AutismKB 2.0

Annotation Detail for TFPI


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Basic Information Top
Gene Symbol:TFPI ( EPI,LACI,TFI,TFPI1 )
Gene Full Name: tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Band: 2q32.1
Quick LinksEntrez ID:7035; OMIM: 152310; Uniprot ID:TFPI1_HUMAN; ENSEMBL ID: ENSG00000003436; HGNC ID: 11760
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200115Syndecan-4-mediated signaling events
Pathway IDPathway Name
P00011Blood coagulation
Pathway IDPathway Name
500301Extrinsic Pathway
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
bleeding complications
METABOLIC
thromboembolism, venous
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TFPI mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TFPI mRNAaffects expression 16483693
D000661 Amphetamine Amphetamine results in decreased expression of TFPI proteindecreases expression 20118172
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of TFPI mRNAincreases expression 18687144
D001554 Benzene Benzene results in decreased expression of TFPI mRNAdecreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TFPI mRNAdecreases expression 20018196
D002995 Clofibric Acid Clofibric Acid affects the expression of TFPI mRNAaffects expression 17602206
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TFPI mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of TFPI mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TFPI mRNAaffects cotreatment|affects expression 17602206
D004317 Doxorubicin TFPI protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TFPI mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of and results in decreased secretion of TFPI proteindecreases expression|decreases secretion 17029634
D004958 Estradiol Estradiol results in increased expression of TFPI mRNAincreases expression 19619570
D004966 Estrogens, Conjugated (USP) Estrogens, Conjugated (USP) affects the expression of TFPI mRNAaffects expression 15964915
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of and results in decreased secretion of TFPI proteindecreases expression|decreases secretion 17029634
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased activity of TFPI proteindecreases activity 15857755
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TFPI mRNAdecreases expression 17557909
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TFPI proteindecreases expression 15857755
D004997 Ethinyl Estradiol fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]decreases activity|decreases reaction 15857755
D004997 Ethinyl Estradiol norethindrone acetate promotes the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]decreases activity|increases reaction 15857755
D005047 Etoposide TFPI protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil TFPI protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C065180 fluvastatin fluvastatin results in increased expression of TFPI proteinincreases expression 16142594
C070081 fulvestrant [fulvestrant co-treated with Raloxifene] results in increased secretion of TFPI proteinaffects cotreatment|increases secretion 17029634
C070081 fulvestrant fulvestrant inhibits the reaction [Raloxifene results in decreased expression of and results in decreased secretion of TFPI protein]decreases expression|decreases reaction|decreases secretion 17029634
C070081 fulvestrant fulvestrant results in decreased secretion of TFPI proteindecreases secretion 17029634
C070081 fulvestrant fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]decreases activity|decreases reaction 15857755
C070081 fulvestrant fulvestrant inhibits the reaction [norethindrone acetate results in decreased activity of TFPI protein]decreases activity|decreases reaction 15857755
D019833 Genistein Genistein results in decreased expression of TFPI mRNAdecreases expression 18847459
D019833 Genistein Genistein results in increased expression of TFPI mRNAincreases expression 17341692
C051890 irinotecan irinotecan analog results in decreased expression of TFPI mRNAdecreases expression 18927307
D016685 Mitomycin TFPI protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C024262 norethindrone acetate fulvestrant inhibits the reaction [norethindrone acetate results in decreased activity of TFPI protein]decreases activity|decreases reaction 15857755
C024262 norethindrone acetate norethindrone acetate promotes the reaction [Ethinyl Estradiol results in decreased activity of TFPI protein]decreases activity|increases reaction 15857755
C024262 norethindrone acetate norethindrone acetate results in decreased activity of TFPI proteindecreases activity 15857755
C024262 norethindrone acetate norethindrone acetate results in decreased expression of TFPI proteindecreases expression 15857755
D020849 Raloxifene [fulvestrant co-treated with Raloxifene] results in increased secretion of TFPI proteinaffects cotreatment|increases secretion 17029634
D020849 Raloxifene fulvestrant inhibits the reaction [Raloxifene results in decreased expression of and results in decreased secretion of TFPI protein]decreases expression|decreases reaction|decreases secretion 17029634
D020849 Raloxifene Raloxifene results in decreased expression of and results in decreased secretion of TFPI proteindecreases expression|decreases secretion 17029634
C017947 sodium arsenite sodium arsenite results in increased expression of TFPI mRNAincreases expression 19072884
D013629 Tamoxifen Tamoxifen results in decreased expression of and results in decreased secretion of TFPI proteindecreases expression|decreases secretion 17029634
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TFPI mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TFPI mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TFPI mRNAincreases expression 19619570
