AutismKB 2.0

Annotation Detail for TGM3


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Basic Information Top
Gene Symbol:TGM3 ( MGC126249,MGC126250,TGE )
Gene Full Name: transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Band: 20p13
Quick LinksEntrez ID:7053; OMIM: 600238; Uniprot ID:TGM3_HUMAN; ENSEMBL ID: ENSG00000125780; HGNC ID: 11779
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C059514 resveratrol resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM3 mRNA]decreases reaction|increases expression 16985168
C059514 resveratrol resveratrol results in increased expression of TGM3 mRNAincreases expression 16985168
D013749 Tetrachlorodibenzodioxin resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM3 mRNA]decreases reaction|increases expression 16985168
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TGM3 mRNAincreases expression 16985168
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of TGM3 mRNAdecreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5914514962 15322242 11752688
MESH:D058186 Acute Kidney Injury resveratrol 4.3316538975
MESH:D000236 Adenoma resveratrol 3.5415688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000544 Alzheimer Disease resveratrol 2.6416162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D001169 Arthritis, Experimental resveratrol 3.7517115116
MESH:D050197 Atherosclerosis resveratrol 3.5116873680 17967414
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D002545 Brain Ischemia resveratrol 5.0217600658
MESH:D001943 Breast Neoplasms resveratrol 2.1016393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D006528 Carcinoma, Hepatocellular resveratrol 2.3419321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 5.3316675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.8116227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5816120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.7615458977
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2512621046 15340226 16354765 8697196 15668235
MESH:D003092 Colitis resveratrol 12.2016474422
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 12.2018023891 16867261 16782535 17936198 11698051 17991707 16474422 18200517 16804969
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5517276891
MESH:D003110 Colonic Neoplasms resveratrol 2.5116338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4814669216 17141729
MESH:D003327 Coronary Disease resveratrol 4.0116507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 4.1616873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.3816286809
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema resveratrol 8.508985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.5011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.6117872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.479294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.5017923197
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.1920067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 11.1917994277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5416120746 15340226 12621046
MESH:D006561 Herpes Simplex resveratrol 4.9216876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9118606429 16354765 16959395 15340226 8697196
MESH:D006937 Hypercholesterolemia resveratrol 4.4917188708
MESH:D006949 Hyperlipidemias resveratrol 4.5616873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.7517488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 5.3017600658
MESH:D007249 Inflammation resveratrol 5.7316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.7312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.7118200517
MESH:D007251 Influenza, Human resveratrol 5.4116624496
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 5.2617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.8416087638
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms resveratrol 5.0219812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 5.0216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 4.8317088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.2614749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.9915688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.378985016 11606380
MESH:D008545 Melanoma resveratrol 2.4117992120
MESH:D008659 Metabolic Diseases resveratrol 4.8617112576
MESH:D009101 Multiple Myeloma resveratrol 3.7717935668 16267019 17049120 17164350 16490592 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.6117962980
MESH:D009203 Myocardial Infarction resveratrol 3.1716317513 17125593 16525036 17015251 17188708 16456233
MESH:D017202 Myocardial Ischemia resveratrol 10.2517015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 10.2512213967
MESH:D009205 Myocarditis resveratrol 5.5017322642
MESH:D009374 Neoplasms, Experimental resveratrol 4.658985016
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D019636 Neurodegenerative Diseases resveratrol 4.1917652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.9317929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.7817513867
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.7317698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 12.2016679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.2011222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms resveratrol 3.5717675339 16731767 15767336 17804756 17636462 17718901
MESH:D051436 Renal Insufficiency, Chronic resveratrol 6.4516325855
MESH:D015427 Reperfusion Injury resveratrol 3.4516317513 16314181 17058453 17520802 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012878 Skin Neoplasms resveratrol 6.308985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.3016192470
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.9316321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D014062 Tongue Neoplasms resveratrol 4.6616227395
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.5517473185
MESH:D014594 Uterine Neoplasms resveratrol 4.7217044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.9517488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36492
    • No data
    No data
    Releated drug ID Related drug Name
    PA449748gemcitabine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00130 - L-Glutamine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB01864 - 5'-Guanosine-Diphosphate-Monothiophosphate
    DB01972 - Guanosine-5'-Monophosphate
    DB03152 - B-2-Octylglucoside
    DB04315 - Guanosine-5'-Diphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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