AutismKB 2.0

Annotation Detail for THBS2


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Basic Information Top
Gene Symbol:THBS2 ( TSP2 )
Gene Full Name: thrombospondin 2
Band: 6q27
Quick LinksEntrez ID:7058; OMIM: 188061; Uniprot ID:TSP2_HUMAN; ENSEMBL ID: ENSG00000186340; HGNC ID: 11786
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa05144Malaria
hsa04350TGF-beta signaling pathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Signaling by PDGF
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
atherosclerosis, coronary
CARDIOVASCULAR
myocardial infarct
Intervertebral Disk Displacement
METABOLIC
diabetes, type 2
No data
Desease Name
Lumbar disc herniation, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of THBS2 mRNAdecreases expression 16514628
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of THBS2 mRNAaffects expression 17484886
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS2 mRNAaffects cotreatment|decreases expression 16054899
D004958 Estradiol Estradiol results in increased expression of THBS2 mRNAincreases expression 16514628
C070081 fulvestrant fulvestrant results in decreased expression of THBS2 mRNAdecreases expression 16514628
D005665 Furosemide Furosemide results in increased expression of THBS2 mRNAincreases expression 16526316
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS2 mRNAaffects cotreatment|decreases expression 16054899
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of THBS2 mRNAaffects binding|increases activity|increases expression 19710929
D011794 Quercetin Quercetin results in increased expression of THBS2 mRNAincreases expression 15309432
D020849 Raloxifene Raloxifene results in decreased expression of THBS2 mRNAdecreases expression 16514628
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of THBS2 mRNAaffects cotreatment|decreases expression 16054899
D018038 Sodium Selenite Sodium Selenite results in increased expression of THBS2 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000419 Albuminuria Raloxifene 4.7217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 4.6015800139
MESH:D000544 Alzheimer Disease rosiglitazone 4.6019621015
MESH:D000743 Anemia, Hemolytic Quercetin 4.3517084956
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6017659584
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1315336622
MESH:D001284 Atrophy fulvestrant 4.9711514358
MESH:D001327 Autoimmune Diseases Quercetin 4.5519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Estradiol 2.0517018787 17261762 16675129 17289903 18497071 19861407 12948864 14630087
MESH:D001943 Breast Neoplasms fulvestrant 2.0518984771
MESH:D001943 Breast Neoplasms Quercetin 2.0518628248
MESH:D001943 Breast Neoplasms Raloxifene 2.0517440819 17893378 17242785 17261762 16912660 17049068 15775269 17952589 16837676 15758505 17595753 15572757
MESH:D002105 Cadmium Poisoning Quercetin 5.7216962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216192424 16124888 16050911 18705752 3786805 16227642 16097048 15673190 10355542 15700767 15721981 16011737
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7316924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.7319519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0917234771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D006332 Cardiomegaly Quercetin 3.3719794523
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8418566989
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003110 Colonic Neoplasms Dexamethasone 4.0615824018
MESH:D003110 Colonic Neoplasms Quercetin 4.0619440933 11134977 15741050 17191121 17148506 19056647 16640504
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2817728286
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.5412438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus rosiglitazone 9.7517446233
MESH:D003920 Diabetes Mellitus Sodium Selenite 9.7516285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8219496084
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9612642470
MESH:D003928 Diabetic Nephropathies Estradiol 9.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3415920148 17451421 17308373
MESH:D003967 Diarrhea Dexamethasone 3.827237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0915027814 11566570 10092053 3732212 21278145 7120509 6884620 19085960 9327722 16177239 10915739 6623471 4309450 16227642 2869522 15998439 7179309 7440962 17522070 19336974 15968718 3786805
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0915131321
MESH:D004417 Dyspnea Furosemide 5.1116935035
MESH:D004485 Eczema Dexamethasone 4.5912438553
MESH:D004487 Edema Dexamethasone 22.9419703484
MESH:D004487 Edema Furosemide 22.9411834646
MESH:D004487 Edema pirinixic acid 22.9412083418
MESH:D004487 Edema Raloxifene 22.9415860553
MESH:D004487 Edema rosiglitazone 22.9412083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1215845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.0219148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.0211473722 18566989 19148513
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7716045604 15959796 17595544 19224547 16239168 61145 12795759 12631006
MESH:D005234 Fatty Liver pirinixic acid 19.7720131406 19236843
MESH:D005234 Fatty Liver Raloxifene 19.7717473493
MESH:D005234 Fatty Liver rosiglitazone 19.7719196556
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4118705752
MESH:D005355 Fibrosis Quercetin 9.4119474275
MESH:D005909 Glioblastoma Quercetin 3.4619804834
MESH:D005910 Glioma Quercetin 3.0917643826
MESH:D034381 Hearing Loss Furosemide 4.9317868369
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006333 Heart Failure Furosemide 7.5316845234 16011733 12660669
MESH:D006333 Heart Failure pirinixic acid 7.5320558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 18467677 19176532 16221962
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.107520565
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia rosiglitazone 4.0012083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006934 Hypercalcemia Furosemide 5.1817652376
MESH:D053565 Hypercalciuria Furosemide 5.8117652376
MESH:D006943 Hyperglycemia pirinixic acid 9.5920558911
MESH:D006943 Hyperglycemia Quercetin 9.5918262572 11834736
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.0515086907
