AutismKB 2.0

Annotation Detail for TH


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Basic Information Top
Gene Symbol:TH ( DYT14,DYT5b,TYH )
Gene Full Name: tyrosine hydroxylase
Band: 11p15.5
Quick LinksEntrez ID:7054; OMIM: 191290; Uniprot ID:TY3H_HUMAN; ENSEMBL ID: ENSG00000180176; HGNC ID: 11782
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-301catecholamine biosynthesis
Pathway IDPathway Name
hsa05012Parkinson's disease
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Synaptic Transmission
Hormone biosynthesis
Metabolism of amino acids and derivatives
Pathway IDPathway Name
200187Alpha-synuclein signaling
200135p38 signaling mediated by MAPKAP kinases
200118AP-1 transcription factor network
200116ATF-2 transcription factor network
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
P00049Parkinson disease
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Tobacco Use Disorder
blood pressure, arterial
CARDIOVASCULAR
CHEMDEPENDENCY
left ventricular structure
prostate cancer
nicotine dependence
blood pressure
CANCER
PSYCH
alcoholism
body mass
alcohol-withdrawal delirium
hypertension
left ventricular function
schizophrenia
METABOLIC
mood disorder.
triglycerides
obesity
insulin
catecholamine turnover
Insulin Resistance
No data
Desease Name
Segawa syndrome, recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C084981 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]affects binding|increases activity|increases chemical synthesis|increases reaction 10661506
C084981 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]increases chemical synthesis|increases reaction 10661506
C084981 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]decreases reaction|increases chemical synthesis|increases reaction 10661506
C044563 24-hydroxycholesterol 24-hydroxycholesterol results in increased expression of and results in increased phosphorylation of TH proteinincreases expression|increases phosphorylation 19014385
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the expression of TH mRNAaffects expression 12641731
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNAincreases expression 17540007
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]affects reaction|increases expression 17540007
C016276 8-bromocyclic GMP 8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]affects binding|decreases activity|decreases reaction|increases activity 16023617
C016276 8-bromocyclic GMP 8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]affects binding|decreases activity|decreases reaction|increases activity 16023617
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of TH mRNAincreases expression 16543374
D024502 alpha-Tocopherol alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein]decreases expression|decreases reaction 15790535
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TH mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of TH proteindecreases expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of TH mRNAincreases expression 18681898
D000661 Amphetamine Amphetamine results in increased expression of TH mRNAincreases expression 16916582
D000661 Amphetamine Amphetamine results in decreased expression of TH proteindecreases expression 19145071
D000661 Amphetamine Amphetamine results in increased expression of TH mRNAincreases expression 16126238
C027423 aroclor 1242 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH proteinaffects cotreatment|decreases expression 17324953
C028617 aroclor 1248 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH proteinaffects cotreatment|decreases expression 17324953
C026987 aroclor 1260 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH proteinaffects cotreatment|decreases expression 17324953
D001280 Atrazine Atrazine results in decreased expression of TH proteindecreases expression 14550852
C006780 bisphenol A bisphenol A affects the expression of TH proteinaffects expression 16427766
C006780 bisphenol A bisphenol A results in decreased expression of TH proteindecreases expression 17689037
16909604
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNAaffects cotreatment|decreases expression 20360939
D002395 Catecholamines TH protein results in increased chemical synthesis of Catecholaminesincreases chemical synthesis 11911850
D002698 Chloralose [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH proteinaffects cotreatment|increases expression 12088752
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of TH proteindecreases expression 17229471
D020111 Chlorodiphenyl (54% Chlorine) IL6 gene mutant form inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of TH protein]decreases expression|decreases reaction 17229471
D020111 Chlorodiphenyl (54% Chlorine) [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of TH proteinaffects cotreatment|decreases expression 17324953
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of TH mRNAincreases expression 18812211
D003024 Clozapine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]increases activity|increases metabolic processing|increases reaction 16402076
D003024 Clozapine Clozapine results in increased activity of TH proteinincreases activity 16415089
D003024 Clozapine [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamineincreases activity|increases metabolic processing 16415089
D003024 Clozapine Clozapine results in decreased activity of TH proteindecreases activity 15983997
D003024 Clozapine Clozapine results in decreased expression of TH mRNAdecreases expression 15983997
12645084
D003024 Clozapine Clozapine results in decreased expression of TH proteindecreases expression 12645084
15983997
D003024 Clozapine Clozapine results in increased expression of TH proteinincreases expression 17028028
D003024 Clozapine Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]decreases expression|decreases reaction 15983997
C018021 cobaltous chloride [cobaltous chloride co-treated with Y 27632] results in increased expression of TH proteinaffects cotreatment|increases expression 16772336
C018021 cobaltous chloride cobaltous chloride results in increased expression of TH mRNAincreases expression 9458725
C007168 cyanazine cyanazine results in increased expression of TH proteinincreases expression 14550852
C072247 cyclo(Trp-Asp-Pro-Val-Leu) cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein]decreases reaction|increases activity 11911850
C072247 cyclo(Trp-Asp-Pro-Val-Leu) cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]decreases reaction|increases expression 11911850
D015084 2,4-Dichlorophenoxyacetic Acid 2,4-Dichlorophenoxyacetic Acid results in increased expression of TH proteinincreases expression 16931444
C017180 decamethrin decamethrin results in decreased activity of TH proteindecreases activity 16673815
C017180 decamethrin decamethrin results in decreased expression of and results in decreased activity of TH proteindecreases activity|decreases expression 15461254
C017180 decamethrin decamethrin results in decreased expression of TH mRNAdecreases expression 16673815
16229977
15461254
C017180 decamethrin decamethrin results in decreased expression of TH proteindecreases expression 16673815
16229977
D003676 Deferoxamine Deferoxamine results in increased expression of TH mRNAincreases expression 9458725
D003907 Dexamethasone Dexamethasone results in increased expression of TH proteinincreases expression 14550852
D003976 Diazinon Diazinon results in decreased expression of and results in decreased activity of TH proteindecreases activity|decreases expression 11757738
D003976 Diazinon Diazinon results in decreased expression of TH mRNAdecreases expression 11757738
D003976 Diazinon Diazinon results in increased expression of TH mRNAincreases expression 18812211
17452286
D002945 Cisplatin Cisplatin results in increased expression of TH mRNAincreases expression 15464296
15471895
D004006 Dichlorvos Dichlorvos results in increased activity of TH proteinincreases activity 12186780
D004006 Dichlorvos Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein]decreases reaction|increases activity 12186780
D004026 Dieldrin Dieldrin results in increased expression of TH mRNAincreases expression 18812211
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of TH mRNAaffects cotreatment|decreases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of TH proteindecreases expression 16329116
