AutismKB 2.0

Annotation Detail for TGFBI


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Basic Information Top
Gene Symbol:TGFBI ( BIGH3,CDB1,CDG2,CDGG1,CSD,CSD1,CSD2,CSD3,EBMD,LCD1 )
Gene Full Name: transforming growth factor, beta-induced, 68kDa
Band: 5q31.1
Quick LinksEntrez ID:7045; OMIM: 601692; Uniprot ID:BGH3_HUMAN; ENSEMBL ID: ENSG00000120708; HGNC ID: 11771
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
BIGH3 gene mutations
Lattice corneal dystrophy type 1
CHEMDEPENDENCY
smoking cessation
granular corneal dystrophy
No data
Desease Name
Corneal dystrophy, Reis-Bucklers type
Corneal dystrophy, lattice type IIIA
Corneal dystrophy, epithelial basement membrane
Corneal dystrophy, lattice type I
Corneal dystrophy, Groenouw type I
Corneal dystrophy, Avellino type
Corneal dystrophy, Thiel-Behnke type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TGFBI mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TGFBI mRNAaffects expression 21346803
C105260 4-tert-octylphenol 4-tert-octylphenol results in decreased expression of TGFBI mRNAdecreases expression 17011747
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of TGFBI mRNAincreases expression 17011747
D000082 Acetaminophen Acetaminophen affects the expression of TGFBI mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of TGFBI mRNAaffects expression 19483382
D001194 Asbestos Asbestos results in decreased expression of TGFBI mRNAdecreases expression 16920672
D001553 Benzbromarone Benzbromarone affects the expression of TGFBI mRNAaffects expression 19483382
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TGFBI mRNAaffects expression 17484886
D002994 Clofibrate Clofibrate affects the expression of TGFBI mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TGFBI mRNAaffects cotreatment|affects expression 17602206
C121718 dicyclanil dicyclanil results in decreased expression of TGFBI mRNAdecreases expression 15664270
D004041 Dietary Fats Dietary Fats results in decreased expression of TGFBI mRNAdecreases expression 18042831
18457598
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TGFBI mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of TGFBI mRNAdecreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of TGFBI mRNAdecreases expression 15289156
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of TGFBI mRNAdecreases expression 17011747
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of TGFBI mRNAincreases expression 17011747
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFBI mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TGFBI mRNAincreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of TGFBI mRNAdecreases expression 15289156
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBI mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TGFBI mRNAdecreases expression 16174780
D005001 Ethionine Ethionine affects the expression of TGFBI mRNAaffects expression 19483382
D005472 Fluorouracil TGFBI protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D019833 Genistein Genistein results in decreased expression of TGFBI mRNAdecreases expression 15289156
C051890 irinotecan irinotecan analog results in decreased expression of TGFBI mRNAdecreases expression 18927307
C533894 LG 100815 LG 100815 results in increased expression of TGFBI mRNAincreases expression 16951191
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of TGFBI mRNAincreases expression 16951191
D009853 Omeprazole Omeprazole affects the expression of TGFBI mRNAaffects expression 19483382
C041786 palm oil palm oil results in decreased expression of TGFBI mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TGFBI mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TGFBI mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of TGFBI mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid affects the expression of TGFBI mRNAaffects expression 19483382
D011374 Progesterone Progesterone results in increased expression of TGFBIincreases expression 17510236
D011441 Propylthiouracil Propylthiouracil affects the expression of TGFBI mRNAaffects expression 19483382
D020849 Raloxifene Raloxifene affects the expression of TGFBI mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in decreased expression of TGFBI mRNAaffects cotreatment|decreases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of TGFBI mRNAaffects cotreatment|increases expression 19059307
C009277 sodium arsenate sodium arsenate results in decreased expression of TGFBI mRNAdecreases expression 16882884
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in decreased expression of TGFBI mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of TGFBI mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFBI mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNAincreases expression 20106945
19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGFBI mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNAincreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGFBI mRNAincreases expression 15644576
D013853 Thioacetamide Thioacetamide affects the expression of TGFBI mRNAaffects expression 19483382
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of TGFBI mRNAdecreases expression 18087596
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of TGFBI mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in increased expression of TGFBI mRNAincreases expression 16951191
D014810 Vitamin E Vitamin E results in increased expression of TGFBI mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1614745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.036195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Estradiol 9.2811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.2814692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.2817638652
MESH:D000230 Adenocarcinoma Genistein 9.2811473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.1415814487
