AutismKB 2.0

Annotation Detail for TIAM1


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Basic Information Top
Gene Symbol:TIAM1 ( FLJ36302 )
Gene Full Name: T-cell lymphoma invasion and metastasis 1
Band: 21q22.11
Quick LinksEntrez ID:7074; OMIM: 600687; Uniprot ID:TIAM1_HUMAN; ENSEMBL ID: ENSG00000156299; HGNC ID: 11805
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200185EPHA2 forward signaling
200128Neurotrophic factor-mediated Trk receptor signaling
200079Arf6 downstream pathway
200098Class I PI3K signaling events
200173Ephrin B reverse signaling
200165Regulation of RAC1 activity
200011LPA receptor mediated events
200105E-cadherin signaling in the nascent adherens junction
200057CDC42 signaling events
Pathway IDPathway Name
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2027Connective tissue disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TIAM1 mRNAincreases expression 19933214
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of TIAM1 mRNAaffects cotreatment|increases expression 18585445
C015001 arsenite arsenite results in decreased expression of TIAM1 mRNAdecreases expression 18191166
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of TIAM1 mRNAaffects cotreatment|increases expression 18585445
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TIAM1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TIAM1 mRNAaffects expression 20382639
D004041 Dietary Fats Dietary Fats results in decreased expression of TIAM1 mRNAdecreases expression 18042831
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIAM1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TIAM1 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIAM1 mRNAaffects cotreatment|increases expression 17942748
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of TIAM1 mRNAincreases expression 12634122
C029938 nickel sulfate nickel sulfate results in increased expression of TIAM1 mRNAincreases expression 16780908
C041786 palm oil palm oil results in decreased expression of TIAM1 mRNAdecreases expression 18042831
C006253 pirinixic acid NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of TIAM1 mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of TIAM1 mRNAdecreases expression 17950772
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TIAM1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TIAM1 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TIAM1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TIAM1 mRNAincreases expression 19933214
C025643 vinclozolin vinclozolin affects the expression of TIAM1 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of TIAM1 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury nickel sulfate 9.2519131640 12718980 11954676 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 9.2518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0420464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.0411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.676695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.2711874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.0515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Estradiol 1.9218497071 17261762 17018787 16675129 14630087 12948864 17289903 19861407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7616924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.4520889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4518566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 11.452727394
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8117681005 15861022 16919318 17110522 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 7.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.118697196 15340226 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms arsenite 2.5915037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.7116780908 16823706 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0011473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver arsenite 19.0418296743
MESH:D005234 Fatty Liver Dietary Fats 19.0419004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.0415345470
MESH:D005234 Fatty Liver pirinixic acid 19.0419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis arsenite 15.1018296743
MESH:D005355 Fibrosis Dietary Fats 15.1018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1020067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly pirinixic acid 8.4019772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 15340226 16959395 16354765 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Atrazine 11.4212948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.4217937319
MESH:D007248 Infertility, Male vinclozolin 11.4216467254
MESH:D007249 Inflammation Dietary Fats 4.9620412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9612200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 12.4011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.4016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.4016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Estradiol 2.6015618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0015610895
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008103 Liver Cirrhosis arsenite 6.9018296743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3912878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.3720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1212151625
MESH:D008175 Lung Neoplasms arsenite 3.4416809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4420135361 20464547 18816296 18520028 6695378 20064080 20869020 17053015 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5811807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008654 Mesothelioma Atrazine 3.541916698
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.9417671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8611141357
MESH:D009369 Neoplasms pirinixic acid 4.8617405874
MESH:D009389 Neovascularization, Pathologic arsenite 10.3215738583
MESH:D009389 Neovascularization, Pathologic Estradiol 10.3217289903
MESH:D009421 Nervous System Malformations Estradiol 9.5911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D009765 Obesity Dietary Fats 4.4518457598 19632207 11836018 18674790 20518802 21332399 16723640 17217161 20132043
MESH:D009765 Obesity pirinixic acid 4.4520558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010300 Parkinson Disease Atrazine 3.2817218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6611118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.6618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012135 Respiratory Sounds Atrazine 4.5611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1917053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36514
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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