D007980 Levodopa [Paraquat co-treated with Levodopa] results in decreased expression of TH proteinaffects cotreatment|decreases expression 16321246
D004298 Dopamine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]increases activity|increases metabolic processing|increases reaction 16402076
D004298 Dopamine [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamineincreases activity|increases metabolic processing 16415089
D004298 Dopamine [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]affects binding|increases activity|increases chemical synthesis|increases reaction 10661506
D004298 Dopamine 1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]increases chemical synthesis|increases reaction 10661506
D004298 Dopamine [Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamineincreases activity|increases chemical synthesis 11113527
D004298 Dopamine TH protein results in increased chemical synthesis of Dopamineincreases chemical synthesis 10661506
D004298 Dopamine Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]decreases reaction|increases chemical synthesis|increases reaction 10661506
C074283 estradiol 3-benzoate estradiol 3-benzoate results in decreased expression of TH proteindecreases expression 16329116
D004958 Estradiol Estradiol results in decreased expression of TH mRNAdecreases expression 16543374
D004958 Estradiol Estradiol affects the expression of TH mRNAaffects expression 14699072
D004958 Estradiol Estradiol affects the expression of TH proteinaffects expression 16427766
D005033 Ethylmaleimide Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]decreases expression|decreases reaction 15983997
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of TH geneincreases mutagenesis 16495775
D005231 Fatty Acids, Unsaturated Fatty Acids, Unsaturated deficiency results in increased expression of TH proteinincreases expression 11916751
D005419 Flavonoids Flavonoids results in increased expression of TH mRNAincreases expression 18035473
D005576 Forskolin Forskolin results in increased expression of TH proteinincreases expression 14550852
D005632 Fructose Fructose results in increased expression of TH mRNAincreases expression 16843071
D019833 Genistein Genistein affects the expression of TH proteinaffects expression 16427766
D005905 Glyburide Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]decreases expression|increases reaction 16725203
D006220 Haloperidol Haloperidol results in increased expression of TH proteinincreases expression 17028028
D006533 Heptachlor Heptachlor results in increased expression of TH proteinincreases expression 16112329
C062018 HU 211 CNR1 protein affects the reaction [HU 211 results in decreased expression of TH mRNA]affects reaction|decreases expression 17540007
C062018 HU 211 HU 211 results in decreased expression of TH mRNAdecreases expression 17540007
C062018 HU 211 HU 211 results in decreased expression of TH proteindecreases expression 17540007
D006861 Hydrogen Peroxide Hydrogen Peroxide affects the expression of TH mRNAaffects expression 9458725
D006861 Hydrogen Peroxide TH protein affects the abundance of Hydrogen Peroxideaffects abundance 9458725
D016627 Oxidopamine Oxidopamine results in decreased expression of TH mRNAdecreases expression 17803225
D016627 Oxidopamine Oxidopamine results in decreased expression of TH proteindecreases expression 16914382
D016627 Oxidopamine PARK2 protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]decreases expression|decreases reaction 16914382
D016627 Oxidopamine Oxidopamine results in decreased expression of TH mRNAdecreases expression 16480889
D016627 Oxidopamine Oxidopamine results in decreased expression of TH proteindecreases expression 16480889
D016627 Oxidopamine Tea inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]decreases expression|decreases reaction 16480889
D016627 Oxidopamine Tea inhibits the reaction [Oxidopamine results in decreased expression of TH protein]decreases expression|decreases reaction 16480889
C440499 lipopolysaccharide, Escherichia coli 0111 B4 lipopolysaccharide, Escherichia coli 0111 B4 results in decreased expression of TH proteindecreases expression 17573159
D008094 Lithium Lithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein]decreases expression|decreases reaction 19149911
D008344 Maneb [Paraquat co-treated with Maneb] results in decreased expression of TH proteinaffects cotreatment|decreases expression 11124998
D008345 Manganese Manganese results in decreased expression of TH mRNAdecreases expression 16943606
C039798 manganese sulfate manganese sulfate results in decreased expression of TH mRNAdecreases expression 16943606
D008694 Methamphetamine Lithium inhibits the reaction [Methamphetamine results in decreased expression of TH protein]decreases expression|decreases reaction 19149911
D008694 Methamphetamine Methamphetamine results in decreased expression of TH proteindecreases expression 19149911
D008694 Methamphetamine Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein]decreases expression|decreases reaction 19149911
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH proteinaffects cotreatment|decreases expression 19653878
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]increases activity|increases metabolic processing|increases reaction 16402076
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH proteindecreases expression 17555550
16725203
19199078
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]decreases expression|increases reaction 16725203
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH proteinaffects activity|affects cotreatment 19948168
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]decreases expression|decreases reaction 19199078
D015735 Mifepristone Mifepristone results in decreased expression of TH mRNAdecreases expression 17584828
D005677 G(M1) Ganglioside G(M1) Ganglioside results in increased activity of TH proteinincreases activity 14552908
D009151 Mustard Gas Mustard Gas results in increased expression of TH mRNAincreases expression 15674843
C407426 neurotensin 69L neurotensin 69L results in increased expression of TH mRNAincreases expression 17113052
D009532 Nickel Nickel results in increased expression of TH mRNAincreases expression 18812211
D009553 Nimodipine Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein]decreases reaction|increases activity 12186780
D009599 Nitroprusside [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH proteinaffects cotreatment|increases expression 12088752
D009599 Nitroprusside Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]affects binding|decreases activity|decreases reaction|increases activity 16023617
D009599 Nitroprusside Nitroprusside inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]affects binding|decreases activity|decreases reaction|increases activity 16023617
D009599 Nitroprusside Nitroprusside results in increased expression of TH proteinincreases expression 12088752
C474055 octylphenol octylphenol results in decreased expression of TH proteindecreases expression 15620428
D010100 Oxygen Oxygen deficiency results in increased expression of TH mRNAincreases expression 10486562
D010269 Paraquat [Paraquat co-treated with Levodopa] results in decreased expression of TH proteinaffects cotreatment|decreases expression 16321246
D010269 Paraquat [Paraquat co-treated with Maneb] results in decreased expression of TH proteinaffects cotreatment|decreases expression 11124998
D010269 Paraquat Paraquat results in decreased expression of TH proteindecreases expression 16190885
D026023 Permethrin Permethrin results in decreased expression of and results in decreased activity of TH proteindecreases activity|decreases expression 15461254
D026023 Permethrin Permethrin results in decreased expression of TH mRNAdecreases expression 15461254
D010622 Phencyclidine Phencyclidine results in increased expression of TH mRNAincreases expression 12105081
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TH mRNAaffects binding|decreases expression|increases activity 19710929
D011339 Probenecid [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH proteinaffects cotreatment|decreases expression 19653878
D011374 Progesterone Progesterone results in decreased activity of TH proteindecreases activity 18096660