MESH:D000236 Adenoma Diethylnitrosamine 2.636695378 10737359
MESH:D018248 Adenoma, Liver Cell dicyclanil 28.6217162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 28.6219061943 17162532 19052882 16434500 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 28.6217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 28.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 28.6216835633
MESH:D000419 Albuminuria Raloxifene 4.2317308373 17451421
MESH:D000505 Alopecia Tretinoin 3.3215955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4515800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1215469931
MESH:D000740 Anemia Fluorouracil 7.5916511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5911748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4720041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 8.6715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.4116412693
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.5619898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5616292516
MESH:D001249 Asthma Tretinoin 2.2216456186
MESH:D050197 Atherosclerosis Asbestos 3.9918795166
MESH:D001281 Atrial Fibrillation Amiodarone 3.6218651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001471 Barrett Esophagus Tretinoin 4.0416935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 58.7119483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 58.7119483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 58.7119483382
MESH:D001778 Blood Coagulation Disorders Ethionine 58.7119483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 58.7119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 58.7119483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 58.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 58.7112125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 58.7119483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 58.7116197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9517868700
MESH:D001930 Brain Injuries Progesterone 9.7315665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.7316580743
MESH:D001943 Breast Neoplasms Dietary Fats 7.7720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.7717474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 7.7715324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 7.7717289903 18497071 17261762 19861407 14630087 12948864 17018787 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 7.7719217205 15136595 16110121 18608205 16557594 16595493 18357371
MESH:D001943 Breast Neoplasms Genistein 7.7717200150 16873071 16541309
MESH:D001943 Breast Neoplasms Progesterone 7.7717614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 7.7717261762 16837676 17893378 17242785 17049068 16912660 15572757 15775269 17952589 17440819 15758505 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 7.7719200415 20005174 19189212 19103187 20544844 19066611 19487384 19011961 17440819 18855134 17261762 17242785 20859285 17893378 20390343 18815881 17049068 15668708 19288272 18351453 21152245 19059307 19115204 18821012 15565566 18984771 19410462 19155303 16873071 16273361 19189210 16818667 21138602 19244106 20065188 18629630 16202921 19289846 19084267 11161223 18425577 20135344 19221464 18997820 19142967
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.7720435547
MESH:D001943 Breast Neoplasms Tretinoin 7.7716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.7010355542 15673190 16050911 18705752 3786805 15721981 16192424 16124888 16011737 15700767 16097048 16227642
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.7016050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2816051944
MESH:D002277 Carcinoma Fluorouracil 7.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 34.1716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 34.173084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 34.171701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 34.1718788625
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 34.1717162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 34.1718494052 18393292 18978308 19052882 16328049 16807293 10672840 17138121 19919837 18506893 17055752 16540662 20101231 16681979 20514400 3084413 16935385 18691550 17162532 18665156 20512989 17428255 20727157 16830150 19107877 20007298 16569478 17761372 18788625 16288022 19208518 20935162 20214788 11831363 16878318 19418558 19383236 16779866 16502159 19701751 20524982 18056438 19539802 17978847 19822196 21159647 20432363 16698587 19519916 17173139 20084675 3581430 19335982 19394651 18971187 19171122 18785209 10737359 18210153
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 34.1716924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 34.1716924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 34.1717045692 17971768 16799960 17088986 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Genistein 34.1716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 34.1720007298 6705139 17173139 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 34.1716924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 34.1717997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 34.171917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.2911212258
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.9618986760 16280240 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 6.9611212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.9616051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.4117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.4117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7615710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 6.6216332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.6215775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7018974383
MESH:D002386 Cataract Acetaminophen 6.4710977129
