AutismKB 2.0

Annotation Detail for TSPO


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Basic Information Top
Gene Symbol:TSPO ( BPBS,BZRP,DBI,IBP,MBR,PBR,PBS,PKBS,PTBR,mDRC,pk18 )
Gene Full Name: translocator protein (18kDa)
Band: 22q13.2
Quick LinksEntrez ID:706; OMIM: 109610; Uniprot ID:TSPOA_HUMAN; ENSEMBL ID: ENSG00000100300; HGNC ID: 1158
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1836Panic disorder
1934Cancer
2091Hypertension
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TSPO mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TSPO mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TSPO mRNAaffects expression 17562736
C052036 alpidem SSR180575 inhibits the reaction [alpidem binds to TSPO protein]affects binding|decreases reaction 12023539
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TSPO mRNAaffects expression 16483693
D000643 Ammonium Chloride TSPO protein affects the susceptibility to Ammonium Chlorideaffects response to substance 17893919
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of TSPO mRNAdecreases expression 17484886
D003345 Corticosterone Corticosterone results in increased expression of TSPO mRNAincreases expression 15755911
C118941 DAA 1097 DAA 1097 analog binds to TSPO proteinaffects binding 16640334
C118941 DAA 1097 DAA 1097 binds to TSPO proteinaffects binding 16640334
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of TSPO proteindecreases expression 15141095
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of TSPO mRNAincreases expression 15141095
D004041 Dietary Fats Dietary Fats results in decreased expression of TSPO mRNAdecreases expression 18042831
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of TSPO mRNAdecreases expression 16690193
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of TSPO proteindecreases expression 16690193
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TSPO mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in decreased expression of TSPO mRNAdecreases expression 20144698
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of TSPO mRNA]affects reaction|decreases expression 15016801
C056933 fumonisin B1 fumonisin B1 results in increased expression of TSPO mRNAincreases expression 16221962
D006533 Heptachlor Heptachlor results in increased expression of TSPOincreases expression 14699885
D006534 Heptachlor Epoxide Heptachlor Epoxide results in increased expression of TSPOincreases expression 14699885
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TSPO mRNAaffects cotreatment|increases expression 17183730
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of TSPO mRNAincreases expression 17412507
C545830 N-benzyl-N-methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide N-benzyl-N-methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide binds to TSPO proteinaffects binding 19720292
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of TSPO mRNAdecreases expression 17616710
C030110 oxaliplatin oxaliplatin results in decreased expression of TSPO mRNAdecreases expression 17762391
C041786 palm oil palm oil results in decreased expression of TSPO mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TSPO mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TSPO mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of TSPO mRNAincreases expression 18301758
C037850 PK 11195 PK 11195 binds to TSPO proteinaffects binding 15519653
C037850 PK 11195 PK 11195 binds to and results in decreased activity of TSPO proteinaffects binding|decreases activity 12730627
D011166 Porphyrins TSPO protein affects the transport of Porphyrinsaffects transport 11020479
C035988 procymidone procymidone results in decreased expression of TSPO mRNAdecreases expression 15686871
C028025 protoporphyrin IX TSPO protein results in decreased abundance of protoporphyrin IXdecreases abundance 11020479
D020156 Salicylic Acid Salicylic Acid results in decreased expression of TSPO mRNAdecreases expression 16551645
C456740 SSR180575 SSR180575 binds to TSPO proteinaffects binding 12023539
C456740 SSR180575 SSR180575 binds to TSPO proteinaffects binding 12023539
C456740 SSR180575 SSR180575 inhibits the reaction [alpidem binds to TSPO protein]affects binding|decreases reaction 12023539
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TSPO mRNAincreases expression 12377990
19684285
D013752 Tetracycline Tetracycline results in decreased expression of TSPO mRNAdecreases expression 16917069
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TSPO mRNAaffects expression 21346803
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TSPO mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin results in decreased expression of TSPO mRNAdecreases expression 15686871
C017802 zinc hematoporphyrin TSPO protein results in increased abundance of zinc hematoporphyrinincreases abundance 11020479
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 22.646734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 22.646195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 22.6415322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 22.647525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 22.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5919490988
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Estradiol 6.6011473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.6017638652
MESH:D000230 Adenocarcinoma Methylnitrosourea 6.6015688392 15113128
MESH:D000236 Adenoma Diethylnitrosamine 2.6310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.7216434500 19052882 19061943 17620307 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.7217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.7216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.7216835633
MESH:D000382 Agricultural Workers' Diseases Heptachlor 4.7912661182
MESH:D000550 Amblyopia Valproic Acid 4.8417688650
MESH:D000740 Anemia Fluorouracil 7.5915504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5911748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001008 Anxiety Disorders Valproic Acid 7.8617497229
MESH:D001008 Anxiety Disorders vinclozolin 7.8619015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.5215238619
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 16609825 18316065 19460635 17688650 18396377 20603192 18775368 18985861 19232924 17507914 18177632 17157402 18940202 18558336
MESH:D001714 Bipolar Disorder Valproic Acid 2.8817594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.208888407
MESH:D001943 Breast Neoplasms Dietary Fats 4.3820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.3817474063
