AutismKB 2.0

Annotation Detail for TLR4


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Basic Information Top
Gene Symbol:TLR4 ( ARMD10,CD284,TOLL,hToll )
Gene Full Name: toll-like receptor 4
Band: 9q33.1
Quick LinksEntrez ID:7099; OMIM: 603030; Uniprot ID:TLR4_HUMAN; ENSEMBL ID: ENSG00000136869; HGNC ID: 11850
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa05142Chagas disease
hsa05140Leishmaniasis
hsa05146Amoebiasis
hsa05144Malaria
hsa05145Toxoplasmosis
hsa04620Toll-like receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200177Endogenous TLR signaling
Pathway IDPathway Name
P00054Toll receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1723Brucellosis
1739Oral cancer
1740Alzheimer's disease
1770Melanoma
1774Necrotizing enterocolitis
1803Periodontitis
1804Chronic obstructive airway disease
1807Autoimmune disease
1826Cystic fibrosis
1831Prostate cancer
1832Congenital abnormality
1840Macular degeneration
1848Embryoma
1857Porcine reproductive and respiratory syndrome
1869Behcet syndrome
1877Multiple sclerosis
1902Kidney failure
1904Diabetes mellitus
1918Atherosclerosis
1932Pancreatitis
1936Hypercholesterolemia
1943Adenocarcinoma
1954Stroke
1964Primary biliary cirrhosis
2025Polyarthritis
1991Mycoses
1998Enteritis
1841Stomach cancer
2028Nasopharyngeal cancer
2038Gastritis
2044Pre-Eclampsia
2053Colon cancer
2057Premature birth
2059Communicable disease
2066Lung cancer
2074Asthma
2075Heart failure
2094Ulcerative colitis
2100Hepatitis C
2111Systemic infection
2151Neuroblastoma
2166Influenza
2169Pituitary tumor
2171Celiac disease
2179Mycosis fungoides
2193Helicobacter infection
2240Anemia
2248Cytomegalovirus infection
2255Intermediate coronary syndrome
Desease Name
HEMATOLOGICAL
endotoxin hyporesponsiveness
periodontitis
Acute Coronary Syndrome
systemic inflammatory hyporesponsiveness
Atherosclerosis
diabetes, neurological manifestations
atherosclerosis, coronary
C-reactive protein
colorectal cancer
CARDIOVASCULAR
myocardial infarct
pancreatic necrosis pancreatitis, acute
prostate cancer
graft-versus-host disease
Systemic responsiveness to lipopolysaccharide
CANCER
acute pancreatitis
stroke, ischemic
vaginal micro-flora
ulcerative colitis
Mycoses
kidney transplant
nasopharyngeal cancer
Septic shock
Asthma
RENAL
malaria
meningococcal disease
inflammatory bowel disease
IMMUNE
metabolic syndrome
sepsis
METABOLIC
FEV1
Crohn's disease
REPRODUCTION
diabetes, type 2
Legionnaire's disease
Meningococcal Infections
esophageal cancer noncardia gastric carcinoma stomach cancer
INFECTION
sarcoidosis
lipopolysaccharide hyporesponsiveness
shortened gestation
respiratory syncytial virus
No data
Desease Name
Endotoxin hyporesponsiveness
Macular degeneration, age-related, 10
Colorectal cancer, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C477819 15-deoxyprostaglandin J2 15-deoxyprostaglandin J2 results in decreased expression of TLR4 proteindecreases expression 17965732
D000082 Acetaminophen Acetaminophen affects the expression of TLR4 mRNAaffects expression 17562736
D000119 Acetylmuramyl-Alanyl-Isoglutamine Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR4 proteinincreases activity 15905553
D000119 Acetylmuramyl-Alanyl-Isoglutamine Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR4 proteinincreases activity 15905553
D000119 Acetylmuramyl-Alanyl-Isoglutamine TLR4 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analogincreases response to substance 15905553
D013196 Dihydrotestosterone bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]]decreases reaction|increases expression 16317058
D013196 Dihydrotestosterone Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]decreases reaction|increases expression 16317058
D013196 Dihydrotestosterone Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of TLR4 mRNA]decreases reaction|increases expression 16317058
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TLR4 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in increased expression of TLR4 mRNAincreases expression 19945496
C015001 arsenite arsenite results in decreased expression of TLR4 mRNAdecreases expression 18191166
C065179 atorvastatin atorvastatin results in increased expression of TLR4 proteinincreases expression 16387846
D001310 Auranofin Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]]affects binding|decreases reaction|increases reaction 17034761
C053541 bicalutamide bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]]decreases reaction|increases expression 16317058
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TLR4 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of TLR4 mRNAincreases expression 17504260
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of TLR4 proteinincreases expression 17504260
D002251 Carbon Tetrachloride Lipopolysaccharides promotes the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]increases expression|increases reaction 17504260
D003474 Curcumin Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]affects binding|decreases reaction|increases activity 16678799
D003474 Curcumin Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]affects binding|decreases reaction|increases reaction 16678799
D003474 Curcumin Curcumin results in decreased expression of TLR4 mRNAdecreases expression 17965732
D003474 Curcumin Curcumin results in decreased expression of TLR4 proteindecreases expression 17965732
