AutismKB 2.0

Annotation Detail for KLF10


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Basic Information Top
Gene Symbol:KLF10 ( EGRA,TIEG,TIEG1 )
Gene Full Name: Kruppel-like factor 10
Band: 8q22.3
Quick LinksEntrez ID:7071; OMIM: 601878; Uniprot ID:KLF10_HUMAN; ENSEMBL ID: ENSG00000155090; HGNC ID: 11810
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
1944Breast cancer
1965Clear cell carcinoma
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KLF10 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of KLF10 mRNAdecreases expression 18648102
D000638 Amiodarone Amiodarone results in increased expression of KLF10 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KLF10 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of KLF10 mRNAincreases expression 18687144
C095105 bexarotene bexarotene results in decreased expression of KLF10 mRNAdecreases expression 17178900
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of KLF10 mRNAincreases expression 17553608
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KLF10 mRNAaffects expression 17484886
D002857 Chromium Chromium results in increased expression of KLF10 mRNAincreases expression 17547211
D003474 Curcumin Curcumin results in decreased expression of KLF10 mRNAdecreases expression 17999991
C017180 decamethrin decamethrin results in decreased expression of KLF10 mRNAdecreases expression 19017407
C014347 decitabine [decitabine co-treated with TGFB1 protein] promotes the reaction [KLF10 protein binds to FOXP3 promoter]affects binding|affects cotreatment|increases reaction 19109157
D004041 Dietary Fats Dietary Fats results in decreased expression of KLF10 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of KLF10 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of KLF10 mRNA]decreases reaction|increases expression 17942915
C444299 diindolylmethane diindolylmethane inhibits the reaction [Estradiol results in decreased expression of KLF10 mRNA]decreases expression|decreases reaction 11179685
D004958 Estradiol diindolylmethane inhibits the reaction [Estradiol results in decreased expression of KLF10 mRNA]decreases expression|decreases reaction 11179685
D004958 Estradiol Estradiol affects the expression of KLF10 mRNAaffects expression 14699072
D004958 Estradiol Estradiol results in decreased expression of KLF10 mRNAdecreases expression 11179685
D004958 Estradiol Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of KLF10 mRNA]decreases expression|increases reaction 11179685
D004958 Estradiol Estradiol affects the expression of KLF10 mRNAaffects expression 15598610
D011345 Fenofibrate Fenofibrate results in decreased expression of KLF10 mRNAdecreases expression 11798191
D005947 Glucose Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]increases expression|increases reaction 19225232
D005947 Glucose valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]decreases reaction|increases expression|increases reaction 19225232
C029424 hydrazine hydrazine results in decreased expression of KLF10 mRNAdecreases expression 15282401
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of KLF10 mRNAdecreases expression 15120970
C022838 nickel chloride nickel chloride results in increased expression of KLF10 mRNAincreases expression 17547211
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of KLF10 mRNAincreases expression 17616710
C041786 palm oil palm oil results in decreased expression of KLF10 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of KLF10 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of KLF10 mRNAincreases expression 19270015
D019800 Phenol Phenol results in increased expression of KLF10 mRNAincreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLF10 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLF10 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of KLF10 mRNAdecreases expression 18445702
11798191
C006253 pirinixic acid pirinixic acid results in increased expression of KLF10 mRNAincreases expression 18301758
17426115
D011192 Potassium Dichromate Potassium Dichromate results in increased expression of KLF10 mRNAincreases expression 17547211
D011374 Progesterone Progesterone results in decreased expression of KLF10 mRNAdecreases expression 18037150
D020849 Raloxifene Raloxifene affects the expression of KLF10 mRNAaffects expression 14699072
D019821 Simvastatin [valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]affects cotreatment|decreases reaction|increases expression 19225232
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of KLF10 mRNA]decreases expression|increases reaction 11179685
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of KLF10 mRNA]affects reaction|decreases expression 16891777
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of KLF10 mRNA]decreases reaction|increases expression 15667827
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KLF10 mRNAdecreases expression 16891777
18691609
C081489 valsartan [valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]affects cotreatment|decreases reaction|increases expression 19225232
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]decreases reaction|increases expression 19225232
C081489 valsartan valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]decreases reaction|increases expression|increases reaction 19225232
D014638 Vanadates Vanadates results in increased expression of KLF10 proteinincreases expression 17874149
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.226195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.2214514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma Estradiol 2.0211473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.043712494
MESH:D000236 Adenoma Diethylnitrosamine 6.046695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.1717620307 19061943 19052882 18056438 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.1717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.1716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.1716835633
