AutismKB 2.0

Annotation Detail for THBS1


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Basic Information Top
Gene Symbol:THBS1 ( THBS,THBS-1,TSP,TSP-1,TSP1 )
Gene Full Name: thrombospondin 1
Band: 15q14
Quick LinksEntrez ID:7057; OMIM: 188060; Uniprot ID:TSP1_HUMAN; ENSEMBL ID: ENSG00000137801; HGNC ID: 11785
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa05144Malaria
hsa05219Bladder cancer
hsa04350TGF-beta signaling pathway
hsa04115p53 signaling pathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Hemostasis
Signaling by PDGF
Integrin cell surface interactions
Pathway IDPathway Name
200115Syndecan-4-mediated signaling events
Pathway IDPathway Name
P00059p53 pathway
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
No data
No data
Desease Name
atherosclerosis, coronary
CARDIOVASCULAR
myocardial infarct
stroke, lacunar
brain hemorrhage
Stroke
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of THBS1 mRNAdecreases expression 15982314
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of THBS1 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in decreased expression of THBS1 mRNAdecreases expression 15982314
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of THBS1 mRNAincreases expression 17023530
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of THBS1 mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of THBS1 mRNAdecreases expression 15894712
C503983 axitinib axitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein]decreases reaction|increases expression 18202011
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of THBS1 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of THBS1 mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of THBS1 mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of THBS1 mRNAdecreases expression 19150397
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of THBS1 mRNAincreases expression 20018196
C006780 bisphenol A bisphenol A results in increased expression of THBS1 mRNAincreases expression 16474171
19371625
D002104 Cadmium Cadmium results in increased expression of THBS1 mRNAincreases expression 15010501
D002104 Cadmium O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Cadmium results in increased expression of THBS1 mRNA]decreases reaction|increases expression 15010501
D002166 Camptothecin Camptothecin results in decreased expression of THBS1 mRNAdecreases expression 16962673
D002166 Camptothecin Camptothecin results in decreased secretion of THBS1 proteindecreases secretion 16962673
D002166 Camptothecin THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]decreases reaction|increases activity 16962673
D002166 Camptothecin THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]decreases reaction|increases cleavage 16962673
C459604 candoxin candoxin results in increased expression of THBS1 mRNAincreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of THBS1 mRNAincreases expression 15056808
D002995 Clofibric Acid Clofibric Acid affects the expression of THBS1 mRNAaffects expression 17602206
C055162 clopidogrel clopidogrel results in increased expression of THBS1increases expression 11875746
C055162 clopidogrel clopidogrel results in increased expression of THBS1 mRNAincreases expression 9447704
C055162 clopidogrel clopidogrel results in increased expression of THBS1 proteinincreases expression 9447704
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA]decreases reaction|increases expression 18200517
D003513 Cycloheximide Cycloheximide inhibits the reaction [Testosterone results in decreased expression of THBS1 mRNA]decreases expression|decreases reaction 16723184
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of THBS1 mRNAincreases expression 15331540
D003520 Cyclophosphamide axitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein]decreases reaction|increases expression 18202011
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of THBS1 proteinincreases expression 18202011
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS1 mRNAaffects cotreatment|decreases expression 16054899
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of THBS1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of THBS1 mRNAincreases expression 19638242
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of THBS1 proteinincreases expression 18407596
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of THBS1 mRNAincreases expression 19371625
C472511 dimethylarsinous acid dimethylarsinous acid results in decreased expression of THBS1 mRNAdecreases expression 16507463
C025034 doxifluridine THBS1 protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
D004317 Doxorubicin Doxorubicin affects the expression of THBS1 mRNAaffects expression 15205334
D004317 Doxorubicin Doxorubicin results in decreased expression of THBS1 mRNAdecreases expression 16962673
D004317 Doxorubicin Doxorubicin results in decreased secretion of THBS1 proteindecreases secretion 16962673
D004317 Doxorubicin THBS1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]decreases reaction|increases activity 16962673
D004317 Doxorubicin THBS1 protein inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]decreases reaction|increases cleavage 16962673
D004317 Doxorubicin [THBS1 protein alternative form co-treated with Doxorubicin] results in increased expression of FASLG proteinaffects cotreatment|increases expression 15818399
D004317 Doxorubicin [THBS1 protein alternative form co-treated with Doxorubicin] results in increased expression of FAS proteinaffects cotreatment|increases expression 15818399
D004391 Dust Dust results in increased expression of THBS1 mRNAincreases expression 17805423
C007610 equol equol results in decreased expression of THBS1 mRNAdecreases expression 16865672
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of THBS1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of THBS1 mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of THBS1 mRNAincreases expression 16474171
D015025 Zearalenone Zearalenone results in increased expression of THBS1 mRNAincreases expression 19371625
D005472 Fluorouracil EGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 mRNA]affects reaction|increases expression 18757417
D005472 Fluorouracil EGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 protein]affects reaction|increases expression 18757417
D005472 Fluorouracil Fluorouracil affects the expression of THBS1 mRNAaffects expression 15205334
D005472 Fluorouracil Fluorouracil promotes the reaction [EGR1 protein binds to THBS1 promoter]affects binding|increases reaction 18757417
D005472 Fluorouracil Fluorouracil results in increased expression of THBS1 mRNAincreases expression 18757417
D005472 Fluorouracil Fluorouracil results in increased expression of THBS1 proteinincreases expression 18757417
D005472 Fluorouracil SB 203580 inhibits the reaction [Fluorouracil results in increased expression of THBS1 mRNA]decreases reaction|increases expression 18757417
D005472 Fluorouracil THBS1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005665 Furosemide Furosemide affects the expression of THBS1 mRNAaffects expression 16526316
D019833 Genistein Genistein results in increased expression of THBS1 mRNAincreases expression 19371625
16474171
D007052 Ibuprofen Ibuprofen results in increased expression of THBS1 proteinincreases expression 18261746
C056493 imiquimod imiquimod results in increased expression of THBS1increases expression 16302556
D007213 Indomethacin Indomethacin results in decreased expression of THBS1 mRNAdecreases expression 16984733
D007213 Indomethacin Indomethacin results in increased expression of THBS1 mRNAincreases expression 18261746
D007213 Indomethacin Indomethacin results in increased expression of THBS1 proteinincreases expression 16227405
18261746
C051890 irinotecan THBS1 protein results in decreased susceptibility to irinotecandecreases response to substance 16734730
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS1 mRNAaffects cotreatment|decreases expression 16054899
D008274 Magnesium Magnesium results in increased expression of THBS1 proteinincreases expression 10397942
D015735 Mifepristone Mifepristone results in increased expression of THBS1 mRNAincreases expression 17584828
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of THBS1 mRNAincreases expression 16809437
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of THBS1 mRNAincreases expression 15913567
D015058 1-Naphthylisothiocyanate O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of THBS1 mRNA]decreases reaction|increases expression 15913567
C029938 nickel sulfate nickel sulfate results in increased expression of THBS1 mRNAincreases expression 16100012
C069741 norcantharidin norcantharidin results in increased expression of THBS1 proteinincreases expression 16681930