D004041 Dietary Fats Dietary Fats results in decreased expression of TLR4 mRNAdecreases expression 18042831
C472511 dimethylarsinous acid dimethylarsinous acid results in increased expression of TLR4 mRNAincreases expression 19945496
C547156 dimethylthioarsinic acid dimethylthioarsinic acid results in increased expression of TLR4 mRNAincreases expression 19945496
D005419 Flavonoids Flavonoids results in decreased expression of TLR4 mRNAdecreases expression 18035473
C001329 helenalin helenalin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]affects binding|decreases reaction|increases reaction 16678799
D006854 Hydrocortisone Hydrocortisone results in decreased expression of TLR4 mRNAdecreases expression 17033190
D007213 Indomethacin TLR4 protein affects the reaction [Indomethacin results in decreased activity of CYP1A2 protein]affects reaction|decreases activity 12927920
D007213 Indomethacin TLR4 protein affects the reaction [Indomethacin results in decreased activity of CYP2D9 protein]affects reaction|decreases activity 12927920
D007213 Indomethacin TLR4 protein affects the reaction [Indomethacin results in decreased activity of CYP3A11 protein]affects reaction|decreases activity 12927920
D008050 Lipid A Lipid A binds to and results in increased activity of TLR4 proteinaffects binding|increases activity 16299289
C014643 lipopeptidophosphoglycan CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein]increases activity|increases reaction 15910421
C014643 lipopeptidophosphoglycan lipopeptidophosphoglycan binds to and results in increased activity of TLR4 proteinaffects binding|increases activity 15910421
C014643 lipopeptidophosphoglycan [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein]affects binding|increases activity 15910421
C014643 lipopeptidophosphoglycan [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 proteinaffects binding|increases activity|increases secretion 15910421
C014643 lipopeptidophosphoglycan [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B proteinaffects binding|increases activity|increases secretion 15910421
C014643 lipopeptidophosphoglycan [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL8 proteinaffects binding|increases activity|increases secretion 15910421
C014643 lipopeptidophosphoglycan [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF proteinaffects binding|increases activity|increases secretion 15910421
C014643 lipopeptidophosphoglycan lipopeptidophosphoglycan binds to and results in increased activity of TLR4 proteinaffects binding|increases activity 15910421
C014643 lipopeptidophosphoglycan TLR4 protein results in increased susceptibility to lipopeptidophosphoglycanincreases response to substance 15910421
C082161 lipopolysaccharide A Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]]affects binding|decreases reaction|increases reaction 17034761
D008070 Lipopolysaccharides bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]]decreases reaction|increases expression 16317058
D008070 Lipopolysaccharides Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]decreases reaction|increases expression 16317058
D008070 Lipopolysaccharides Lipopolysaccharides binds to and results in increased activity of TLR4 proteinaffects binding|increases activity 12734376
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of TLR4 proteindecreases expression 12176910
D008070 Lipopolysaccharides Lipopolysaccharides results in increased activity of TLR4 proteinincreases activity 10835634
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TLR4 mRNAincreases expression 16317058
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA]affects reaction|decreases expression 12574384
D008070 Lipopolysaccharides TLR4 protein mutant form affects the susceptibility to Lipopolysaccharidesaffects response to substance 10835634
D008070 Lipopolysaccharides Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]affects binding|decreases reaction|increases activity 16678799
D008070 Lipopolysaccharides Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]affects binding|decreases reaction|increases reaction 16678799
D008070 Lipopolysaccharides helenalin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]affects binding|decreases reaction|increases reaction 16678799
D008070 Lipopolysaccharides Lipopolysaccharides binds to TLR4 proteinaffects binding 16678799
D008070 Lipopolysaccharides [Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 proteinaffects binding|increases activity 16678799
D008070 Lipopolysaccharides [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR4 mRNAaffects cotreatment|increases expression 16864405
D008070 Lipopolysaccharides Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]affects binding|increases reaction 16678799
D008070 Lipopolysaccharides Lipopolysaccharides results in increased activity of TLR4 proteinincreases activity 12848851
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TLR4 mRNAincreases expression 16864405
19136613
19433076
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TLR4 proteinincreases expression 19433076
D008070 Lipopolysaccharides Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]decreases reaction|increases expression 19433076
D008070 Lipopolysaccharides Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]decreases reaction|increases expression 19433076
D008070 Lipopolysaccharides TLR4 affects the reaction [Lipopolysaccharides results in decreased expression of CLEC10A mRNA]affects reaction|decreases expression 17342418