MESH:D001943 Breast Neoplasms Estradiol 4.3817261762 19861407 17289903 16675129 18497071 14630087 17018787 12948864
MESH:D001943 Breast Neoplasms Fluorouracil 4.3816110121 18608205 16595493 16557594 18357371 15136595 19217205
MESH:D001943 Breast Neoplasms Heptachlor 4.388738476
MESH:D001943 Breast Neoplasms Heptachlor Epoxide 4.3815770527 8738476
MESH:D001943 Breast Neoplasms Methylnitrosourea 4.3816253758 14633655 11306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4110355542 15673190 16050911 16227642 3786805 16011737 16192424 15721981 18705752 16124888 15700767 16097048
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2816051944
MESH:D002277 Carcinoma Fluorouracil 7.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.1916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.6616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.663084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.6618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.6619208518 18210153 10672840 17761372 17162532 18785209 16878318 20432363 19107877 20935162 20514400 19418558 19919837 16288022 20512989 19052882 17055752 3084413 18788625 18665156 19383236 17428255 16935385 11831363 20101231 10737359 16328049 20524982 20727157 16540662 16830150 19701751 20214788 21159647 16569478 16698587 18978308 16779866 16502159 18691550 18494052 17173139 16681979 17978847 18971187 20084675 19335982 19394651 3581430 19519916 18393292 19171122 16807293 19822196 18506893 20007298 18056438 17138121 19539802
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.6616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.6617045692 17971768 18930000 17088986 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 15.6620935162 6705139 17173139 1701930 20007298
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.3818986760 17066447 16757204 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 11.2110977129
MESH:D002386 Cataract Methylnitrosourea 11.2112484553
MESH:D002386 Cataract Trinitrotoluene 11.2114694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 13.916135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.917505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.9118566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 13.917505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.884080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5620734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.5519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9416354765 12621046 8697196 15340226 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9117287894 18772588 16340194 15001691 17016597 17725105 17169374 16510598 17172411 17018589
MESH:D003110 Colonic Neoplasms oxaliplatin 3.9116510598 16004971 16024531
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8417695437 17401013 16282729 16391804 18448328 15289873 16524972 17094418 18802399 14970324 20501625 17594712 17016601 16331619 17454858 15148649 18288408 18949393 17255274 18383874 16303861 18509181
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.8417255274 18448328 17401013 17695437 17594712 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2114669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.2115095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.348888407 16575769 17688650
MESH:D003456 Cryptorchidism Dibutyl Phthalate 10.4916037377
MESH:D003456 Cryptorchidism vinclozolin 10.4914966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 16.6518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 16.6518551238
MESH:D003490 Cyanosis Trinitrotoluene 16.6518551238
MESH:D007644 Darier Disease Fluorouracil 4.4116733453
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.3616882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.8720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.8717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 26.9821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 26.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 26.9819416960 10663392 19164858 18071297 14986274 11739529 16781746 11529661 16393943 12153990 10774834 12705907 15968718 18713872 11421492 11287661 14725611 11743745 14550746 12540782 19370779 10915739 15619225 12392966 16227642 11834606 19739265 12594235 2444490 16177239 17562736 19420014 16485898 19923254 17522070 16081117 12958197 19085960 17906064 11461765 16109766
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 26.9816227642 6884620 15998439 15027814 7440962 7179309 3732212 4309450 6623471 15968718 3786805 7120509 11566570 17522070 19336974 10092053 19085960 9327722 16177239 21278145 10915739 2869522
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 26.9819107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 26.9816221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 26.9820420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 26.9817522070
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 26.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 26.981733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1818367378
MESH:D004421 Dystonia Phenobarbital 9.271851702
MESH:D004421 Dystonia Valproic Acid 9.271851702
MESH:D004487 Edema pirinixic acid 5.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5118230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 2.7319148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.553659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.553659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 8.6811558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 8.6816628512 3922381
MESH:D004827 Epilepsy Phenobarbital 5.9920417680
MESH:D004827 Epilepsy Valproic Acid 5.9918234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.806401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.806254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.067750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.213659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.213659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4117638652 16481741 16337965 16785472 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.4116510608 16805852 15264214 15623463 15547721 15547733 16704527 15150132 15878914
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 26.3116239168 15959796 17595544 12795759 12631006 61145 16045604 19224547
MESH:D005234 Fatty Liver Dietary Fats 26.3119004024 18296743 17967931 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 26.3121071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 26.3119236843 20131406
MESH:D005234 Fatty Liver Tetracycline 26.3116917069 19224547