MESH:D002386 Cataract Tretinoin 6.4717460283
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 9.761399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.767505956 2727394 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.7618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.884080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2116129372
MESH:D002637 Chest Pain Omeprazole 4.7215447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.2719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.2716835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.2718291259
MESH:D002779 Cholestasis Ethinyl Estradiol 6.8117110522 16919318 16105132 11677210 17333356 15861022 17681005
MESH:D002779 Cholestasis pirinixic acid 6.8119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2012621046 16354765 8697196 15668235 15340226
MESH:D002972 Cleft Palate Tretinoin 5.209407595
MESH:D003072 Cognition Disorders Raloxifene 4.2515800139
MESH:D003092 Colitis Tretinoin 3.3317035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.4317287894 15001691 17018589 18772588 16340194 17725105 17016597 16510598 17172411 17169374
MESH:D003110 Colonic Neoplasms Genistein 5.4317182828
MESH:D003110 Colonic Neoplasms irinotecan 5.4317287894 17725105
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6316282729 16331619 18802399 17594712 20501625 18509181 16524972 17016601 18448328 17094418 16303861 17255274 17454858 15289873 17695437 16391804 17401013 18288408 18383874 18949393 15148649 14970324
MESH:D015179 Colorectal Neoplasms irinotecan 2.6316391804 18509181 17159606 16303861 17454858 18259882 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7417141729 14669216
MESH:C535474 Corneal dystrophy Avellino type marker/mechanism
MESH:C535477 Corneal dystrophy, epithelial basement membrane marker/mechanism
OMIM:608471 CORNEAL DYSTROPHY, LATTICE TYPE IIIA marker/mechanism
MESH:C535476 Corneal dystrophy of Bowman layer, type 1 marker/mechanism
MESH:C535942 Corneal dystrophy, Thiel-Behnke type marker/mechanism
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.0410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.049142499 17551590 9211117 10589399 9125849 9664655 9224671 14991402 8800419 16925845
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.0419769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1912952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6418551238
MESH:D007644 Darier Disease Fluorouracil 4.4116733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.4820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.4816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.4817107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.1819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.1815920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.1819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1217187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 20.0221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 20.0210774834 12153990 11421492 11743745 19923254 11529661 17906064 11287661 19164858 12540782 16177239 10915739 11834606 18713872 11461765 18071297 12594235 14550746 16393943 11739529 15968718 16485898 19739265 10663392 14986274 17562736 16227642 19370779 12958197 12705907 15619225 14725611 16781746 19085960 16081117 12392966 17522070 19420014 19416960 16109766 2444490
MESH:D056486 Drug-Induced Liver Injury Amiodarone 20.0218218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 20.0219336974 15968718 16227642 10092053 19085960 6884620 15998439 17522070 11566570 15027814 3786805 21278145 3732212 9327722 7120509 10915739 6623471 4309450 16177239 2869522 7440962 7179309
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.0219107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 20.0218186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.0220420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 20.0212963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.9717151854 16613094 21218061 15991576
MESH:D050171 Dyslipidemias Clofibrate 7.9116707586
MESH:D050171 Dyslipidemias Dietary Fats 7.9118367378
MESH:D004421 Dystonia Phenobarbital 3.651851702
MESH:C538011 Eales disease Vitamin E 4.329068938
MESH:D004487 Edema pirinixic acid 9.4812083418
MESH:D004487 Edema Raloxifene 9.4815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.6518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.9612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.9617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 18.9615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.9619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.6216402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.6216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 20.6815700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 20.6819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 20.6811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 20.6816202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 20.6816569247
MESH:D004715 Endometriosis Progesterone 7.8416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.743659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.493922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.236401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.887750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.643659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3517638652 16481741 15173087 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.9016938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.3316456712
MESH:D005234 Fatty Liver Amiodarone 43.1814986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 43.1816239168 16045604 17595544 12631006 19224547 12795759 61145 15959796
MESH:D005234 Fatty Liver Clofibrate 43.1819224547