D011374 Progesterone Progesterone results in decreased phosphorylation of TH proteindecreases phosphorylation 18096660
D018967 Risperidone Risperidone results in increased expression of TH proteinincreases expression 17028028
C085989 Ro 32-0432 Ro 32-0432 inhibits the reaction [EDN1 protein results in increased activity of TH protein]decreases reaction|increases activity 11911850
C085989 Ro 32-0432 Ro 32-0432 inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]decreases reaction|increases expression 11911850
D012402 Rotenone alpha-Tocopherol inhibits the reaction [Rotenone results in decreased expression of TH protein]decreases expression|decreases reaction 15790535
D012402 Rotenone Rotenone results in decreased expression of TH proteindecreases expression 15790535
18579341
D012642 Selegiline Selegiline results in decreased expression of TH mRNAdecreases expression 11862330
D012643 Selenium Selenium deficiency results in increased activity of TH proteinincreases activity 11113527
D012643 Selenium [Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamineincreases activity|increases chemical synthesis 11113527
D012643 Selenium Selenium deficiency results in increased expression of TH mRNAincreases expression 11113527
D012839 Simazine Simazine results in decreased expression of TH proteindecreases expression 14550852
C017947 sodium arsenite sodium arsenite results in decreased expression of TH mRNAdecreases expression 19121333
D013662 Tea Tea inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]decreases expression|decreases reaction 16480889
D013662 Tea Tea inhibits the reaction [Oxidopamine results in decreased expression of TH protein]decreases expression|decreases reaction 16480889
D013739 Testosterone Testosterone results in increased expression of TH mRNAincreases expression 16543374
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of TH proteindecreases expression 16329116
D013749 Tetrachlorodibenzodioxin AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TH mRNA]increases expression|increases reaction 19500377
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of TH proteinincreases activity 19500377
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TH mRNAincreases expression 19500377
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TH proteinincreases expression 19500377
D014212 Tretinoin [Tretinoin co-treated with CNTF protein] results in increased expression of THaffects cotreatment|increases expression 17017122
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH mRNAaffects cotreatment|increases expression 17085092
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH proteinaffects cotreatment|increases expression 17085092
D014212 Tretinoin Tretinoin results in increased expression of TH proteinincreases expression 15464216
D014311 Triprolidine Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]decreases reaction|increases chemical synthesis|increases reaction 10661506
D014520 Urethane [Nitroprusside co-treated with Urethane co-treated with Chloralose] results in increased expression of TH proteinaffects cotreatment|increases expression 12088752
D014635 Valproic Acid CREB1 protein affects the reaction [Valproic Acid results in increased expression of TH mRNA]affects reaction|increases expression 18976638
D014635 Valproic Acid Valproic Acid affects the expression of TH proteinaffects expression 19460635
D014635 Valproic Acid Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein]decreases expression|decreases reaction 19149911
D014635 Valproic Acid Valproic Acid results in decreased expression of TH mRNAdecreases expression 18976638
D014635 Valproic Acid Valproic Acid results in decreased expression of TH proteindecreases expression 18976638
D014635 Valproic Acid Valproic Acid results in increased expression of TH mRNAincreases expression 18976638
D014635 Valproic Acid Valproic Acid results in increased expression of TH proteinincreases expression 18976638
C108830 Y 27632 [cobaltous chloride co-treated with Y 27632] results in increased expression of TH proteinaffects cotreatment|increases expression 16772336
C022189 zonisamide zonisamide results in increased expression of TH mRNAincreases expression 20196486
C022189 zonisamide zonisamide results in increased expression of TH proteinincreases expression 20196486
C022189 zonisamide [zonisamide co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] affects the activity of TH proteinaffects activity|affects cotreatment 19948168
C022189 zonisamide zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]decreases expression|decreases reaction 19199078
C022189 zonisamide zonisamide results in increased expression of TH proteinincreases expression 19199078
D015054 Zymosan Zymosan results in increased expression of TH mRNAincreases expression 18178496
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Maneb 9.79982313
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.7914514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.798875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.1919490988
MESH:D000138 Acidosis Ammonium Chloride 2.7518287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.2317670903 12690470 15814532
MESH:D055371 Acute Lung Injury Nickel 11.0616166738
MESH:D055371 Acute Lung Injury Oxygen 11.0616759491
MESH:D055371 Acute Lung Injury pirinixic acid 11.0618653653
MESH:D000230 Adenocarcinoma Cisplatin 7.7717638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.7711473722
MESH:D000230 Adenocarcinoma Genistein 7.7711473722
MESH:D000230 Adenocarcinoma Urethane 7.7718316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 4.8815814487
MESH:D000236 Adenoma Diethylnitrosamine 8.3010737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 8.306695378
MESH:D000236 Adenoma Urethane 8.3017195641 10822126 11497255 16926031 6695378 10530776 17093202
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 12.5918056438 19061943 17162532 19052882 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 12.5916835633
MESH:D000303 Adrenal Cortex Diseases Catecholamines 6.496895166
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.0716712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.2614617031 12649775 16160616
MESH:D000382 Agricultural Workers' Diseases 2,4-Dichlorophenoxyacetic Acid 37.7616132792
MESH:D000382 Agricultural Workers' Diseases Atrazine 37.7611874814
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 37.7617119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 37.7616487989
MESH:D000382 Agricultural Workers' Diseases Dichlorvos 37.7612661182 17119214 16611668
MESH:D000382 Agricultural Workers' Diseases Heptachlor 37.7612661182
MESH:D000382 Agricultural Workers' Diseases Maneb 37.768807224
MESH:D000382 Agricultural Workers' Diseases Paraquat 37.7611874814
MESH:D000382 Agricultural Workers' Diseases Simazine 37.7612661182
MESH:D000505 Alopecia Tretinoin 2.9415955085
MESH:D000544 Alzheimer Disease 24-hydroxycholesterol 4.4914523054
MESH:D000544 Alzheimer Disease Lithium 4.4919621015
MESH:D000550 Amblyopia Valproic Acid 4.4017688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.2416916582 15010207 18475255 16459022
MESH:D000686 Amyloidosis Diethylstilbestrol 3.7015469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.6011748828
MESH:D000740 Anemia Zymosan 6.6018664788
MESH:D000756 Anemia, Sideroblastic Manganese 4.1216910769
MESH:D000855 Anorexia Amphetamine 4.2916084549 12183048 16101753 12005258
MESH:D000860 Anoxia Oxygen 4.2420872349
MESH:D000987 Antisocial Personality Disorder Testosterone 5.027506515
MESH:D001008 Anxiety Disorders Valproic Acid 2.9017497229
MESH:D001169 Arthritis, Experimental Dexamethasone 9.1917659584
MESH:D001169 Arthritis, Experimental Tretinoin 9.1916412693
MESH:D001169 Arthritis, Experimental Zymosan 9.1916872482 15188379 15944321 17659584 15142272
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.0216292516
MESH:D020817 Asperger Syndrome Risperidone 4.7816401163
MESH:D001249 Asthma Mustard Gas 3.8510378619
MESH:D001249 Asthma Tretinoin 3.8516456186
MESH:D050197 Atherosclerosis Oxygen 3.2816391483
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 7.0814699433
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 7.0818349709
MESH:D001321 Autistic Disorder Haloperidol 2.2819368416 18080171