MESH:D005234 Fatty Liver Valproic Acid 26.3119224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.7718558336 8888407
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.8511555667
MESH:D005355 Fibrosis Carbon Tetrachloride 12.6118705752
MESH:D005355 Fibrosis Dietary Fats 12.6118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6120067830
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9116417039
MESH:D005910 Glioma Fluorouracil 5.8416145905
MESH:D005910 Glioma Methylnitrosourea 5.849825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1315102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2419900420 19110552
MESH:D006529 Hepatomegaly fumonisin B1 23.1916221962
MESH:D006529 Hepatomegaly Phenobarbital 23.1916109766
MESH:D006529 Hepatomegaly pirinixic acid 23.1919772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 23.1912621046 15340226 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 23.1915817613
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006849 Hydrocephalus Valproic Acid 4.4817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6618606429 15340226 16959395 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.0516870215
MESH:D006930 Hyperalgesia oxaliplatin 7.0517418472
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2621332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2516612254
MESH:D007248 Infertility, Male Methylnitrosourea 9.997193160
MESH:D007248 Infertility, Male Trinitrotoluene 9.9912150543
MESH:D007248 Infertility, Male vinclozolin 9.9916467254
MESH:D007249 Inflammation Dietary Fats 7.0920412841
MESH:D007249 Inflammation Diethylnitrosamine 7.0918785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.0912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 10.8311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.8316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007674 Kidney Diseases Acetaminophen 5.1415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.1415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.2416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 15.2416705839
MESH:D007680 Kidney Neoplasms Estradiol 15.2415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 15.2416985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0816294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3516417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 3.9315526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.9816221502 11903743 17174718 17157831 17334410 16943688 11408273 21278145 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 13.9818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.9818522880 20032147 18665156 18407596 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 13.9821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.4818210741 14620537 10355542 17823541 18205269 18481824 18339082 12445421 15673190 17640975 18279442 12741479 16027843 18006644 17761835 11481614 12546737 12586293 17721639 15052691 17805973 17481882 18395914 17869086 15730626 12667390 15362042 20821823 18376398 14716833 17708605 18263696 18251166 18054572 18412020 17976157 12632514 17525996 15123356 14716496 15818738 12649538 17714472 16033810 16248980 12666154 15338365 18418968 12898905 15893842 17557913 18472332 18429990 13678700 12958196 16015684 15996030 17631135 12632512 16192424 17698563 18156304 17900296 15650968 18395095 18472094 15370692 15931870 14724832 14748882 18187930 17565644 12609069 16136751 17944888 16097048 17922224 18317297 18705752 15057751 16116963 17766677 14512876 12389079 15959796 16638106 16011737 12445418 18166357 18420326 18277467 15925388 15876570
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.4814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.4812878042
MESH:D008107 Liver Diseases Acetaminophen 8.4411587558 19460945 16610002 16611625 12587719 12969438 19014921 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.4416246199 15830285 15720792 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 8.4417034775
MESH:D008107 Liver Diseases Phenobarbital 8.4419363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.3116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.3116899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 31.067678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 31.0619294768
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 31.0611940454
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.0615175105 21047994 19254457 2862719 20101389 19255062 18648771 19073162 19294768 18978307 15885732 19426721 18977376 19256749 20434301 9163691 19850985 19833225 21167192 16942905 18644402 20583210 20501860 19638242 19090486 20118626 20137499 19499222 19427195 19812893 12112319 20405173 19690152 19642983 2422723 20492335 10737359 20452335 21071580 18754104 19996281 21278145 19551842 12771043
MESH:D008113 Liver Neoplasms Fluorouracil 31.0617045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Heptachlor 31.062422723 9544696
MESH:D008113 Liver Neoplasms Heptachlor Epoxide 31.0611246134
MESH:D008113 Liver Neoplasms Phenobarbital 31.0615975961 19482888 21047994 19073162 19812893 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 31.0620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.0616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.086135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.0812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.0816267830 2563599 19539802 19519916 18308698 18164116 16842330 18093689 21159647 9362446 17854601 18544905 19009564 19004024 18282651 17174075 17942915 18079962 19126423 18775883 18253720 3124819
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.081399818 6150874 2563599 18308698 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.0812151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.0916080182
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8717228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.4620970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 4.4615246190
MESH:D008175 Lung Neoplasms Methylnitrosourea 4.4618062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.4611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4115086387
MESH:D008223 Lymphoma Methylnitrosourea 3.7411418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.4214633661
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 8.7712807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.7716891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 8.7714999141 10838139 16944150 16827153 14633655 16051031 12931682 15313902 16619500 11751437 15688392 10767621 15113128 17020996 11807958 17131329 19196723
