AutismKB 2.0

Annotation Detail for TFAP2C


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Basic Information Top
Gene Symbol:TFAP2C ( AP2-GAMMA,ERF1,TFAP2G,hAP-2g )
Gene Full Name: transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Band: 20q13.31
Quick LinksEntrez ID:7022; OMIM: 601602; Uniprot ID:AP2C_HUMAN; ENSEMBL ID: ENSG00000087510; HGNC ID: 11744
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of TFAP2C mRNAincreases expression 19774075
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TFAP2C mRNAdecreases expression 15761015
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of TFAP2C mRNAincreases expression 18687144
C014347 decitabine [decitabine co-treated with TFAP2C protein] results in increased expression of ESR1 mRNAaffects cotreatment|increases expression 19458056
C014347 decitabine [decitabine co-treated with TFAP2C protein] results in increased expression of RERG mRNAaffects cotreatment|increases expression 19458056
C014347 decitabine [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein binds to ESR1 promoter]affects binding|affects cotreatment|increases reaction 19458056
C014347 decitabine [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein results in increased expression of ESR1 mRNA]affects cotreatment|increases expression|increases reaction 19458056
C014347 decitabine decitabine results in increased expression of TFAP2C mRNAincreases expression 16367923
C014347 decitabine TFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA]affects cotreatment|increases expression|increases reaction 19458056
C014347 decitabine TFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of RERG mRNA]affects cotreatment|increases expression|increases reaction 19458056
D017239 Paclitaxel Paclitaxel results in decreased expression of TFAP2C mRNAdecreases expression 19682730
C059514 resveratrol resveratrol results in increased localization of and results in increased activity of TFAP2C proteinincreases activity|increases localization 16488535
D013749 Tetrachlorodibenzodioxin SRC protein promotes the reaction [Tetrachlorodibenzodioxin affects the expression of TFAP2C mRNA]affects expression|increases reaction 14708085
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of TFAP2C mRNAaffects expression 14708085
C012589 trichostatin A [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein binds to ESR1 promoter]affects binding|affects cotreatment|increases reaction 19458056
C012589 trichostatin A [decitabine co-treated with trichostatin A] promotes the reaction [TFAP2C protein results in increased expression of ESR1 mRNA]affects cotreatment|increases expression|increases reaction 19458056
C012589 trichostatin A TFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of ESR1 mRNA]affects cotreatment|increases expression|increases reaction 19458056
C012589 trichostatin A TFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of RERG mRNA]affects cotreatment|increases expression|increases reaction 19458056
C012589 trichostatin A [trichostatin A co-treated with TFAP2C protein] results in increased expression of ESR1 mRNAaffects cotreatment|increases expression 19458056
C012589 trichostatin A [trichostatin A co-treated with TFAP2C protein] results in increased expression of RERG mRNAaffects cotreatment|increases expression 19458056
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 14514962 15322242
MESH:D058186 Acute Kidney Injury resveratrol 4.0916538975
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D000236 Adenoma resveratrol 3.4415688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000544 Alzheimer Disease resveratrol 2.6116183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318218290 20041841 18057881
MESH:D001169 Arthritis, Experimental resveratrol 3.6417115116
MESH:D050197 Atherosclerosis resveratrol 3.4017967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 4.0819698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 16.8419483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.8416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.8412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.8315867366
MESH:D002545 Brain Ischemia resveratrol 4.6217600658
MESH:D001943 Breast Neoplasms decitabine 2.0319208741 18320071
MESH:D001943 Breast Neoplasms Paclitaxel 2.0316244791 18223236 16273361 18234424 15136595 18323546 16115903 11325840
MESH:D001943 Breast Neoplasms resveratrol 2.0316393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.9415553829 15073043 16217749 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.9416313753
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.9419321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9316675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1219215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.1216227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002318 Cardiovascular Diseases resveratrol 3.6315458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 16354765 12621046 15340226
MESH:D003092 Colitis resveratrol 4.4316474422
MESH:D003110 Colonic Neoplasms decitabine 4.0717616700
MESH:D003110 Colonic Neoplasms resveratrol 4.0716338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.9920501625
MESH:D015179 Colorectal Neoplasms decitabine 4.9918981723
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.9918802399
MESH:D015179 Colorectal Neoplasms resveratrol 4.9916550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8916507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9716873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.1816286809
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.0515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema resveratrol 7.688985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3117872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 15.3219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 15.3219294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1617923197
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.9312903497
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.9316481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Amiodarone 8.8114986274
MESH:D005234 Fatty Liver arsenic trioxide 8.8115073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005909 Glioblastoma trichostatin A 3.9818801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Amiodarone 9.5815265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.5816120746 15340226 12621046
MESH:D006561 Herpes Simplex resveratrol 4.5216876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 8697196 16959395 18606429