MESH:D000419 Albuminuria Raloxifene 4.2917308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7517887948
MESH:D000544 Alzheimer Disease Curcumin 4.1715590663
MESH:D000544 Alzheimer Disease Raloxifene 4.1715800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5218218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 3.5715238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6616807698
MESH:D050197 Atherosclerosis Curcumin 3.1318704882
MESH:D001281 Atrial Fibrillation Amiodarone 3.6618651412 19698954
MESH:D001327 Autoimmune Diseases Curcumin 4.1719761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.691440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 13.6319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001859 Bone Neoplasms Phenol 4.9110556009
MESH:D001913 Bowen's Disease Phenol 5.4219293009
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0117868700
MESH:D001930 Brain Injuries Progesterone 9.9115845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 9.9116580743
MESH:D002545 Brain Ischemia Curcumin 4.0116770732
MESH:D001932 Brain Neoplasms Curcumin 3.6617596214
MESH:D001943 Breast Neoplasms bexarotene 6.6316344269 16818667
MESH:D001943 Breast Neoplasms Chromium 6.6315986119
MESH:D001943 Breast Neoplasms Curcumin 6.6318593918 16243823 19250217 18462866
MESH:D001943 Breast Neoplasms decitabine 6.6318320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 6.6320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.6317474063
MESH:D001943 Breast Neoplasms Estradiol 6.6317289903 16675129 12948864 17018787 19861407 14630087 18497071 17261762
MESH:D001943 Breast Neoplasms Progesterone 6.6317614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 6.6317049068 15572757 16837676 16912660 17242785 17893378 17261762 15758505 17595753 17440819 17952589 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4616192424 16227642 16050911 15673190 18705752 15700767 10355542 15721981 3786805 16124888 16097048 16011737
MESH:D002277 Carcinoma Curcumin 7.4418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.6216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 10.623581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.6218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.6218971187 18210153 20432363 17173139 17162532 19171122 11831363 18393292 19335982 17761372 18978308 19539802 21159647 16288022 18785209 16878318 19519916 20514400 17055752 17138121 3581430 18506893 16807293 20727157 16698587 17978847 17428255 19701751 20935162 19208518 19107877 3084413 19822196 18788625 19418558 19052882 19394651 16502159 18691550 16328049 20007298 19919837 16830150 10672840 10737359 16935385 20512989 20214788 18494052 16569478 16681979 20524982 16540662 18665156 16779866 20084675 19383236 20101231 18056438
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.6216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.6217173139 20935162 20007298 6705139 1701930
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.4516247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.4518414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.527296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.6018462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6019215824
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5118850075 18670907 16120746
MESH:D006332 Cardiomegaly valsartan 6.5119597038
MESH:D009202 Cardiomyopathies valsartan 4.2316247790
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7819225199 15710769
MESH:D002318 Cardiovascular Diseases Raloxifene 7.1315775269
MESH:D002318 Cardiovascular Diseases valsartan 7.1311230374
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7618974383
MESH:D002386 Cataract Simvastatin 4.4412518039
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.257505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.2521159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.2518566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 14.252727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.934080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.4219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.0519486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.0519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9715668235 8697196 12621046 15340226 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.3015800139
MESH:D003092 Colitis Curcumin 3.8616782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 4.2618809619
MESH:D003110 Colonic Neoplasms Curcumin 3.7519359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 3.7517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7917141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5818497527
MESH:D003324 Coronary Artery Disease valsartan 3.7817719468
MESH:D003384 Coxsackievirus Infections valsartan 5.5220392896
MESH:D019465 Craniofacial Abnormalities decamethrin 2.8319861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8310048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7018551238
MESH:D003550 Cystic Fibrosis Simvastatin 4.6719747007
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8917474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.3412868966 14531868 18759878 11906362 8156756 2524372 11298694 8970840
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 6.3416823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.192952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.3411508273
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.6218403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.6220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6217107852
MESH:D003928 Diabetic Nephropathies Curcumin 19.2718204486
MESH:D003928 Diabetic Nephropathies Estradiol 19.2719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 19.2715920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies valsartan 19.2718630688 11427623