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of TFPI mRNAincreases expression 18087596
D019772 Topotecan TFPI protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D000230 Adenocarcinoma Doxorubicin 12.9117418594
MESH:D000230 Adenocarcinoma Estradiol 12.9111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9114692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.9117638652
MESH:D000230 Adenocarcinoma Genistein 12.9111473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.3015814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.233712494
MESH:D000236 Adenoma Diethylnitrosamine 6.236695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.2919061943 17162532 17620307 18056438 19052882 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6716712894 17306315
MESH:D000419 Albuminuria Doxorubicin 10.7321441931
MESH:D000419 Albuminuria Raloxifene 10.7317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4915800139
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.8315010207 16916582 18475255 16459022
MESH:D000740 Anemia Fluorouracil 8.0215504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0211748828
MESH:D000741 Anemia, Aplastic Benzene 4.2011369114 14761424 17661222
MESH:D000855 Anorexia Amphetamine 4.8112183048 16084549 16101753 12005258
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1319898480
MESH:D001284 Atrophy fulvestrant 4.6311514358
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0016183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.3914601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.3914601052
MESH:D001930 Brain Injuries Raloxifene 4.2516580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.6117150277
MESH:D001943 Breast Neoplasms Benzene 8.0511921183 17162533
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.0517474063
MESH:D001943 Breast Neoplasms Doxorubicin 8.0515136595 15692762 18382427 16935488 17426702 17983394 18695136 15634643 16264153 15993339 15567936 19526202 15939500 15994142 17369602 18628466 16595493 18234424 16322301 16115903 16096432 15668708 16826403 11325840
MESH:D001943 Breast Neoplasms Estradiol 8.0512948864 16675129 17289903 19861407 17018787 14630087 18497071 17261762
MESH:D001943 Breast Neoplasms Etoposide 8.0516322251
MESH:D001943 Breast Neoplasms Fluorouracil 8.0515136595 18608205 19217205 16557594 16110121 16595493 18357371
MESH:D001943 Breast Neoplasms fulvestrant 8.0518984771
MESH:D001943 Breast Neoplasms Genistein 8.0516541309 16873071 17200150
MESH:D001943 Breast Neoplasms Raloxifene 8.0516912660 17595753 17893378 16837676 17261762 17440819 17242785 15572757 17952589 15775269 17049068 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 8.0519103187 20859285 20005174 18815881 18997820 17261762 17242785 19084267 19059307 17893378 19289846 15565566 16818667 19189210 16273361 21152245 20065188 19189212 20135344 19115204 11161223 18629630 18984771 19142967 19066611 19288272 19244106 20544844 18821012 16202921 19155303 15668708 18425577 19011961 18351453 19487384 21138602 18855134 17440819 19410462 19200415 17049068 20390343 16873071 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.0520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.5816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.5816051944
MESH:D002277 Carcinoma Fluorouracil 7.5917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.267296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.2617138121 3581430 19052882 16830150 17173139 18665156 17761372 10737359 18393292 16328049 18506893 18978308 20007298 19919837 16288022 20514400 19701751 18788625 19171122 16807293 18210153 18494052 3084413 20524982 16779866 11831363 16569478 19383236 20727157 19519916 19539802 18971187 21159647 19335982 17978847 19394651 19822196 20084675 17055752 20432363 10672840 19107877 16502159 20512989 17428255 16698587 16681979 20214788 17162532 20935162 19208518 18056438 16540662 20101231 18691550 18785209 16878318 19418558 16935385
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.2616234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.2616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.2617088986 16332177 18930000 16799960 17971768 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.2616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.2617306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.2616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.3511212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.167296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.161485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.1618695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.306189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.3018986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.3018572023
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 10.3011212258
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.8417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3817007740 17329180 17131338 17974986 16364871 18627295 16952015 16109756 16612575 16651473 16242529 15476868 16455267 17924179 15811867 15505089 16278810 16269455 17382496 15792986 17351982 17519947 17928571 17308081 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8717334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 6.9816332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9815775269
