AutismKB 2.0

Annotation Detail for TLE1


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Basic Information Top
Gene Symbol:TLE1 ( ESG,ESG1,GRG1 )
Gene Full Name: transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Band: 9q21.32
Quick LinksEntrez ID:7088; OMIM: 600189; Uniprot ID:TLE1_HUMAN; ENSEMBL ID: ENSG00000196781; HGNC ID: 11837
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
200196Notch-mediated HES/HEY network
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00057Wnt signaling pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
2051Leukemia
2260Synovial sarcoma
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TLE1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TLE1 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TLE1 mRNAdecreases expression 17351261
D008727 Methotrexate TLE1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D010634 Phenobarbital Phenobarbital results in decreased expression of TLE1 mRNAdecreases expression 19270015
D020849 Raloxifene Raloxifene affects the expression of TLE1 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TLE1 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 16.7512039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 16.756195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.7515322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4416835633
MESH:D000419 Albuminuria Raloxifene 4.9217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1517286800
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Methotrexate 2.0016978400
MESH:D001943 Breast Neoplasms Raloxifene 2.0017952589 17595753 17893378 16912660 17049068 15572757 15775269 15758505 17440819 17242785 17261762 16837676
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7320935162 1701930 20007298 17173139 6705139
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0716919318 17333356 17681005 15861022 16105132 11677210 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 12621046 15668235 15340226 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.8212039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8220055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.5019747007
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003882 Dermatomyositis Methotrexate 5.4520191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Raloxifene 4.1817451421 15920148 17308373
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5219164858 11529661 12594235 10915739 19923254 19416960 12392966 11461765 17522070 19739265 18713872 12705907 16485898 11287661 16109766 14725611 16393943 11739529 11421492 12540782 19370779 14550746 17562736 16781746 2444490 11743745 14986274 16177239 19420014 17906064 10663392 18071297 12958197 16081117 12153990 19085960 16227642 11834606 10774834 15968718 15619225
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema Raloxifene 7.8015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.2315845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.8115345470
MESH:D005234 Fatty Liver Raloxifene 8.8117473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.5116518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Phenobarbital 9.6616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6612621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Raloxifene 5.5217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D007805 Language Development Disorders Methotrexate 5.419562676
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D008103 Liver Cirrhosis Methotrexate 7.4214986274
MESH:D008103 Liver Cirrhosis Phenobarbital 7.4221047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.1319014921 12587719 19784758 16610002 19460945 16611625 12969438 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.7219073162 19482888 8742319 19812893 15975961 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7216984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.331399818 6150874 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3312151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.4618516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008223 Lymphoma Methotrexate 4.1417352296
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D052016 Mucositis Methotrexate 5.6817488658
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010024 Osteoporosis Raloxifene 3.5515775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5315758505 15579764 17823083 17893378
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5615731164 16536755 16220300
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011565 Psoriasis Methotrexate 3.5117410198
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D051437 Renal Insufficiency Methotrexate 5.0717352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5318551238
MESH:D012640 Seizures Phenobarbital 6.5311442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013576 Syndactyly Methotrexate 5.369562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D013978 Tibial Fractures Raloxifene 5.6519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5116049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5117572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36539
    • No data
    Releated disease ID Related disease Name
    PA444451Hernia
    PA164924624Pelvic Floor Disorders
    PA445990Urinary Incontinence
    PA445991Urinary Incontinence, Stress
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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