MESH:D003929 Diabetic Neuropathies Progesterone 4.1717187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 13.8918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 13.8918692083 18648102 18289764 6482804 9022650 7440962 1440618 8291058 9328219 11289319 16192314 6679447 9653073
MESH:D056486 Drug-Induced Liver Injury Amiodarone 13.8915265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.8919085960 3732212 7440962 6884620 16177239 3786805 21278145 10092053 15968718 15027814 9327722 7120509 2869522 19336974 11566570 7179309 4309450 15998439 17522070 6623471 10915739 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.8919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.8920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004381 Duodenal Ulcer Curcumin 3.7417351913
MESH:D050171 Dyslipidemias Dietary Fats 8.1818367378
MESH:D050171 Dyslipidemias Fenofibrate 8.1816707586
MESH:D004421 Dystonia Phenobarbital 3.701851702
MESH:D004487 Edema pirinixic acid 9.7612083418
MESH:D004487 Edema Raloxifene 9.7615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.7612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.3117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.3115845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7819294695
MESH:D016889 Endometrial Neoplasms Estradiol 7.0711473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Fenofibrate 7.0716569247
MESH:D004715 Endometriosis Progesterone 8.0016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.009294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.793659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.543922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.276401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.937750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.693659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.343581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.3415264214 15547721 16510608 15150132 15878914 15623463 15547733 16704527 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver Amiodarone 32.5114986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 32.5161145 12795759 19224547 15959796 16045604 12631006 16239168 17595544
MESH:D005234 Fatty Liver Curcumin 32.5119297423
MESH:D005234 Fatty Liver Dietary Fats 32.5117967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 32.5121071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 32.5119236843 20131406
MESH:D005234 Fatty Liver Raloxifene 32.5117473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.696705139
MESH:D005355 Fibrosis Carbon Tetrachloride 24.3718705752
MESH:D005355 Fibrosis Curcumin 24.3718705752
MESH:D005355 Fibrosis Dietary Fats 24.3718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.3720067830
MESH:D005355 Fibrosis valsartan 24.3716893502
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3818462866
MESH:D005909 Glioblastoma Curcumin 3.2717596214
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.2316928621
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.747505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.2818462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 7.2819215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1610048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.3111110106
MESH:D006333 Heart Failure pirinixic acid 6.7220558911
MESH:D006333 Heart Failure valsartan 6.7219027736
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.206705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2019110552 19900420
MESH:D006529 Hepatomegaly Amiodarone 18.0615265979
MESH:D006529 Hepatomegaly Phenobarbital 18.0616109766
MESH:D006529 Hepatomegaly pirinixic acid 18.0618467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.0616120746 12621046 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7217701891
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D019584 Hot Flashes Estradiol 3.4217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.718697196 16959395 15340226 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2116899240
MESH:D006937 Hypercholesterolemia Amiodarone 13.678137927 9751232
MESH:D006937 Hypercholesterolemia Curcumin 13.6718704882
MESH:D006937 Hypercholesterolemia Dietary Fats 13.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3221332399
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 4.9516238680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6215034207
MESH:D006973 Hypertension Raloxifene 8.0515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0518850075 18670907
MESH:D006973 Hypertension valsartan 8.0520102058 16475468 18344623 18390891 12850387 12692753 11427623 10903974
MESH:D006974 Hypertension, Malignant valsartan 6.0811560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7715338365
MESH:D007037 Hypothyroidism Amiodarone 4.2017991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0815869954
MESH:D007248 Infertility, Male decitabine 2.9917581917
MESH:D007249 Inflammation Curcumin 14.0318403477 16956363 17151092
MESH:D007249 Inflammation Dietary Fats 14.0320412841
MESH:D007249 Inflammation Diethylnitrosamine 14.0318785209
MESH:D007249 Inflammation Progesterone 14.0315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.0312878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0818200517 18596194
MESH:D007299 Insect Bites and Stings decamethrin 5.4715189238
MESH:D007333 Insulin Resistance Dietary Fats 11.0618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.0616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.0616306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.9410783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.699022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D055623 Keratosis, Actinic Phenol 6.1119293009
MESH:D007674 Kidney Diseases Chromium 13.0817934191
MESH:D007674 Kidney Diseases Estradiol 13.0815618244
MESH:D007674 Kidney Diseases Potassium Dichromate 13.0819665454
MESH:D007674 Kidney Diseases valsartan 13.0810903974 12164870 16893502
