AutismKB 2.0

Annotation Detail for TG


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Basic Information Top
Gene Symbol:TG ( AITD3,TGN )
Gene Full Name: thyroglobulin
Band: 8q24.22
Quick LinksEntrez ID:7038; OMIM: 188450; Uniprot ID:THYG_HUMAN; ENSEMBL ID: ENSG00000042832; HGNC ID: 11764
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05320Autoimmune thyroid disease
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
thyroiditis, chronic lymphocytic
autoimmune thyroid disease
IMMUNE
Graves' disease
No data
Desease Name
Autoimmune thyroid disease, susceptibility to 3
Thyroid dyshormonogenesis 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in decreased expression of TG mRNAdecreases expression 18020914
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TG mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of TG mRNAincreases expression 16648578
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TG mRNAaffects cotreatment|increases expression 20360939
C014347 decitabine [decitabine co-treated with Tretinoin] results in increased expression of TG mRNAaffects cotreatment|increases expression 19524134
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of TG mRNAaffects cotreatment|increases expression 20360939
D008713 Methimazole Methimazole results in decreased expression of TG proteindecreases expression 17332529
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TG mRNAincreases expression 17616710
C494474 perchlorate perchlorate results in decreased expression of TG proteindecreases expression 17332529
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TG mRNAdecreases expression 18175754
D013974 Thyroxine Thyroxine inhibits the reaction [Thiourea results in increased expression of TG mRNA]decreases reaction|increases expression 17888916
D013890 Thiourea Thiourea results in increased expression of TG mRNAincreases expression 17888916
D013890 Thiourea Thyroxine inhibits the reaction [Thiourea results in increased expression of TG mRNA]decreases reaction|increases expression 17888916
D014212 Tretinoin [decitabine co-treated with Tretinoin] results in increased expression of TG mRNAaffects cotreatment|increases expression 19524134
D014212 Tretinoin Tretinoin results in increased expression of TG mRNAincreases expression 17679169
D014638 Vanadates Vanadates results in increased expression of TG proteinincreases expression 17874149
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000236 Adenoma Diethylnitrosamine 2.8810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.9816434500 19052882 19061943 17162532 17620307 18056438
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8520041841 18057881 18218290
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.9418651412 19698954
OMIM:608175 AUTOIMMUNE THYROID DISEASE, SUSCEPTIBILITY TO, 3 marker/mechanism
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.4419483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4416197459 16206674
MESH:D001943 Breast Neoplasms bexarotene 2.0216818667 16344269
MESH:D001943 Breast Neoplasms decitabine 2.0219208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0217474063
MESH:D001943 Breast Neoplasms Tretinoin 2.0216443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0618978308 19701751 18691550 20524982 16935385 19052882 16569478 17978847 16540662 20007298 10737359 17173139 19107877 16288022 18494052 19171122 20214788 19394651 19383236 10672840 18056438 17138121 19208518 20084675 19919837 19539802 16698587 20935162 18971187 3581430 16830150 19335982 16681979 3084413 20101231 17055752 17162532 21159647 18665156 16779866 20512989 16502159 20432363 17761372 19418558 18210153 18506893 11831363 16878318 16328049 17428255 19822196 18788625 20727157 19519916 18785209 20514400 16807293 18393292
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.061917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2416247446
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8119215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8116051514 16096774
MESH:D006332 Cardiomegaly Thyroxine 4.1318093424
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9119225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1718974383
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.897505956 21159647 17174075 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7319052882
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002972 Cleft Palate Tretinoin 2.699407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829224671 17551590 16925845 9664655 9211117 8800419 9142499 10589399 14991402 9125849
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.4215265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4219107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.4215131321
MESH:D004489 Edema, Cardiac Tretinoin 4.5618230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7916510608 15264214 15547733 15547721 16805852 16704527 15150132 15623463 15878914
MESH:D005124 Eye Abnormalities Tretinoin 3.6216938888 9664655
MESH:D005234 Fatty Liver Amiodarone 8.1414986274
MESH:D005234 Fatty Liver Diethylnitrosamine 8.1421071580 20387270
MESH:D005355 Fibrosis Tretinoin 3.5817994277
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D006042 Goiter marker/mechanism 8094490
MESH:D006042 Goiter perchlorate 5.3618801409
MESH:D006258 Head and Neck Neoplasms decitabine 7.9519215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.929664655 14991402
MESH:D006529 Hepatomegaly Amiodarone 3.8215265979
MESH:D006930 Hyperalgesia Tretinoin 3.2516870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.938137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006980 Hyperthyroidism Methimazole 5.6814678291