MESH:D001321 Autistic Disorder Risperidone 2.2818026891 18278980 16239862 18349709 16948927 17069546 19368416 15492353 15994720 17019624 16379507 16601648 19013209 19154706 15543515 17929164 18080171 19232924 16730335 15930063 18775368
MESH:D001321 Autistic Disorder Valproic Acid 2.2817507914 18985861 18316065 18177632 18558336 20603192 15238991 19460635 17157402 18940202 16609825 19232924 17688650 18775368 18396377
MESH:D001471 Barrett Esophagus Tretinoin 3.6216935849
MESH:D001480 Basal Ganglia Diseases Dichlorvos 5.1615303389
MESH:D001714 Bipolar Disorder Lithium 13.0719153942 17594078 20046352 20338123
MESH:D001714 Bipolar Disorder Risperidone 13.0718278980 19154706
MESH:D001714 Bipolar Disorder Valproic Acid 13.0720046352 17594078
MESH:D001714 Bipolar Disorder zonisamide 13.0716855456 15383137
MESH:D001768 Blister Mustard Gas 4.3419167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 11.0019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 11.0012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 11.0016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.0815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.088888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.0614601052
MESH:D001862 Bone Resorption bisphenol A 3.1311985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.1514991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.5017868700
MESH:D001930 Brain Injuries Nitroprusside 8.7714637104
MESH:D001930 Brain Injuries Progesterone 8.7715845082 15665606 15380490
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.5816651633 16436596 18412241 15144691 16357521
MESH:D001943 Breast Neoplasms bisphenol A 11.6117123778
MESH:D001943 Breast Neoplasms Cisplatin 11.6118382427 19526202
MESH:D001943 Breast Neoplasms Deferoxamine 11.6115993339
MESH:D001943 Breast Neoplasms Dieldrin 11.6115770527 11859874
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.6117474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 11.6115324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 11.6117261762 16675129 18497071 12948864 19861407 17018787 14630087 17289903
MESH:D001943 Breast Neoplasms Genistein 11.6116541309 16873071 17200150
MESH:D001943 Breast Neoplasms Heptachlor 11.618738476
MESH:D001943 Breast Neoplasms Nickel 11.6115986119
MESH:D001943 Breast Neoplasms Oxygen 11.6117263869
MESH:D001943 Breast Neoplasms Progesterone 11.6115562024 16175315 17614352
MESH:D001943 Breast Neoplasms Testosterone 11.6117261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.6120435547
MESH:D001943 Breast Neoplasms Tretinoin 11.6116443354 16873071 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.3415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.1517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.7716813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.6516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.1316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.3316168501
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 10.8217982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.8219052882 21159647 18056438 20935162 3084413 19394651 16935385 16807293 20214788 20084675 16288022 19539802 17173139 18393292 18665156 19701751 20727157 18978308 16681979 20524982 19107877 20007298 10737359 18785209 20101231 19822196 10672840 11831363 17978847 19335982 19383236 17428255 20512989 3581430 18210153 19519916 19919837 16779866 16502159 16830150 16569478 17055752 16328049 19418558 16878318 17162532 19171122 18788625 17138121 17761372 18971187 20432363 20514400 16540662 18506893 18494052 18691550 16698587 19208518
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 10.8216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.8216924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.8217306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.821917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.1717123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.6916685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.6817066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.6818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.6816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.8616120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 5.5016332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 5.5016936243
MESH:D002375 Catalepsy Haloperidol 4.1015215559 1977408
MESH:D002386 Cataract Tretinoin 2.5517460283
MESH:D002418 Cattle Diseases Dichlorvos 4.8314651886
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.7417174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.7418566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 14.7416003739
MESH:D002471 Cell Transformation, Neoplastic manganese sulfate 14.748243401
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.7420056578 19524636
MESH:D002493 Central Nervous System Diseases Dichlorvos 4.9612670839
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.1517160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.7716129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 4.9820678186
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 4.9820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 6.9719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 6.9716835633
MESH:D002779 Cholestasis pirinixic acid 2.1919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 7.4112621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 7.419407595
MESH:D002972 Cleft Palate Urethane 7.4112810352
MESH:D003072 Cognition Disorders Clozapine 4.1717123785
MESH:D003092 Colitis Selenium 6.8717936198
MESH:D003092 Colitis Tretinoin 6.8717035595
MESH:D003110 Colonic Neoplasms Dexamethasone 3.2115824018
MESH:D003110 Colonic Neoplasms Genistein 3.2117182828
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3415273666
MESH:D003128 Coma Dichlorvos 5.1715303389
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.3617141729 14669216
MESH:D003327 Coronary Disease Fructose 3.9018504504
MESH:D019465 Craniofacial Abnormalities decamethrin 7.4719861644
MESH:D019465 Craniofacial Abnormalities Dexamethasone 7.4717728286
MESH:D019465 Craniofacial Abnormalities Permethrin 7.4719861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.4720055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.479142499 9125849 9211117 9664655 8800419 16925845 9224671 14991402 17551590 10589399
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.4716575769 8888407 17688650
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.7812952375 16002989
MESH:D007644 Darier Disease Lithium 5.0920338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 8.9320210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 8.9320210726
MESH:D003704 Dementia Haloperidol 8.0911575062
MESH:D003704 Dementia Risperidone 8.0911575062
MESH:D003715 Dengue 24-hydroxycholesterol 5.3919427377
MESH:D003866 Depressive Disorder zonisamide 4.3016855456
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 10.3515059100 16823706 11298694
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 10.3512438553
MESH:D017449 Dermatitis, Allergic Contact Maneb 10.358807224
MESH:D017449 Dermatitis, Allergic Contact Nickel 10.3517100760 19470301 17244072
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9718249437
MESH:D003877 Dermatitis, Contact Nickel 7.582952479
MESH:D003877 Dermatitis, Contact Permethrin 7.5814617103
MESH:D009783 Dermatitis, Occupational Maneb 5.058807224
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 4.9519244398
MESH:D003921 Diabetes Mellitus, Experimental Fructose 3.8118603373
MESH:D003924 Diabetes Mellitus, Type 2 alpha-Tocopherol 13.3516506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 13.3516402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 13.3520387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 13.3518603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 13.3516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 13.3517107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.7119279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.6917187935
MESH:D003967 Diarrhea 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 6.1410611417
MESH:D003967 Diarrhea Dexamethasone 6.147237001
MESH:D006970 Disorders of Excessive Somnolence Clozapine 11.6815331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 11.6816379507
MESH:D053207 Diurnal Enuresis Risperidone 5.8417822346