C107010 O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of THBS1 mRNA]decreases reaction|increases expression 15913567
C107010 O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Cadmium results in increased expression of THBS1 mRNA]decreases reaction|increases expression 15010501
C016340 o,p'-DDT o,p'-DDT results in increased expression of THBS1 mRNAincreases expression 19371625
D010126 Ozone Ozone results in increased expression of THBS1 mRNAincreases expression 19555225
12763052
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] affects the expression of THBS1 mRNAaffects cotreatment|affects expression 17715259
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] results in decreased expression of THBS1 proteinaffects cotreatment|decreases expression 17715259
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] affects the expression of THBS1 mRNAaffects cotreatment|affects expression 17715259
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] results in decreased expression of THBS1 proteinaffects cotreatment|decreases expression 17715259
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of THBS1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of THBS1 mRNAincreases expression 18445702
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of THBS1 mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in decreased expression of THBS1 mRNAdecreases expression 18037150
18070364
D011794 Quercetin Quercetin results in decreased expression of THBS1 mRNAdecreases expression 19729006
D020849 Raloxifene Raloxifene results in increased expression of THBS1 mRNAincreases expression 17010073
D015474 Isotretinoin Isotretinoin results in decreased expression of THBS1 mRNAdecreases expression 15982314
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS1 mRNAaffects cotreatment|decreases expression 16054899
C079198 S 1 (combination) THBS1 protein results in decreased susceptibility to S 1 (combination)decreases response to substance 16734730
C093642 SB 203580 SB 203580 inhibits the reaction [Fluorouracil results in increased expression of THBS1 mRNA]decreases reaction|increases expression 18757417
C410733 scriptaid scriptaid affects the expression of THBS1 mRNAaffects expression 18813790
C017947 sodium arsenite sodium arsenite results in decreased expression of THBS1 mRNAdecreases expression 16014739
C025462 sulindac sulfide EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]affects reaction|increases expression 16227405
C025462 sulindac sulfide RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]increases expression|increases reaction 18261746
C025462 sulindac sulfide [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 proteinincreases activity|increases expression 18261746
C025462 sulindac sulfide sulindac sulfide results in increased expression of THBS1 mRNAincreases expression 16227405
18261746
C025462 sulindac sulfide sulindac sulfide results in increased expression of THBS1 proteinincreases expression 18261746
16227405
C025462 sulindac sulfide [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 proteinincreases expression|increases phosphorylation 18261746
C025462 sulindac sulfide [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 proteinincreases expression|increases phosphorylation 18261746
C025462 sulindac sulfide U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]decreases reaction|increases expression 18261746
C025462 sulindac sulfide U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]decreases reaction|increases expression 18261746
D013629 Tamoxifen Tamoxifen affects the expression of THBS1 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen results in increased expression of THBS1 mRNAincreases expression 19155303
D013739 Testosterone Cycloheximide inhibits the reaction [Testosterone results in decreased expression of THBS1 mRNA]decreases expression|decreases reaction 16723184
D013739 Testosterone Testosterone results in decreased expression of THBS1 mRNAdecreases expression 16723184
D013739 Testosterone Testosterone results in decreased expression of THBS1 proteindecreases expression 16723184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of THBS1 mRNAincreases expression 18495758
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of THBS1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of THBS1 mRNAdecreases expression 19619570
20106945
D013749 Tetrachlorodibenzodioxin AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of THBS1 mRNA]decreases expression|decreases reaction 14728982
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of THBS1 mRNAaffects expression 16962184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of THBS1 mRNAdecreases expression 14728982
D014212 Tretinoin Tretinoin metabolite results in increased expression of THBS1 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of THBS1 mRNAdecreases expression 15982314
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNAincreases expression 18200517
C113580 U 0126 U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]decreases reaction|increases expression 18261746
C113580 U 0126 U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]decreases reaction|increases expression 18261746
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8714745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 6.5218769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.5214514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.3818769834
MESH:D017486 Acneiform Eruptions Isotretinoin 5.6116232082
MESH:D000152 Acne Vulgaris Isotretinoin 4.8016185265 18769834
MESH:D000168 Acrocephalosyndactylia U 0126 4.8317694057
MESH:D054058 Acute Coronary Syndrome clopidogrel 5.3419106084
MESH:D058186 Acute Kidney Injury Ibuprofen 3.866375363
MESH:D055371 Acute Lung Injury nickel sulfate 7.1111954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 7.1118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 17.3920464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 17.3917418594
MESH:D000230 Adenocarcinoma Estradiol 17.3911473722
MESH:D000230 Adenocarcinoma Fluorouracil 17.3917638652
MESH:D000230 Adenocarcinoma Genistein 17.3911473722
MESH:D000230 Adenocarcinoma Ibuprofen 17.3910697514
MESH:D000230 Adenocarcinoma Indomethacin 17.3916537180
MESH:D000236 Adenoma Benzo(a)pyrene 16.566695378
MESH:D000236 Adenoma beta-Naphthoflavone 16.5619389873
MESH:D000236 Adenoma Diethylnitrosamine 16.5610737359 6695378
MESH:D000236 Adenoma Indomethacin 16.5611497255
MESH:D000236 Adenoma Magnesium 16.5617823441
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 13.4519052882 19061943 18056438 16434500 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 13.4516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 13.4516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.2217306315 16712894
MESH:D000419 Albuminuria Doxorubicin 9.3621441931
MESH:D000419 Albuminuria Raloxifene 9.3617451421 17308373
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4017887948
MESH:D000505 Alopecia Tretinoin 3.0815955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.6917225004
MESH:D000544 Alzheimer Disease Curcumin 16.1815590663
MESH:D000544 Alzheimer Disease Ibuprofen 16.1818351690
MESH:D000544 Alzheimer Disease Indomethacin 16.1815579461 17627676
MESH:D000544 Alzheimer Disease Ozone 16.1815513908
MESH:D000544 Alzheimer Disease Raloxifene 16.1815800139
MESH:D000544 Alzheimer Disease rosiglitazone 16.1819621015
MESH:D000544 Alzheimer Disease sulindac sulfide 16.1818759972
MESH:D000686 Amyloidosis Diethylstilbestrol 3.8515469931
MESH:D000707 Anaphylaxis Ibuprofen 4.609532969
MESH:D000740 Anemia Fluorouracil 6.7515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.7511748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.6417084956
MESH:D000987 Antisocial Personality Disorder Testosterone 5.187506515
MESH:D001014 Aortic Aneurysm Indomethacin 4.2210231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 9.5619183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 9.5610388637
MESH:D001161 Arteriosclerosis Cyclophosphamide 3.9515014928
MESH:D018771 Arthralgia Indomethacin 4.492160914
MESH:D001169 Arthritis, Experimental Dexamethasone 6.0517659584
MESH:D001169 Arthritis, Experimental Tretinoin 6.0516412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 8.8216807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 8.8211248219
MESH:D001172 Arthritis, Rheumatoid Ozone 8.8215570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 8.8216292516
MESH:D001249 Asthma Ozone 4.1017854713 16373670
MESH:D001249 Asthma Tretinoin 4.1016456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.3115336622
MESH:D050197 Atherosclerosis Cadmium 5.6215687053
MESH:D050197 Atherosclerosis Curcumin 5.6218704882
