AutismKB 2.0

Annotation Detail for TMPO


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Basic Information Top
Gene Symbol:TMPO ( CMD1T,LAP2,LEMD4,MGC61508,PRO0868,TP )
Gene Full Name: thymopoietin
Band: 12q23.1
Quick LinksEntrez ID:7112; OMIM: 188380; Uniprot ID:LAP2A_HUMAN; ENSEMBL ID: ENSG00000120802; HGNC ID: 11875
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2067Primary tumor
No data
No data
Desease Name
Cardiomyopathy, dilated, 1T
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TMPO mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of TMPO mRNAdecreases expression 16514628
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of TMPO mRNAdecreases expression 14583596
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TMPO mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of TMPO mRNAincreases expression 20458559
D001374 Azacitidine [Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNAaffects cotreatment|affects expression 18720364
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TMPO mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TMPO proteindecreases expression 20097212
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMPO mRNAdecreases expression 19150397
20382639
C006780 bisphenol A bisphenol A results in increased expression of TMPO mRNAincreases expression 16474171
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TMPO mRNAdecreases expression 12414654
15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of TMPO mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TMPO mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TMPO mRNA]decreases reaction|increases expression 17854601
D004317 Doxorubicin TMPO protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of TMPO mRNAincreases expression 16474171
16514628
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TMPO mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPO mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant fulvestrant results in decreased expression of TMPO mRNAdecreases expression 16514628
D019833 Genistein Genistein results in increased expression of TMPO mRNAincreases expression 16474171
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of TMPO mRNAdecreases expression 12414654
D005996 Nitroglycerin Nitroglycerin results in increased expression of TMPO mRNAincreases expression 12102619
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of TMPO mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid results in decreased expression of TMPO mRNAdecreases expression 17426115
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of TMPO mRNAincreases expression 16474171
D011374 Progesterone Progesterone affects the expression of TMPO mRNAaffects expression 17251523
C045950 propiconazole propiconazole results in increased expression of TMPO mRNAincreases expression 19363144
D020849 Raloxifene Raloxifene results in decreased expression of TMPO mRNAdecreases expression 16514628
C017947 sodium arsenite sodium arsenite results in decreased expression of TMPO mRNAdecreases expression 17998272
C025462 sulindac sulfide sulindac sulfide results in decreased expression of TMPO mRNAdecreases expression 16184548
C020806 tetrabromobisphenol A tetrabromobisphenol A affects the expression of TMPO mRNAaffects expression 18976794
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TMPO mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TMPO mRNAincreases expression 17942748
15328365
D013792 Thalidomide [Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNAaffects cotreatment|affects expression 18720364
C032910 triadimefon triadimefon results in increased expression of TMPO mRNAincreases expression 19363144
D014747 Vinblastine TMPO protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D024483 Vitamin K 3 Vitamin K 3 results in decreased expression of TMPO mRNAdecreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6314514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 7.638333272
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 15.9511798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.9520464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 15.9517418594
MESH:D000230 Adenocarcinoma Estradiol 15.9511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.9514692618
MESH:D000230 Adenocarcinoma Genistein 15.9511473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.006695378
MESH:D000236 Adenoma Diethylnitrosamine 6.0010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.3918056438 19052882 17162532 19061943 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.3916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5717306315 16712894
MESH:D000419 Albuminuria Doxorubicin 10.4321441931
MESH:D000419 Albuminuria Raloxifene 10.4317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 4.3415800139
MESH:D000544 Alzheimer Disease sulindac sulfide 4.3418759972
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.1516510725
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9615885639
MESH:D001169 Arthritis, Experimental Thalidomide 6.969598899
MESH:D001284 Atrophy fulvestrant 4.5411514358
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.6016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.6012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3714601052
MESH:D001862 Bone Resorption bisphenol A 3.5711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0117868700
MESH:D001930 Brain Injuries Progesterone 9.9115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 9.9116580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.5317150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.6317474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 6.6317123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.6317474063