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 24.347505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 24.3420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 24.3412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 24.3421159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 24.3418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 24.3419524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.4219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.4219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4217110522 11677210 17333356 16919318 15861022 17681005 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0112621046 8697196 15668235 16354765 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.3915800139
MESH:D003110 Colonic Neoplasms Fluorouracil 5.6516340194 18772588 16510598 17169374 17172411 17725105 17016597 15001691 17018589 17287894
MESH:D003110 Colonic Neoplasms Genistein 5.6517182828
MESH:D003110 Colonic Neoplasms irinotecan 5.6517725105 17287894
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.4218259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4216303861 16282729 17401013 18448328 15148649 16524972 18509181 17094418 18383874 17695437 15289873 18949393 14970324 18288408 17454858 17594712 16331619 20501625 18802399 16391804 17255274 17016601
MESH:D015179 Colorectal Neoplasms irinotecan 3.4217159606 18509181 18259882 16303861 17454858 16391804 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D003327 Coronary Disease fluvastatin 4.6716142594
MESH:D019465 Craniofacial Abnormalities Benzene 2.6015643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6020055451 15322242 10048152
MESH:D007644 Darier Disease Fluorouracil 4.5616733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9717474826
MESH:D003872 Dermatitis Benzene 4.5415902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.592524372 11298694 14531868 12868966 11906362 8970840 8156756 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.282952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7617107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.9119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.9115920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.9119279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.4011289319 7440962 18289764 8291058 18692083 9328219 9022650 1440618 16192314 9653073 6679447 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.4019107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.4017416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4020420201
MESH:D004362 Drug Toxicity Doxorubicin 7.5618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5611462148
MESH:D004487 Edema Raloxifene 6.1815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.0812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.0815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.0819031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3616402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.5917359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.5919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 16.5911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.5919155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9318037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.883581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.8815173087 16481741 17638652 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005221 Fatigue Amphetamine 5.3719890266
MESH:D005234 Fatty Liver Cyclosporine 22.4719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.4720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.4715345470
MESH:D005234 Fatty Liver Raloxifene 22.4717473493
MESH:D005234 Fatty Liver Tamoxifen 22.4719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.6819069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.6819069698
MESH:D005355 Fibrosis Cyclosporine 7.7412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7420067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Doxorubicin 6.8517150277
MESH:D005909 Glioblastoma Genistein 6.8516598420
MESH:D005910 Glioma Fluorouracil 2.7816145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.4115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.4115162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2111294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 7.3214766674 17875725 16144979 16495754 16244371 16879835 18674790 16244372 16707910 18006777 17888722 12587719 16330681
MESH:D006331 Heart Diseases Raloxifene 7.3211110106
MESH:D006333 Heart Failure Doxorubicin 3.2017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7015692506
MESH:D006402 Hematologic Diseases Benzene 4.4416183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.306705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6716120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D006561 Herpes Simplex Etoposide 4.3310809021
MESH:D006689 Hodgkin Disease Doxorubicin 11.2718501091 17606976 15147373
MESH:D006689 Hodgkin Disease Etoposide 11.2718180244 15147373 16200630 16135485 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 11.2712676792
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.818697196 18606429 16959395 15340226 16354765
MESH:D006948 Hyperkinesis Amphetamine 5.201977408 14960337
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Benzene 11.6717940673
MESH:D006973 Hypertension Cyclosporine 11.6710903974
MESH:D006973 Hypertension Raloxifene 11.6715787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.6718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.4317937319
MESH:D007248 Infertility, Male fulvestrant 10.4311514358
MESH:D007248 Infertility, Male sodium arsenite 10.4312646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 11.0118785209
MESH:D007249 Inflammation Tamoxifen 11.0119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0112200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 11.0118590791