MESH:D006937 Hypercholesterolemia Amiodarone 10.149751232 8137927
MESH:D006937 Hypercholesterolemia resveratrol 10.1417188708
MESH:D006949 Hyperlipidemias resveratrol 4.2916873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5317488730
MESH:D007037 Hypothyroidism Amiodarone 4.8218020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9517600658
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007249 Inflammation resveratrol 5.4416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4412878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.9216624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007938 Leukemia arsenic trioxide 6.8115070760
MESH:D007938 Leukemia decitabine 6.8118980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.4119077051
MESH:D007951 Leukemia, Myeloid decitabine 10.4118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.4816968895 16467208 17050201 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.4819010910 18704418 18206229 17679729 19387464 18460780
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.4818206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2916823087 16966277 15622746 17712046 19075265 11468182 17649720 16331271 15213294 17217047 17107899 19225113 16891316 16330433 16112521 11161223 15748426 19642359 19035177 12712474 15336539 12679006 9834237 17869043 12018890
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 8.2916087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 5.0817353645
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9314682389
MESH:D008113 Liver Neoplasms resveratrol 7.9319812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2720377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2712151625
MESH:D008133 Long QT Syndrome Amiodarone 8.8117391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 8.8115213294
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3511798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3511884234 19555203
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5617088997
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 9.6714749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 9.6714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.258985016 11606380
MESH:D008545 Melanoma decitabine 7.7017785578 16505122
MESH:D008545 Melanoma Paclitaxel 7.7012040289 12025231 16342250
MESH:D008545 Melanoma resveratrol 7.7017992120
MESH:D008545 Melanoma trichostatin A 7.7016505122
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2616966607 18303189 16166281
MESH:D008659 Metabolic Diseases resveratrol 4.6217112576
MESH:D009101 Multiple Myeloma arsenic trioxide 24.5419417148 19549372 14977855 11468182 15949261
MESH:D009101 Multiple Myeloma decitabine 24.5418172295
MESH:D009101 Multiple Myeloma Paclitaxel 24.5414749477
MESH:D009101 Multiple Myeloma resveratrol 24.5416267019 16490592 17164350 14749477 17935668 17049120
MESH:D009101 Multiple Myeloma trichostatin A 24.5418172295
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2117962980
MESH:D009181 Mycoses Amiodarone 5.2817974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.9216882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.9219157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction resveratrol 3.1116456233 17188708 17015251 17125593 16317513 16525036
MESH:D017202 Myocardial Ischemia resveratrol 9.6617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.6612213967
MESH:D009205 Myocarditis resveratrol 5.1017322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3315867366
MESH:D009369 Neoplasms decitabine 2.8117925555 19116145 19470736
MESH:D009374 Neoplasms, Experimental resveratrol 4.318985016
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D019636 Neurodegenerative Diseases resveratrol 4.0117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6617929310
MESH:D010014 Osteolysis Paclitaxel 5.3215867366
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5217513867
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.9212452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms decitabine 11.9219259094 19331143
MESH:D010051 Ovarian Neoplasms Paclitaxel 11.9211161223
MESH:D010051 Ovarian Neoplasms trichostatin A 11.9219331143
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.2015580305
MESH:D010190 Pancreatic Neoplasms decitabine 9.2019294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 9.2019294695
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.7416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.7411222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 13.4717616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.4717616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1419131511
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.1417172428 17136230 16729912 16356831
MESH:D011471 Prostatic Neoplasms resveratrol 2.1415767336 17804756 17718901 17636462 16731767 17675339
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1418798265 19789329
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.1511597910 12832656 12490602
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.1515814490 17975199 17322281 17365031
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3716314181 17520802 16317513 17058453 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012878 Skin Neoplasms resveratrol 6.058985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0516192470
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.6017007042
MESH:D013274 Stomach Neoplasms decitabine 3.6019037991
MESH:D013274 Stomach Neoplasms Paclitaxel 3.6018396642 18506536
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7116321402
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D024801 Tauopathies Paclitaxel 5.1516930453
MESH:D013959 Thyroid Diseases Amiodarone 13.3419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.3412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9319014326
MESH:D013964 Thyroid Neoplasms decitabine 7.9317967635
MESH:D013971 Thyrotoxicosis Amiodarone 5.1719584973 18020914
MESH:D014062 Tongue Neoplasms resveratrol 4.4416227395
MESH:D016171 Torsades de Pointes Amiodarone 11.4117467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 11.4115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5120435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5119087683 17616700
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3317473185
MESH:D014594 Uterine Neoplasms resveratrol 4.4217044934
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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