalcitabine 22.2018299183
MESH:D005234 Fatty Liver Zidovudine 22.2018299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005355 Fibrosis Fructose 8.1818504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1820067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4216452187
MESH:D005909 Glioblastoma Fenretinide 3.7216187019
MESH:D018149 Glucose Intolerance Fructose 5.0819165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1911294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.4220558911
MESH:D006333 Heart Failure Selenium 6.4217162251
MESH:D006402 Hematologic Diseases Zidovudine 4.4712579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006529 Hepatomegaly pirinixic acid 7.4119772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006561 Herpes Simplex resveratrol 3.9216876885
MESH:D015658 HIV Infections Zalcitabine 6.8117457083
MESH:D015658 HIV Infections Zidovudine 6.8111363243 11141242 11698656 17358032 20032539
MESH:D006689 Hodgkin Disease sodium arsenite 2.9412676792
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7816959395 18606429 15340226 8697196 16354765
MESH:D006937 Hypercholesterolemia resveratrol 3.7717188708
MESH:D006943 Hyperglycemia kaempferol 8.8418262572
MESH:D006943 Hyperglycemia pirinixic acid 8.8420558911
MESH:D006946 Hyperinsulinism Fructose 4.6814757778 18563319 15752949 19008412 18360027
MESH:D006949 Hyperlipidemias Fructose 8.9015752949
MESH:D006949 Hyperlipidemias resveratrol 8.9016873680
MESH:D006973 Hypertension Fructose 5.1716843071 14573337 14568997 14633139 19008412
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.8519342510 19799862
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0717488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516945680 16569931
MESH:D007022 Hypotension Norepinephrine 4.756740701
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.6315869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.6317600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0717937319
MESH:D007248 Infertility, Male sodium arsenite 6.0715346721 12646999
MESH:D007249 Inflammation Flavonoids 10.8617296493
MESH:D007249 Inflammation Progesterone 10.8615869954
MESH:D007249 Inflammation resveratrol 10.8616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.8612200463 12878042
MESH:D007251 Influenza, Human resveratrol 10.1916624496
MESH:D007251 Influenza, Human Selenium 10.1916624496
MESH:D007333 Insulin Resistance Estradiol 11.4616393666 16627594
MESH:D007333 Insulin Resistance Fructose 11.4618563319 19799862 19008412 14757778 14633139 18057795 18981581 19342510 14573337 17133782 19586609
MESH:D007333 Insulin Resistance pirinixic acid 11.4616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007674 Kidney Diseases Acrolein 9.3812488133
MESH:D007674 Kidney Diseases Estradiol 9.3815618244
MESH:D007674 Kidney Diseases sodium arsenite 9.3820008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.6516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.2816705839
MESH:D007680 Kidney Neoplasms Estradiol 11.2815610895
MESH:D007680 Kidney Neoplasms Zidovudine 11.2812579204
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6.7612970779
MESH:D007938 Leukemia kaempferol 6.7617468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.1820370541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4116087638
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7816707609
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.1914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.1912878042
MESH:D008107 Liver Diseases Carbon Monoxide 4.0217173083
MESH:D008113 Liver Neoplasms pirinixic acid 9.8620007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 9.8619812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 9.8616712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.8616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9512151625
MESH:D008171 Lung Diseases Acrolein 7.2411504702
MESH:D008171 Lung Diseases sodium arsenite 7.2419095001
MESH:D008175 Lung Neoplasms sodium arsenite 3.3115276417 17306315 17077188 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3111884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 3.3118800350
MESH:D008223 Lymphoma Zalcitabine 4.4617941976 8764131 11980663 8840982 9205081 18798262 9488045
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6614749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9815688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.0611408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 17.0610697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 17.0611408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 17.0611606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 17.0615318939
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D008545 Melanoma Fenretinide 4.9916270382
MESH:D008545 Melanoma resveratrol 4.9917992120
MESH:D008545 Melanoma sodium arsenite 4.9916487513 19082730
MESH:D008546 Melanoma, Experimental Acrolein 4.9510803710
MESH:D008654 Mesothelioma Selenium 2.6915107826
MESH:D008659 Metabolic Diseases resveratrol 4.1417112576