MESH:D004314 Down Syndrome Risperidone 4.4418349709
OMIM:607208 DRAVET SYNDROME zonisamide 5.2611748493
MESH:D056486 Drug-Induced Liver Injury aroclor 1260 13.476156243
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 13.4717851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.4719107877
MESH:D056486 Drug-Induced Liver Injury Selenium 13.4715131321
MESH:D056486 Drug-Induced Liver Injury Tea 13.4719370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.4720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 13.4719641884 1733752
MESH:D004362 Drug Toxicity Cisplatin 6.0512649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.0511462148
MESH:D004409 Dyskinesia, Drug-Induced Levodopa 5.5415893579 3690436
MESH:D050171 Dyslipidemias Clozapine 3.5616402076
MESH:D004417 Dyspnea Diazinon 8.0116487989
MESH:D004417 Dyspnea Oxygen 8.0120016425
MESH:D004421 Dystonia Valproic Acid 3.291851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.1518357618
MESH:D004485 Eczema Dexamethasone 3.6812438553
MESH:D004487 Edema Dexamethasone 13.9919703484
MESH:D004487 Edema Mustard Gas 13.9911428647 11428631 11402378 9260866
MESH:D004487 Edema pirinixic acid 13.9912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9912711302 11000095
MESH:D004487 Edema Zymosan 13.997907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.1916714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 9.1918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 24-hydroxycholesterol 7.3917410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.3917692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 9.1916402032
MESH:D004714 Endometrial Hyperplasia Genistein 9.1916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.9816804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 12.9811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 12.9811473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.9816569247
MESH:D004715 Endometriosis Mifepristone 11.1616134523
MESH:D004715 Endometriosis Progesterone 11.1616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 11.1610568697 9294722
MESH:D019446 Endotoxemia lipopolysaccharide, Escherichia coli 0111 B4 4.7812954792
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 8.7817275665 3659116
MESH:D004831 Epilepsies, Myoclonic zonisamide 8.783659116 3691417
MESH:D004828 Epilepsies, Partial Valproic Acid 7.8616628512 3922381
MESH:D004828 Epilepsies, Partial zonisamide 7.8615140322 11558140 3691417
MESH:D004827 Epilepsy Valproic Acid 5.6420417680 18234410
MESH:D004827 Epilepsy zonisamide 5.6420196486
MESH:D004832 Epilepsy, Absence Valproic Acid 2.896254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.507750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.413659116
MESH:D004830 Epilepsy, Tonic-Clonic zonisamide 8.413659116 3691417
MESH:D004890 Erythema Mustard Gas 4.349357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.2816302075
MESH:D004938 Esophageal Neoplasms Cisplatin 2.5216785472 15464296 17638652 15173087 16481741
MESH:D020329 Essential Tremor zonisamide 5.3718297619 17149715
MESH:D005076 Exanthema zonisamide 5.2615140322
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.6911564622
MESH:D005124 Eye Abnormalities Tretinoin 6.6916938888 9664655
MESH:D005221 Fatigue Amphetamine 10.0719890266
MESH:D005221 Fatigue zonisamide 10.0717149715
MESH:D005234 Fatty Liver Diethylnitrosamine 12.8321071580 20387270
MESH:D005234 Fatty Liver Fructose 12.8318395287 19196556 18641190
MESH:D005234 Fatty Liver pirinixic acid 12.8320131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 12.8314986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.1016534752 16513791 16611131 16002989 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.6611858732
MESH:D005315 Fetal Diseases Valproic Acid 4.0516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.3518558336 8888407
MESH:D005334 Fever lipopolysaccharide, Escherichia coli 0111 B4 4.4916997862
MESH:D005355 Fibrosis Fructose 10.3618504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.3620067830
MESH:D005355 Fibrosis Tretinoin 10.3617994277
MESH:D005391 Firesetting Behavior Testosterone 5.027506515
MESH:D005739 Gas Poisoning Oxygen 4.3920016425
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.1116452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.1116452187
MESH:D005909 Glioblastoma Ethylnitrosourea 16.1016436596
MESH:D005909 Glioblastoma Genistein 16.1016598420
MESH:D005909 Glioblastoma Manganese 16.1017043766
MESH:D005909 Glioblastoma Testosterone 16.1017162496
MESH:D005909 Glioblastoma Tretinoin 16.1017312396
MESH:D005910 Glioma Ethylnitrosourea 3.1018412241 16357521 16651633
MESH:D005911 Gliosis Maneb 11.6711124998
MESH:D005911 Gliosis Paraquat 11.6711124998
MESH:D018149 Glucose Intolerance Fructose 4.5619165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7610696789
MESH:D006261 Headache zonisamide 4.9317149715
MESH:D006258 Head and Neck Neoplasms Cisplatin 5.9115102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 5.9116096774
MESH:D034381 Hearing Loss Cisplatin 3.5919898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.3316084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.7215464296
MESH:D006330 Heart Defects, Congenital Lithium 8.3619638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.3610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 8.369664655 14991402
MESH:D006331 Heart Diseases Urethane 3.6416046796
MESH:D006333 Heart Failure pirinixic acid 5.0820558911
MESH:D006333 Heart Failure Selenium 5.0817162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5911000095
MESH:D006505 Hepatitis Diazinon 7.4516487989
MESH:D006505 Hepatitis Zymosan 7.4519110552
MESH:D006529 Hepatomegaly pirinixic acid 5.6516221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 5.6516120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.717520565
MESH:D006558 Herpes Genitalis Estradiol 4.2015709030
MESH:D006628 Hirsutism Testosterone 4.8217019078
MESH:D015658 HIV Infections Nickel 3.3317263646
MESH:D006689 Hodgkin Disease Cisplatin 5.2516170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 5.2512676792
MESH:D006734 Horse Diseases Dichlorvos 5.1716402567
MESH:D019584 Hot Flashes Estradiol 2.9317088409
MESH:D006849 Hydrocephalus Valproic Acid 4.0517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.218697196 18606429 16354765 16959395 15340226
MESH:D006930 Hyperalgesia Tretinoin 2.5616870215
MESH:D017588 Hyperandrogenism Testosterone 4.4817019078
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.7716778211
MESH:D006941 Hyperesthesia Dichlorvos 5.8612563396
MESH:D006943 Hyperglycemia pirinixic acid 7.2620558911
MESH:D006943 Hyperglycemia Risperidone 7.2618278980
MESH:D020138 Hyperhomocysteinemia Levodopa 4.9916275827 16787708
MESH:D006946 Hyperinsulinism Fructose 4.2019008412 14757778 18563319 15752949 18360027
MESH:D006948 Hyperkinesis Amphetamine 14.621977408 14960337
MESH:D006948 Hyperkinesis Clozapine 14.6216046005
MESH:D006948 Hyperkinesis Methamphetamine 14.6217658665
MESH:D006949 Hyperlipidemias Fructose 4.0015752949
MESH:D006951 Hyperlipoproteinemias Fatty Acids, Unsaturated 5.4418435438
MESH:D006965 Hyperplasia Diethylstilbestrol 3.6414722030 12960047
MESH:D006973 Hypertension Dexamethasone 6.4617042910
MESH:D006973 Hypertension Fructose 6.4614573337 14633139 19008412 16843071 14568997
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 6.4618670907 18850075
MESH:D006976 Hypertension, Pulmonary cyclo(Trp-Asp-Pro-Val-Leu) 4.5716327149
MESH:D015228 Hypertriglyceridemia Fructose 4.3519342510 19799862
MESH:D007003 Hypoglycemia Glyburide 5.1910918110
MESH:D007006 Hypogonadism Testosterone 3.9612002444
MESH:D007018 Hypopituitarism Testosterone 5.3717426086
MESH:D007021 Hypospadias Diethylstilbestrol 3.7816002989
MESH:D007022 Hypotension Dopamine 4.276740701
MESH:D007174 Impulse Control Disorders Testosterone 5.027506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.6015869954
MESH:D007246 Infertility Diethylstilbestrol 3.5815036965
MESH:D007247 Infertility, Female Dieldrin 4.1810630421
MESH:D007248 Infertility, Male 2,4-Dichlorophenoxyacetic Acid 14.8912948887
MESH:D007248 Infertility, Male Atrazine 14.8912948887
MESH:D007248 Infertility, Male Diazinon 14.8916466525 12948887
MESH:D007248 Infertility, Male Paraquat 14.894850670
MESH:D007248 Infertility, Male sodium arsenite 14.8915346721 12646999
