AutismKB 2.0

Annotation Detail for TMPRSS2


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Basic Information Top
Gene Symbol:TMPRSS2 ( FLJ41954,PP9284,PRSS10 )
Gene Full Name: transmembrane protease, serine 2
Band: 21q22.3
Quick LinksEntrez ID:7113; OMIM: 602060; Uniprot ID:TMPS2_HUMAN; ENSEMBL ID: ENSG00000184012; HGNC ID: 11876
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200102Regulation of Androgen receptor activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TMPRSS2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TMPRSS2 mRNAaffects expression 17562736
C109238 acyline acyline results in decreased expression of TMPRSS2 mRNAdecreases expression 17510436
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TMPRSS2 proteinaffects expression 20106945
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of TMPRSS2 mRNAdecreases expression 12711008
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of TMPRSS2 mRNAincreases expression 20601956
D013196 Dihydrotestosterone Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]decreases reaction|increases expression 20601956
D013196 Dihydrotestosterone merbarone inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]decreases reaction|increases expression 20601956
D013196 Dihydrotestosterone TOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]increases expression|increases reaction 20601956
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TMPRSS2 mRNAaffects expression 16483693
D000728 Androgens Androgens promotes the reaction [TOP2B protein results in increased mutagenesis of TMPRSS2 gene]increases mutagenesis|increases reaction 20601956
C006780 bisphenol A bisphenol A affects the expression of TMPRSS2 mRNAaffects expression 20170705
D003474 Curcumin Curcumin results in decreased expression of TMPRSS2 mRNAdecreases expression 18719366
D016572 Cyclosporine Cyclosporine results in decreased expression of TMPRSS2 mRNAdecreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMPRSS2 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TMPRSS2 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TMPRSS2 mRNAaffects expression 20170705
D005047 Etoposide Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]decreases reaction|increases expression 20601956
D005419 Flavonoids Flavonoids results in increased expression of TMPRSS2 mRNAincreases expression 18035473
C106014 gedunin gedunin results in decreased expression of TMPRSS2 mRNAdecreases expression 17010675
D019833 Genistein Genistein results in decreased expression of TMPRSS2 mRNAdecreases expression 15378649
C071834 glycidamide glycidamide results in decreased expression of TMPRSS2 mRNAdecreases expression 17822822
C045459 merbarone merbarone inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]decreases reaction|increases expression 20601956
C008493 methylselenic acid methylselenic acid affects the expression of TMPRSS2 mRNAaffects expression 14617803
D015741 Metribolone Metribolone results in decreased expression of TMPRSS2 mRNAdecreases expression 12711008
D015741 Metribolone Metribolone results in increased expression of TMPRSS2 mRNAincreases expression 17010675
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TMPRSS2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TMPRSS2 mRNAincreases expression 19482888
C011978 phentin acetate phentin acetate affects the expression of TMPRSS2 mRNAaffects expression 12711008
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMPRSS2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of TMPRSS2 mRNAdecreases expression 17426115
D011374 Progesterone Progesterone affects the expression of TMPRSS2 mRNAaffects expression 17251523
D012643 Selenium Selenium results in increased expression of TMPRSS2 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TMPRSS2 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TMPRSS2 mRNAincreases expression 19619570
C009424 tetramethrin tetramethrin results in increased expression of TMPRSS2 mRNAincreases expression 12711008
C050414 tripterine tripterine results in decreased expression of TMPRSS2 mRNAdecreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Estradiol 6.6911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6914692618
MESH:D000230 Adenocarcinoma Genistein 6.6911473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.8517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.8516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.8516835633
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8317887948
MESH:D000544 Alzheimer Disease Androgens 4.6417182789 17917157
MESH:D000544 Alzheimer Disease Curcumin 4.6415590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6816807698
MESH:D050197 Atherosclerosis Curcumin 3.1818704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Curcumin 4.2519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.9114601052
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0917868700
MESH:D001930 Brain Injuries Progesterone 4.0215380490 15845082 15665606
MESH:D002545 Brain Ischemia Curcumin 4.0916770732
MESH:D001932 Brain Neoplasms Curcumin 3.7317596214
MESH:D001943 Breast Neoplasms Androgens 4.5317018787
MESH:D001943 Breast Neoplasms bisphenol A 4.5317123778
MESH:D001943 Breast Neoplasms Curcumin 4.5319250217 16243823 18462866 18593918
MESH:D001943 Breast Neoplasms Estradiol 4.5316675129 12948864 19861407 17261762 17018787 14630087 17289903 18497071
MESH:D001943 Breast Neoplasms Etoposide 4.5316322251
MESH:D001943 Breast Neoplasms Genistein 4.5316873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 4.5316175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002277 Carcinoma Curcumin 7.6518593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.843084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.8412907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.8416924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.8417173139 1701930 20007298 6705139 20935162
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8918414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.6918462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.1416332659
MESH:D002386 Cataract Acetaminophen 2.4410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.0212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.0218566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Cyclosporine 12.3019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3015861022 16105132 17110522 11677210 17333356 17681005 16919318
MESH:D002779 Cholestasis pirinixic acid 12.3019176532
MESH:D002869 Chromosome Aberrations phentin acetate 6.9810477351
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0015668235 15340226 12621046 16354765 8697196
MESH:D003092 Colitis Curcumin 8.8716804969 18200517 16782535
MESH:D003092 Colitis Selenium 8.8717936198
MESH:D003103 Coloboma Curcumin 4.3318809619
MESH:D003110 Colonic Neoplasms Curcumin 3.7919359593 16340194
MESH:D003110 Colonic Neoplasms Genistein 3.7917182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.6518497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 20055451 10048152
MESH:D016638 Critical Illness Androgens 5.8116670151
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.8018403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8017107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.3518204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.3218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.3219923254 16109766 19420014 17906064 2444490 11287661 12594235 10915739 10774834 17522070 19370779 10663392 12392966 12540782 17562736 16081117 14986274 18713872 16485898 11739529 16393943 11529661 12958197 15968718 15619225 19739265 19085960 12705907 11834606 12153990 19164858 14725611 14550746 16781746 16177239 11461765 16227642 19416960 18071297 11743745 11421492
MESH:D056486 Drug-Induced Liver Injury Selenium 8.3215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8217351913
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.2517692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.3416402032
MESH:D016889 Endometrial Neoplasms Estradiol 6.9819148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 6.9811473722