MESH:D001943 Breast Neoplasms Doxorubicin 6.6315668708 16322301 18234424 15634643 16096432 16264153 18628466 16595493 19526202 15994142 17983394 15993339 15692762 18695136 15136595 18382427 11325840 15567936 16115903 16935488 17426702 15939500 16826403 17369602
MESH:D001943 Breast Neoplasms Estradiol 6.6317261762 16675129 17289903 18497071 14630087 19861407 17018787 12948864
MESH:D001943 Breast Neoplasms fulvestrant 6.6318984771
MESH:D001943 Breast Neoplasms Genistein 6.6316541309 16873071 17200150
MESH:D001943 Breast Neoplasms Progesterone 6.6317614352 16175315 15562024
MESH:D001943 Breast Neoplasms Raloxifene 6.6317049068 16912660 15758505 17440819 17893378 17952589 15572757 16837676 17595753 17242785 17261762 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.8916705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.8914691202 16217749 11135700 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.8919383236 17173139 20214788 20432363 16878318 19171122 16698587 19519916 18788625 16807293 20514400 18691550 20101231 18785209 18494052 20084675 16540662 16681979 19107877 3084413 19919837 19335982 19208518 19394651 20512989 3581430 10672840 18056438 16502159 19701751 16569478 18978308 17162532 18971187 17055752 11831363 16328049 17978847 16830150 19539802 16935385 21159647 20727157 18210153 17761372 17138121 10737359 17428255 20007298 16288022 18393292 20935162 18506893 16779866 19418558 19822196 18665156 20524982 19052882
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 15.8916023760 17876044 18059187 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.8916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.8916924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.8916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 15.8916313753
MESH:D002278 Carcinoma in Situ bisphenol A 4.6617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3312391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5419014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.4416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.441485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.9620419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 6.966189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.9618572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1916120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.3217382496 16242529 15792986 17519947 15811867 17007740 17351982 15476868 17974986 15505089 16278810 16109756 17928571 16364871 18627295 16455267 17924179 16651473 16952015 16731534 16612575 17329180 16269455 17308081 17131338
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8316243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 10.9616332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.9616936243
MESH:D002318 Cardiovascular Diseases Raloxifene 10.9615775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.7220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.7212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.7217174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.7218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.7219524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.6319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.6316835633
MESH:D018281 Cholangiocarcinoma Thalidomide 14.6318291259
MESH:D002779 Cholestasis Cyclosporine 11.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.9616919318 11677210 15861022 16105132 17681005 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 11.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6916354765 15340226 8697196 12621046 15668235
MESH:D002972 Cleft Palate triadimefon 5.6916781842
MESH:D003072 Cognition Disorders Raloxifene 4.3015800139
MESH:D003092 Colitis Thalidomide 4.5316680017
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.5320423518
MESH:D003110 Colonic Neoplasms Genistein 2.2317182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.1320501625
MESH:D015179 Colorectal Neoplasms Azacitidine 6.1319934284
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.1318259882 18802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 6.1315531428
MESH:D015179 Colorectal Neoplasms Vinblastine 6.1318802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D016510 Corneal Neovascularization Thalidomide 5.259301478
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8812609071
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.979200351
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.1710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Thalidomide 5.179200351
MESH:D019465 Craniofacial Abnormalities triadimefon 5.1716875885 15834900
MESH:D003424 Crohn Disease Thalidomide 4.0016078585
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7018551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8015213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.4116140633
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8917474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.5916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5917107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.1119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.1115920148 17308373 17451421
MESH:D003929 Diabetic Neuropathies Progesterone 4.1717187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.1221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.1219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.1217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1220420201
MESH:D004362 Drug Toxicity Doxorubicin 7.3218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3211462148
MESH:D004487 Edema pirinixic acid 9.7612083418
