AutismKB 2.0

Annotation Detail for TNFAIP1


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Basic Information Top
Gene Symbol:TNFAIP1 ( B12,B61,EDP1,MGC2317,hBACURD2 )
Gene Full Name: tumor necrosis factor, alpha-induced protein 1 (endothelial)
Band: 17q11.2
Quick LinksEntrez ID:7126; OMIM: 191161; Uniprot ID:BACD2_HUMAN; ENSEMBL ID: ENSG00000109079; HGNC ID: 11894
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Malaria infection
systemic lupus erythematosus
IMMUNE
INFECTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TNFAIP1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of TNFAIP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TNFAIP1 mRNAaffects expression 17562736
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TNFAIP1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TNFAIP1 mRNAaffects cotreatment|affects expression 17602206
C006253 pirinixic acid pirinixic acid results in decreased expression of TNFAIP1 mRNAdecreases expression 17426115
C031280 pyrazole pyrazole results in increased expression of TNFAIP1 mRNAincreases expression 17945193
D012402 Rotenone Rotenone results in decreased expression of TNFAIP1 mRNAdecreases expression 19013527
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2417620307 19061943 18056438 17162532 16434500 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7019519916 16878318 19394651 19418558 19052882 20101231 18210153 20214788 17978847 17162532 3084413 16540662 17761372 16935385 19701751 16569478 17138121 20524982 18785209 19383236 19171122 19107877 11831363 18494052 16807293 20432363 19539802 16830150 17173139 16502159 18393292 19919837 17428255 16779866 20935162 18788625 16288022 20514400 18506893 19822196 20084675 18056438 10672840 20727157 18971187 19335982 3581430 16698587 20007298 10737359 21159647 19208518 18665156 16328049 18978308 16681979 20512989 18691550 17055752
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8514694615
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0117174075 7505956 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.7121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.7121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.7115619225 19085960 16393943 19416960 15968718 12540782 19420014 11421492 19164858 12153990 16485898 19739265 10774834 16781746 19370779 10915739 19923254 14725611 17562736 17522070 2444490 11287661 12392966 10663392 12594235 12705907 12958197 14986274 14550746 18713872 16081117 11743745 11739529 16227642 11529661 17906064 11834606 16177239 16109766 18071297 11461765
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.7119107877
MESH:D056486 Drug-Induced Liver Injury pyrazole 12.7112499123
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.5021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.5019236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 19772884 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1716705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418407596 18522880 19638242 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0812969438 16611625 19784758 16610002 19460945 11587558 12587719 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Clofibric Acid 7.9317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9310737359 19642983 12112319 21047994 19690152 19294768 19812893 20501860 20405173 20583210 19499222 19833225 19256749 18978307 20492335 20118626 19638242 2862719 20452335 19427195 19426721 18648771 21278145 21071580 18754104 19255062 12771043 19996281 9163691 15175105 18644402 19073162 20137499 18977376 2422723 20101389 19090486 19254457 19850985 15885732 16942905 20434301 21167192 19551842
MESH:D008113 Liver Neoplasms pirinixic acid 7.9320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7718775883 2563599 18544905 19539802 18079962 19009564 17942915 18093689 19126423 21159647 17174075 18282651 9362446 19519916 18164116 18253720 18308698 16842330 19004024 17854601 3124819 16267830
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 21163286 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009410 Nerve Degeneration Rotenone 4.0618619942 15790535 17356569
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9016049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.9014694615
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D010300 Parkinson Disease Rotenone 3.0519232380 15451049 11445065 19114014 11535288 18191903 18619942 16412576 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.3018197244 15927086 15795934 15574749
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013733 Testicular Diseases pyrazole 5.156499806
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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