AutismKB 2.0

Annotation Detail for TGFB1I1


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Basic Information Top
Gene Symbol:TGFB1I1 ( ARA55,HIC-5,HIC5,TSC-5 )
Gene Full Name: transforming growth factor beta 1 induced transcript 1
Band: 16p11.2
Quick LinksEntrez ID:7041; OMIM: 602353; Uniprot ID:TGFI1_HUMAN; ENSEMBL ID: ENSG00000140682; HGNC ID: 11767
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
Pathway IDPathway Name
P00056VEGF signaling pathway
P00005Angiogenesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of TGFB1I1 mRNAincreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of TGFB1I1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TGFB1I1 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of TGFB1I1 mRNAincreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TGFB1I1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of TGFB1I1 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TGFB1I1 mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TGFB1I1 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of TGFB1I1 mRNAincreases expression 20106945
C004742 daidzein daidzein promotes the reaction [TGFB1I1 protein results in increased activity of AR protein]increases activity|increases reaction 17252558
C014347 decitabine decitabine results in increased expression of TGFB1I1 mRNAincreases expression 19194470
D004041 Dietary Fats Dietary Fats results in increased expression of TGFB1I1 mRNAincreases expression 18042831
D004317 Doxorubicin TGFB1I1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D005419 Flavonoids Flavonoids results in decreased expression of TGFB1I1 mRNAdecreases expression 18035473
C041786 palm oil palm oil results in increased expression of TGFB1I1 mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of TGFB1I1 proteinincreases expression 19540241
D010656 Phenylephrine [Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 proteinaffects expression|increases phosphorylation 19540241
D010656 Phenylephrine [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 proteinaffects expression|increases phosphorylation 19540241
D010656 Phenylephrine TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]increases expression|increases reaction 19540241
D010656 Phenylephrine TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]increases expression|increases reaction 19540241
D010656 Phenylephrine TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]increases expression|increases reaction 19540241
D015474 Isotretinoin Isotretinoin results in increased expression of TGFB1I1 mRNAincreases expression 15982314
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGFB1I1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TGFB1I1 mRNAdecreases expression 19465110
D014212 Tretinoin Tretinoin metabolite results in increased expression of TGFB1I1 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of TGFB1I1 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of TGFB1I1 mRNAincreases expression 16604517
D014415 Tunicamycin Tunicamycin results in increased expression of TGFB1I1 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 8.4118769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4111752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.9018769834
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.2016232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.4016185265 18769834
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1520127859 20464547
MESH:D000230 Adenocarcinoma daidzein 7.1511473722
MESH:D000230 Adenocarcinoma Doxorubicin 7.1517418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0317460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.8015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6214601052
MESH:D001919 Bradycardia Phenylephrine 4.4615306635
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms alitretinoin 3.7216344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7220146248 17474063
MESH:D001943 Breast Neoplasms decitabine 3.7219208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 3.7220435547
MESH:D001943 Breast Neoplasms Doxorubicin 3.7215994142 15136595 18382427 16935488 11325840 16264153 17983394 17426702 17369602 15567936 15668708 15939500 16595493 18695136 16826403 16096432 15692762 18234424 18628466 19526202 15993339 16322301 15634643 16115903
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7220435547
MESH:D001943 Breast Neoplasms Tretinoin 3.7216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.473084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.4712907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.4716234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.471917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.1216201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.0920419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 14.0919215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.096189445
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 14.0911237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.0916051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 6.7211754973 16170337 15728586 11179087 17124262 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7216120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.4717924179 16242529 16278810 16612575 16269455 17007740 17308081 17131338 18627295 16455267 17928571 16364871 17351982 17519947 16651473 17974986 17382496 15811867 16731534 15476868 15792986 16952015 15505089 16109756 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002318 Cardiovascular Diseases daidzein 4.1916332659
MESH:D002386 Cataract Acetaminophen 7.0510977129
MESH:D002386 Cataract Tretinoin 7.0517460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.4712371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 2.8519486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6412621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis Tretinoin 3.6217035595
MESH:D003110 Colonic Neoplasms decitabine 2.3217616700
MESH:D015179 Colorectal Neoplasms decitabine 2.6718981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6718802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.8518769834 9879862
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8520055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.859142499 17551590 16925845 8800419 10589399 14991402 9664655 9125849 9211117 9224671
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 4.6016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0310774834 17522070 11834606 11421492 16227642 12153990 15619225 11743745 2444490 12540782 12392966 14725611 19085960 16781746 14986274 11529661 16081117 19739265 19420014 18713872 19923254 11739529 16177239 10663392 19164858 15968718 12594235 12958197 16485898 17906064 19370779 12705907 16393943 11287661 17562736 19416960 16109766 18071297 11461765 14550746 10915739
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.0317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Doxorubicin 7.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0319294695
MESH:D016889 Endometrial Neoplasms daidzein 12.3311473722
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.3317359293
MESH:D016889 Endometrial Neoplasms Tretinoin 12.3316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.949294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D007172 Erectile Dysfunction daidzein 4.9314972507
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 7.4619224547
MESH:D005234 Fatty Liver Dietary Fats 7.4617967931 19551842 19004024 18296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005355 Fibrosis Cyclosporine 20.4312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.4318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.4320067830
MESH:D005355 Fibrosis Tretinoin 20.4317994277
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 7.0517150277