MESH:D004487 Edema Raloxifene 9.7615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.7611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.5912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.5917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.5915845917
MESH:D004714 Endometrial Hyperplasia Genistein 4.2616402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 16.1019148513
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.1017359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.1019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 16.1011473722
MESH:D004715 Endometriosis Progesterone 8.0016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0010568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8318037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.6712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.6716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver arsenic trioxide 26.9415073043
MESH:D005234 Fatty Liver Cyclosporine 26.9419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 26.9421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.9415345470
MESH:D005234 Fatty Liver pirinixic acid 26.9419236843 20131406
MESH:D005234 Fatty Liver Raloxifene 26.9417473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2619069698
MESH:D005355 Fibrosis Cyclosporine 7.4312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.4320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9516904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3516452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.9712701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.898708960
MESH:D005909 Glioblastoma Doxorubicin 6.6317150277
MESH:D005909 Glioblastoma Genistein 6.6316598420
MESH:D005910 Glioma Thalidomide 3.6816327979
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006261 Headache Nitroglycerin 4.8611284996 11554966
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3115692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8711294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 7.0916244371 16244372 17875725 16495754 16879835 18674790 14766674 18006777 17888722 12587719 16330681 16707910 16144979
MESH:D006331 Heart Diseases Raloxifene 7.0911110106
MESH:D006333 Heart Failure Doxorubicin 6.3817481944
MESH:D006333 Heart Failure pirinixic acid 6.3820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6115692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006529 Hepatomegaly pirinixic acid 18.1516221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly propiconazole 18.1517178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.1512621046 15340226 16120746
MESH:D006529 Hepatomegaly triadimefon 18.1517178688 17178689
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D006689 Hodgkin Disease Doxorubicin 10.8315147373 17606976 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 10.8312676792
MESH:D006689 Hodgkin Disease Vinblastine 10.8318180244 18501091
MESH:D019584 Hot Flashes Estradiol 3.4217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116959395 18606429 16354765 15340226 8697196
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006973 Hypertension Cyclosporine 7.8310903974
MESH:D006973 Hypertension Raloxifene 7.8317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.0517937319
MESH:D007248 Infertility, Male fulvestrant 10.0511514358
MESH:D007248 Infertility, Male sodium arsenite 10.0512646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 10.5918785209
MESH:D007249 Inflammation Progesterone 10.5915869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.5912200463 12878042
MESH:D007249 Inflammation Thalidomide 10.5916134734
MESH:D007333 Insulin Resistance bisphenol A 11.0916393666
MESH:D007333 Insulin Resistance Estradiol 11.0916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.0916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities triadimefon 9.3615992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1115604871
MESH:D007674 Kidney Diseases Cyclosporine 12.908314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 12.9015699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 12.9015618244
MESH:D007674 Kidney Diseases sodium arsenite 12.9020008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.1616707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.1616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.8516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 10.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 10.8515610895
MESH:D007889 Leiomyoma Raloxifene 4.2016973256
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.1016514283
MESH:D007938 Leukemia arsenic trioxide 9.6615070760
MESH:D007938 Leukemia Azacitidine 9.6619148494
MESH:D007938 Leukemia Genistein 9.6618980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.8519077051
MESH:D007951 Leukemia, Myeloid Azacitidine 8.8519077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.9920471514 19850784 17050201 16968895 16467208
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 5.9917596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 5.9918720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.8919299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0017712046 19225113 11468182 15622746 16112521 17869043 16891316 16823087 9834237 11161223 15213294 16966277 12018890 12679006 17107899 16331271 12712474 19642359 17649720 15336539 16330433 19035177 17217047 15748426 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0416882451
MESH:D017880 Limb Deformities, Congenital Thalidomide 4.2210473037
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4520032147 18407596 18665156 19638242 18522880
MESH:D008103 Liver Cirrhosis Thalidomide 6.4516943688 17174718