MESH:D001321 Autistic Disorder Magnesium 3.6916846101
MESH:D001327 Autoimmune Diseases Curcumin 8.7219761891
MESH:D001327 Autoimmune Diseases Quercetin 8.7219761891
MESH:D001471 Barrett Esophagus Tretinoin 3.7716935849
MESH:D001477 Bartter Syndrome Indomethacin 4.3310684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 11.8219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 11.8212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 11.8216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.0214601052
MESH:D001862 Bone Resorption bisphenol A 3.2711985600
MESH:D001913 Bowen's Disease imiquimod 5.7711207687
MESH:D001929 Brain Edema Indomethacin 4.3511481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.6617868700
MESH:D001930 Brain Injuries Progesterone 8.8115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 8.8116580743
MESH:D002545 Brain Ischemia Curcumin 13.3716770732
MESH:D002545 Brain Ischemia Ibuprofen 13.3715837124
MESH:D002545 Brain Ischemia Indomethacin 13.3712524144
MESH:D001932 Brain Neoplasms Curcumin 7.0417596214
MESH:D001932 Brain Neoplasms Doxorubicin 7.0417150277
MESH:D001943 Breast Neoplasms alitretinoin 20.7816344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 20.7817474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 20.7817123778
MESH:D001943 Breast Neoplasms Curcumin 20.7819250217 18462866 16243823 18593918
MESH:D001943 Breast Neoplasms Cyclophosphamide 20.7811325840 15136595 12006526 17388661 15093573 17020986 16978400 18234424 18323546
MESH:D001943 Breast Neoplasms Diethylnitrosamine 20.7817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 20.7817129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 20.7817426702 18628466 16115903 15634643 18234424 15692762 15668708 15993339 17983394 15567936 17369602 16264153 16096432 15136595 11325840 18695136 16322301 16935488 18382427 16595493 15994142 15939500 19526202 16826403
MESH:D001943 Breast Neoplasms equol 20.7816898868
MESH:D001943 Breast Neoplasms Estradiol 20.7816675129 17261762 17289903 19861407 12948864 18497071 14630087 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 20.7818608205 16110121 15136595 16595493 19217205 18357371 16557594
MESH:D001943 Breast Neoplasms Genistein 20.7816541309 16873071 17200150
MESH:D001943 Breast Neoplasms Indomethacin 20.7817401462
MESH:D001943 Breast Neoplasms Progesterone 20.7817614352 15562024 16175315
MESH:D001943 Breast Neoplasms Quercetin 20.7818628248
MESH:D001943 Breast Neoplasms Raloxifene 20.7815775269 17242785 17049068 16837676 15758505 17595753 17952589 15572757 17261762 16912660 17440819 17893378
MESH:D001943 Breast Neoplasms Tamoxifen 20.7815668708 19200415 18815881 19142967 17893378 21152245 19115204 20390343 19189210 20005174 19084267 18984771 19221464 16818667 15565566 19155303 19011961 18629630 20859285 18351453 20544844 16202921 17440819 20065188 16873071 17261762 19189212 19487384 19066611 18997820 18821012 11161223 20135344 19288272 19244106 21138602 18855134 19103187 19289846 17049068 19410462 19059307 18425577 16273361 17242785
MESH:D001943 Breast Neoplasms Testosterone 20.7817261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 20.7820435547
MESH:D001943 Breast Neoplasms Tretinoin 20.7816166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.1414754758 18315731 16777450 15516495 17626835 19059883 18417511
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9316813970
MESH:D002056 Burns Indomethacin 4.0610459503
MESH:D002100 Cachexia Ibuprofen 17.3115141370
MESH:D002100 Cachexia Indomethacin 17.3115141370 16537180 15625704 11239499
MESH:D002100 Cachexia Ozone 17.3116183385
MESH:D002105 Cadmium Poisoning Quercetin 4.8716962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.1416192424 16011737 15673190 16124888 16227642 16097048 15700767 3786805 15721981 18705752 16050911 10355542
MESH:D002276 Carcinoid Tumor Doxorubicin 10.1016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.1016051944
MESH:D002277 Carcinoma Curcumin 10.8618593918
MESH:D002277 Carcinoma Fluorouracil 10.8617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 10.8616835633
MESH:D002280 Carcinoma, Basal Cell imiquimod 4.7616302556
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.4816168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 31.4012619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 31.4018788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 31.4019701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 31.4018056438 3084413 16698587 19171122 20432363 16878318 16935385 19539802 19107877 19208518 18691550 21159647 19418558 18785209 17055752 17761372 10672840 20514400 18494052 16502159 16830150 20084675 16569478 16288022 17162532 18788625 16540662 19701751 20214788 17173139 18978308 19519916 19383236 20727157 18971187 16779866 19919837 19394651 20101231 11831363 16681979 19052882 20512989 3581430 18665156 20524982 10737359 19822196 16328049 18393292 20007298 20935162 19335982 18506893 18210153 16807293 17138121 17428255 17978847
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 31.4015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 31.4017876044 16234567 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 31.4016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 31.4017971768 16332177 17088986 18930000 16799960 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 31.4016924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 31.4016391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 31.4019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 31.4016507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 31.4016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 31.401917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.3217123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 9.3316152834
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.3311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.6914736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 7.5918414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 7.5918347146 18212800
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 7.5912391285
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.3017234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 12.4516201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 12.451485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 12.4518695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 12.4517341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 29.0020419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 29.0018462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 29.006189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 29.0016280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell imiquimod 29.0016302556
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 29.0012636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 29.0011237771
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 29.0015984520
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 29.0018572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 29.0016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.5617572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.5617572228
MESH:D006332 Cardiomegaly Quercetin 5.4419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.4416120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.0717351982 17007740 16278810 16612575 16269455 16455267 16952015 17329180 16731534 17382496 16651473 17928571 16109756 16364871 17974986 17519947 17924179 15811867 18627295 17308081 15505089 15476868 15792986 17131338 16242529
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.6716243910 17334414
MESH:D002318 Cardiovascular Diseases clopidogrel 9.6020180610
MESH:D002318 Cardiovascular Diseases Genistein 9.6016332659
MESH:D002318 Cardiovascular Diseases Raloxifene 9.6015775269
MESH:D002386 Cataract Tretinoin 2.6717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 16.0117332340
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.017505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.0118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.0119524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9316129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.3920678186
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.4419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.4416835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.5212912871
MESH:D002764 Cholecystitis Indomethacin 4.4911181007
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 6.5816629650 7624871 15500046 18590720 19486331 12927374 18164287 15913567
MESH:D002779 Cholestasis pirinixic acid 6.5819176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.1810220858 19407337