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of HFE2 mRNA]affects reaction|decreases expression 17255318
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]affects reaction|increases expression 17255318
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IRF8 mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]affects reaction|decreases reaction|increases expression 19433076
D008070 Lipopolysaccharides TLR4 protein affects the susceptibility to Lipopolysaccharidesaffects response to substance 11581577
D008070 Lipopolysaccharides Lipopolysaccharides promotes the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]increases expression|increases reaction 17504260
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of TLR4 mRNAdecreases expression 16309824
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TLR4 proteinincreases expression 17504260
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TLR4 mRNAincreases expression 15998543
D008070 Lipopolysaccharides Lipopolysaccharides binds to and results in increased activity of TLR4 proteinaffects binding|increases activity 15778123
17630198
19426678
D008070 Lipopolysaccharides [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of NOS2 proteinaffects binding|increases activity|increases expression 17630198
D008070 Lipopolysaccharides Lipopolysaccharides binds to TLR4 proteinaffects binding 15851485
C009900 lipoteichoic acid lipoteichoic acid results in increased expression of TLR4 mRNAincreases expression 15998543
C009900 lipoteichoic acid lipoteichoic acid binds to and affects the activity of TLR4 proteinaffects activity|affects binding 16373689
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of TLR4 mRNAincreases expression 15120970
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of TLR4 mRNAincreases expression 19945496
D009151 Mustard Gas Mustard Gas results in increased expression of TLR4 mRNAincreases expression 18955075
D009151 Mustard Gas Mustard Gas results in increased expression of TLR4 mRNAincreases expression 18988085
D010126 Ozone [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR4 mRNAaffects cotreatment|increases expression 16864405
D010126 Ozone Ozone results in decreased expression of TLR4 mRNA mutant formdecreases expression 11159012
D010126 Ozone Ozone results in increased expression of TLR4 mRNAincreases expression 16864405
11159012
17626835
D010126 Ozone TLR4 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]decreases reaction|increases expression 17626835
D010126 Ozone TLR4 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 protein]decreases reaction|increases expression 17626835
D010126 Ozone TLR4 gene mutant form results in decreased susceptibility to Ozonedecreases response to substance 17626835
D010126 Ozone TLR4 protein affects the reaction [Ozone results in increased expression of NOS2 mRNA]affects reaction|increases expression 11159012
D010126 Ozone TLR4 protein mutant form results in decreased susceptibility to Ozonedecreases response to substance 11159012
D010126 Ozone TLR4 protein results in increased susceptibility to Ozoneincreases response to substance 11159012
D017239 Paclitaxel TLR4 protein affects the reaction [Paclitaxel results in increased expression of CXCL10 mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel TLR4 protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel TLR4 protein affects the reaction [Paclitaxel results in increased expression of IL12B mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel TLR4 protein affects the reaction [Paclitaxel results in increased expression of IRF8 mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel TLR4 protein affects the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel TLR4 protein affects the reaction [Paclitaxel results in increased expression of TNF mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel TLR4 protein affects the susceptibility to Paclitaxelaffects response to substance 11581577
D017239 Paclitaxel Paclitaxel binds to and affects the activity of TLR4 proteinaffects activity|affects binding 16373689
C041786 palm oil palm oil results in decreased expression of TLR4 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of TLR4 mRNAdecreases expression 16985257
D011374 Progesterone Progesterone results in increased expression of TLR4 mRNAincreases expression 17701593
D011374 Progesterone Progesterone results in increased expression of TLR4 proteinincreases expression 17701593
D015742 Propofol Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]decreases reaction|increases expression 19433076
D015742 Propofol Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]decreases reaction|increases expression 19433076
D015742 Propofol TLR4 protein affects the reaction [Propofol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]affects reaction|decreases reaction|increases expression 19433076
D019821 Simvastatin Simvastatin results in increased expression of TLR4 proteinincreases expression 16387846
D010853 Picryl Chloride TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride]affects reaction|increases response to substance 18725520
D010853 Picryl Chloride TLR4 protein results in increased susceptibility to Picryl Chlorideincreases response to substance 18725520
C025643 vinclozolin vinclozolin results in increased expression of TLR4 mRNAincreases expression 18629315