MESH:D006973 Hypertension Dexamethasone 9.0417042910
MESH:D006973 Hypertension Quercetin 9.0418356687
MESH:D006973 Hypertension Raloxifene 9.0415787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.4216612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.8111041285
MESH:D007019 Hypoproteinemia Furosemide 6.0516096441
MESH:D007022 Hypotension Furosemide 4.7311041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.5915811171
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.6218306037
MESH:D007248 Infertility, Male fulvestrant 3.8211514358
MESH:D007249 Inflammation Dexamethasone 5.7311099482 8960868
MESH:D007249 Inflammation rosiglitazone 5.7312083418
MESH:D007251 Influenza, Human Quercetin 4.6816624496
MESH:D007333 Insulin Resistance Estradiol 18.2616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 18.2616306350
MESH:D007333 Insulin Resistance rosiglitazone 18.2616306350
MESH:D007333 Insulin Resistance Sodium Selenite 18.2614714311
MESH:C535531 Intervertebral disc disease marker/mechanism
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.6218306037
MESH:D007627 Keloid Quercetin 5.0917086741
MESH:D007674 Kidney Diseases Estradiol 10.6415618244
MESH:D007674 Kidney Diseases Furosemide 10.6411041285
MESH:D007674 Kidney Diseases Quercetin 10.6416962696
MESH:D007680 Kidney Neoplasms Estradiol 3.0715610895
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D007938 Leukemia Quercetin 3.2017468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616239168 11903743 17334410 17157831 17174718 16943688 11408273 16221502 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.9218277467 17557913 15876570 16248980 18006644 15362042 15057751 15818738 18705752 15338365 16116963 12632514 17900296 10355542 14620537 18210741 14724832 15673190 12958196 18205269 15996030 17714472 18156304 14512876 16097048 17805973 18263696 16027843 17869086 18376398 15650968 15730626 18420326 12898905 15893842 17761835 17922224 18395914 15931870 15123356 12445418 18412020 13678700 18429990 12609069 18279442 11481614 14716496 16011737 18251166 12649538 17721639 17823541 18339082 15959796 17708605 17481882 12546737 18187930 15370692 12586293 15925388 18054572 17976157 12445421 17766677 17640975 17698563 17525996 18472332 12667390 18481824 18166357 20821823 16136751 18418968 18395095 16638106 17631135 18472094 15052691 12632512 16192424 14716833 12741479 12666154 17565644 12389079 16015684 17944888 18317297 16033810 14748882
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.9216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.9214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.9212741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.9217347453 15980055
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016246199 16964402 17285989 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6919294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.6920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 7.6918980244
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.3319519916
MESH:D008175 Lung Neoplasms Dexamethasone 2.8215824018 11195469
MESH:D008175 Lung Neoplasms Quercetin 2.8216280456
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4811408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.4816827153
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4717261469
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Dexamethasone 7.8215744524 16118317 15867202
MESH:D009101 Multiple Myeloma Raloxifene 7.8216497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.609809623
MESH:D009203 Myocardial Infarction pirinixic acid 5.8619151258
MESH:D009203 Myocardial Infarction Quercetin 5.8619595682
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.6916411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 14.6919207477
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009369 Neoplasms Quercetin 5.2215185748
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009397 Nephrocalcinosis Furosemide 6.0515086907
MESH:D009421 Nervous System Malformations Estradiol 3.7816427766 11399458
MESH:D020078 Neurogenic Inflammation Quercetin 4.4817929310
MESH:D053206 Nocturnal Enuresis Furosemide 6.0517945291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Raloxifene 3.4615775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.5919495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.5917893378 17823083 15579764 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms Quercetin 5.0519005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8816965848
MESH:D011141 Polyuria Furosemide 5.8117945291
MESH:D011230 Precancerous Conditions Quercetin 4.0819056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6021297632
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.0914715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0916536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0918760546
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D015427 Reperfusion Injury Furosemide 6.9716526316
MESH:D015427 Reperfusion Injury pirinixic acid 6.9719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 9.9218379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 9.9215912074 12394941 16096441
MESH:D012554 Schistosomiasis japonica Quercetin 5.7216862918
MESH:D013272 Stomach Diseases Dexamethasone 4.4715472012
MESH:D013274 Stomach Neoplasms Furosemide 2.8617052386
MESH:D013276 Stomach Ulcer Dexamethasone 3.5915138204
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D013978 Tibial Fractures Estradiol 14.3019048282
MESH:D013978 Tibial Fractures Raloxifene 14.3019048282
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.5216720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5217572228
MESH:D014605 Uveitis Dexamethasone 4.991336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
Pathway ID Pathway Name
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05144 Malaria
KEGG:04145 Phagosome
REACT:16888 Signaling by PDGF
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36498
    • Releated gene ID Related gene Name
    PA30877MMP2
    PA30889MMP9
    Releated disease ID Related disease Name
    PA161614136Lumbar Disc Herniation
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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