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008881 Migraine Disorders Valproic Acid 2.9218765137 18803445
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3416757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.698888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9317596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 15.5818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 15.587678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 15.5818551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.419029167 3581430
MESH:D009369 Neoplasms Fluorouracil 7.2318600527 16928823 18239605
MESH:D009369 Neoplasms Methylnitrosourea 7.2315533788
MESH:D009369 Neoplasms pirinixic acid 7.2317405874
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.1012696579
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.409884423
MESH:D009421 Nervous System Malformations Estradiol 8.2616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2614600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.8816359493 8888407
MESH:D009442 Neurilemmoma Methylnitrosourea 5.1011555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.6418514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.6420387270
MESH:D019636 Neurodegenerative Diseases SSR180575 12.6412023539
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1816436463
MESH:D009765 Obesity Dietary Fats 4.0811836018 18674790 20518802 19632207 20132043 16723640 17217161 18457598 21332399
MESH:D009765 Obesity pirinixic acid 4.0820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.2816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.2816049721
MESH:D009784 Occupational Diseases Trinitrotoluene 13.2812819281 17852074 14694615
MESH:D010018 Osteomalacia Phenobarbital 3.9817016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1019401270
MESH:D010146 Pain Acetaminophen 2.1016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.1616540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.1616500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 11.1616965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.1616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0411026799
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.032563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.032563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.0311222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.0320603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.0319015723 18042343 18220299
MESH:D017096 Prion Diseases Tetracycline 5.0310903871
MESH:D011469 Prostatic Diseases vinclozolin 4.5518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.2816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2818626508 19082440
MESH:D011471 Prostatic Neoplasms Heptachlor 2.2812661182
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.2812376480 15682402
MESH:D011472 Prostatitis vinclozolin 4.5518629315
MESH:D019310 Pseudolymphoma Phenobarbital 10.9012752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.9011422049 12752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6918722050 16160472 15538739 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1318172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.1011555667
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0215737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 15.8218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 15.8218551238
MESH:D012640 Seizures Phenobarbital 15.823137016 16876388 11442880 4039156
MESH:D012640 Seizures Trinitrotoluene 15.8218551238
MESH:D012640 Seizures Valproic Acid 15.821511512 14763951 11044598 17978042 3137016 15475178 11738929 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.446407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8616192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4919490988
MESH:D013163 Splenomegaly Trinitrotoluene 4.8315817613
MESH:D013226 Status Epilepticus Valproic Acid 4.1512833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4318396642 18567086 19015929 15786421 16951190 16424979 17522103 17498489 19084572 17172411
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.4316257854 18593901 15930296
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.4317575124 12958204
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.8511418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.427505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 10.423078959 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.421399818
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6616280240
MESH:D014178 Translocation, Genetic Valproic Acid 4.8417262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.143119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.4916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.4916049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.278888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.7210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.7210091137
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.5516803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Dietary Fats 3.4216723640
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25473
    • Releated gene ID Related gene Name
    PA27158DBI
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    PA447196Anxiety Disorders
    PA447212Panic Disorder
    Releated drug ID Related drug Name
    PA449283diazepam
    PA164781320flunitrazepam
    PA450496midazolam
    PA164712507Anxiolytics
    PA449502estazolam
    PA450266loratadine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00186 other Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
    DB00231 other Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00402 agonist Eszopiclone Hypnotics and Sedatives
    DB00404 other Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00628 agonist Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00897 other Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00962 other Zaleplon Hypnotics and Sedatives;Anticonvulsants;Anxiolytics sedatives and hypnotics
    DB01068 other/unknown Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
    DB01178 agonist Myoflex Anti-anxiety Agents;Benzodiazepines;Antipsychotics;Muscle Relaxants, Central
    DB01198 agonist Zopiclone Hypnotics and Sedatives
    DB01544 agonist Flunitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01587 agonist Ketazolam Anti-anxiety Agents;Benzodiazepines
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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