MESH:D002822 Choriocarcinoma Tretinoin 4.4816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.6715340226 16354765 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 4.679407595
MESH:D003072 Cognition Disorders Raloxifene 3.9715800139
MESH:D003092 Colitis Curcumin 12.4218200517 16804969 16782535
MESH:D003092 Colitis Tretinoin 12.4217035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 12.4217991707 16782535 11698051 18023891 18200517 16474422 17936198 16867261 16804969
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.1717276891
MESH:D003103 Coloboma Curcumin 3.9518809619
MESH:D003110 Colonic Neoplasms arsenite 17.4415037631
MESH:D003110 Colonic Neoplasms Curcumin 17.4419359593 16340194
MESH:D003110 Colonic Neoplasms Dexamethasone 17.4415824018
MESH:D003110 Colonic Neoplasms Fluorouracil 17.4417169374 18772588 15001691 17018589 17725105 16510598 17287894 17016597 16340194 17172411
MESH:D003110 Colonic Neoplasms Genistein 17.4417182828
MESH:D003110 Colonic Neoplasms Indomethacin 17.4415963497 15786552 15625704 15936596 11260862 15637740
MESH:D003110 Colonic Neoplasms irinotecan 17.4417725105 17287894
MESH:D003110 Colonic Neoplasms Quercetin 17.4416640504 17191121 11134977 19056647 19440933 17148506 15741050
MESH:D003111 Colonic Polyps Magnesium 5.4217823441
MESH:D015179 Colorectal Neoplasms Doxorubicin 8.9718259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 8.9716391804 17594712 18448328 18949393 15289873 17255274 17695437 18802399 17016601 17454858 16282729 18288408 17094418 15148649 16303861 18383874 16524972 17401013 16331619 14970324 20501625 18509181
MESH:D015179 Colorectal Neoplasms Indomethacin 8.9712606626 17054584 18059344 11197048
MESH:D015179 Colorectal Neoplasms irinotecan 8.9716391804 17159606 17454858 16303861 18509181 15273666 18259882
MESH:D015179 Colorectal Neoplasms Magnesium 8.9717823441
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 8.9715531428
MESH:D015179 Colorectal Neoplasms Quercetin 8.9718852136 18095365
MESH:D003218 Condylomata Acuminata imiquimod 6.4616302556 11362904
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4917141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.2518497527
MESH:D018352 Coronavirus Infections Indomethacin 5.0417302372
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.5917728286
MESH:D019465 Craniofacial Abnormalities Isotretinoin 4.5918769834 9879862
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.5910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.599125849 17551590 8800419 10589399 14991402 9211117 9664655 16925845 9224671 9142499
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.9216002989 12952375
MESH:D003556 Cystitis Cyclophosphamide 4.3110498854 17979934 12388444 12913760 16413132 16651033 18093676 10700343 15276878 18710439 16614059 16989017 18372110 11948286 18483878 18295254 12161096 17010015 18433785 15643279
MESH:D007644 Darier Disease Fluorouracil 4.1316733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.1016140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7119031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.5917474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 5.2912438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 5.2916823706 16780908 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0818249437
MESH:D002658 Developmental Disabilities Magnesium 4.4316846101
MESH:D003920 Diabetes Mellitus rosiglitazone 3.7317446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 6.8415331540 10990075 11751995
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 6.8419496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 2.9718772604
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 11.2718403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 11.2720387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 11.2716647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 11.2712642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 11.2717107852
MESH:D003928 Diabetic Nephropathies Curcumin 16.8018204486
MESH:D003928 Diabetic Nephropathies Estradiol 16.8019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.8015920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.8019279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.8417187935
MESH:D003967 Diarrhea Dexamethasone 6.217237001
MESH:D003967 Diarrhea Indomethacin 6.217237001 7907874
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 11.9420133375 17522070 7624871 18289764
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.9416177239 6884620 17522070 15027814 15968718 21278145 6623471 10092053 7440962 7179309 11566570 2869522 4309450 3732212 15998439 3786805 9327722 19336974 16227642 10915739 19085960 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.9419107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.9417416283
MESH:D056486 Drug-Induced Liver Injury O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate 11.9412540782
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9420420201
MESH:D004362 Drug Toxicity Doxorubicin 6.4118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.4111462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 11.0318446180 16133044 18450898
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 11.0318446180 18043480 12774134 16133044 16326151 17190690
MESH:D004381 Duodenal Ulcer Curcumin 7.3317351913
MESH:D004381 Duodenal Ulcer Indomethacin 7.3317202747 11595415 17045617 17351913 10671773 16699067 11535926 11991626 17151854 11595431 17329845
MESH:D004387 Dupuytren Contracture imiquimod 6.1116368197
MESH:D004417 Dyspnea Furosemide 4.2716935035
MESH:D004485 Eczema Dexamethasone 3.8312438553
MESH:D004487 Edema Dexamethasone 23.5919703484
MESH:D004487 Edema Furosemide 23.5911834646
MESH:D004487 Edema Indomethacin 23.5919703484 8985016 16100529 7990266 7907874 10653021 8273558
MESH:D004487 Edema pirinixic acid 23.5912083418
MESH:D004487 Edema Raloxifene 23.5915860553
MESH:D004487 Edema rosiglitazone 23.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 23.5912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.7015322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 9.7018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 11.8017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 11.8015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 11.8019031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 9.6916402032
MESH:D004714 Endometrial Hyperplasia Genistein 9.6916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 23.1116804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 23.1117359293
MESH:D016889 Endometrial Neoplasms Estradiol 23.1119148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 23.1111473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 23.1116202921 19155303 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 23.1116569247
MESH:D004715 Endometriosis Ibuprofen 22.4815652904
MESH:D004715 Endometriosis Indomethacin 22.4815652904
MESH:D004715 Endometriosis Mifepristone 22.4816134523
MESH:D004715 Endometriosis Progesterone 22.4816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 22.4810568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.4818037988
MESH:D019446 Endotoxemia Ibuprofen 8.6611545620
MESH:D019446 Endotoxemia Indomethacin 8.6618509659
MESH:D004751 Enteritis Indomethacin 4.0710567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.3317980183
MESH:D004802 Eosinophilia Cyclophosphamide 7.1011006010
MESH:D004802 Eosinophilia Indomethacin 7.1011298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.4416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 8.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.5216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 8.5216337965 16481741 17638652 15173087 16785472
MESH:D004938 Esophageal Neoplasms Indomethacin 8.5211005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.1311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.1316938888 9664655
MESH:D005234 Fatty Liver arsenite 32.9018296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 32.9015959796 19224547 12795759 16239168 16045604 17595544 12631006 61145
MESH:D005234 Fatty Liver Curcumin 32.9019297423
MESH:D005234 Fatty Liver Diethylnitrosamine 32.9021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 32.9019236843 20131406
MESH:D005234 Fatty Liver Raloxifene 32.9017473493
MESH:D005234 Fatty Liver rosiglitazone 32.9019196556
MESH:D005234 Fatty Liver Tamoxifen 32.9019224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.7416534752 16513791 15751030 16002989 16611131
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.7416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8111858732
MESH:D005334 Fever Ibuprofen 7.6316997862
MESH:D005334 Fever Indomethacin 7.6311852909 10431976 17627676