MESH:D007249 Inflammation Dexamethasone 19.848960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 19.8418785209
MESH:D007249 Inflammation Flavonoids 19.8417296493
MESH:D007249 Inflammation Mustard Gas 19.8411428631 17524151 11428647 11428620 11402378 8975870 16001271 9357497 9260866
MESH:D007249 Inflammation Nickel 19.8416166738
MESH:D007249 Inflammation Progesterone 19.8415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.8412200463 12878042
MESH:D007249 Inflammation Zymosan 19.848014878 11289658
MESH:D007251 Influenza, Human Selenium 3.3716624496
MESH:D007299 Insect Bites and Stings decamethrin 10.3815189238
MESH:D007299 Insect Bites and Stings Permethrin 10.3815189238 12971516 12749493
MESH:D007333 Insulin Resistance bisphenol A 12.8716393666
MESH:D007333 Insulin Resistance Estradiol 12.8716393666 16627594
MESH:D007333 Insulin Resistance Fructose 12.8718563319 14757778 19586609 17133782 14633139 18057795 14573337 19342510 19008412 18981581 19799862
MESH:D007333 Insulin Resistance pirinixic acid 12.8716306350
MESH:D007410 Intestinal Diseases Tretinoin 2.9817994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 3.8610783313
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.0217553498
MESH:D002546 Ischemic Attack, Transient zonisamide 6.079372210
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.4716580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.4715992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.3115464296
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 13.4315369732
MESH:D007674 Kidney Diseases Cisplatin 13.4318289764 12649298 12231392 15190930 19839026
MESH:D007674 Kidney Diseases Dichlorvos 13.4316798900
MESH:D007674 Kidney Diseases Estradiol 13.4315618244
MESH:D007674 Kidney Diseases sodium arsenite 13.4320008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 7.5616518626
MESH:D007676 Kidney Failure, Chronic Selenium 7.5616518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.6616762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 8.6615610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.6617379185
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 3.9711231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.2717184923
MESH:D007938 Leukemia Genistein 7.8418980019 17468513
MESH:D007938 Leukemia Permethrin 7.8412937054
MESH:D007938 Leukemia Tretinoin 7.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 2.9619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Deferoxamine 4.9420368581
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.9417596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.9417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 5.9616766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 5.9617107899 17294898 17368321 19225113 16331271 17649720 9834237 17506722 16766008 16935935 19642359 12679006 19035177 17301526 17712046 16788101 17339181 19075265 15748426 17361223 16891316 17217047 16823087 16140955 19029980
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.689224671
MESH:D008064 Lipidoses Clozapine 3.3417567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.3218407596 18522880 19638242 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.3116718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.3117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3116248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Y 27632 8.3113678700
MESH:D008107 Liver Diseases Chlorpyrifos 3.4815991261
MESH:D008107 Liver Diseases Diethylnitrosamine 3.4817034775
MESH:D008113 Liver Neoplasms Dieldrin 18.858742319 9539021
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.8519426721 19254457 19256749 2422723 19833225 19551842 20492335 18978307 19073162 21167192 2862719 19294768 16942905 19850985 10737359 19996281 9163691 20137499 19427195 12771043 21047994 19499222 20405173 18754104 19690152 21278145 19090486 19638242 20452335 12112319 19812893 20101389 19642983 20501860 18977376 15885732 21071580 20118626 18648771 19255062 15175105 20583210 18644402 20434301
MESH:D008113 Liver Neoplasms Diethylstilbestrol 18.8515890375 16712894
MESH:D008113 Liver Neoplasms Heptachlor 18.859544696 2422723
MESH:D008113 Liver Neoplasms pirinixic acid 18.8515890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 18.8516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.8516984957
MESH:D008113 Liver Neoplasms Urethane 18.8517093202 17559639 16391232
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 3.923124819 2563599 19126423 18775883 18164116 17854601 17942915 17174075 18093689 19519916 18253720 9362446 19004024 21159647 16267830 18079962 18544905 19539802 19009564 18282651 16842330 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 3.9212151625
MESH:D008171 Lung Diseases Mustard Gas 5.5518161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 5.5519095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 9.0517228818
MESH:D017563 Lung Diseases, Interstitial zonisamide 9.0517228818
MESH:D055370 Lung Injury Oxygen 3.7318339021
MESH:D008175 Lung Neoplasms alpha-Tocopherol 11.9916401635
MESH:D008175 Lung Neoplasms Cisplatin 11.9917225452 6189445 11798837
MESH:D008175 Lung Neoplasms Dexamethasone 11.9915824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.9920970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Ethylnitrosourea 11.996695378 16019985 17703301 16271038
MESH:D008175 Lung Neoplasms Mustard Gas 11.993148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 11.9917306315 16712894 17077188 19931552 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.9919555203 11884234
MESH:D008175 Lung Neoplasms Urethane 11.9911307925 11807781 11074608 16204055 16788158 10997738 17195641 6695378 11992545 11497255 17093202 16926031 10530776 12466968 12117781 16391232 11552296 12957351 15136453 11323394 7750092 11544531 17255336 10779650 11062179 16337739 16007126 15902970 14587096 15166089 12765245 10822126 16289808 11246140 11893704
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.3315166399
MESH:D008223 Lymphoma Diethylstilbestrol 5.8515700306
MESH:D008223 Lymphoma Ethylnitrosourea 5.8515790496
MESH:D008228 Lymphoma, Non-Hodgkin 2,4-Dichlorophenoxyacetic Acid 4.4716132792
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.2515375218
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.6816002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.1211807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 16.1215375486
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 16.1210838139 18041768 10767621
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.1212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.1217203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 16.1215318939
MESH:D020149 Manganese Poisoning Estradiol 10.2519453300
MESH:D020149 Manganese Poisoning Manganese 10.2516551646 16568477 19453300
MESH:D008527 Medulloblastoma Tretinoin 2.3817453147
MESH:D008545 Melanoma 8-bromocyclic GMP 5.5718004088
MESH:D008545 Melanoma Cisplatin 5.5718505091 17761969 18176117 16248763 12374674 17023156 12393984 16809738 15577323 16432458 11135225 18332650 12883367
MESH:D008545 Melanoma sodium arsenite 5.5716487513 19082730
MESH:D008545 Melanoma Tretinoin 5.5716752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 3.9615990972
MESH:D008579 Meningioma Ethylnitrosourea 5.1517943659
MESH:D008591 Meningomyelocele Tretinoin 3.6216940565
MESH:D001523 Mental Disorders Clozapine 8.8316856516
MESH:D001523 Mental Disorders Haloperidol 8.8316856516
MESH:D001523 Mental Disorders Risperidone 8.8316856516 16596465
MESH:D008607 Mental Retardation Risperidone 3.7618349709
MESH:D008654 Mesothelioma Atrazine 7.901916698
MESH:D008654 Mesothelioma Cisplatin 7.9017638057
MESH:D008654 Mesothelioma Selenium 7.9015107826
MESH:D024821 Metabolic Syndrome X Clozapine 12.2619142101
MESH:D024821 Metabolic Syndrome X Fructose 12.2619165636 18497449 17261469 17098227 16815490
MESH:D024821 Metabolic Syndrome X Risperidone 12.2619142101
MESH:D008881 Migraine Disorders Valproic Acid 2.5818765137 18803445
MESH:D019964 Mood Disorders Risperidone 5.0317019624
MESH:D009041 Motion Sickness Dextroamphetamine 4.691613127
MESH:D016472 Motor Neuron Disease Dichlorvos 5.5111282359
MESH:D009069 Movement Disorders Manganese 4.2516551646
MESH:D009101 Multiple Myeloma Dexamethasone 5.9915867202 15744524 16118317
MESH:D009101 Multiple Myeloma zonisamide 5.9911868602