D014801 Vitamin A Vitamin A results in increased expression of TLR4 mRNAincreases expression 17033190
D015054 Zymosan Zymosan results in increased expression of TLR4 proteinincreases expression 17321468
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000015 Abnormalities, Multiple Vitamin A 4.5110992263
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.8418653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.8418653653
MESH:D000230 Adenocarcinoma Indomethacin 2.6816537180
MESH:D000236 Adenoma Indomethacin 3.2211497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.0916434500
MESH:D018246 Adrenocortical Adenoma Arsenic 4.8117306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6817887948
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9717225004
MESH:D000544 Alzheimer Disease Curcumin 6.1415590663
MESH:D000544 Alzheimer Disease Indomethacin 6.1415579461 17627676
MESH:D000544 Alzheimer Disease Ozone 6.1415513908
MESH:D000740 Anemia Vitamin A 8.4416960172
MESH:D000740 Anemia Zymosan 8.4418664788
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.4616960172
MESH:D000799 Angioedema Acetaminophen 3.4410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3319015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.4710231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.4910388637
MESH:D020261 Arsenic Poisoning Arsenic 2.7516835338 16251483 12569548 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 3.5115238619
MESH:D018771 Arthralgia Indomethacin 4.772160914
MESH:D001169 Arthritis, Experimental Zymosan 3.8815142272 15944321 15188379 16872482 17659584
MESH:D001172 Arthritis, Rheumatoid Auranofin 9.8316510263
MESH:D001172 Arthritis, Rheumatoid Curcumin 9.8316807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 9.8311248219
MESH:D001172 Arthritis, Rheumatoid Ozone 9.8315570426
MESH:D001249 Asthma Mustard Gas 7.3110378619
MESH:D001249 Asthma Ozone 7.3116373670 17854713
MESH:D001249 Asthma Vitamin A 7.3116732791
MESH:D050197 Atherosclerosis Arsenic 6.1112928151 19371607
MESH:D050197 Atherosclerosis Curcumin 6.1118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001327 Autoimmune Diseases Curcumin 4.1119761891
MESH:D001477 Bartter Syndrome Indomethacin 4.6010684365
MESH:D001768 Blister Mustard Gas 4.7619167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8019483382
MESH:D001859 Bone Neoplasms Paclitaxel 4.2015867366
MESH:D001929 Brain Edema Indomethacin 4.6211481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9417868700
MESH:D001930 Brain Injuries Progesterone 3.8715665606 15845082 15380490
MESH:D002545 Brain Ischemia Curcumin 9.0616770732
MESH:D002545 Brain Ischemia Indomethacin 9.0612524144
MESH:D001932 Brain Neoplasms Curcumin 3.6017596214
MESH:D001943 Breast Neoplasms Curcumin 2.2318593918 19250217 18462866 16243823
MESH:D001943 Breast Neoplasms Dietary Fats 2.2320435547
MESH:D001943 Breast Neoplasms Indomethacin 2.2317401462
MESH:D001943 Breast Neoplasms Paclitaxel 2.2316244791 18323546 16273361 11325840 15136595 18223236 18234424 16115903
MESH:D001943 Breast Neoplasms Progesterone 2.2315562024 16175315 17614352
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3714754758 18417511 15516495 19059883 16777450 17626835 18315731
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5817687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.2017426644 17377406
MESH:D002056 Burns Indomethacin 4.3210459503
MESH:D002100 Cachexia Indomethacin 11.0811239499 15141370 15625704 16537180
MESH:D002100 Cachexia Ozone 11.0816183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4016097048 3786805 15700767 16124888 18705752 15673190 16050911 15721981 16227642 16011737 16192424 10355542
MESH:D002277 Carcinoma Curcumin 3.5318593918
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.103084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.1017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.1018788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.1016391822
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.1016313753
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9611352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8318414057
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1817341418
MESH:D002294 Carcinoma, Squamous Cell Arsenic 6.9718922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.9718462866
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 6.9715482327 12636206
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7418640142
MESH:D006332 Cardiomegaly atorvastatin 4.2118360054
MESH:D002318 Cardiovascular Diseases Arsenic 3.1819152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 3.9818022660 16973168
MESH:D002386 Cataract Acetaminophen 7.0010977129
MESH:D002386 Cataract Simvastatin 7.0012518039
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 6.642727394
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 6.6419716837
MESH:D015362 Child Nutrition Disorders Vitamin A 5.0716153327
MESH:D002764 Cholecystitis Indomethacin 4.7711181007
MESH:D002779 Cholestasis pirinixic acid 7.3019176532
MESH:D002779 Cholestasis Vitamin A 7.3016175620
MESH:D002972 Cleft Palate Hydrocortisone 6.3115826874
MESH:D002972 Cleft Palate Vitamin A 6.3116054864
MESH:D003092 Colitis Curcumin 3.7916782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.2018809619
MESH:D003110 Colonic Neoplasms arsenite 7.6815037631