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.8816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.886582329
MESH:D007680 Kidney Neoplasms Estradiol 10.8815610895
MESH:D007889 Leiomyoma Curcumin 10.1618555241
MESH:D007889 Leiomyoma Raloxifene 10.1616973256
MESH:D007938 Leukemia Curcumin 6.0518462866
MESH:D007938 Leukemia decitabine 6.0519235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9116106398
MESH:D007951 Leukemia, Myeloid decitabine 3.7119117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3218704418 17679729 19387464 19010910 18206229 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1318055864
MESH:D015458 Leukemia, T-Cell Curcumin 4.4516106398
MESH:D008064 Lipidoses Amiodarone 3.2817567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.2617334410 11408273 16239168 16943688 11903743 21278145 16221502 17174718 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 14.2618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.2619638242 18665156 18407596 20032147 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 14.2621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.999327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.2215931870 18187930 15925388 15673190 14620537 10355542 16638106 17525996 12546737 17640975 18006644 16097048 17922224 17721639 17869086 12632512 12389079 16027843 18412020 16192424 15818738 16011737 17761835 14724832 17698563 12586293 18472094 12667390 12666154 15650968 14512876 18481824 15370692 17976157 17714472 17631135 17708605 18705752 14716496 15123356 17481882 12609069 18277467 18395095 17557913 12632514 18395914 17766677 18251166 18418968 14748882 18156304 18376398 15730626 16136751 15893842 17823541 15057751 16015684 14716833 12649538 15052691 12898905 17900296 12445418 17565644 18054572 18339082 18472332 18317297 15338365 18429990 17805973 18420326 18210741 18166357 16248980 18205269 12741479 12958196 17944888 15876570 16116963 15959796 16033810 20821823 12445421 13678700 11481614 18279442 18263696 15362042 15996030
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.2217355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.2214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 10.2215474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.2215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.2212878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 10.2216872305 15619341 15504291
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6516964402 15830285 16246199 17285989 15720792
MESH:D008107 Liver Diseases Curcumin 8.6516956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6517034775
MESH:D008107 Liver Diseases Phenobarbital 8.6519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.3019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.3018977376 20137499 2862719 12771043 16942905 20101389 19833225 12112319 20434301 18648771 2422723 19294768 21167192 20452335 19551842 19812893 21047994 21278145 10737359 19690152 19850985 15175105 20405173 19638242 20492335 19254457 20501860 18644402 19073162 19426721 20583210 18754104 19427195 19499222 19996281 9163691 18978307 19256749 15885732 19642983 19255062 19090486 20118626 21071580
MESH:D008113 Liver Neoplasms Fenofibrate 16.3018978307
MESH:D008113 Liver Neoplasms Phenobarbital 16.3021047994 19812893 15975961 19482888 8742319 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 16.3020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 20.733712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 20.7315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 20.7319009564 19004024 18079962 18253720 18544905 18164116 19539802 19126423 18775883 9362446 16267830 17942915 17174075 18282651 21159647 19519916 17854601 2563599 16842330 3124819 18093689 18308698
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 20.7318775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 20.732563599 17172636 6150874 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.7312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.1612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1518516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.7117365036
MESH:D008175 Lung Neoplasms bexarotene 4.5417849452
MESH:D008175 Lung Neoplasms Curcumin 4.5419359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.546695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5419555203 11884234
MESH:D008223 Lymphoma Curcumin 7.0118462866
MESH:D008223 Lymphoma decitabine 7.0119470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3816173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8311161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 8.8715591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8717203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.8717203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1519453300
MESH:D008545 Melanoma Curcumin 4.9818462866 17885582
MESH:D008545 Melanoma decitabine 4.9816505122 17785578
MESH:D008545 Melanoma Glucose 4.9814993021
MESH:D008569 Memory Disorders Curcumin 3.8517263510
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0516966607 16166281 18303189
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5617671175
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2215863610
MESH:D009101 Multiple Myeloma Curcumin 10.9019372569
MESH:D009101 Multiple Myeloma decitabine 10.9018172295
MESH:D009101 Multiple Myeloma Raloxifene 10.9016497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009181 Mycoses Amiodarone 4.5717974566 12754197
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2019010910 18608210 19157545 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.0119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1517484760
MESH:D009232 Myxoma Raloxifene 5.2216343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5318551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0618495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.253581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.253581430 9029167
