AutismKB 2.0

Annotation Detail for TGM1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TGM1 ( ICR2,KTG,LI,LI1,TGASE,TGK )
Gene Full Name: transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
Band: 14q12
Quick LinksEntrez ID:7051; OMIM: 190195; Uniprot ID:TGM1_HUMAN; ENSEMBL ID: ENSG00000092295; HGNC ID: 11777
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Ichthyosis, lamellar, autosomal recessive
Self-healing collodion baby
Ichthyosiform erythroderma, congenital
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in decreased expression of TGM1 mRNAdecreases expression 19784758
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TGM1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TGM1 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of TGM1 mRNAaffects expression 21346803
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of TGM1 mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of TGM1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of TGM1 mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of TGM1 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of TGM1 mRNAincreases expression 19784758
C103303 alitretinoin alitretinoin results in decreased expression of TGM1 mRNAdecreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TGM1 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of TGM1 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of TGM1 mRNA]affects reaction|decreases expression 18929588
D002118 Calcium Calcium results in increased expression of TGM1 mRNAincreases expression 10469331
D002118 Calcium NPS R-467 promotes the reaction [Calcium results in increased expression of TGM1 mRNA]increases expression|increases reaction 10469331
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of TGM1 mRNAdecreases expression 19784758
D002117 Calcitriol Calcitriol results in decreased expression of TGM1 mRNAdecreases expression 16002434
D005419 Flavonoids Flavonoids results in increased expression of TGM1 mRNAincreases expression 18035473
D006854 Hydrocortisone [Hydrocortisone co-treated with sodium arsenate] results in increased expression of TGM1 mRNAaffects cotreatment|increases expression 11485391
D006854 Hydrocortisone [Hydrocortisone co-treated with sodium arsenite] results in increased expression of TGM1 mRNAaffects cotreatment|increases expression 11485391
D006854 Hydrocortisone Hydrocortisone results in increased expression of TGM1 mRNAincreases expression 11485391
D006854 Hydrocortisone sodium arsenate inhibits the reaction [Hydrocortisone results in increased expression of TGM1 mRNA]decreases reaction|increases expression 11485391
D006854 Hydrocortisone sodium arsenite inhibits the reaction [Hydrocortisone results in increased expression of TGM1 mRNA]decreases reaction|increases expression 11485391
D008743 Methyl Parathion Methyl Parathion results in decreased expression of TGM1 mRNAdecreases expression 19784758
D009578 Nitrobenzenes Nitrobenzenes analog results in decreased expression of TGM1 mRNAdecreases expression 19784758
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TGM1 mRNAincreases expression 17616710
C111654 NPS R-467 NPS R-467 promotes the reaction [Calcium results in increased expression of TGM1 mRNA]increases expression|increases reaction 10469331
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TGM1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of TGM1 mRNAdecreases expression 19482888
C059514 resveratrol resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM1 mRNA]decreases reaction|increases expression 16985168
C059514 resveratrol resveratrol results in increased expression of TGM1 mRNAincreases expression 16985168
D015474 Isotretinoin Isotretinoin results in decreased expression of TGM1 mRNAdecreases expression 15982314
C009277 sodium arsenate [Hydrocortisone co-treated with sodium arsenate] results in increased expression of TGM1 mRNAaffects cotreatment|increases expression 11485391
C009277 sodium arsenate sodium arsenate inhibits the reaction [Hydrocortisone results in increased expression of TGM1 mRNA]decreases reaction|increases expression 11485391
C009277 sodium arsenate sodium arsenate results in decreased expression of TGM1 mRNAdecreases expression 11485391
C017947 sodium arsenite [Hydrocortisone co-treated with sodium arsenite] results in increased expression of TGM1 mRNAaffects cotreatment|increases expression 11485391
C017947 sodium arsenite sodium arsenite inhibits the reaction [Hydrocortisone results in increased expression of TGM1 mRNA]decreases reaction|increases expression 11485391
C017947 sodium arsenite sodium arsenite results in decreased expression of TGM1 mRNAdecreases expression 11485391
D013749 Tetrachlorodibenzodioxin resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM1 mRNA]decreases reaction|increases expression 16985168
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGM1 mRNAincreases expression 16985168
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGM1 proteinincreases expression 16985168
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGM1 mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGM1 mRNAincreases expression 16960034
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of TGM1 mRNAincreases expression 11485391
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of TGM1 mRNAincreases expression 10866668
D013853 Thioacetamide Thioacetamide results in decreased expression of TGM1 mRNAdecreases expression 19784758
D014212 Tretinoin Tretinoin metabolite results in decreased expression of TGM1 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of TGM1 mRNAdecreases expression 16985168
15982314
17147502
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 18.517525203
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 18.5118769834
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 18.516195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 18.5111752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.7718769834
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.0516232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.2516185265 18769834