MESH:D024821 Metabolic Syndrome X Fructose 4.6019165636 17098227 17261469 18497449 16815490
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5717358032
MESH:D009062 Mouth Neoplasms Fenretinide 4.1216274795
MESH:D009101 Multiple Myeloma resveratrol 3.2817049120 16490592 17935668 17164350 14749477 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.3719151258
MESH:D009203 Myocardial Infarction resveratrol 5.3717188708 16317513 16525036 17015251 16456233 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.3317125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1816810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 13.1815642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.1816411023
MESH:D009205 Myocarditis resveratrol 4.5017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6018551238
MESH:D009369 Neoplasms Acrolein 10.8717329238
MESH:D009369 Neoplasms Fenretinide 10.8717353921 15958647
MESH:D009369 Neoplasms pirinixic acid 10.8717405874
MESH:D009369 Neoplasms sodium arsenite 10.8711559025
MESH:D009374 Neoplasms, Experimental resveratrol 14.008985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 14.0020056578
MESH:D009374 Neoplasms, Experimental Zalcitabine 14.009488045 9205081 8764131
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009393 Nephritis Acrolein 6.0212653641
MESH:D009421 Nervous System Malformations Estradiol 8.6311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6314600291
MESH:D009437 Neuralgia Zalcitabine 6.0517292584
MESH:D009436 Neural Tube Defects sodium arsenite 2.9712854658
MESH:D019636 Neurodegenerative Diseases Acrolein 8.2511342003
MESH:D019636 Neurodegenerative Diseases resveratrol 8.2517652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1617929310
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4116303764
MESH:D009765 Obesity Fructose 4.6217707055 18585860
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2012819281 16049721
MESH:D010024 Osteoporosis kaempferol 4.1916756079
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0117513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 14.0916211241
MESH:D010051 Ovarian Neoplasms Estradiol 14.0919401270
MESH:D010051 Ovarian Neoplasms Fenretinide 14.0916133793
MESH:D010051 Ovarian Neoplasms Progesterone 14.0916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.0915276417 17306315
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.2615580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010300 Parkinson Disease Acrolein 3.4917690948
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 5.0518606552
MESH:D010787 Photosensitivity Disorders Acrolein 5.4711550810
MESH:D010954 Plasmacytoma Selenium 4.6215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.7216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7211222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.1816740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.1817024972
MESH:D011471 Prostatic Neoplasms resveratrol 2.1817675339 17804756 16731767 17718901 15767336 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1816039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.0516919318 15861022
MESH:D051437 Renal Insufficiency Acrolein 4.7512732208
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3216325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.1419058328
MESH:D015427 Reperfusion Injury resveratrol 6.1417058453 16314181 16317513 17520802 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012162 Retinal Degeneration Fenretinide 4.2116303925
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3618551238
MESH:D012878 Skin Neoplasms Fenretinide 12.6016467112
MESH:D012878 Skin Neoplasms resveratrol 12.608985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 12.6018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0215862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6012854658
MESH:D013274 Stomach Neoplasms Zidovudine 2.4717696246
MESH:D020521 Stroke Acrolein 4.3516269634
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2516321402
MESH:D013610 Tachycardia Norepinephrine 5.183261545
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D014062 Tongue Neoplasms resveratrol 3.9816227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.8316049721
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 7.8316720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.8311723127 17306315 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0510091137
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 14.6916154183
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.6917473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.6911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6614692618
MESH:D014594 Uterine Neoplasms resveratrol 8.6617044934
MESH:D014625 Vaginal Neoplasms Zidovudine 4.5012579204
MESH:D014652 Vascular Diseases sodium arsenite 4.1617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36458
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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