MESH:D007037 Hypothyroidism Amiodarone 12.0618020914 17991464
MESH:D007037 Hypothyroidism Methimazole 12.0618031379
MESH:D007248 Infertility, Male decitabine 3.2417581917
MESH:D007249 Inflammation Diethylnitrosamine 2.4018785209
MESH:D007333 Insulin Resistance Sodium Selenite 3.3114714311
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6410783313
MESH:D007569 Jaw Abnormalities Tretinoin 3.9517551590 15992940
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.5815369732
MESH:D007938 Leukemia decitabine 6.5118980019 19235587
MESH:D007938 Leukemia Tretinoin 6.5117143497
MESH:D007951 Leukemia, Myeloid decitabine 9.7518454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 9.7516932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0019010910 18460780 19387464 17679729 18206229 18704418
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0017596541 19850784 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.0316766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.0319075265 17217047 17294898 16935935 16823087 16766008 16788101 17506722 16891316 16331271 17361223 9834237 17649720 15748426 12679006 19225113 16140955 17339181 17712046 19035177 17107899 19642359 17301526 19029980 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008064 Lipidoses Amiodarone 3.5515342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8518407596 20032147 18522880 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8016248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.2615175105 19499222 15885732 19812893 20583210 10737359 19850985 19294768 21071580 19690152 20434301 19833225 2862719 18644402 18977376 12771043 18648771 21047994 19090486 20137499 20118626 12112319 21167192 19073162 19254457 19256749 19642983 21278145 2422723 20452335 19427195 19426721 19996281 18754104 18978307 9163691 20501860 16942905 20101389 19638242 19551842 20492335 19255062 20405173
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.6618253720 19009564 19519916 19126423 16842330 18544905 17174075 18079962 18164116 17942915 9362446 19539802 18282651 18775883 2563599 18093689 19004024 16267830 21159647 3124819 17854601 18308698
MESH:D008133 Long QT Syndrome Amiodarone 3.6217391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.4112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5818516814
MESH:D008175 Lung Neoplasms bexarotene 2.7417849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.7420970405 20512841 21163286 6695378
MESH:D008223 Lymphoma decitabine 3.4619470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.2211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.4419196722 19196723 15591091
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma decitabine 3.4516505122 17785578
MESH:D008545 Melanoma Tretinoin 3.4516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D009101 Multiple Myeloma decitabine 3.3818172295
MESH:D009181 Mycoses Amiodarone 5.0012754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 7.5816882708 19157545 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5817596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms decitabine 5.2717925555 19470736 19116145
MESH:D009369 Neoplasms Tretinoin 5.2716594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8819196722
MESH:D009421 Nervous System Malformations Tretinoin 3.849125849
MESH:D009436 Neural Tube Defects Tretinoin 3.099142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D010051 Ovarian Neoplasms decitabine 5.0119331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0116936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.7519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.7516540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7515976015
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3918760546
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011654 Pulmonary Edema Thiourea 6.0110849556
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8711597910 12490602 12832656
MESH:D012208 Rhabdomyosarcoma decitabine 11.1519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.1516116481 16283617
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1718724381
MESH:D012878 Skin Neoplasms Tretinoin 2.6316467112
MESH:D013274 Stomach Neoplasms decitabine 4.8019037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.8018456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.8017575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 4.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.3718087811
MESH:D013610 Tachycardia Amiodarone 4.3511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2519225199
MESH:D013959 Thyroid Diseases Amiodarone 13.0219731979
MESH:D013959 Thyroid Diseases Thyroxine 13.0219910387
OMIM:274700 THYROID DYSHORMONOGENESIS 3 marker/mechanism
MESH:D013964 Thyroid Neoplasms decitabine 12.2617967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.267505956
MESH:D013964 Thyroid Neoplasms Tretinoin 12.2617045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.9318020914 19584973
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D016171 Torsades de Pointes Amiodarone 4.2711989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7417616700 19087683
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014604 Uveal Neoplasms decitabine 13.1617785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.1616752155
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
Pathway ID Pathway Name
KEGG:05320 Autoimmune thyroid disease
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36479
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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