MESH:D004715 Endometriosis Progesterone 8.2216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver Curcumin 16.9519297423
MESH:D005234 Fatty Liver Cyclosporine 16.9519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.9515345470
MESH:D005234 Fatty Liver pirinixic acid 16.9519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005355 Fibrosis Curcumin 13.3818705752
MESH:D005355 Fibrosis Cyclosporine 13.3812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.3820067830
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4518462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Curcumin 6.8617596214
MESH:D005909 Glioblastoma Genistein 6.8616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.4918829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.4520558911
MESH:D006333 Heart Failure Selenium 6.4517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Phenobarbital 12.9816109766
MESH:D006529 Hepatomegaly pirinixic acid 12.9819176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.9812621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8017701891
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D006561 Herpes Simplex Etoposide 4.3210809021
MESH:D006628 Hirsutism Androgens 5.8316914592 17019078
MESH:D006689 Hodgkin Disease Etoposide 3.6715147373 16200630 17606976 18180244 16135485
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5116870215
MESH:D017588 Hyperandrogenism Androgens 5.4817019078
MESH:D006937 Hypercholesterolemia Curcumin 3.8318704882
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006973 Hypertension Cyclosporine 4.6310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6318670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Curcumin 10.9416956363 18403477 17151092
MESH:D007249 Inflammation Flavonoids 10.9417296493
MESH:D007249 Inflammation Progesterone 10.9415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.9412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1118596194 18200517
MESH:D007251 Influenza, Human Selenium 3.9516624496
MESH:D007333 Insulin Resistance bisphenol A 11.4016393666
MESH:D007333 Insulin Resistance Estradiol 11.4016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.4016306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.0110783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.1615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.1618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.1615618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.6716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 11.2215610895
MESH:D007889 Leiomyoma Curcumin 4.3418555241
MESH:D007938 Leukemia Curcumin 6.1818462866
MESH:D007938 Leukemia Genistein 6.1817468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9816106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.5316106398
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7621047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.3918705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3912878042
MESH:D008107 Liver Diseases Acetaminophen 6.1619784758 12969438 11587558 16611625 12587719 19460945 19014921 16610002
MESH:D008107 Liver Diseases Curcumin 6.1616956363
MESH:D008107 Liver Diseases Phenobarbital 6.1619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0216871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 9.8915890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 9.8919812893 8742319 19073162 15975961 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 9.8915890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.8916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 8.948603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.9418308698 1399818 2563599 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.9412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.2914755239
MESH:D008175 Lung Neoplasms Curcumin 3.2918462866 19359593 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2919555203 11884234
MESH:D008223 Lymphoma Curcumin 7.3818462866
MESH:D008223 Lymphoma Etoposide 7.3812854902 12556972
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4516173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.0011408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.0014578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.0011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.0015318939
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008545 Melanoma Curcumin 2.3818462866 17885582
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008569 Memory Disorders Curcumin 3.9217263510
MESH:D008654 Mesothelioma Selenium 2.6915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009101 Multiple Myeloma Curcumin 3.3419372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009203 Myocardial Infarction Genistein 5.3317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.0917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6118551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1318495463
MESH:D009369 Neoplasms pirinixic acid 1.8317405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2812497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.5116427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 21.5111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.5116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.5114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.3818462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6718514411
MESH:D009765 Obesity Curcumin 4.3919297423
MESH:D009765 Obesity pirinixic acid 4.3920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2216049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010024 Osteoporosis Curcumin 6.8618719352
MESH:D010024 Osteoporosis Genistein 6.8619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Curcumin 10.6719020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 10.6719401270
MESH:D010051 Ovarian Neoplasms Genistein 10.6719005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.6716525653 17393432
MESH:D010146 Pain Acetaminophen 2.2016870215
MESH:D010190 Pancreatic Neoplasms Curcumin 8.2619196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms Etoposide 8.2619003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.2616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2912371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.292563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.6910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6911118676 11399792 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8220887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 18798265
MESH:D011471 Prostatic Neoplasms Androgens 2.0716998812 17909013 15389811
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0716740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.0710851300 18156803 11398177 18226269 18769126 15129424 12497104
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.0717172428
MESH:D011471 Prostatic Neoplasms Genistein 2.0715378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0716205645
MESH:D011537 Pruritus Ethinyl Estradiol 3.0716919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.3119168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8010666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7718045962
MESH:D012509 Sarcoma Curcumin 3.9018462866
MESH:D012512 Sarcoma, Ewing's Etoposide 4.4714601052
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3818551238
MESH:D012640 Seizures Phenobarbital 5.3811442880 4039156 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D018805 Sepsis Curcumin 3.8818389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6916709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0316503802 15862959
MESH:D013276 Stomach Ulcer Curcumin 3.2819188055 16631530
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.871399818
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.9116049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 4.9118593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.0218462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0710091137
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D014591 Uterine Diseases bisphenol A 4.7614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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