MESH:D005909 Glioblastoma Tretinoin 7.0517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms decitabine 12.6519215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.6515692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.6516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.829664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.4216244372 17888722 16495754 16707910 18006777 14766674 16879835 16244371 17875725 16144979 18674790 16330681 12587719
MESH:D006333 Heart Failure Doxorubicin 3.2917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8112621046 15340226 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.3318501091 17606976 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9616959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.3916870215
MESH:D006930 Hyperalgesia Tretinoin 7.3916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006973 Hypertension Cyclosporine 12.1610903974
MESH:D006973 Hypertension daidzein 12.1617169123
MESH:D006973 Hypertension Phenylephrine 12.1612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.1618670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.4718502941 12791704
MESH:D007248 Infertility, Male decitabine 3.1417581917
MESH:D007249 Inflammation Dietary Fats 8.0520412841
MESH:D007249 Inflammation Flavonoids 8.0517296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.0518457598 11836018
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6615992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.5516144296
MESH:D007674 Kidney Diseases Acetaminophen 9.7415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.7418776723 8314463 10903974
MESH:D007674 Kidney Diseases Doxorubicin 9.7415369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0716707910
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6612371664
MESH:D007938 Leukemia decitabine 6.2819235587 18980019
MESH:D007938 Leukemia Tretinoin 6.2817143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D007951 Leukemia, Myeloid decitabine 9.2918454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9218460780 17679729 19010910 18704418 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9216294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0916331271 17712046 19225113 17506722 15748426 16788101 16766008 12679006 17368321 19642359 19035177 9834237 17217047 16891316 16140955 17301526 16935935 19029980 17339181 17294898 16823087 17649720 19075265 17361223 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8318296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4518397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6119460945 12969438 16610002 16611625 19784758 12587719 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1617185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.1918177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.1920195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.1916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.548603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.5417085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5412151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9417365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.4314755239
MESH:D008175 Lung Neoplasms alitretinoin 8.4316413115
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.4320064080 6695378 20869020 20464547 18569708 17053015 18816296 20135361 18520028
MESH:D008175 Lung Neoplasms Doxorubicin 8.4317418594 6189445
MESH:D008175 Lung Neoplasms Isotretinoin 8.4315899809
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.4311884234 19555203
MESH:D008223 Lymphoma decitabine 7.5119470736
MESH:D008223 Lymphoma Doxorubicin 7.5116098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 2.9715458769
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma decitabine 7.2516505122 17785578
MESH:D008545 Melanoma Doxorubicin 7.2516827129
MESH:D008545 Melanoma Isotretinoin 7.2517237267
MESH:D008545 Melanoma Tretinoin 7.2516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.3218303189 16166281 16966607
MESH:D008654 Mesothelioma Doxorubicin 6.3217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009101 Multiple Myeloma decitabine 3.2818172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.3119010910 16882708 18608210 19157545
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3117596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.9115857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9218259882
MESH:D009369 Neoplasms alitretinoin 11.5616946489
MESH:D009369 Neoplasms Benzo(a)pyrene 11.5611141357
MESH:D009369 Neoplasms decitabine 11.5619116145 17925555 19470736
MESH:D009369 Neoplasms Tretinoin 11.5616594593 16946489
MESH:D009401 Nephrosis Doxorubicin 4.6816636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0416889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2214600291
MESH:D009421 Nervous System Malformations Tretinoin 9.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.009142499
MESH:D009447 Neuroblastoma Doxorubicin 7.2115555623
MESH:D009447 Neuroblastoma Isotretinoin 7.2117368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009765 Obesity Dietary Fats 2.2719632207 18674790 20132043 21332399 17217161 18457598 16723640 11836018 20518802
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010051 Ovarian Neoplasms decitabine 4.8719331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8716936753
MESH:D010146 Pain Acetaminophen 6.3416870215
MESH:D010146 Pain Tretinoin 6.3416870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.2719294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2715976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8110923243
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D017499 Porokeratosis alitretinoin 5.9216144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 9.5618769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611118676 11399792 11222880 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.6417616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3117292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3116729912 16888761 15897917 18437689 16868541 15749863
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.8318769834
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0017975199 17322281 17365031 15814490
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.6719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.6716116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.9117710206 16767912 17203757 15625365 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012852 Sinusitis Phenylephrine 4.627327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.4810029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 17.4815692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.488532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.4816192470
MESH:D012878 Skin Neoplasms Tretinoin 17.4816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4816767912 15625365 17203757
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.332093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.3319037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.3317261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms decitabine 11.6717967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.6717909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 11.6716026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1917053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.1917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.1917653716
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6016129372
MESH:D014604 Uveal Neoplasms decitabine 12.5617785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.5616752155
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1317638931 17334414 17678736 16364871
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:04510 Focal adhesion
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04370 VEGF signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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