MESH:D007333 Insulin Resistance Estradiol 2.8216627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.799022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Cyclosporine 13.3810903974 8314463 18776723
MESH:D007674 Kidney Diseases Doxorubicin 13.3815369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 13.3815618244
MESH:D007674 Kidney Diseases sodium arsenite 13.3820008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9516707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 21.376582329
MESH:D007680 Kidney Neoplasms Cyclosporine 21.3712371664
MESH:D007680 Kidney Neoplasms Estradiol 21.3715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 21.3716985049
MESH:D007680 Kidney Neoplasms Tamoxifen 21.3718625569
MESH:D007889 Leiomyoma Raloxifene 4.2816973256
MESH:D007938 Leukemia Benzene 6.2617119257 18335105 15935818 14694614
MESH:D007938 Leukemia Genistein 6.2618980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9316085563
MESH:D007951 Leukemia, Myeloid Benzene 4.1117506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6619478238
MESH:D008064 Lipidoses Tamoxifen 2.9915342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7019638242 20032147 18522880 18665156 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.4216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.4217823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4212878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0517034775
MESH:D008113 Liver Neoplasms Clofibric Acid 20.5617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.5615885732 19427195 20101389 19499222 19996281 19638242 21071580 16942905 21167192 19812893 2422723 19690152 20434301 20137499 18977376 20452335 18648771 19426721 19642983 12771043 15175105 18754104 20118626 21278145 19850985 19073162 19254457 19833225 19294768 18644402 20405173 12112319 20492335 2862719 20583210 9163691 19256749 19551842 10737359 20501860 18978307 19255062 19090486 21047994
MESH:D008113 Liver Neoplasms Fluorouracil 20.5615113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms Mitomycin 20.5615113037
MESH:D008113 Liver Neoplasms sodium arsenite 20.5616712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 20.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.5616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.163712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.1612562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.1619004024 18544905 3124819 18093689 9362446 18775883 18308698 19126423 21159647 18079962 17174075 17942915 19539802 18164116 18282651 18253720 19009564 16842330 17854601 16267830 2563599 19519916
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.1617085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.1612151625
MESH:D008171 Lung Diseases sodium arsenite 3.0219095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5814698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8017365036
MESH:D008175 Lung Neoplasms Benzene 12.4812562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.486695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Doxorubicin 12.486189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 12.4815246190
MESH:D008175 Lung Neoplasms sodium arsenite 12.4816712894 17306315 19931552 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 12.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.4819555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 12.4816288123 3440675 11091918 12111688
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5615086387
MESH:D008223 Lymphoma Benzene 11.8117119257 17584886
MESH:D008223 Lymphoma Doxorubicin 11.8116098063
MESH:D008223 Lymphoma Etoposide 11.8112854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3415621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.3112562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.3119428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 17.2911921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 17.2915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.2911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.2914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.2919196722 11731420 19196723 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.8719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8719453300
MESH:D008545 Melanoma Doxorubicin 4.8916827129
MESH:D008545 Melanoma sodium arsenite 4.8919082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.8912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.1316166281 16966607 18303189
MESH:D008654 Mesothelioma Doxorubicin 6.1317638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2915792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3215863610
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3816757204 18986760
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 8.3815006635
MESH:D052016 Mucositis Doxorubicin 11.6517415656
MESH:D052016 Mucositis irinotecan 11.6517159606
MESH:D009101 Multiple Myeloma Benzene 11.4817119195
MESH:D009101 Multiple Myeloma fluvastatin 11.4816996129
MESH:D009101 Multiple Myeloma Raloxifene 11.4816497877
MESH:D009203 Myocardial Infarction Doxorubicin 5.6619429709 15857846
MESH:D009203 Myocardial Infarction Genistein 5.6617141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9417141266
MESH:D009232 Myxoma Raloxifene 5.3216343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 16.963581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 16.969029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 16.9618259882