MESH:D009102 Multiple Organ Failure Zymosan 4.4510890648 15834315 12130978 17724436 15241586 15259001 18160304 10479408 12879239 15213630
MESH:D009128 Muscle Spasticity 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 5.2817220914
MESH:D009135 Muscular Diseases pirinixic acid 2.7116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.288888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 9.259809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 9.2517596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 9.2517596541
MESH:D009203 Myocardial Infarction alpha-Tocopherol 10.1319595682
MESH:D009203 Myocardial Infarction Genistein 10.1317141266
MESH:D009203 Myocardial Infarction Lithium 10.1316288908
MESH:D009203 Myocardial Infarction pirinixic acid 10.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.3512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.3716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 10.3717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 10.3716411023
MESH:D020191 Myoclonic Epilepsies, Progressive zonisamide 5.379477142
MESH:D009325 Nausea zonisamide 5.1816855456
MESH:D009349 Nematode Infections Dichlorvos 5.3116402567
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.179029167 3581430
MESH:D009369 Neoplasms Cisplatin 16.6516773208
MESH:D009369 Neoplasms Dieldrin 16.658820588
MESH:D009369 Neoplasms Diethylstilbestrol 16.6515313581
MESH:D009369 Neoplasms pirinixic acid 16.6517405874
MESH:D009369 Neoplasms sodium arsenite 16.6511559025
MESH:D009369 Neoplasms Tretinoin 16.6516594593 16946489
MESH:D009369 Neoplasms Urethane 16.6515625555
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 10.9216707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 10.9220056578
MESH:D009374 Neoplasms, Experimental Urethane 10.9215582191
MESH:D009389 Neovascularization, Pathologic Estradiol 2.9217289903
MESH:D009395 Nephritis, Interstitial Cisplatin 3.6715464296
MESH:D009410 Nerve Degeneration Dichlorvos 19.3011282359 17850875
MESH:D009410 Nerve Degeneration Maneb 19.3015350641 16893418
MESH:D009410 Nerve Degeneration Manganese 19.3016551646
MESH:D009410 Nerve Degeneration Paraquat 19.3016893418
MESH:D009410 Nerve Degeneration Rotenone 19.3015790535 18619942 17356569
MESH:D009421 Nervous System Malformations bisphenol A 28.3016427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.3011399458
MESH:D009421 Nervous System Malformations Estradiol 28.3016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 28.3016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.3014600291
MESH:D009421 Nervous System Malformations Tretinoin 28.309125849
MESH:D009436 Neural Tube Defects sodium arsenite 8.7512854658
MESH:D009436 Neural Tube Defects Tretinoin 8.759142499
MESH:D009436 Neural Tube Defects Valproic Acid 8.758888407 16359493
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.6016003739 16651423 17160924
MESH:D009447 Neuroblastoma Cisplatin 2.968761367
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 24.0012349958
MESH:D019636 Neurodegenerative Diseases Amphetamine 24.0015183010
MESH:D019636 Neurodegenerative Diseases Dichlorvos 24.0016635102
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 24.0020387270
MESH:D019636 Neurodegenerative Diseases Nimodipine 24.0016635102
MESH:D019636 Neurodegenerative Diseases Oxidopamine 24.0018514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 3.888761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.2820387270
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 14.2416725203
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 14.2415081274
MESH:D020258 Neurotoxicity Syndromes Dichlorvos 14.2412186780
MESH:D020258 Neurotoxicity Syndromes Glyburide 14.2416725203
MESH:D009503 Neutropenia Mustard Gas 3.227688884 16761898
MESH:D053206 Nocturnal Enuresis Risperidone 5.5017822346
MESH:D009765 Obesity Clozapine 5.8918515891 19142110
MESH:D009765 Obesity Fructose 5.8918585860 17707055
MESH:D009765 Obesity pirinixic acid 5.8920558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.1517160924
MESH:D010024 Osteoporosis Genistein 2.7019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.3316169203
MESH:D010049 Ovarian Diseases bisphenol A 4.1711985600
MESH:D010051 Ovarian Neoplasms Cisplatin 20.906897625 15464296 17225452 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 20.9019401270
MESH:D010051 Ovarian Neoplasms Genistein 20.9019005980
MESH:D010051 Ovarian Neoplasms Mifepristone 20.9016525653
MESH:D010051 Ovarian Neoplasms Progesterone 20.9016525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 20.9017306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 20.9016936753
MESH:D010051 Ovarian Neoplasms Urethane 20.9016391232
MESH:D010146 Pain Tretinoin 5.2016870215
MESH:D010146 Pain zonisamide 5.2017666864 16217643 15140322
MESH:D010190 Pancreatic Neoplasms Cisplatin 6.4319003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 6.4316540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 6.4315976015
MESH:D010195 Pancreatitis Dichlorvos 4.1516258382
MESH:D010212 Papilloma Hydrogen Peroxide 3.3012065085
MESH:D010292 Paresthesia zonisamide 6.0717149715
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 29.9311181820 16140633 15451049
MESH:D010300 Parkinson Disease Atrazine 29.9317218051
MESH:D010300 Parkinson Disease Dieldrin 29.9316809432 17291500 11445065 16112328 11181820
MESH:D010300 Parkinson Disease Levodopa 29.9319594199 18328768 11432539 20334432 7566641
MESH:D010300 Parkinson Disease Maneb 29.9316510128 12911755 16140633 11124998 15824117
MESH:D010300 Parkinson Disease Manganese 29.9311181820
MESH:D010300 Parkinson Disease Paraquat 29.9311124998 15451049 11181820 16140633 12911755 15824117 11445065 16510128
MESH:D010300 Parkinson Disease Rotenone 29.9319232380 16140633 16412576 19114014 18619942 18191903 11445065 15451049 11535288
MESH:D010300 Parkinson Disease Selegiline 29.9318328768
MESH:D010300 Parkinson Disease zonisamide 29.9317200492 20196486 19594199 11755227 13677302
MESH:D010302 Parkinson Disease, Secondary Dichlorvos 14.1512645970
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 14.1511771942 15893579
MESH:D010302 Parkinson Disease, Secondary Paraquat 14.1516190885
MESH:D020734 Parkinsonian Disorders marker/mechanism 11246459 8817341
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 15.9612349958
MESH:D020734 Parkinsonian Disorders Levodopa 15.9618722529 8817341 11246459
MESH:D020734 Parkinsonian Disorders Manganese 15.9616140633
MESH:D020734 Parkinsonian Disorders Rotenone 15.9618197244 15927086 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.4212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.5415464296
MESH:D010538 Peritonitis Zymosan 4.0915259001 17826846 19088179 19641140 17371808 18760300 14761945 18977430 15979727 18557954 11985352
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.3414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 9.4815687265 16977796
MESH:D010911 Pituitary Neoplasms Urethane 9.4816391232
MESH:D010954 Plasmacytoma Selenium 4.0615087411
MESH:D010997 Pleural Neoplasms Cisplatin 4.5117638057
MESH:D011014 Pneumonia Paraquat 3.6412504350
MESH:D011041 Poisoning Diazinon 10.3817603234
MESH:D011041 Poisoning Dichlorvos 10.3816036766 18072136 12460839 17603234 17157343 15303389
MESH:D011041 Poisoning Mustard Gas 10.3815727166
MESH:D011115 Polyneuropathies Dichlorvos 4.8212563396
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 2.852563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0221297632
MESH:D011248 Pregnancy Complications 2,4-Dichlorophenoxyacetic Acid 4.932087686
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.6310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.6317184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.6311896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.6320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 13.7620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 13.7620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 13.7620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1416740699
MESH:D011471 Prostatic Neoplasms Dichlorvos 2.1412661182
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1415046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.1416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1416925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Heptachlor 2.1412661182