MESH:D003110 Colonic Neoplasms Curcumin 7.6819359593 16340194
MESH:D003110 Colonic Neoplasms Indomethacin 7.6815637740 15936596 15625704 15786552 11260862 15963497
MESH:D003110 Colonic Neoplasms Vitamin A 7.6817219422 16267017
MESH:D015179 Colorectal Neoplasms marker/mechanism
MESH:D015179 Colorectal Neoplasms Indomethacin 2.7911197048 18059344 17054584 12606626
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.7918802399
MESH:D016510 Corneal Neovascularization Curcumin 4.5118497527
MESH:D003324 Coronary Artery Disease atorvastatin 3.9916368305
MESH:D018352 Coronavirus Infections Indomethacin 5.3217302372
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 3.4317728286
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.4310992263
MESH:D003424 Crohn Disease marker/mechanism 17914947
MESH:D003456 Cryptorchidism vinclozolin 3.9714966744
MESH:D003550 Cystic Fibrosis Simvastatin 4.6119747007
MESH:D003872 Dermatitis Picryl Chloride 5.7916442096 15734285 18854230
MESH:D017449 Dermatitis, Allergic Contact Picryl Chloride 4.6012484431
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact marker/mechanism 18725520
MESH:D003877 Dermatitis, Contact Picryl Chloride 5.2912631246 12188032 17392825 12811023
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3816506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6018403477
MESH:D003928 Diabetic Nephropathies Curcumin 3.6818204486
MESH:D003929 Diabetic Neuropathies marker/mechanism 14693986
MESH:D003929 Diabetic Neuropathies Progesterone 4.1117187935
MESH:D003967 Diarrhea Hydrocortisone 7.427237001
MESH:D003967 Diarrhea Indomethacin 7.427237001 7907874
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.3315619225 17522070 14550746 12958197 12153990 19164858 17906064 15968718 10774834 16081117 18713872 11421492 16781746 17562736 10915739 19085960 11743745 16177239 18071297 14986274 12392966 16109766 19416960 11834606 19739265 16485898 11739529 12594235 12705907 2444490 11529661 19923254 12540782 16227642 19420014 16393943 11287661 19370779 14725611 11461765 10663392
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.336884620 3732212 7179309 7120509 10915739 17522070 21278145 7440962 2869522 3786805 15968718 4309450 15998439 6623471 10092053 16177239 16227642 9327722 19336974 15027814 19085960 11566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7019426721
MESH:D015352 Dry Eye Syndromes Vitamin A 5.4116146918
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7518446180 17190690 16133044 16326151 12774134 18043480
MESH:D004381 Duodenal Ulcer Curcumin 8.1817351913
MESH:D004381 Duodenal Ulcer Indomethacin 8.1817202747 11535926 11595431 11991626 10671773 17351913 11595415 16699067 17329845 17151854 17045617
MESH:D050171 Dyslipidemias Dietary Fats 3.1718367378
MESH:C538011 Eales disease Vitamin A 5.229068938
MESH:D004480 Ectromelia Vitamin A 5.4216054864
MESH:D004485 Eczema Picryl Chloride 5.6517429439
MESH:D004487 Edema Indomethacin 13.6716100529 10653021 7907874 8273558 8985016 7990266 19703484
MESH:D004487 Edema Mustard Gas 13.6711428631 9260866 11402378 11428647
MESH:D004487 Edema pirinixic acid 13.6712083418
MESH:D004487 Edema Zymosan 13.677907874
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4117692515
MESH:D004715 Endometriosis Indomethacin 8.2115652904
MESH:D004715 Endometriosis Progesterone 8.2116134523
MESH:D019446 Endotoxemia Indomethacin 9.3418509659
MESH:D019446 Endotoxemia Lipopolysaccharides 9.3417637181 15821434 15328337
MESH:D004751 Enteritis Indomethacin 4.3510567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6017980183
MESH:D004802 Eosinophilia Indomethacin 3.6711298111
MESH:D004890 Erythema Mustard Gas 4.769357497
MESH:D004938 Esophageal Neoplasms Indomethacin 4.5711005569
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.5716481741
MESH:D005234 Fatty Liver marker/mechanism 18641190
MESH:D005234 Fatty Liver arsenite 20.9418296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.9419224547 16045604 61145 12795759 17595544 12631006 16239168 15959796
MESH:D005234 Fatty Liver Curcumin 20.9419297423
MESH:D005234 Fatty Liver Dietary Fats 20.9417967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 20.9420131406 19236843
MESH:D005327 Fetal Resorption Vitamin A 4.9616054864
MESH:D005334 Fever Indomethacin 8.2211852909 17627676 10431976
MESH:D005334 Fever Lipopolysaccharides 8.229205823 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.5010962813
MESH:D005355 Fibrosis arsenite 23.6918296743
MESH:D005355 Fibrosis Carbon Tetrachloride 23.6918705752
MESH:D005355 Fibrosis Curcumin 23.6918705752
MESH:D005355 Fibrosis Dietary Fats 23.6918296743
MESH:D005355 Fibrosis Indomethacin 23.6917994277
MESH:D005499 Folliculitis Indomethacin 4.7711298111
MESH:D005534 Foot Diseases Arsenic 5.166392382
MESH:D005756 Gastritis Acetaminophen 9.8116983495
MESH:D005756 Gastritis Indomethacin 9.8115046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3118462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9016417039
MESH:D005909 Glioblastoma Curcumin 6.6317596214
MESH:D005909 Glioblastoma Indomethacin 6.6312870263
MESH:D005910 Glioma Indomethacin 3.0616487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9711849393
MESH:D006073 Gout Indomethacin 4.9611248219
MESH:D006258 Head and Neck Neoplasms Curcumin 7.2118829502 18462866
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.2115482327