MESH:D005234 Fatty Liver Dietary Fats 43.1819004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 43.1821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 43.1815345470
MESH:D005234 Fatty Liver pirinixic acid 43.1820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 43.1817473493
MESH:D005234 Fatty Liver Tamoxifen 43.1814986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.4316611131 16513791 15751030 16002989 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.4316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 18.0918705752
MESH:D005355 Fibrosis Dietary Fats 18.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.0920067830
MESH:D005355 Fibrosis Tretinoin 18.0917994277
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5716452187
MESH:D005909 Glioblastoma Genistein 6.3816598420
MESH:D005909 Glioblastoma Tretinoin 6.3817312396
MESH:D005910 Glioma Fluorouracil 2.7116145905
MESH:D018149 Glucose Intolerance sodium arsenate 4.7319446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:C537304 Groenouw type I corneal dystrophy marker/mechanism
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.9315102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.939664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 9.9316080930
MESH:D006331 Heart Diseases Raloxifene 3.2711110106
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2317276928 18665440 15929193
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2819110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.2816456712
MESH:D006529 Hepatomegaly Amiodarone 17.6215265979
MESH:D006529 Hepatomegaly Phenobarbital 17.6216109766
MESH:D006529 Hepatomegaly pirinixic acid 17.6219772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.6216120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D019584 Hot Flashes Estradiol 8.7617088409
MESH:D019584 Hot Flashes Vitamin E 8.7614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6618606429 16959395 16354765 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 6.6316870215
MESH:D006930 Hyperalgesia Tretinoin 6.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.049751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.0421332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2721332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0614722030 12960047
MESH:D006973 Hypertension Raloxifene 4.7117577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.0016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.0016569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.3718020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.378137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0315869954
MESH:D007246 Infertility Diethylstilbestrol 3.9915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2417937319
MESH:D007249 Inflammation Dietary Fats 17.3020412841
MESH:D007249 Inflammation Diethylnitrosamine 17.3018785209
MESH:D007249 Inflammation Progesterone 17.3015869954
MESH:D007249 Inflammation Tamoxifen 17.3019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.3012200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 17.3018590791
MESH:D007251 Influenza, Human Vitamin E 3.8316624496
MESH:D007333 Insulin Resistance Dietary Fats 10.8318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 10.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.8316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 8.7415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 8.7415618244
MESH:D007674 Kidney Diseases Vitamin E 8.7412488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.0816705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 20.0816762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 20.0815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 20.0816985049
MESH:D007680 Kidney Neoplasms Tamoxifen 20.0818625569
MESH:C537881 Lattice corneal dystrophy type 1 marker/mechanism
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6917184923
MESH:D007889 Leiomyoma Raloxifene 4.1416973256
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7919248655
MESH:D007938 Leukemia Genistein 5.7618980019 17468513
MESH:D007938 Leukemia Tretinoin 5.7617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0117596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9017107899 12679006 17217047 17506722 17361223 16935935 16331271 17649720 17712046 17294898 19642359 16823087 16766008 19225113 19075265 19029980 19035177 16788101 16891316 17301526 17339181 9834237 16140955 17368321 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.049224671
MESH:D008064 Lipidoses Amiodarone 7.0115342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.0115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.9816221502 16943688 21278145 11903743 16239168 17157831 17174718 17334410 11408273
MESH:D008103 Liver Cirrhosis Dietary Fats 13.9818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.9818522880 20032147 18665156 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 13.9821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.5917721639 17525996 15338365 16638106 15673190 17922224 14620537 18420326 18395914 14724832 15362042 15370692 18205269 15996030 17708605 18418968 18429990 17823541 12632514 18054572 18376398 18263696 18006644 12445418 10355542 14716496 15818738 12958196 17698563 11481614 15925388 15876570 18412020 20821823 18210741 17900296 17714472 12666154 15730626 15052691 17557913 12741479 16027843 17640975 18251166 12445421 18279442 16033810 18339082 15959796 17761835 15650968 15123356 15893842 12898905 17869086 16248980 12649538 17805973 17631135 12546737 12609069 17976157 12632512 16015684 18395095 14512876 14716833 13678700 16011737 15931870 18317297 17944888 17766677 16116963 18705752 15057751 16136751 18277467 18472094 18156304 18187930 17565644 12389079 16097048 18166357 18481824 12586293 17481882 18472332 16192424 14748882 12667390