MESH:D011471 Prostatic Neoplasms Simazine 2.1412661182
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1416039940
MESH:D011507 Proteinuria Tretinoin 2.8516636307
MESH:D011537 Pruritus Mustard Gas 3.2918058305
MESH:D019310 Pseudolymphoma Valproic Acid 3.7112752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 4.1611575062
MESH:D011618 Psychotic Disorders Clozapine 7.0615331141
MESH:D011618 Psychotic Disorders Haloperidol 7.0611575062
MESH:D011625 Pterygium Tretinoin 3.9716723453
MESH:D011629 Puberty, Precocious bisphenol A 3.9710548101
MESH:D011657 Pulmonary Eosinophilia alpha-Tocopherol 5.1614606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 4.5317720292 17266442 17620002 17894541 10334151
MESH:D011658 Pulmonary Fibrosis Paraquat 4.5317997886 16324872
MESH:D051437 Renal Insufficiency Cisplatin 3.6215464296
MESH:D015427 Reperfusion Injury pirinixic acid 1.9219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 10.9618379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 10.9617627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 10.9611700416
MESH:D012131 Respiratory Insufficiency Dichlorvos 4.8715303389 17350689
MESH:D012135 Respiratory Sounds Atrazine 16.5011874814
MESH:D012135 Respiratory Sounds Chlorpyrifos 16.5011874814 16611668 17119214
MESH:D012135 Respiratory Sounds Dichlorvos 16.5017119214 16611668
MESH:D012135 Respiratory Sounds Paraquat 16.5011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0618990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 8.5116611668 17119214
MESH:D012140 Respiratory Tract Diseases Dichlorvos 8.5117119214 16611668
MESH:D012162 Retinal Degeneration Paraquat 3.2216458197
MESH:D012174 Retinitis Pigmentosa alpha-Tocopherol 3.6716849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.3416283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.3419155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4918045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 3.6514601052
MESH:D012559 Schizophrenia Clozapine 6.3220452607 20168265 20521326 19369910 11763009 20580759 11151749 17123785 20107430 17667964 20521320 18855531 18806925 16141801 17726453
MESH:D012559 Schizophrenia Haloperidol 6.3220107430 19369910 18513383 1830565
MESH:D012559 Schizophrenia Risperidone 6.3218278980 19154706 20107430
MESH:D012559 Schizophrenia Valproic Acid 6.3215737665 19110320
MESH:C537537 Segawa syndrome, autosomal recessive marker/mechanism 8817341 8528210
MESH:C537537 Segawa syndrome, autosomal recessive Levodopa 5.878817341
MESH:D012640 Seizures Dichlorvos 9.4112660363 17157343
MESH:D012640 Seizures Lithium 9.4119660546
MESH:D012640 Seizures Valproic Acid 9.4111738929 11044598 14763951 17978042 16876388 15475178 1511512 3137016
MESH:D012640 Seizures zonisamide 9.4111044598 12941455 15946322 9844417 11442880 11755227 9806000 16876388 11518630 11879338 16938433 16180713 9046859 10029267 18455367
MESH:D018805 Sepsis Zymosan 3.9611441115
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.266418539
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.3716631401
MESH:D012772 Shock, Septic Triprolidine 5.4118063050
MESH:D012852 Sinusitis Triprolidine 5.527327846
MESH:D012871 Skin Diseases Mustard Gas 2.4416961503 15451306 12880345
MESH:D012878 Skin Neoplasms 8-bromocyclic GMP 16.4318004088
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 16.4312065085
MESH:D012878 Skin Neoplasms sodium arsenite 16.4319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.4316192470
MESH:D012878 Skin Neoplasms Tretinoin 16.4316467112
MESH:D012878 Skin Neoplasms Urethane 16.4311807781
MESH:D012893 Sleep Disorders Risperidone 4.7018278980
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.5115464296
MESH:D019082 Smith-Lemli-Opitz Syndrome 24-hydroxycholesterol 5.7311254748
MESH:D013088 Spermatocele Diethylstilbestrol 3.8816002989 16709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.4716503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 7.3412854658
MESH:D016135 Spinal Dysraphism Valproic Acid 7.3419490988
MESH:D013226 Status Epilepticus Lithium 16.6419951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 16.6412833885
MESH:D013226 Status Epilepticus zonisamide 16.6412833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.591977408
MESH:D013262 Stevens-Johnson Syndrome zonisamide 5.0212239465
MESH:D013272 Stomach Diseases Dexamethasone 3.5115472012
MESH:D013274 Stomach Neoplasms Cisplatin 3.7415958060 18396642 17522103
MESH:D013274 Stomach Neoplasms Dichlorvos 3.7411397402
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.7418456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.7417261132
MESH:D013276 Stomach Ulcer Dexamethasone 2.7915138204
MESH:D013322 Strongyloidiasis Dichlorvos 5.3114651886
MESH:D019966 Substance-Related Disorders bisphenol A 3.1816045194 16684133
MESH:D013398 Sudden Infant Death Oxygen 4.7312563064
MESH:D013610 Tachycardia Nitroprusside 4.8315306635
MESH:D017180 Tachycardia, Ventricular Haloperidol 8.4020210726
MESH:D017180 Tachycardia, Ventricular Risperidone 8.4020210726
MESH:D013736 Testicular Neoplasms Cisplatin 3.8717225452 15464296
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.3515790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.0712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 5.037505956
MESH:D013964 Thyroid Neoplasms Tretinoin 5.0316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 3.8519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.0616051514
MESH:D005879 Tourette Syndrome Risperidone 5.1419154706
MESH:D014178 Translocation, Genetic Valproic Acid 4.4017262798
MESH:D014376 Tuberculosis Tretinoin 2.6616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 10.053119515
MESH:D020194 Unverricht-Lundborg Syndrome zonisamide 10.0511814737
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 6.0912973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 6.0916712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 6.0917306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.848888407
MESH:D014570 Urologic Diseases Diazinon 4.4516487989
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 16.7416803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 16.7416175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.7411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 16.7416129372
MESH:D014591 Uterine Diseases bisphenol A 11.0614652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.0614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.3015809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 3.7816752155
MESH:D014605 Uveitis Dexamethasone 9.531336536
MESH:D014605 Uveitis Zymosan 9.5311006244
MESH:D014625 Vaginal Neoplasms Cisplatin 8.4415577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 8.4416513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 3.6117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7612125929
MESH:D019043 Vascular Neoplasms Urethane 5.0810620525
MESH:D014820 Vitiligo Tretinoin 3.2816761959
MESH:D014839 Vomiting Cisplatin 9.2111897121
MESH:D014839 Vomiting zonisamide 9.2117157078
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.4215886252
MESH:D015430 Weight Gain Clozapine 8.0317502770 16402076 20521320 16141801 20107430 20564506
MESH:D015430 Weight Gain Risperidone 8.0316379507 20564506
MESH:D015431 Weight Loss Clozapine 4.2617933447
MESH:D009396 Wilms Tumor Tretinoin 3.2616287080
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:05012 Parkinson's disease
REACT:13685 Synaptic Transmission
KEGG:00350 Tyrosine metabolism
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA351
  • No data
    Releated disease ID Related disease Name
    PA447062Parkinsonian Disorders
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    PA133822447catecholamines
    PA450213levodopa
    PA147358765alpha-methyl-para-tyrosine
    PA450649norepinephrine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00120 binder L-Phenylalanine Dietary supplement;Micronutrient;Essential Amino Acids
    DB00135 binder L-Tyrosine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00360 cofactor Tetrahydrobiopterin Dietary supplement;Cofactor
    DB00765 binder Metyrosine Enzyme Inhibitors
    DB03552 - Meta-Tyrosine
    DB04400 - 7,8-dihydrobiopterin
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018