AutismKB 2.0

Annotation Detail for TLE2


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Basic Information Top
Gene Symbol:TLE2 ( ESG,ESG2,FLJ41188,GRG2 )
Gene Full Name: transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Band: 19p13.3
Quick LinksEntrez ID:7089; OMIM: 601041; Uniprot ID:TLE2_HUMAN; ENSEMBL ID: ENSG00000065717; HGNC ID: 11838
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TLE2 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of TLE2 mRNAincreases expression 20458559
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TLE2 mRNAaffects expression 17555576
C008493 methylselenic acid methylselenic acid results in increased expression of TLE2 mRNAincreases expression 18548127
D012643 Selenium Selenium results in increased expression of TLE2 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of TLE2 mRNAaffects expression 17555576
D014635 Valproic Acid Valproic Acid results in increased expression of TLE2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4811798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618316065 18396377 17507914 19232924 17157402 18775368 17688650 18558336 18940202 19460635 15238991 18177632 18985861 16609825 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001943 Breast Neoplasms Tamoxifen 2.1818997820 19155303 17242785 16873071 18821012 19011961 18984771 19189210 16273361 16202921 19066611 19115204 19059307 20544844 19244106 11161223 18629630 19084267 18855134 19200415 18425577 20859285 16818667 15565566 19289846 19288272 20065188 15668708 20005174 21152245 19103187 19410462 17049068 17440819 19189212 20390343 18815881 17893378 20135344 19142967 19221464 18351453 17261762 21138602 19487384
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7414691202 15073043 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7416924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717110522 16919318 17333356 17681005 15861022 16105132 11677210
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7710525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7717688650 8888407 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6319370779 11529661 17562736 12705907 15619225 14986274 2444490 18713872 10774834 10915739 11421492 19739265 12594235 11461765 12540782 11287661 16485898 16081117 19164858 14725611 12392966 16109766 15968718 12153990 19923254 14550746 17522070 19416960 19420014 17906064 16393943 11739529 16781746 19085960 16227642 11743745 18071297 10663392 16177239 11834606 12958197
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6315131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.631733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2120544844 16202921 17893378 19155303
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 21.2515073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.2515345470
MESH:D005234 Fatty Liver Tamoxifen 21.2519224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 21.2514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0417050201 19850784 20471514 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.389834237 17217047 12712474 15748426 15213294 16966277 16891316 15336539 17712046 12018890 19225113 16331271 17869043 16330433 15622746 19642359 11468182 17107899 11161223 17649720 12679006 16823087 16112521 19035177 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases Acetaminophen 1.6812969438 16611625 19014921 16610002 11587558 19784758 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9214682389
MESH:D008113 Liver Neoplasms Tamoxifen 4.9216684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8920377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5411798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 2.5418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6016827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2911468182 19417148 19549372 15949261 14977855
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8917596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419200415 19189210 19196722
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9010525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.908888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4712452020 16624393 19769630
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6019131511
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6016205645
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.913137016 14763951 11738929 11044598 1511512 17978042 16876388 15475178
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4112845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.418653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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