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.1516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.1517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1512878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 8.1515465738
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3017034775
MESH:D008107 Liver Diseases propiconazole 6.3019363144
MESH:D008107 Liver Diseases triadimefon 6.3019363144
MESH:D008113 Liver Neoplasms arsenic trioxide 23.6914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.6921137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.6912771043 15885732 19426721 18977376 19812893 19996281 20405173 18644402 19638242 19294768 20492335 20101389 10737359 15175105 19551842 20434301 19642983 20583210 19073162 19255062 2862719 19850985 18754104 18648771 21047994 19254457 21071580 19090486 2422723 21167192 12112319 20501860 21278145 9163691 16942905 19833225 19499222 19256749 20137499 20118626 18978307 19427195 19690152 20452335
MESH:D008113 Liver Neoplasms pirinixic acid 23.6920007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 23.6919028983
MESH:D008113 Liver Neoplasms sodium arsenite 23.6916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.6916984957
MESH:D008113 Liver Neoplasms triadimefon 23.6919028983
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 25.1520377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.1518093689 19009564 18164116 18775883 16842330 17854601 2563599 19539802 19004024 16267830 9362446 21159647 17942915 18282651 3124819 18079962 18308698 19126423 17174075 18544905 19519916 18253720
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 25.1516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 25.151423854
MESH:D008114 Liver Neoplasms, Experimental propiconazole 25.1517178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.1512151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 25.1517178689
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1115213294
MESH:D008171 Lung Diseases sodium arsenite 2.9619095001
MESH:D008175 Lung Neoplasms arsenic trioxide 10.0119825857 11798837
MESH:D008175 Lung Neoplasms Azacitidine 10.0121224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0118520028 20135361 20464547 6695378 17053015 20869020 18816296 18569708 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.0120970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 10.016189445 17418594
MESH:D008175 Lung Neoplasms sodium arsenite 10.0115276417 19931552 17306315 16712894 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0119555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.2316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2515621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.5815458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.5817203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.5814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.5817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1519453300
MESH:D008545 Melanoma Doxorubicin 9.1616827129
MESH:D008545 Melanoma sodium arsenite 9.1616487513 19082730
MESH:D008545 Melanoma Thalidomide 9.1612829675 17089043 16098027
MESH:D008545 Melanoma Vinblastine 9.1618176117 18505091 15577323 17761969 16809738 15577320 18332650 12374674 16248763 16432458
MESH:D008545 Melanoma Vitamin K 3 9.1619082730
MESH:D008654 Mesothelioma Doxorubicin 2.9317638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4616801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.443537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.8214659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2115792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2215863610
MESH:D009006 Monosomy Azacitidine 5.7519299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9416381670
MESH:D052016 Mucositis Doxorubicin 4.4617415656
MESH:D009101 Multiple Myeloma arsenic trioxide 15.4715949261 19417148 14977855 19549372 11468182
MESH:D009101 Multiple Myeloma Azacitidine 15.4718443271 19549372
MESH:D009101 Multiple Myeloma Raloxifene 15.4716497877
MESH:D009101 Multiple Myeloma Thalidomide 15.4719112201 15744524 17168659 15920492 16445831 19112817 15939924 15741222 19372569 15867202
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.4916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Azacitidine 11.4919805378 17611569 17596541 18720364
MESH:D009190 Myelodysplastic Syndromes Thalidomide 11.4918720364
MESH:D009203 Myocardial Infarction Doxorubicin 12.4519429709 15857846
MESH:D009203 Myocardial Infarction Genistein 12.4517141266
MESH:D009203 Myocardial Infarction Nitroglycerin 12.4514729435
MESH:D009203 Myocardial Infarction pirinixic acid 12.4519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.7416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.7417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.7416411023
MESH:D009232 Myxoma Raloxifene 5.2216343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5318551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6516624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.433581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4318259882
MESH:D009369 Neoplasms 4-phenylbutyric acid 10.5419116145
MESH:D009369 Neoplasms Benzo(a)pyrene 10.5411141357
MESH:D009369 Neoplasms pirinixic acid 10.5417405874
MESH:D009369 Neoplasms sodium arsenite 10.5411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3520056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009401 Nephrosis Doxorubicin 4.4516899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.3919348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.3916889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 27.4611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 27.4611399458 16427766
MESH:D009421 Nervous System Malformations Genistein 27.4616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 27.4614600291
