AutismKB 2.0

Annotation Detail for THBS4


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Basic Information Top
Gene Symbol:THBS4 ( TSP4 )
Gene Full Name: thrombospondin 4
Band: 5q14.1
Quick LinksEntrez ID:7060; OMIM: 600715; Uniprot ID:TSP4_HUMAN; ENSEMBL ID: ENSG00000113296; HGNC ID: 11788
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa05144Malaria
hsa04350TGF-beta signaling pathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Signaling by PDGF
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
myocardial infarct
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of THBS4 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of THBS4 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of THBS4 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of THBS4 mRNA]affects reaction|decreases expression 18929588
D004041 Dietary Fats Dietary Fats results in increased expression of THBS4 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBS4 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of THBS4 mRNAincreases expression 18035473
D005665 Furosemide Furosemide affects the expression of THBS4 mRNAaffects expression 16526316
C041786 palm oil palm oil results in increased expression of THBS4 mRNAincreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of THBS4 mRNAincreases expression 17275934
D013311 Streptozocin Streptozocin results in increased expression of THBS4 mRNAincreases expression 16684804
D013311 Streptozocin vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of THBS4 mRNA]decreases reaction|increases expression 16684804
C004648 testosterone enanthate testosterone enanthate affects the expression of THBS4 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBS4 mRNAaffects cotreatment|increases expression 17942748
C034028 vanadyl sulfate vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of THBS4 mRNA]decreases reaction|increases expression 16684804
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.8811874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002276 Carcinoid Tumor Streptozocin 5.7316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7716705839
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.826135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9317681005 17333356 11677210 16919318 17110522 15861022 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 8697196 15668235 15340226
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D003920 Diabetes Mellitus Streptozocin 4.8016285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 9.2815831366 16684804 2177838 8740154 19496084 19960420 1374869 12093613 12083368 15862027 17874149 7637645 19586609 18603373 12446591 15298345 11260395 19298542 18715473 6379147 11055810 12644472 17442507 16286809
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 9.2816684804
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.6518603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 4.7119647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7117107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.8416025228
MESH:D003928 Diabetic Nephropathies Streptozocin 4.7419960420 19682444
MESH:D003930 Diabetic Retinopathy Streptozocin 5.5217662242
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.7718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004417 Dyspnea Furosemide 5.0716935035
MESH:D004487 Edema Furosemide 7.3711834646
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenite 13.6718296743
MESH:D005234 Fatty Liver Dietary Fats 13.6718296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis arsenite 15.4818296743
MESH:D005355 Fibrosis Dietary Fats 15.4818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.4820067830
MESH:D005911 Gliosis Paraquat 5.3011124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D034381 Hearing Loss Furosemide 4.9017868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006331 Heart Diseases Streptozocin 4.3312093613
MESH:D006333 Heart Failure Furosemide 4.1112660669 16011733 16845234
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0012621046 15340226 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 16959395 15340226 16354765 8697196
MESH:D006934 Hypercalcemia Furosemide 5.1517652376
MESH:D053565 Hypercalciuria Furosemide 5.7717652376
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 6.0115086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.3916612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.7711041285
MESH:D007019 Hypoproteinemia Furosemide 6.0116096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007022 Hypotension Furosemide 4.7011041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.5515811171
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9217937319
MESH:D007248 Infertility, Male Paraquat 6.924850670
MESH:D007249 Inflammation Dietary Fats 8.5520412841
MESH:D007249 Inflammation Flavonoids 8.5517296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5512200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1518457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Furosemide 7.0811041285
MESH:D007674 Kidney Diseases Streptozocin 7.0812093613
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0416705839
MESH:D008103 Liver Cirrhosis arsenite 7.0018296743
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0018296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.467678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.902876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008175 Lung Neoplasms arsenite 2.5016809336
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5011884234 19555203
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009389 Neovascularization, Pathologic arsenite 4.5315738583
MESH:D009397 Nephrocalcinosis Furosemide 6.0115086907
MESH:D009410 Nerve Degeneration Paraquat 3.7816893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D053206 Nocturnal Enuresis Furosemide 6.0117945291
MESH:D009765 Obesity Dietary Fats 2.3018457598 18674790 16723640 21332399 17217161 20132043 19632207 20518802 11836018
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010300 Parkinson Disease Paraquat 2.8411124998 15451049 11445065 15824117 16510128 16140633 12911755 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.5316190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011014 Pneumonia Paraquat 4.5712504350
MESH:D011141 Polyuria Furosemide 5.7717945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11399792 11896295 11118676
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9417997886 16324872
MESH:D015427 Reperfusion Injury Furosemide 3.9516526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 9.7816096441 15912074 12394941
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 9.7811700416
MESH:D012135 Respiratory Sounds Paraquat 4.1611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration Paraquat 3.9316458197
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Furosemide 2.8617052386
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
Pathway ID Pathway Name
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05144 Malaria
KEGG:04145 Phagosome
REACT:16888 Signaling by PDGF
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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