MESH:D006330 Heart Defects, Congenital Vitamin A 3.6916080930 10992263
MESH:D006333 Heart Failure atorvastatin 6.6516360360
MESH:D006333 Heart Failure pirinixic acid 6.6520558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0416366002
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2215633222
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4219110552 19900420
MESH:D006505 Hepatitis Zymosan 8.4219110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3115135802
MESH:D006529 Hepatomegaly pirinixic acid 2.6219176532 18467677 16221962 19772884
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6517701891
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.4716490937 16863852 16292552 16877224 17436238 15707848
MESH:D015658 HIV Infections Vitamin A 3.6116960176
MESH:D006679 HIV Seropositivity Vitamin A 5.2017209195
MESH:D006930 Hyperalgesia Acetaminophen 6.8016870215
MESH:D006930 Hyperalgesia Indomethacin 6.8012727271
MESH:D034321 Hyperamylasemia Indomethacin 5.3217883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006937 Hypercholesterolemia atorvastatin 13.4811583720
MESH:D006937 Hypercholesterolemia Curcumin 13.4818704882
MESH:D006937 Hypercholesterolemia Dietary Fats 13.4821332399
MESH:D006940 Hyperemia Indomethacin 4.6112524144
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1117050553
MESH:D006949 Hyperlipidemias Dietary Fats 8.1421332399
MESH:D006949 Hyperlipidemias Indomethacin 8.1417546600
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 9.4316238680
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 9.4316238680
MESH:D006968 Hypersensitivity, Delayed Picryl Chloride 5.9811275354
MESH:D006973 Hypertension Arsenic 5.4511953799 16076760 9931084
MESH:D006973 Hypertension atorvastatin 5.4517042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D006986 Hypervitaminosis A Vitamin A 5.7716054864
MESH:D006987 Hypesthesia Arsenic 5.1616093927
MESH:D007077 Ileal Diseases Indomethacin 4.6218306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9610651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9716133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0215869954
MESH:D007248 Infertility, Male vinclozolin 2.7816467254
MESH:D007249 Inflammation atorvastatin 29.0016908763
MESH:D007249 Inflammation Curcumin 29.0017151092 18403477 16956363
MESH:D007249 Inflammation Dietary Fats 29.0020412841
MESH:D007249 Inflammation Flavonoids 29.0017296493
MESH:D007249 Inflammation Indomethacin 29.003291741 7812673 12568917
MESH:D007249 Inflammation Lipopolysaccharides 29.0017255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation Mustard Gas 29.009260866 11402378 9357497 11428647 17524151 11428631 8975870 16001271 11428620
MESH:D007249 Inflammation Progesterone 29.0015869954
MESH:D007249 Inflammation Zymosan 29.008014878 11289658
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0418596194 18200517
MESH:D007333 Insulin Resistance Dietary Fats 6.3811836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.3816306350
MESH:D007410 Intestinal Diseases Indomethacin 3.9415610444 15831440 17994277 11686837 18236018 17329856 11855677 11713966 10210152
MESH:D007414 Intestinal Neoplasms Curcumin 3.8810783313
MESH:D019586 Intracranial Hypertension Indomethacin 12.8515241188
MESH:D019586 Intracranial Hypertension Vitamin A 12.8515955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2717255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.4417553498
MESH:D007579 Jejunal Diseases Indomethacin 4.6210574470 18306037 16133968
MESH:D007642 Keratosis Arsenic 4.6016930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 5.3715629191 12587719
MESH:D007674 Kidney Diseases Indomethacin 5.3717190690
MESH:D007889 Leiomyoma Curcumin 4.2118555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5911703811 10320625 12228301
MESH:D007938 Leukemia Curcumin 3.0418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8516106398
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6315631656 10785260 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.5718360721
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.2917339181
MESH:D015458 Leukemia, T-Cell Curcumin 4.3916106398
MESH:D007964 Leukocytosis Indomethacin 4.9716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3217980183
MESH:D007970 Leukopenia Lipopolysaccharides 4.3015821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3416417039
MESH:D017880 Limb Deformities, Congenital Vitamin A 4.0316054864
MESH:D008080 Liposarcoma Paclitaxel 4.4617353645
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3211479899
MESH:D008103 Liver Cirrhosis arsenite 13.9918296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.9917157831 11903743 16221502 16943688 11408273 21278145 16239168 17174718 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 13.9918296743
MESH:D008103 Liver Cirrhosis Vitamin A 13.9916256175
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 10.0317347453
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.0314724832 18279442 12666154 12898905 18705752 15818738 20821823 13678700 15057751 17761835 17823541 14512876 16116963 17481882 17766677 15673190 18395095 16192424 14716496 10355542 18481824 12741479 12609069 17557913 16011737 18339082 15052691 16248980 18277467 18418968 18317297 17922224 18472332 15876570 17565644 17869086 11481614 17721639 18420326 17714472 14748882 12958196 16033810 18210741 16097048 17640975 17976157 15338365 14716833 16015684 15650968 18156304 18263696 12445421 17944888 18251166 15123356 12649538 15893842 12445418 18166357 16027843 15959796 15931870 17900296 15362042 12546737 18472094 16638106 17708605 15925388 18395914 14620537 15996030 18006644 18205269 15370692 18412020 12632512 12389079 15730626 17805973 12667390 17698563 18429990 17631135 17525996 12632514 12586293 18376398 18187930 16136751 18054572