MESH:D009369 Neoplasms decitabine 4.4819470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 4.4817405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.0319196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.0312497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009421 Nervous System Malformations Estradiol 8.4411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4414600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.3018462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.706679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7920387270
MESH:D009765 Obesity Curcumin 6.9119297423
MESH:D009765 Obesity Dietary Fats 6.9121332399 19632207 17217161 18457598 20132043 11836018 16723640 20518802 18674790
MESH:D009765 Obesity pirinixic acid 6.9120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.954026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.693988306
MESH:D010018 Osteomalacia Phenobarbital 4.0417016548
MESH:D010024 Osteoporosis Curcumin 6.7418719352
MESH:D010024 Osteoporosis Raloxifene 6.7417882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9317823083 15758505 17893378 15579764
MESH:D010051 Ovarian Neoplasms Curcumin 10.4218462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 10.4219259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 10.4219401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.4216525653 17393432
MESH:D010146 Pain Phenol 3.9417610455
MESH:D010190 Pancreatic Neoplasms Curcumin 11.3517440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 11.3519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.3516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.3516965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.177296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010392 Pemphigus Phenol 6.1116522979 17163923
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.146228378
MESH:D010864 Pilonidal Sinus Phenol 6.1119655223 15622588
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5710923243
MESH:D011041 Poisoning Phenol 4.428825745
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 5.0617105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.192563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.192563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8711118676 11399792 11896295 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.4117616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5920887781
MESH:D011471 Prostatic Neoplasms Curcumin 2.7611398177 18769126 12497104 10851300 15129424 18156803 18226269
MESH:D011471 Prostatic Neoplasms Estradiol 2.7616740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7616536755 16220300 15731164
MESH:D011507 Proteinuria valsartan 4.5617664856 18344623 12164870
MESH:D019310 Pseudolymphoma Phenobarbital 4.1612752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.2519168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 8.7211597910 12832656 12490602
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.7217365031 17975199 15814490 17322281
MESH:D011658 Pulmonary Fibrosis valsartan 8.7217241526
MESH:D011693 Purpura Raloxifene 5.2215770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7318379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.143692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.1019155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012509 Sarcoma Curcumin 3.8418462866
MESH:D012640 Seizures 2,4-dinitrotoluene 5.2018551238
MESH:D012640 Seizures Phenobarbital 5.203137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.506407741
MESH:D018805 Sepsis Curcumin 3.8118389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7618724381
MESH:D012878 Skin Neoplasms Glucose 5.4514993021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4516192470
MESH:D013088 Spermatocele Phenol 5.3118646496
MESH:D013119 Spinal Cord Injuries Progesterone 3.9516503802 15862959
MESH:D013274 Stomach Neoplasms decitabine 3.2819037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2818456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.2812958204 17575124
MESH:D013276 Stomach Ulcer Amiodarone 6.5218087811
MESH:D013276 Stomach Ulcer Curcumin 6.5216631530 19188055
MESH:D020521 Stroke Raloxifene 3.5716837676
MESH:D013610 Tachycardia Amiodarone 3.9811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8819225199
MESH:D013959 Thyroid Diseases Amiodarone 10.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.093712494 7505956 1399818 6582329 6587162
MESH:D013964 Thyroid Neoplasms decitabine 15.0917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.097505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.091399818
MESH:D013971 Thyrotoxicosis Amiodarone 4.5418020914 19584973
MESH:D013978 Tibial Fractures Estradiol 12.6119048282
MESH:D013978 Tibial Fractures Raloxifene 12.6119048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8711989578 17467628
MESH:D014277 Trigeminal Neuralgia Phenol 6.1116527771 10223447
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.4016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.408074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 14.4018593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.4017616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.4017572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.9418462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9910091137
MESH:D014604 Uveal Neoplasms decitabine 4.5817785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8816837676
MESH:D020257 Ventricular Remodeling valsartan 5.3719027736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2216343187
MESH:D014860 Warts Phenol 5.7719122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D015430 Weight Gain Dietary Fats 3.4716723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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