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.5917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 14.5917292413 15465738 15288472 15316131 18031379 12679928 15158331 11481614 18615449 16098781 15716488 11682029 16489207 18416461 15362042 12891558 18458672 17629604 16248980 15334695 16343077 18295389 18380797 16097051 16511523 12531686 12175628 18395095 17355460 17050028 12557150 15095483 12085344 15078482 18263696 15288473 15474484 18032466 16126171 18606216 17127702 10677585 11172339 14739098 15075984
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 14.5916248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 14.5916169303
MESH:D008107 Liver Diseases Acetaminophen 11.3312587719 19784758 11587558 16611625 16610002 12969438 19460945 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.3316246199 15720792 15830285 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 11.3317034775
MESH:D008107 Liver Diseases Phenobarbital 11.3319363144
MESH:D008107 Liver Diseases Thioacetamide 11.3315158337 16337175 18374380
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.3517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.3516899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 14.3517276928 15633222 12479984 15313186
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 31.0619294768
MESH:D008113 Liver Neoplasms Clofibric Acid 31.0617602206
MESH:D008113 Liver Neoplasms dicyclanil 31.0620118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.0620434301 20137499 19850985 18754104 19254457 19812893 19294768 19996281 15885732 9163691 18977376 18644402 15175105 19833225 18648771 19551842 20452335 19499222 20101389 19426721 21167192 18978307 19255062 19256749 12112319 21278145 20583210 16942905 2422723 19073162 2862719 12771043 20405173 20501860 19642983 20492335 10737359 21071580 19427195 19690152 19090486 20118626 21047994 19638242
MESH:D008113 Liver Neoplasms Diethylstilbestrol 31.0615890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 31.0617045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 31.068742319 19812893 19073162 19482888 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 31.0616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 31.0616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.0616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.1212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.1217854601 18544905 21159647 19004024 19539802 17174075 18308698 2563599 16267830 18164116 19009564 18093689 16842330 18079962 18775883 9362446 18282651 17942915 3124819 19126423 19519916 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.121399818 6150874 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.1212151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 6.6612587719
MESH:D008171 Lung Diseases Vitamin E 6.6616863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0918516814
MESH:D008175 Lung Neoplasms Asbestos 9.8512111688
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.8520970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 9.8515246190
MESH:D008175 Lung Neoplasms Tamoxifen 9.8518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.8511884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 9.8511091918 16288123 3440675 12111688
MESH:D008175 Lung Neoplasms Vitamin E 9.8511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4115086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2015700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1316002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.2416891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.2414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.2417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.2414580682 11731420 19196723 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.3519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.3519453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Tamoxifen 3.0512393984 19393235
MESH:D008545 Melanoma Tretinoin 3.0516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008591 Meningomyelocele Tretinoin 4.0516940565
MESH:D008654 Mesothelioma Asbestos 3.9316319530 18709470 16919927 18310086 16564556
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1715863610
MESH:D009062 Mouth Neoplasms Fluorouracil 7.9916757204 18986760
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 7.9915006635
MESH:D052016 Mucositis irinotecan 4.6317159606
MESH:D009101 Multiple Myeloma Raloxifene 3.1716497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.5218186108
MESH:D009181 Mycoses Amiodarone 4.5112754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8617596541
MESH:D009203 Myocardial Infarction Genistein 5.1217141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.4916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.4917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.4916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0917484760
MESH:D009232 Myxoma Raloxifene 5.1716343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4818551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.619029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 8.6118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Diethylstilbestrol 10.2615313581
MESH:D009369 Neoplasms Fluorouracil 10.2616928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 10.2617405874
MESH:D009369 Neoplasms Tretinoin 10.2616594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6119196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 26.8911399458
MESH:D009421 Nervous System Malformations Estradiol 26.8916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 26.8916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 26.8914600291
MESH:D009421 Nervous System Malformations Tretinoin 26.899125849
MESH:D009436 Neural Tube Defects sodium arsenate 6.7819446573 18186108 11749123 10525206