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.0318705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 10.0318194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.0312878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 10.0316248980
MESH:D008107 Liver Diseases Acetaminophen 11.3012969438 19460945 16611625 19784758 19014921 16610002 11587558 12587719
MESH:D008107 Liver Diseases Arsenic 11.3011134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.3017285989 16246199 15830285 15720792 16964402
MESH:D008107 Liver Diseases Curcumin 11.3016956363
MESH:D008107 Liver Diseases Vitamin A 11.3016175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.7716762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.2816899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 6.5316368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.5319294768
MESH:D008113 Liver Neoplasms pirinixic acid 6.5315890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.5215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 5.5217113696
MESH:D008171 Lung Diseases Mustard Gas 10.9818702808 18161513
MESH:D008171 Lung Diseases Ozone 10.9819066396 8266340
MESH:D008171 Lung Diseases Vitamin A 10.9816863852
MESH:D055370 Lung Injury Lipopolysaccharides 7.9721114838
MESH:D055370 Lung Injury Ozone 7.9720417186
MESH:D008175 Lung Neoplasms marker/mechanism 19925653
MESH:D008175 Lung Neoplasms Arsenic 7.8219168569 17976673 17306315
MESH:D008175 Lung Neoplasms arsenite 7.8216809336
MESH:D008175 Lung Neoplasms Curcumin 7.8218462866 16243823 19359593
MESH:D008175 Lung Neoplasms Indomethacin 7.8211497255 11053908 16537180
MESH:D008175 Lung Neoplasms Mustard Gas 7.823148597 8781369
MESH:D008175 Lung Neoplasms Ozone 7.827614698 8597069
MESH:D008223 Lymphoma Curcumin 3.3118462866
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.7714749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3116173963
MESH:D008268 Macular Degeneration marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.6211408345 17203775
MESH:D008545 Melanoma Curcumin 3.4718462866 17885582
MESH:D008545 Melanoma Paclitaxel 3.4716342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1819513568
MESH:D008569 Memory Disorders Curcumin 3.7817263510
MESH:D008679 Metaplasia Ozone 4.7010496685
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.4917671175
MESH:D008881 Migraine Disorders Indomethacin 3.4011903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.6912636206
MESH:D009101 Multiple Myeloma Curcumin 10.7319372569
MESH:D009101 Multiple Myeloma Paclitaxel 10.7314749477
MESH:D009101 Multiple Myeloma Vitamin A 10.7316374440
MESH:D009102 Multiple Organ Failure Zymosan 4.8512130978 15834315 10890648 10479408 12879239 17724436 15241586 15259001 18160304 15213630
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5217962980
MESH:D009135 Muscular Diseases atorvastatin 9.4716239165
MESH:D009135 Muscular Diseases pirinixic acid 9.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D017202 Myocardial Ischemia Arsenic 3.6715371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6516411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0018495463
MESH:D009362 Neoplasm Metastasis Indomethacin 5.6511239499 11053908 16537180
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.6515867366
MESH:D009369 Neoplasms pirinixic acid 1.7617405874
MESH:D009374 Neoplasms, Experimental Indomethacin 3.7510663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.1312497104
MESH:D009389 Neovascularization, Pathologic arsenite 4.0215738583
MESH:D009404 Nephrotic Syndrome atorvastatin 4.8219348381
MESH:D009423 Nervous System Neoplasms Curcumin 5.2318462866
MESH:D009436 Neural Tube Defects Arsenic 6.9316620997
MESH:D009436 Neural Tube Defects Vitamin A 6.9317400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3418514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.3412349958
MESH:D020078 Neurogenic Inflammation Arsenic 4.0117056641
MESH:D009503 Neutropenia Mustard Gas 3.6116761898 7688884
MESH:D009765 Obesity Curcumin 6.7819297423
MESH:D009765 Obesity Dietary Fats 6.7818674790 17217161 19632207 11836018 21332399 16723640 20132043 18457598 20518802
MESH:D009765 Obesity pirinixic acid 6.7820558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.776374098
MESH:D010003 Osteoarthritis Indomethacin 3.437009135
MESH:D010014 Osteolysis Paclitaxel 4.5915867366
MESH:D010024 Osteoporosis Curcumin 3.2318719352
MESH:D010051 Ovarian Neoplasms Arsenic 10.2417306315
MESH:D010051 Ovarian Neoplasms Curcumin 10.2418462866 19020741
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.2411161223
MESH:D010051 Ovarian Neoplasms Progesterone 10.2417393432 16525653
MESH:D010146 Pain Acetaminophen 5.7516870215
MESH:D010146 Pain Indomethacin 5.753291741 17627676 13679232 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.2812538197 18702446
MESH:D010190 Pancreatic Neoplasms Curcumin 2.7917440100 19196508 19401701
MESH:D010195 Pancreatitis Indomethacin 3.5617883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3216537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3211903285