MESH:D009362 Neoplasm Metastasis irinotecan 16.9618259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 16.9619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Fluorouracil 4.8118600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 4.8111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009401 Nephrosis Doxorubicin 4.5416636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.6619348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.6615640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 15.1011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.1016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.366679447
MESH:D009436 Neural Tube Defects Benzene 11.3615643154
MESH:D009436 Neural Tube Defects sodium arsenite 11.3612854658
MESH:D009447 Neuroblastoma Doxorubicin 10.9115555623
MESH:D009447 Neuroblastoma irinotecan 10.918761367
MESH:D009447 Neuroblastoma Topotecan 10.9115176712
MESH:D019636 Neurodegenerative Diseases Amphetamine 8.2215183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2220387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.508761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2916436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.504026338 6482804
MESH:D009784 Occupational Diseases Benzene 8.5015935809 15727169 16737584 17479406 15913788 15612468 17119257 17178637 15576619
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010024 Osteoporosis Genistein 6.8719401787
MESH:D010024 Osteoporosis Raloxifene 6.8717882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.4416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.4415579764 17823083 17893378 15758505
MESH:D012516 Osteosarcoma Doxorubicin 3.9315930896
MESH:D010051 Ovarian Neoplasms Benzene 10.7212562636
MESH:D010051 Ovarian Neoplasms Estradiol 10.7219401270
MESH:D010051 Ovarian Neoplasms Genistein 10.7219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.7215276417 17306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7416540662
MESH:D010190 Pancreatic Neoplasms Etoposide 11.7419003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.7419003803 16500647 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 11.7415113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9317983394
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6710923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.312563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9611118676 11399792 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.4116888761 15897917 16868541 18437689 16729912 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 2.4116740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.4117172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.4119082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.4116925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Raloxifene 2.4116536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.0916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9417365031 17975199 15814490 17322281
MESH:D011693 Purpura Raloxifene 5.3215770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8218722050 18286688 16160472 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 4.0017922066
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.4018410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012509 Sarcoma Doxorubicin 3.7915675481 18313854 17710206 17203757 15625365 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.8216326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 9.8214601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5617846226
MESH:D012878 Skin Neoplasms Doxorubicin 12.7415692506
MESH:D012878 Skin Neoplasms sodium arsenite 12.7419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7416192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 12.7418590791
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3417203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7916709447
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8119457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.191977408
MESH:D013274 Stomach Neoplasms Benzene 4.5912562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5917498489 17522103 17172411 16424979 18567086 19084572 19015929 15786421 18396642 16951190
MESH:D013274 Stomach Neoplasms irinotecan 4.5915723263
MESH:D020521 Stroke Raloxifene 3.6416837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013953 Thymus Neoplasms Benzene 4.7310850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.003712494 7505956 1399818 6582329 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.007505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.0016010429 17909728
MESH:D013978 Tibial Fractures Estradiol 12.9419048282
MESH:D013978 Tibial Fractures Raloxifene 12.9419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7916280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.728074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.7217653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.7217572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.7216712894 17306315 11723127 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.7216712894 17572228 8653321
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 18.7212846360
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.8316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.8311813266
MESH:D014594 Uterine Neoplasms Benzene 8.8412562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8414692618
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0016364871 17678736 17638931 17334414
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00036 - Coagulation factor VIIa Coagulants;Thrombotic Agents
DB06779 other Dalteparin Anticoagulants;Antithrombotics;Heparins
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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