MESH:D009436 Neural Tube Defects Tretinoin 6.789142499
MESH:D009447 Neuroblastoma irinotecan 3.288761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.1620387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.358761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1816436463
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.579802331
MESH:D009765 Obesity Dietary Fats 4.0818674790 11836018 19632207 20518802 21332399 20132043 18457598 17217161 16723640
MESH:D009765 Obesity pirinixic acid 4.0820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1012819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 3.9817016548
MESH:D010024 Osteoporosis Genistein 6.5419401787
MESH:D010024 Osteoporosis Raloxifene 6.5415775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.9816169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 8.9817893378 15758505 15579764 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 10.2119401270
MESH:D010051 Ovarian Neoplasms Genistein 10.2119005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.2117393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 10.2116936753
MESH:D010146 Pain Acetaminophen 5.5816870215
MESH:D010146 Pain Tretinoin 5.5816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.1116540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.1116500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.1116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.1115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3015687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.032563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.032563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.3017184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3011896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0315846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.0316740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0318626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.0315256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0315067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0315084515
MESH:D011507 Proteinuria Tretinoin 3.2616636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.1112752131
MESH:D011625 Pterygium Tretinoin 4.4116723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7012490602 11597910 12832656
MESH:D011693 Purpura Raloxifene 5.1715770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6918286688 15538739 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.2518410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7516283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.0718551238
MESH:D012640 Seizures Phenobarbital 5.0716876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.446407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7018724381
MESH:D012871 Skin Diseases Vitamin E 2.3418709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.4516192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 8.4518590791
MESH:D012878 Skin Neoplasms Tretinoin 8.4516467112
MESH:D013088 Spermatocele Diethylstilbestrol 17.8816002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 17.8816709447
MESH:D013088 Spermatocele Tamoxifen 17.8816709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.6015862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.6019457130
MESH:D013272 Stomach Diseases Omeprazole 4.2318545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.3919015929 15786421 18396642 17522103 19084572 18567086 16424979 17498489 17172411 16951190
MESH:D013274 Stomach Neoplasms irinotecan 4.3915723263
MESH:D013274 Stomach Neoplasms Tretinoin 4.3917261132
MESH:D013276 Stomach Ulcer Amiodarone 6.4618087811
MESH:D013276 Stomach Ulcer Omeprazole 6.4617977527 11906479 16755016 18237397 15991576 10750652
MESH:D020521 Stroke Raloxifene 7.7216837676
MESH:D020521 Stroke Vitamin E 7.7216517955
MESH:D013610 Tachycardia Amiodarone 3.9311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013959 Thyroid Diseases Amiodarone 10.7619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.7612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.767505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.761399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 14.7615710170
MESH:D013964 Thyroid Neoplasms Tretinoin 14.7616026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.4918020914 19584973
MESH:D013978 Tibial Fractures Estradiol 12.4219048282
MESH:D013978 Tibial Fractures Raloxifene 12.4219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.7316280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.7316051514
MESH:D016171 Torsades de Pointes Amiodarone 3.8111989578 17467628
MESH:D014376 Tuberculosis Tretinoin 2.9916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.1316049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 14.1316452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.1317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.1316712894 17572228 8653321
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 14.1312846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9310091137
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.9916175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 13.9916803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.9916129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.7814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.2716690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.2714692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2216752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0616002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2014671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Dietary Fats 3.4216723640
MESH:D009396 Wilms Tumor Tretinoin 3.6516287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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