MESH:D010437 Peptic Ulcer Indomethacin 4.7511148446
MESH:D010518 Periodontitis Indomethacin 4.5117225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.606392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 9.1316369182
MESH:D010538 Peritonitis Zymosan 9.1317826846 15979727 19641140 15259001 14761945 11985352 18977430 18557954 19088179 17371808 18760300
MESH:D011014 Pneumonia Lipopolysaccharides 9.7912224865 11605937
MESH:D011014 Pneumonia Ozone 9.7918381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 3.4415727166
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 5.0017105841
MESH:D047928 Premature Birth Indomethacin 4.7417000239
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.5118042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5418220299
MESH:D011471 Prostatic Neoplasms marker/mechanism 17301271
MESH:D011471 Prostatic Neoplasms Arsenic 2.2816140617
MESH:D011471 Prostatic Neoplasms bicalutamide 2.2819011039 17914592 18487222 19240160 15638997
MESH:D011471 Prostatic Neoplasms Curcumin 2.2818226269 18156803 15129424 11398177 10851300 18769126 12497104
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.2816356831 17172428 17136230 16729912
MESH:D011472 Prostatitis vinclozolin 4.5418629315
MESH:D011507 Proteinuria Arsenic 8.2821343184
MESH:D011507 Proteinuria Indomethacin 8.2811849393
MESH:D011537 Pruritus Mustard Gas 3.7018058305
MESH:D011656 Pulmonary Emphysema Curcumin 4.1919168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7717266442 10334151 17894541 17620002 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6718379247 10666014
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.4116877224
MESH:D012130 Respiratory Hypersensitivity marker/mechanism 10835634
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4710835634
MESH:D012216 Rheumatic Diseases Auranofin 7.0317034761
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7118045962
MESH:D012509 Sarcoma Curcumin 3.7818462866
MESH:D018805 Sepsis Curcumin 8.6218389075
MESH:D018805 Sepsis Zymosan 8.6211441115
MESH:D012772 Shock, Septic lipoteichoic acid 5.7019573522
MESH:D012871 Skin Diseases Arsenic 10.4815952646 6392382 17453740 16702368 17548696 19834688 17938729 16353154 17050553 16759981 18709164
MESH:D012871 Skin Diseases monomethylarsonous acid 10.4817431481
MESH:D012871 Skin Diseases Mustard Gas 10.4816961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin A 10.4818709164
MESH:D012878 Skin Neoplasms Arsenic 2.8216251483 15504454 17050553 19538983 17029826 17976673
MESH:D013119 Spinal Cord Injuries Progesterone 3.8915862959 16503802
MESH:D013272 Stomach Diseases Indomethacin 4.0310486359 15038085 10215738 16280098 18209964 17207306 16184426 15472012 18545984 17638125 17160473 10192188 16113693
MESH:D013274 Stomach Neoplasms Indomethacin 2.7715609394
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7718506536 18396642
MESH:D013276 Stomach Ulcer Curcumin 6.4216631530 19188055
MESH:D013276 Stomach Ulcer Indomethacin 6.421323529 15104355 17977527 17657623 18209962 14567935 16755016 11145282 18543354 18087811 10878458 11729361 17654042 12500499 17895592 11595415 17135157 12498302 10750652 11523592 10423059 15255614 17918041 18237397 18726076 16150113 16934674 18299717 15138204 16252198 18193104 12467913 12077510 17627676 18431645 16169175 12787963 11906479 16397915 11595431 18181030 16631530
MESH:D024801 Tauopathies Paclitaxel 4.4216930453
MESH:D013742 Tetanus Propofol 6.032903605
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8215821434
MESH:D013964 Thyroid Neoplasms Indomethacin 3.2911352223 14736730 18791128
MESH:D014456 Ulcer Indomethacin 4.5017380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Arsenic 7.6218640142 11144890 15987713 19322015 19429237 17976673 17306315
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.6218593936
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 7.6220375083
MESH:D014565 Urogenital Neoplasms Curcumin 4.8718462866
MESH:D014581 Urticaria Acetaminophen 2.6210982225
MESH:D014605 Uveitis Zymosan 5.0011006244
MESH:D014652 Vascular Diseases Arsenic 4.3417056641
MESH:D014802 Vitamin A Deficiency Vitamin A 4.9116175781 16146918 16960172
MESH:D014839 Vomiting Indomethacin 4.3511897121
MESH:D015430 Weight Gain Dietary Fats 3.4116723640
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:05142 Chagas disease (American trypanosomiasis)
REACT:25035 Innate immune response mediated by toll like receptors
KEGG:05140 Leishmaniasis
KEGG:05144 Malaria
KEGG:05162 Measles
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04145 Phagosome
KEGG:05323 Rheumatoid arthritis
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36552
    • No data
    Releated disease ID Related disease Name
    PA161845799Aspergillosis Infection
    PA444065Epilepsy
    PA446415Gram-Negative Bacterial Infections
    PA443635Cardiovascular Diseases
    PA445019Myocardial Infarction
    PA444859Malaria
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA449972imiquimod
    PA451089pravastatin
    PA451363simvastatin
    PA133950441hmg coa reductase inhibitors
    PA449692folic acid
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02767 - 3-Hydroxy-Myristic Acid
    DB03017 - Lauric Acid
    DB08231 - MYRISTIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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