MESH:D058186 Acute Kidney Injury resveratrol 3.6516538975
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.403712494
MESH:D000236 Adenoma resveratrol 6.4015688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.3217620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000544 Alzheimer Disease resveratrol 2.5216162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001169 Arthritis, Experimental resveratrol 7.0517115116
MESH:D001169 Arthritis, Experimental Tretinoin 7.0516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D050197 Atherosclerosis resveratrol 3.1417967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2212125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 14.2219483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.2216197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D002545 Brain Ischemia resveratrol 4.0617600658
MESH:D001943 Breast Neoplasms alitretinoin 2.2816344269
MESH:D001943 Breast Neoplasms Calcitriol 2.2811237771
MESH:D001943 Breast Neoplasms resveratrol 2.2816393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5616050911 16011737 15721981 16124888 3786805 16097048 10355542 15673190 16227642 18705752 16192424 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.1616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 19.163581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.163084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.1618788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 19.1620007298 20935162 6705139 17173139 1701930
MESH:D006528 Carcinoma, Hepatocellular resveratrol 19.1619321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.1615276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 19.1617997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.161917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3616675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.577296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 17.2111237771
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 17.2111237771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 17.2116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 17.2118572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 17.2118922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 17.2116051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.3215458977
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 11.6114694615
MESH:D002386 Cataract Acetaminophen 11.6110977129
MESH:D002386 Cataract Tretinoin 11.6117460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.227505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.2220056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.9118291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.989022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Hydrocortisone 9.4215826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.428697196 15340226 16354765 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 9.429407595
MESH:D003092 Colitis resveratrol 8.8816474422
MESH:D003092 Colitis Tretinoin 8.8817035595
MESH:D003110 Colonic Neoplasms arsenite 3.9015037631
MESH:D003110 Colonic Neoplasms resveratrol 3.9016338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.5515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.5517141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6116507316
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 7.1017728286
MESH:D019465 Craniofacial Abnormalities Isotretinoin 7.1018769834 9879862
MESH:D019465 Craniofacial Abnormalities sodium arsenate 7.1010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.1015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.1017551590 9125849 10589399 16925845 8800419 9224671 9142499 9211117 14991402 9664655
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5911298694 18759878 8970840 11906362 2524372 8156756 14531868 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.283621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5916873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7716286809
MESH:D003967 Diarrhea Hydrocortisone 4.507237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 21.0321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 21.036679447 9328219 16192314 9022650 7440962 9653073 18692083 18289764 6482804 18648102 11289319 8291058 1440618
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 21.0321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.0311287661 16781746 19416960 10663392 16109766 18713872 2444490 12540782 11834606 14725611 16227642 11743745 16393943 11529661 16485898 14550746 17562736 12153990 16081117 11739529 19085960 19739265 19923254 19420014 10915739 12705907 14986274 12958197 10774834 15619225 15968718 16177239 17522070 12392966 11421492 19164858 19370779 18071297 11461765 17906064 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 21.033786805 10915739 3732212 6884620 4309450 10092053 9327722 15027814 19336974 21278145 6623471 2869522 15968718 7179309 17522070 19085960 7120509 16227642 11566570 16177239 15998439 7440962
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 21.0318186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.0320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 21.0312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D015352 Dry Eye Syndromes marker/mechanism 16146918
MESH:D004421 Dystonia Phenobarbital 3.791851702
MESH:D004487 Edema resveratrol 10.418985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4111000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.418273558 16716910 15177302 11698051 9599246 8113982 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1716714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.6715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.6717872969
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6217923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.883659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.643922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.356401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.793659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.443581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.4415623463 16805852 15264214 15150132 16510608 15547733 16704527 15547721 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.289664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.4916456712