MESH:D009421 Nervous System Malformations Thalidomide 27.4616859833
MESH:D009436 Neural Tube Defects arsenic trioxide 6.6310525206
MESH:D009436 Neural Tube Defects sodium arsenite 6.6312854658
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7920387270
MESH:D009503 Neutropenia Vinblastine 4.2717378895
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1516049721 12819281
MESH:D010024 Osteoporosis Genistein 6.6619401787
MESH:D010024 Osteoporosis Raloxifene 6.6619059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.1516169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.1515758505 15579764 17823083 17893378
MESH:D012516 Osteosarcoma Doxorubicin 3.8615930896
MESH:D010049 Ovarian Diseases bisphenol A 4.6611985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.4516624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 17.4519401270
MESH:D010051 Ovarian Neoplasms Genistein 17.4519005980
MESH:D010051 Ovarian Neoplasms Progesterone 17.4516525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.4515276417 17306315
MESH:D010051 Ovarian Neoplasms Thalidomide 17.4516288038
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.8715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.8716540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.7712065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8619927285
MESH:D010291 Paresis Thalidomide 5.979200351
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.2716702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.0412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.042563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.0517031469
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.4210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4211896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.5820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.5820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 4.0719131511
MESH:D011471 Prostatic Neoplasms Azacitidine 4.0718324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.0717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 4.0716740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.0715897917 18437689 16729912 16868541 16888761 15749863
MESH:D011471 Prostatic Neoplasms Estradiol 4.0716740699
MESH:D011471 Prostatic Neoplasms Genistein 4.0715256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 4.0715721890
MESH:D011471 Prostatic Neoplasms Raloxifene 4.0716220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.0716039940
MESH:D011471 Prostatic Neoplasms Thalidomide 4.0716729912
MESH:D011536 Prurigo Thalidomide 5.9712755975
MESH:D011537 Pruritus Ethinyl Estradiol 2.9916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.4610548101
MESH:D011693 Purpura Raloxifene 5.2215770314
MESH:D051437 Renal Insufficiency Doxorubicin 3.9017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012509 Sarcoma Doxorubicin 3.7117203757 15625365 17710206 15675481 18313854 16767912
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.2516646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.2516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4617846226
MESH:D019873 Schnitzler Syndrome Thalidomide 5.6116096327
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3218551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 20.4419755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 20.4415692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 20.4412065085
MESH:D012878 Skin Neoplasms sodium arsenite 20.4418572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 20.448532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 20.4416192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2515625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9515862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5512854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.1417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.1420155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.1418456281
MESH:D013276 Stomach Ulcer Thalidomide 3.8915138204
MESH:D020521 Stroke Raloxifene 3.5716837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.6616045194 16684133
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.6215864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.1619014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.167505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.1617909728 16010429
MESH:D013964 Thyroid Neoplasms triadimefon 15.1617178689
MESH:D013978 Tibial Fractures Estradiol 12.6119048282
MESH:D013978 Tibial Fractures Raloxifene 12.6119048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 18.1516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.1520435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.1517053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.1517653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.1517572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.1516712894 16452187 11723127 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9910091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4911813266
MESH:D014591 Uterine Diseases bisphenol A 4.6814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6614692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 8.6618645019
MESH:D014605 Uveitis Cyclosporine 3.651336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.7315577323
MESH:D014652 Vascular Diseases sodium arsenite 11.0417056641
MESH:D014652 Vascular Diseases Thalidomide 11.0415741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9017334414 16364871 17638931 17678736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1117120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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