AutismKB 2.0

Annotation Detail for THBS3


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Basic Information Top
Gene Symbol:THBS3 ( MGC119564,MGC119565,TSP3 )
Gene Full Name: thrombospondin 3
Band: 1q22
Quick LinksEntrez ID:7059; OMIM: 188062; Uniprot ID:TSP3_HUMAN; ENSEMBL ID: ENSG00000169231; HGNC ID: 11787
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa05144Malaria
hsa04350TGF-beta signaling pathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Signaling by PDGF
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in increased expression of THBS3 mRNAincreases expression 16982809
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of THBS3 mRNAincreases expression 14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of THBS3 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of THBS3 mRNAincreases expression 18042831
D005665 Furosemide Furosemide affects the expression of THBS3 mRNAaffects expression 16526316
C041786 palm oil palm oil results in increased expression of THBS3 mRNAincreases expression 18042831
C089730 rosiglitazone rosiglitazone results in increased expression of THBS3 mRNAincreases expression 16982809
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of THBS3 mRNAdecreases expression 12167310
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.8919621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816192424 16227642 16124888 15673190 10355542 18705752 15700767 16011737 15721981 3786805 16050911 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002386 Cataract Am 580 4.4817460283
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 12621046 16354765 15668235 15340226
MESH:D003092 Colitis Am 580 5.2717035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003920 Diabetes Mellitus rosiglitazone 4.5117446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.6612642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6617107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9215027814 9327722 10092053 3786805 19085960 15968718 10915739 3732212 4309450 15998439 17522070 7120509 16177239 6623471 7440962 19336974 6884620 11566570 2869522 7179309 16227642 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004417 Dyspnea Furosemide 5.3216935035
MESH:D004487 Edema Furosemide 13.1311834646
MESH:D004487 Edema rosiglitazone 13.1312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.1311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.7117595544 19224547 15959796 12631006 16239168 16045604 61145 12795759
MESH:D005234 Fatty Liver Dietary Fats 14.7118296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver rosiglitazone 14.7119196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.6318705752
MESH:D005355 Fibrosis Dietary Fats 16.6318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.6320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D034381 Hearing Loss Furosemide 5.0417868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure Furosemide 4.2016845234 12660669 16011733
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 18606429 15340226 8697196 16354765
MESH:D006930 Hyperalgesia rosiglitazone 4.1112083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006934 Hypercalcemia Furosemide 5.3217652376
MESH:D053565 Hypercalciuria Furosemide 5.9917652376
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.2515086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.5916612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.9911041285
MESH:D007019 Hypoproteinemia Furosemide 6.2516096441
MESH:D007022 Hypotension Furosemide 4.8811041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.7915811171
MESH:D007249 Inflammation Dietary Fats 9.0520412841
MESH:D007249 Inflammation rosiglitazone 9.0512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 8.1711836018 18457598
MESH:D007333 Insulin Resistance rosiglitazone 8.1716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Furosemide 3.9011041285
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0316221502 17157831 16239168 16943688 17174718 11903743 21278145 11408273 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6717900296 15818738 12586293 18376398 15650968 15876570 17698563 15338365 15893842 17766677 12445418 15370692 17721639 12632514 17922224 12666154 18429990 18418968 18277467 17557913 18279442 17714472 18420326 17823541 20821823 17640975 16011737 15673190 15925388 18156304 14724832 12898905 15052691 17708605 16136751 12667390 17869086 17525996 15959796 14512876 16097048 15730626 18472332 18187930 15123356 18210741 14620537 17631135 15362042 16192424 11481614 12445421 18054572 17761835 15931870 18412020 18339082 12632512 12389079 13678700 18205269 12546737 14716496 18251166 16015684 18395914 18472094 16248980 14716833 17805973 17976157 18481824 18166357 18395095 18263696 12741479 14748882 16033810 10355542 18006644 15057751 18705752 16116963 12609069 17481882 18317297 16638106 17944888 16027843 17565644 15996030 12958196 12649538
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.6717347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 15720792 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.5316827153
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.5817261469
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009397 Nephrocalcinosis Furosemide 6.2515086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D053206 Nocturnal Enuresis Furosemide 6.2517945291
MESH:D009765 Obesity Dietary Fats 2.3316723640 19632207 21332399 18674790 18457598 11836018 17217161 20132043 20518802
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D011141 Polyuria Furosemide 5.9917945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11222880 11118676
MESH:D015427 Reperfusion Injury Furosemide 4.0116526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.8816096441 15912074 12394941
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.928532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9216192470
MESH:D013274 Stomach Neoplasms Furosemide 2.8617052386
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05144 Malaria
KEGG:04145 Phagosome
REACT:16888 Signaling by PDGF
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36499
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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