MESH:D005234 Fatty Liver arsenite 7.3718296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.3716239168 16045604 19224547 12795759 17595544 61145 15959796 12631006
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D005355 Fibrosis arsenite 19.3218296743
MESH:D005355 Fibrosis Carbon Tetrachloride 19.3218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.3220067830
MESH:D005355 Fibrosis Tretinoin 19.3217994277
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005909 Glioblastoma Tretinoin 2.8617312396
MESH:D018149 Glucose Intolerance sodium arsenate 4.8719446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.1414991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3715929193 18665440 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 14.456705139
MESH:D006505 Hepatitis Carbon Tetrachloride 14.4519110552 19900420
MESH:D006505 Hepatitis Thioacetamide 14.4516456712
MESH:D006529 Hepatomegaly Phenobarbital 7.7016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7016120746 15340226 12621046
MESH:D006561 Herpes Simplex resveratrol 3.9516876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.0316870215
MESH:D006930 Hyperalgesia Tretinoin 7.0316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia resveratrol 3.8017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006949 Hyperlipidemias resveratrol 3.8216873680
MESH:D006962 Hyperparathyroidism, Secondary NPS R-467 6.8515086907
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1017488730
OMIM:242100 ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 marker/mechanism
MESH:D017490 Ichthyosis, Lamellar marker/mechanism
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4217600658
MESH:D007248 Infertility, Male sodium arsenite 2.8415346721 12646999
MESH:D007249 Inflammation Flavonoids 11.0417296493
MESH:D007249 Inflammation resveratrol 11.0416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0412200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 11.0415177302 7562506 11698051 8273558 7812673
MESH:D007251 Influenza, Human resveratrol 4.3116624496
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.799022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2515992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.4116144296
MESH:D007674 Kidney Diseases Acetaminophen 5.5315629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 5.5320008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.756582329
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.8116316344
MESH:D007938 Leukemia Tretinoin 2.6617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0416294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.2816087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.289834237 16891316 17217047 17301526 17107899 16935935 17368321 19029980 19035177 17361223 16766008 19225113 16140955 12679006 16788101 17506722 17339181 19075265 17649720 19642359 17294898 15748426 16331271 17712046 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.159224671
MESH:D008103 Liver Cirrhosis arsenite 10.3818296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3816221502 17157831 21278145 11903743 16239168 11408273 17174718 16943688 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7316248980 16097048 15876570 15362042 17714472 17900296 18412020 12741479 17922224 17640975 17761835 17869086 18210741 14716833 15338365 12445421 18395914 12649538 12546737 14724832 17557913 15893842 17805973 18420326 15730626 17525996 12958196 10355542 17766677 15650968 13678700 20821823 12632514 12609069 17708605 18395095 12632512 12666154 16192424 12667390 15673190 17976157 17631135 15370692 18251166 18279442 15818738 15925388 12898905 18705752 18376398 18429990 18187930 11481614 18418968 12586293 16011737 18481824 14620537 14512876 18472332 16638106 15057751 16136751 18166357 15959796 12389079 18156304 16116963 17721639 18277467 12445418 16027843 17944888 18006644 16015684 18472094 18054572 15996030 17823541 17565644 15052691 15931870 14716496 18317297 17698563 18205269 17481882 18263696 15123356 18339082 14748882 16033810
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7312878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.7315288472 11481614 15158331 12175628 16248980 16511523 18458672 16126171 18031379 18416461 17292413 15316131 10677585 15334695 16097051 18395095 18295389 15362042 16343077 15465738 18380797 11172339 15716488 17629604 17355460 18606216 15095483 12085344 18032466 18615449 12557150 12531686 14739098 15474484 15288473 15075984 17127702 16489207 11682029 12679928 16098781 17050028 12891558 15078482 18263696
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7318397230 16248980
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 8.8911587558 12969438 16610002 19014921 12587719 19784758 19460945 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8917285989 16964402 15720792 16246199 15830285
MESH:D008107 Liver Diseases Phenobarbital 8.8919363144
MESH:D008107 Liver Diseases Thioacetamide 8.8918374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.1017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.1016899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 15.1012479984 15313186 17276928 15633222
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.3119294768
MESH:D008113 Liver Neoplasms Phenobarbital 13.3119073162 15975961 19482888 19812893 21047994 8742319
MESH:D008113 Liver Neoplasms resveratrol 13.3119073162 20405173 19812893 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 13.3116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.3116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.943712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.941399818 6150874 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9412151625
MESH:D008171 Lung Diseases sodium arsenite 3.0219095001
MESH:D008175 Lung Neoplasms alitretinoin 8.1916413115
