AutismKB 2.0

Annotation Detail for TLR5


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Basic Information Top
Gene Symbol:TLR5 ( FLJ10052,MGC126430,MGC126431,SLEB1,TIL3 )
Gene Full Name: toll-like receptor 5
Band: 1q41
Quick LinksEntrez ID:7100; OMIM: 603031; Uniprot ID:TLR5_HUMAN; ENSEMBL ID: ENSG00000187554; HGNC ID: 11851
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04620Toll-like receptor signaling pathway
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Signaling in Immune system
No data
No data
Pathway IDPathway Name
500459Toll Like Receptor 5 (TLR5) Cascade
Related Diseases/Disorders Top
Desease IDDesease Name
H00080Systemic lupus erythematosus
Immune system diseases
Allergies and autoimmune diseases
Desease IDDesease Name
1826Cystic fibrosis
1911Intestinal disease
1985Salmonella infection
1998Enteritis
1841Stomach cancer
2146Lupus erythematosus
2247Osteomyelitis
Desease Name
systemic lupus erythematosus
IMMUNE
lupus erythematosus
respiratory syncytial virus bronchiolitis
INFECTION
No data
Desease Name
Systemic lupus erythematosus, susceptibility to, 1
Systemic lupus erythematosus, resistance to
Legionaire disease, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of TLR5 mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TLR5 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of TLR5 mRNAaffects expression 17562736
D000119 Acetylmuramyl-Alanyl-Isoglutamine Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of TLR5 mRNAincreases expression 17087994
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TLR5 mRNAdecreases expression 20064835
C002669 parthenolide parthenolide results in decreased expression of TLR5 mRNAdecreases expression 16921510
C006253 pirinixic acid pirinixic acid results in increased expression of TLR5 mRNAincreases expression 18301758
D011070 Poly I-C Poly I-C results in increased expression of TLR5 mRNAincreases expression 17087994
D011374 Progesterone Progesterone results in increased expression of TLR5 mRNAincreases expression 17701593
C025643 vinclozolin vinclozolin results in increased expression of TLR5 mRNAincreases expression 18629315
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1320146248 17474063
MESH:D001943 Breast Neoplasms parthenolide 2.1316873071
MESH:D001943 Breast Neoplasms Progesterone 2.1317614352 15562024 16175315
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.647296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.046135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.047505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.279022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0118759878 2524372 11298694 8156756 8970840 14531868 11906362 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.436482804 9328219 11289319 18692083 18289764 6679447 9653073 8291058 7440962 18648102 9022650 1440618 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4312594235 15619225 10663392 17562736 11743745 16781746 12540782 11421492 14550746 14725611 10915739 17522070 17906064 16393943 11739529 16177239 11529661 16081117 18071297 16485898 18713872 15968718 11287661 19085960 19164858 12705907 12153990 2444490 19420014 14986274 19416960 10774834 19370779 11461765 12958197 19923254 16227642 11834606 19739265 12392966 16109766
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.493581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4916530937
MESH:D005234 Fatty Liver pirinixic acid 2.9319236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2119176532 16221962 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Progesterone 2.6815869954
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D007877 Legionnaires' Disease marker/mechanism
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Poly I-C 3.0018166357
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 16610002 19460945 11587558 19014921 19784758 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.717678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7120195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.7120007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.232876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.231399818 598648 3712494 6587162
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620064080 20464547 6695378 17053015 20869020 18816296 18569708 20135361 18520028
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9717203775 11408345
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0811141357
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009389 Neovascularization, Pathologic parthenolide 5.7616921510
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.434026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms Progesterone 2.5717393432 16525653
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1319015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms marker/mechanism 16284379
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.7317292933
MESH:D011471 Prostatic Neoplasms parthenolide 3.7316921510
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4410029692 19755658
MESH:D013119 Spinal Cord Injuries Progesterone 4.5216503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016582329 3712494 7505956 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.628074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6217053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
Pathway ID Pathway Name
KEGG:05130 Pathogenic Escherichia coli infection
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36553
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA162370429CBLB502
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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