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8614745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.2419069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.2419069698
MESH:D005354 Fibrosarcoma Indomethacin 4.2310962813
MESH:D005355 Fibrosis arsenite 37.2818296743
MESH:D005355 Fibrosis Carbon Tetrachloride 37.2818705752
MESH:D005355 Fibrosis Curcumin 37.2818705752
MESH:D005355 Fibrosis Indomethacin 37.2817994277
MESH:D005355 Fibrosis Quercetin 37.2819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 37.2820067830
MESH:D005355 Fibrosis Tretinoin 37.2817994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 37.2817994277
MESH:D005391 Firesetting Behavior Testosterone 5.187506515
MESH:D005499 Folliculitis Indomethacin 4.4911298111
MESH:D005706 Gallbladder Neoplasms norcantharidin 10.4716681930
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 10.4719093184
MESH:D005756 Gastritis Indomethacin 4.0715046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.0518462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.6116452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.6116452187
MESH:D005909 Glioblastoma Curcumin 26.3817596214
MESH:D005909 Glioblastoma Doxorubicin 26.3817150277
MESH:D005909 Glioblastoma Genistein 26.3816598420
MESH:D005909 Glioblastoma Indomethacin 26.3812870263
MESH:D005909 Glioblastoma Quercetin 26.3819804834
MESH:D005909 Glioblastoma Testosterone 26.3817162496
MESH:D005909 Glioblastoma Tretinoin 26.3817312396
MESH:D005910 Glioma Fluorouracil 8.1516145905
MESH:D005910 Glioma Indomethacin 8.1516487511 18371953
MESH:D005910 Glioma Quercetin 8.1517643826
MESH:D018316 Gliosarcoma Cyclophosphamide 4.8511389073
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.7411849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9210696789
MESH:D006073 Gout Indomethacin 4.6911248219
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.3916376943 11014644 15172196
MESH:D017789 Granuloma, Pyogenic imiquimod 6.4616302556
MESH:D006258 Head and Neck Neoplasms Curcumin 24.0118829502 18462866
MESH:D006258 Head and Neck Neoplasms Doxorubicin 24.0115692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 24.0115102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 24.0115482327
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 24.0115984520 18607998
MESH:D006258 Head and Neck Neoplasms Tretinoin 24.0116096774
MESH:D034381 Hearing Loss Furosemide 4.2617868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.4816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 8.8020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.8010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 8.809664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 6.2318006777 16330681 16244372 12587719 17875725 16707910 16495754 18674790 16244371 14766674 17888722 16144979 16879835
MESH:D006331 Heart Diseases Raloxifene 6.2311110106
MESH:D006333 Heart Failure Doxorubicin 9.3617481944
MESH:D006333 Heart Failure Furosemide 9.3616011733 12660669 16845234
MESH:D006333 Heart Failure pirinixic acid 9.3620558911
MESH:D006391 Hemangioma imiquimod 6.1116302556
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3115692506
MESH:D006467 Hemophilia A Cyclophosphamide 4.6411918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7411000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.9715633222
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.8614986274
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 7.5718590720
MESH:D006505 Hepatitis Carbon Tetrachloride 7.5719900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.0515135802
MESH:D006529 Hepatomegaly pirinixic acid 6.1319176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.1312621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.3917701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.807520565
MESH:D006558 Herpes Genitalis Estradiol 4.3515709030
MESH:D006628 Hirsutism Testosterone 4.9817019078
MESH:D006689 Hodgkin Disease Cyclophosphamide 9.1216135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 9.1218501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 9.1212676792
MESH:D019584 Hot Flashes Estradiol 3.0817088409
MESH:D018327 Hutchinson's Melanotic Freckle imiquimod 6.4616302556
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3718606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Indomethacin 10.1412727271
MESH:D006930 Hyperalgesia rosiglitazone 10.1412083418
MESH:D006930 Hyperalgesia Tretinoin 10.1416870215
MESH:D034321 Hyperamylasemia Indomethacin 5.0417883296
MESH:D017588 Hyperandrogenism Testosterone 4.6317019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8716899240
MESH:D006934 Hypercalcemia Furosemide 4.4717652376
MESH:D053565 Hypercalciuria Furosemide 4.9917652376
MESH:D006937 Hypercholesterolemia Curcumin 3.4618704882
MESH:D006940 Hyperemia Indomethacin 4.3412524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9216778211
MESH:D006943 Hyperglycemia pirinixic acid 7.3120558911
MESH:D006943 Hyperglycemia Quercetin 7.3118262572 11834736
MESH:D006949 Hyperlipidemias Indomethacin 3.5517546600
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.2015086907
MESH:D006965 Hyperplasia Diethylstilbestrol 3.7914722030 12960047
MESH:D006973 Hypertension Dexamethasone 9.8817042910
MESH:D006973 Hypertension Quercetin 9.8818356687
MESH:D006973 Hypertension Raloxifene 9.8817577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.8818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4415338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.6416612254
MESH:D006984 Hypertrophy Ibuprofen 4.3816672835
MESH:D007006 Hypogonadism Testosterone 4.0912002444
MESH:C537153 Hypomagnesemia primary Furosemide 4.9911041285
MESH:D007018 Hypopituitarism Testosterone 5.5217426086
MESH:D007019 Hypoproteinemia Furosemide 5.2016096441
MESH:D007021 Hypospadias Diethylstilbestrol 3.9316002989
MESH:D007022 Hypotension Furosemide 4.0111041285
MESH:D007024 Hypotension, Orthostatic Furosemide 4.7415811171
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 10.4718306037
MESH:D007077 Ileal Diseases Indomethacin 10.4718306037 10574470
MESH:D007079 Ileitis Indomethacin 4.6910651667 16133968 10647630
MESH:D007154 Immune System Diseases Cyclophosphamide 4.6516076520
MESH:D007174 Impulse Control Disorders Testosterone 5.187506515
MESH:D007235 Infant, Premature, Diseases Ibuprofen 11.9516133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 11.9516133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.7515869954
MESH:D007246 Infertility Diethylstilbestrol 3.7215036965
MESH:D007248 Infertility, Male Cyclophosphamide 5.507193160 16517039
MESH:D007248 Infertility, Male sodium arsenite 5.5015346721 12646999
MESH:D007249 Inflammation Curcumin 25.4218403477 16956363 17151092
MESH:D007249 Inflammation Dexamethasone 25.428960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 25.4218785209
MESH:D007249 Inflammation Ibuprofen 25.423291741
MESH:D007249 Inflammation Indomethacin 25.423291741 12568917 7812673
MESH:D007249 Inflammation Progesterone 25.4215869954
MESH:D007249 Inflammation rosiglitazone 25.4212083418
MESH:D007249 Inflammation Tamoxifen 25.4219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 25.4212200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 5.6318200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 5.6318200517
MESH:D007251 Influenza, Human Quercetin 3.8316624496
MESH:D007333 Insulin Resistance bisphenol A 13.8616393666
MESH:D007333 Insulin Resistance Estradiol 13.8616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.8616306350
MESH:D007333 Insulin Resistance rosiglitazone 13.8616306350
MESH:D007410 Intestinal Diseases Indomethacin 12.8111855677 11713966 17994277 17329856 11686837 10210152 15610444 18236018 15831440
MESH:D007410 Intestinal Diseases Tretinoin 12.8117994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 12.8117994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.6410783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.6915241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.9416580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.9417551590 15992940
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 10.4718306037
MESH:D007579 Jejunal Diseases Indomethacin 10.4710574470 18306037 16133968
MESH:D007627 Keloid Quercetin 4.3017086741
MESH:D007642 Keratosis imiquimod 5.9116302556
MESH:D017492 Keratosis, Seborrheic alitretinoin 4.9716144296
MESH:D007674 Kidney Diseases Cadmium 22.4116226777 16962696 16322080
MESH:D007674 Kidney Diseases Doxorubicin 22.4116775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 22.4115618244
MESH:D007674 Kidney Diseases Furosemide 22.4111041285
MESH:D007674 Kidney Diseases Indomethacin 22.4117190690
MESH:D007674 Kidney Diseases Quercetin 22.4116962696
MESH:D007674 Kidney Diseases sodium arsenite 22.4120008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.5616707910
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.3115003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 13.3115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.3116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.3118625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.4217184923
MESH:D007889 Leiomyoma Curcumin 9.1118555241
MESH:D007889 Leiomyoma Raloxifene 9.1116973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.3610320625 12228301 11703811
MESH:D007938 Leukemia Curcumin 15.7018462866
MESH:D007938 Leukemia Cyclophosphamide 15.7010602166
MESH:D007938 Leukemia Genistein 15.7017468513 18980019
MESH:D007938 Leukemia Quercetin 15.7017468513
MESH:D007938 Leukemia Tretinoin 15.7017143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.4816085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.1717008537 18587576 17296974 17802794 18172266 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.6116106398
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.1010373061
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.1016572323 15631656 10785260
MESH:D007951 Leukemia, Myeloid Tretinoin 3.1016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.5118360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.5117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.6916935935 17107899 17649720 17339181 17361223 17712046 16788101 19225113 17294898 9834237 19642359 15748426 19075265 17368321 16823087 16766008 19035177 17217047 16891316 16331271 17301526 17506722 12679006 19029980 16140955
MESH:D015458 Leukemia, T-Cell Curcumin 4.1316106398
MESH:D007964 Leukocytosis Indomethacin 4.6916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.0417980183
MESH:D007970 Leukopenia Cyclophosphamide 4.3011830472 10052129
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.819224671
MESH:D008064 Lipidoses Tamoxifen 2.6617567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.0411479899
MESH:D008103 Liver Cirrhosis marker/mechanism 18407596
MESH:D008103 Liver Cirrhosis arsenite 8.7218296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 8.7221278145 17174718 17334410 17157831 11408273 16943688 16221502 11903743 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 8.7220032147 19638242 18407596 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 22.8915123356 18395914 12958196 16638106 10355542 18263696 18279442 12445418 18210741 18472094 15996030 12546737 17640975 18277467 16248980 12666154 12632514 17823541 18418968 18166357 18429990 14512876 16027843 15370692 12741479 18481824 13678700 17900296 18156304 18420326 15338365 14716496 15362042 18317297 18187930 17481882 17631135 20821823 17721639 14724832 12667390 17922224 17805973 12609069 12586293 14620537 15893842 15925388 15876570 14748882 18339082 12389079 18205269 17698563 15650968 17869086 17525996 18472332 15673190 12898905 12632512 15818738 17766677 17557913 15730626 17761835 12445421 18395095 16192424 17944888 18705752 16116963 17714472 18054572 15931870 15057751 11481614 16136751 12649538 16011737 15052691 18412020 14716833 18251166 16097048 18376398 17565644 15959796 16033810 18006644 17976157 16015684 17708605
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 22.8917355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 22.8916718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 22.8916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 22.8914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 22.8917823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 22.8918194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 22.8915474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 22.8912741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 22.8915980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 22.8918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 22.8912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 22.8918397230 16248980
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 7.5617184895
MESH:D008107 Liver Diseases Carbon Tetrachloride 7.5616964402 16246199 17285989 15830285 15720792
MESH:D008107 Liver Diseases Curcumin 7.5616956363
MESH:D008107 Liver Diseases Diethylnitrosamine 7.5617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.1116899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 39.089163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 39.0821137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 39.0821295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 39.0819294768
MESH:D008113 Liver Neoplasms Clofibric Acid 39.0817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 39.082422723 19690152 15885732 12771043 18978307 19812893 20118626 19833225 20501860 12112319 19090486 20405173 19255062 20101389 20583210 19073162 21071580 19254457 20434301 20492335 21167192 9163691 19642983 19427195 2862719 18648771 19551842 19256749 19850985 20137499 18977376 18754104 19996281 21278145 19426721 20452335 19294768 21047994 19499222 18644402 15175105 10737359 19638242 16942905
MESH:D008113 Liver Neoplasms Diethylstilbestrol 39.0815890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 39.0816603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 39.0815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 39.0818980244
MESH:D008113 Liver Neoplasms sodium arsenite 39.0815276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 39.0816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 39.0816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.438603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 25.4318164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.4315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.4319519916 18544905 18282651 18253720 18308698 19126423 17174075 18093689 19004024 18079962 16842330 3124819 2563599 17942915 21159647 19009564 17854601 18164116 9362446 16267830 18775883 19539802
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 25.4316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 25.431423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 25.4319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.4312151625
MESH:D008171 Lung Diseases Ozone 5.948266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 5.9419095001
MESH:D055370 Lung Injury Ozone 3.2120417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 30.5814755239
MESH:D008175 Lung Neoplasms alitretinoin 30.5816413115
MESH:D008175 Lung Neoplasms arsenite 30.5816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 30.5820869020 20464547 20135361 18520028 20064080 17053015 18569708 18816296 6695378
MESH:D008175 Lung Neoplasms Curcumin 30.5819359593 18462866 16243823
MESH:D008175 Lung Neoplasms Dexamethasone 30.5815824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 30.5820970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 30.586189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 30.5815246190
MESH:D008175 Lung Neoplasms Indomethacin 30.5811497255 11053908 16537180
MESH:D008175 Lung Neoplasms Isotretinoin 30.5815899809
MESH:D008175 Lung Neoplasms Ozone 30.587614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 30.5816280456
MESH:D008175 Lung Neoplasms sodium arsenite 30.5817306315 19931552 16712894 17077188 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 30.5818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 30.5819555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.1315086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.4815166399
MESH:D008223 Lymphoma Curcumin 13.8718462866
MESH:D008223 Lymphoma Cyclophosphamide 13.8712854902
MESH:D008223 Lymphoma Diethylstilbestrol 13.8715700306
MESH:D008223 Lymphoma Doxorubicin 13.8716098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 3.9816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 7.1611911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.1617654614
MESH:D016399 Lymphoma, T-Cell Curcumin 9.4116173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.4115621674
MESH:D008275 Magnesium Deficiency Magnesium 5.7817823441
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.8416002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 21.5215458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 21.5211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 21.5212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 21.5210697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 21.5211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 21.5216827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 21.5211731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 10.4019453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.4019453300
MESH:D008527 Medulloblastoma Tretinoin 2.4817453147
MESH:D008545 Melanoma Curcumin 10.3018462866 17885582
MESH:D008545 Melanoma Doxorubicin 10.3016827129
MESH:D008545 Melanoma Isotretinoin 10.3017237267
MESH:D008545 Melanoma sodium arsenite 10.3016487513 19082730
MESH:D008545 Melanoma Tamoxifen 10.3012393984 19393235
MESH:D008545 Melanoma Tretinoin 10.3016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5215990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.1516388313
MESH:D008569 Memory Disorders Curcumin 3.5317263510
MESH:D008591 Meningomyelocele Tretinoin 3.7816940565
MESH:D008654 Mesothelioma Doxorubicin 2.7517638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.8217261469
MESH:D008679 Metaplasia Ozone 4.4310496685
MESH:D008881 Migraine Disorders Indomethacin 6.6511903285
MESH:D008881 Migraine Disorders Magnesium 6.6518803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9015792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.8815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 11.3816381670
MESH:D009062 Mouth Neoplasms Fluorouracil 11.3816757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 11.3812636206
MESH:D052016 Mucositis Doxorubicin 10.2117415656
MESH:D052016 Mucositis irinotecan 10.2117159606
MESH:D009101 Multiple Myeloma Curcumin 9.3819372569
MESH:D009101 Multiple Myeloma Dexamethasone 9.3815744524 16118317 15867202
MESH:D009101 Multiple Myeloma Raloxifene 9.3816497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.2517962980
MESH:D009135 Muscular Diseases pirinixic acid 2.8616239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.149809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.1417596541
MESH:D009203 Myocardial Infarction Doxorubicin 10.8519429709 15857846
MESH:D009203 Myocardial Infarction Genistein 10.8517141266
MESH:D009203 Myocardial Infarction pirinixic acid 10.8519151258
MESH:D009203 Myocardial Infarction Quercetin 10.8519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 15.9916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 15.9917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 15.9916411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 15.9919207477
MESH:D009232 Myxoma Raloxifene 4.8816343187
MESH:D009361 Neoplasm Invasiveness Curcumin 3.7418495463
MESH:D009362 Neoplasm Metastasis clopidogrel 22.3211875746
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 22.329029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 22.3218259882
MESH:D009362 Neoplasm Metastasis Indomethacin 22.3211053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis irinotecan 22.3218259882
MESH:D009362 Neoplasm Metastasis norcantharidin 22.3215711181
MESH:D009362 Neoplasm Metastasis Tamoxifen 22.3219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2619410462
MESH:D009369 Neoplasms alitretinoin 25.4416946489
MESH:D009369 Neoplasms Benzo(a)pyrene 25.4411141357
MESH:D009369 Neoplasms Cyclophosphamide 25.4418854779
MESH:D009369 Neoplasms Diethylstilbestrol 25.4415313581
MESH:D009369 Neoplasms Fluorouracil 25.4416928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 25.4417405874
MESH:D009369 Neoplasms Quercetin 25.4415185748
MESH:D009369 Neoplasms sodium arsenite 25.4411559025
MESH:D009369 Neoplasms Tretinoin 25.4416594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 7.1410663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.1420056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 8.6012497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.6019189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 7.9615738583
MESH:D009389 Neovascularization, Pathologic Estradiol 7.9617289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.316375363
MESH:D009397 Nephrocalcinosis Furosemide 5.2015086907
MESH:D009401 Nephrosis Doxorubicin 4.1216899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.4315640375 16889571
MESH:D009410 Nerve Degeneration Ibuprofen 3.8710961664
MESH:D009421 Nervous System Malformations bisphenol A 30.1416427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 30.1411399458
MESH:D009421 Nervous System Malformations Estradiol 30.1416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 30.1416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 30.1414600291
MESH:D009421 Nervous System Malformations Tretinoin 30.149125849
MESH:D009423 Nervous System Neoplasms Curcumin 4.9518462866
MESH:D009436 Neural Tube Defects sodium arsenite 5.7712854658
MESH:D009436 Neural Tube Defects Tretinoin 5.779142499
MESH:D009447 Neuroblastoma Cyclophosphamide 13.148761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 13.1415555623
MESH:D009447 Neuroblastoma irinotecan 13.148761367
MESH:D009447 Neuroblastoma Isotretinoin 13.1417368321
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.7520387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 6.7512349958
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 9.338761367 12837982
MESH:D017599 Neuroectodermal Tumors irinotecan 9.338761367
MESH:D020078 Neurogenic Inflammation Quercetin 3.7517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.4420387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 2.9616436463
MESH:D009503 Neutropenia Cyclophosphamide 3.728291058
MESH:D053206 Nocturnal Enuresis Furosemide 5.2017945291
MESH:D009765 Obesity Curcumin 3.8819297423
MESH:D009765 Obesity pirinixic acid 3.8820558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.496374098
MESH:D009845 Oligospermia Cyclophosphamide 4.0516517039
MESH:D010003 Osteoarthritis Ibuprofen 6.597009135
MESH:D010003 Osteoarthritis Indomethacin 6.597009135
MESH:D010024 Osteoporosis Curcumin 9.3918719352
MESH:D010024 Osteoporosis Genistein 9.3919401787
MESH:D010024 Osteoporosis Raloxifene 9.3917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.3516169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.3519495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 13.3515579764 17823083 17893378 15758505
MESH:D012516 Osteosarcoma Doxorubicin 3.5715930896
MESH:D010049 Ovarian Diseases bisphenol A 4.3211985600
MESH:D010051 Ovarian Neoplasms Curcumin 26.1819020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 26.1819401270
MESH:D010051 Ovarian Neoplasms Genistein 26.1819005980
MESH:D010051 Ovarian Neoplasms Mifepristone 26.1816525653
MESH:D010051 Ovarian Neoplasms Progesterone 26.1816525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 26.1819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 26.1815276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 26.1816936753
MESH:D010051 Ovarian Neoplasms U 0126 26.1816211241
MESH:D010146 Pain Cyclophosphamide 11.7618093676 12161096
MESH:D010146 Pain Ibuprofen 11.763291741
MESH:D010146 Pain Indomethacin 11.7617627676 3291741 17440234 13679232
MESH:D010146 Pain Tretinoin 11.7616870215
MESH:D010149 Pain, Postoperative Ibuprofen 9.2316678543
MESH:D010149 Pain, Postoperative Indomethacin 9.2312538197 18702446
MESH:D010190 Pancreatic Neoplasms Curcumin 20.3517440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 20.3511332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 20.3516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 20.3515113037 16500647 19003803 16929163
MESH:D010190 Pancreatic Neoplasms Ibuprofen 20.3512384795
MESH:D010190 Pancreatic Neoplasms Quercetin 20.3516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 20.3515976015
MESH:D010195 Pancreatitis Indomethacin 6.8117883296 15028970
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 6.8117698068
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.0416537180
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.1116702228
MESH:D020734 Parkinsonian Disorders Indomethacin 3.5412349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.0411903285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 11.5420133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 11.5412520081
MESH:D010437 Peptic Ulcer Indomethacin 4.4811148446
MESH:D010518 Periodontitis Indomethacin 4.2417225004
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.7215687053
MESH:D010538 Peritonitis Ozone 3.4916369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.4817983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.4914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0215687265 16977796
MESH:D010997 Pleural Neoplasms Doxorubicin 4.4817638057
MESH:D011014 Pneumonia Ozone 3.7318381685 18007984 18929643
MESH:D011141 Polyuria Furosemide 4.9917945291
MESH:D017499 Porokeratosis alitretinoin 5.3316144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.342563599
MESH:D011230 Precancerous Conditions Quercetin 7.3419056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 6.4421297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.4421297632
MESH:D047928 Premature Birth Indomethacin 4.4817000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.8910548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.8917184923
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 17.8918769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.8911118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 14.5920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 14.5920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 14.5920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 8.9617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 8.9616740699
MESH:D011471 Prostatic Neoplasms Cadmium 8.9617075824
MESH:D011471 Prostatic Neoplasms Curcumin 8.9612497104 18226269 15129424 18769126 10851300 18156803 11398177
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 8.9617136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 8.9615846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 8.9616729912 16888761 15749863 15897917 16868541 18437689
MESH:D011471 Prostatic Neoplasms equol 8.9616898868 16925846
MESH:D011471 Prostatic Neoplasms Estradiol 8.9616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 8.9618626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 8.9615378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Ibuprofen 8.9617409433
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 8.9615721890
MESH:D011471 Prostatic Neoplasms Quercetin 8.9614715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 8.9616536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 8.9616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 8.9615067354
MESH:D011507 Proteinuria Ibuprofen 12.056375363
MESH:D011507 Proteinuria Indomethacin 12.0511849393
MESH:D011507 Proteinuria Tretinoin 12.0516636307
MESH:D011596 Psychomotor Disorders Isotretinoin 5.2518769834
MESH:D011625 Pterygium Tretinoin 4.1316723453
MESH:D011629 Puberty, Precocious bisphenol A 4.1210548101
MESH:D011656 Pulmonary Emphysema Curcumin 3.9419168576
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 2.9916636934
MESH:D011693 Purpura Raloxifene 4.8815770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.4416160472 15538739 18286688 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 3.5817922066
MESH:D015427 Reperfusion Injury marker/mechanism 16526316
MESH:D015427 Reperfusion Injury Furosemide 5.5616526316
MESH:D015427 Reperfusion Injury pirinixic acid 5.5619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 11.8118379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 11.8118379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 11.8115912074 16096441 12394941
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2018990726
MESH:D012170 Retinal Vein Occlusion clopidogrel 5.4719371211
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.4816283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5818045962
MESH:D012509 Sarcoma Curcumin 7.6318462866
MESH:D012509 Sarcoma Doxorubicin 7.6315625365 17710206 18313854 17203757 15675481 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.6116326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 10.7317846226
MESH:D012514 Sarcoma, Kaposi imiquimod 10.7316302556
MESH:D012554 Schistosomiasis japonica Quercetin 4.8716862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.2016636934
MESH:D018805 Sepsis Curcumin 3.5218389075
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.5216631401
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.0719755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 14.0715692506
MESH:D012878 Skin Neoplasms sodium arsenite 14.0718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.0716192470
MESH:D012878 Skin Neoplasms Tretinoin 14.0716467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9215625365 16767912 17203757
MESH:D013088 Spermatocele Diethylstilbestrol 9.6016709447 16002989
MESH:D013088 Spermatocele Tamoxifen 9.6016709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.8516517039
MESH:D013119 Spinal Cord Injuries Progesterone 8.6716503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.6719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.2712854658
MESH:D013272 Stomach Diseases Dexamethasone 8.1715472012
MESH:D013272 Stomach Diseases Indomethacin 8.1710486359 18545984 18209964 15472012 17160473 10192188 10215738 17638125 16280098 17207306 16113693 15038085 16184426
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 10.782093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 10.7818456281
MESH:D013274 Stomach Neoplasms Fluorouracil 10.7819084572 17498489 18396642 15786421 18567086 16424979 16951190 17522103 19015929 17172411
MESH:D013274 Stomach Neoplasms Furosemide 10.7817052386
MESH:D013274 Stomach Neoplasms Indomethacin 10.7815609394
MESH:D013274 Stomach Neoplasms irinotecan 10.7815723263
MESH:D013274 Stomach Neoplasms S 1 (combination) 10.7818506536 18553229 16557585
MESH:D013274 Stomach Neoplasms Tretinoin 10.7817261132
MESH:D013276 Stomach Ulcer Curcumin 8.7916631530 19188055
MESH:D013276 Stomach Ulcer Dexamethasone 8.7915138204
MESH:D013276 Stomach Ulcer Indomethacin 8.791323529 12077510 18726076 18299717 18209962 15104355 16169175 11906479 16934674 18431645 16252198 18237397 12787963 10423059 11595431 11729361 17657623 17627676 17918041 15255614 18193104 16150113 17654042 12498302 11145282 16631530 18181030 14567935 12500499 17977527 17895592 11523592 18543354 16755016 11595415 10878458 10750652 18087811 16397915 12467913 17135157 15138204
MESH:D020521 Stroke Raloxifene 3.2916837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.3316045194 16684133
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.3912837982
MESH:D024801 Tauopathies Camptothecin 4.9616930453
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.1720133375
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2312697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.887505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 12.8816010429 17909728
MESH:D013964 Thyroid Neoplasms Indomethacin 12.8811352223 18791128 14736730
MESH:D013964 Thyroid Neoplasms Tretinoin 12.8816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 11.4619048282
MESH:D013978 Tibial Fractures Raloxifene 11.4619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 7.8916280240
MESH:D014062 Tongue Neoplasms Tretinoin 7.8916051514
MESH:D014376 Tuberculosis Tretinoin 2.7816040207
MESH:D014456 Ulcer Indomethacin 4.2310574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 26.7917053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 26.7918593936
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 26.7914692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 26.7916452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 26.7917653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 26.7916720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 26.7917572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 26.7916712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 26.798653321 16712894 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.6018462866
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 17.8616175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 17.8616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 17.8611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 17.8616129372
MESH:D014591 Uterine Diseases bisphenol A 11.5714652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.5714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.8815809267 16690809
MESH:D014594 Uterine Neoplasms sulindac sulfide 7.8818645019
MESH:D014604 Uveal Neoplasms Tretinoin 3.9316752155
MESH:D014605 Uveitis Dexamethasone 4.141336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.7916002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 3.7617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9212125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.5319057314
MESH:D054556 Venous Thromboembolism Raloxifene 4.5316837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.5816364871 17678736 17334414 17638931
MESH:D014820 Vitiligo Tretinoin 3.4216761959
MESH:D014839 Vomiting Indomethacin 4.0711897121
MESH:D014846 Vulvar Neoplasms Raloxifene 4.8816343187
MESH:D014860 Warts imiquimod 6.1116368197
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5715886252
MESH:D009396 Wilms Tumor Tretinoin 3.4016287080
Pathway ID Pathway Name
KEGG:05219 Bladder cancer
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:05144 Malaria
KEGG:04115 p53 signaling pathway
KEGG:04145 Phagosome
REACT:16888 Signaling by PDGF
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36497
    • No data
    Releated disease ID Related disease Name
    PA161614136Lumbar Disc Herniation
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03965 - Fucose
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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