MESH:D008175 Lung Neoplasms arsenite 8.1916809336
MESH:D008175 Lung Neoplasms Isotretinoin 8.1915899809
MESH:D008175 Lung Neoplasms sodium arsenite 8.1915276417 19931552 17077188 17306315 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1911884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.1911807781
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0215688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.968985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 5.968985016
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Isotretinoin 7.0117237267
MESH:D008545 Melanoma resveratrol 7.0117992120
MESH:D008545 Melanoma sodium arsenite 7.0119082730 16487513
MESH:D008545 Melanoma Tretinoin 7.0116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008659 Metabolic Diseases resveratrol 4.1717112576
MESH:D009101 Multiple Myeloma resveratrol 3.3117049120 16490592 14749477 17164350 17935668 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6417962980
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6518186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9517596541
MESH:D009203 Myocardial Infarction resveratrol 2.9417188708 16317513 17125593 17015251 16525036 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.4117015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4112213967
MESH:D009205 Myocarditis resveratrol 4.5317322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6318551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.383581430
MESH:D009369 Neoplasms alitretinoin 7.7616946489
MESH:D009369 Neoplasms sodium arsenite 7.7611559025
MESH:D009369 Neoplasms Tretinoin 7.7616594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 8.488985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.4820056578
MESH:D009389 Neovascularization, Pathologic arsenite 4.1815738583
MESH:D009397 Nephrocalcinosis NPS R-467 6.8515086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.789125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.166679447
MESH:D009436 Neural Tube Defects sodium arsenate 16.1611749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 16.1612854658
MESH:D009436 Neural Tube Defects Tretinoin 16.169142499
MESH:D009447 Neuroblastoma Isotretinoin 3.9317368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.7417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1917929310
MESH:D020258 Neurotoxicity Syndromes marker/mechanism 19784758
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 4.6919784758
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.0112819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.016482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.0114694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D010024 Osteoporosis Calcium 3.6417882678
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0417513867
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.6417306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6416936753
MESH:D010146 Pain Acetaminophen 5.9816870215
MESH:D010146 Pain Tretinoin 5.9816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.2216965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.2215976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.2215976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.657296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.658330346 12065085 18404319 18922899
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D011041 Poisoning Methyl Parathion 4.8317603234
MESH:D017499 Porokeratosis alitretinoin 5.7716144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.432563599
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 15.0918769834
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.0916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.0911222880 11896295 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5515572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7416289102 15754350 16644109 18247401 12479363
MESH:D011471 Prostatic Neoplasms resveratrol 2.7417636462 17675339 17804756 16731767 17718901 15767336
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7416039940
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.2612752131
MESH:D011596 Psychomotor Disorders Isotretinoin 5.6918769834
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3516325855
MESH:D015427 Reperfusion Injury resveratrol 3.1617058453 16314181 16317513 17520802 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4218551238
MESH:D012640 Seizures Phenobarbital 5.423137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D012878 Skin Neoplasms resveratrol 16.8015837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 16.8019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.8016192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 16.808330346 18404319 8985016 12065085 11807781
MESH:D012878 Skin Neoplasms Tretinoin 16.8016467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.5712958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 2.5717261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2816321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.973712494 7505956 6587162 6582329 1399818
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.971399818
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9716026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 9.2516227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.2516051514
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.7816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.788074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.7816452187 11723127 17306315 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0910091137
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.7417473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.7411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.7416129372
MESH:D014594 Uterine Neoplasms resveratrol 3.9217044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0817488730
MESH:D014802 Vitamin A Deficiency marker/mechanism 16146918
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00130 - L-Glutamine Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved