AutismKB 2.0

Annotation Detail for TNFAIP2


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Basic Information Top
Gene Symbol:TNFAIP2 ( B94 )
Gene Full Name: tumor necrosis factor, alpha-induced protein 2
Band: 14q32
Quick LinksEntrez ID:7127; OMIM: 603300; Uniprot ID:TNAP2_HUMAN; ENSEMBL ID: ENSG00000185215; HGNC ID: 11895
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TNFAIP2 mRNAincreases expression 19933214
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of TNFAIP2 mRNAaffects expression 18343893
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of TNFAIP2 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of TNFAIP2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFAIP2 mRNAdecreases expression 19150397
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of TNFAIP2 mRNAdecreases expression 12760830
C423222 cotylenin A cotylenin A results in increased expression of TNFAIP2 mRNAincreases expression 16129123
D016572 Cyclosporine Cyclosporine results in increased expression of TNFAIP2 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of TNFAIP2 mRNAincreases expression 16129123
D004391 Dust Dust results in increased expression of TNFAIP2 mRNAincreases expression 17805423
D000431 Ethanol Ethanol results in decreased expression of TNFAIP2 mRNAdecreases expression 16098508
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TNFAIP2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNFAIP2 mRNAaffects cotreatment|increases expression 17942748
D009151 Mustard Gas Mustard Gas results in increased expression of TNFAIP2 mRNAincreases expression 15674844
C001478 N(6)-(delta(2)-isopentenyl)adenine N(6)-(delta(2)-isopentenyl)adenine results in increased expression of TNFAIP2 mRNAincreases expression 16129123
D037742 Nanotubes, Carbon Nanotubes, Carbon results in increased expression of TNFAIP2 mRNAincreases expression 15585362
C017557 nickel subsulfide nickel subsulfide results in decreased expression of TNFAIP2 mRNAdecreases expression 12760830
D010634 Phenobarbital Phenobarbital results in decreased expression of TNFAIP2 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of TNFAIP2 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TNFAIP2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of TNFAIP2 mRNAdecreases expression 18445702
D011374 Progesterone Progesterone affects the expression of TNFAIP2 mRNAaffects expression 17251523
D012643 Selenium Selenium results in increased expression of TNFAIP2 mRNAincreases expression 19244175
C009277 sodium arsenate sodium arsenate results in decreased expression of TNFAIP2 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of TNFAIP2 mRNAdecreases expression 12760830
12727804
C017947 sodium arsenite sodium arsenite results in increased expression of TNFAIP2 mRNAincreases expression 16014739
D013629 Tamoxifen Tamoxifen affects the expression of TNFAIP2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of TNFAIP2 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TNFAIP2 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TNFAIP2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNFAIP2 mRNAincreases expression 19933214
15328365
15800033
18796159
16611356
D024505 Tocopherols Tocopherols results in increased expression of TNFAIP2 mRNAincreases expression 17056531
D014212 Tretinoin Tretinoin results in increased expression of TNFAIP2 mRNAincreases expression 16129123
17218384
D002762 Cholecalciferol Cholecalciferol results in increased expression of TNFAIP2 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.9318926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.936195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.9315322242 14514962 11752688
MESH:D000138 Acidosis Ethanol 4.2711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7614692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.9617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.9616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.9616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0915451039 15451040
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9610965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D000853 Anophthalmos Ethanol 4.5915513904
MESH:D001008 Anxiety Disorders Ethanol 3.8311141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Mustard Gas 4.7410378619
MESH:D001249 Asthma Tretinoin 4.7416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.8116142846
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001768 Blister Mustard Gas 4.9319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.0816197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 4.0315665606 15845082 15380490
MESH:D001943 Breast Neoplasms Calcitriol 2.2611237771
MESH:D001943 Breast Neoplasms Progesterone 2.2617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 2.2621152245 11161223 19487384 18984771 20390343 18629630 15668708 18821012 17261762 16273361 17440819 18855134 20859285 19289846 17049068 18815881 19410462 19011961 21138602 17893378 19200415 18351453 19288272 19103187 16873071 15565566 19084267 19244106 20135344 19059307 16818667 18425577 19155303 19115204 20005174 17242785 19189210 20544844 18997820 20065188 19066611 16202921 19189212 19221464 19142967
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2616873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002056 Burns Ethanol 4.4316374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.893084413
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.8915763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.896705139 1701930 17173139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.8916507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.8916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.891917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.1911237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1918572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.1916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4217572228
MESH:D006332 Cardiomegaly Ethanol 6.4319332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4318850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 6.7810977129
MESH:D002386 Cataract Tretinoin 6.7817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.2712371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.2720056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Cyclosporine 12.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3815861022 17681005 16105132 11677210 17110522 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 12.3819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002971 Cleft Lip Ethanol 3.4715513904
MESH:D002972 Cleft Palate Ethanol 9.2915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.2912621046 8697196 15668235 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 9.299407595
MESH:D003092 Colitis Selenium 8.7517936198
MESH:D003092 Colitis Tretinoin 8.7517035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 5.2410194807 11198716 15513904 11873399 15451040 15451039 19302082
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.2410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.2417551590 9142499 9125849 9211117 8800419 9224671 10589399 16925845 9664655 14991402
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.2816227642 12540782 15968718 14725611 19420014 14550746 17906064 18713872 15619225 16781746 18071297 11461765 16393943 11743745 12958197 12153990 19164858 11529661 19370779 19416960 12392966 19739265 11421492 10663392 11287661 11739529 16485898 17562736 10915739 10774834 12594235 14986274 16081117 2444490 16177239 19923254 16109766 12705907 19085960 17522070 11834606
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.2811566570
MESH:D056486 Drug-Induced Liver Injury Selenium 11.2815131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 11.2818186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004421 Dystonia Phenobarbital 3.791851702
MESH:D004487 Edema Mustard Gas 10.2511428647 11428631 9260866 11402378
MESH:D004487 Edema pirinixic acid 10.2512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 20.1215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.1212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.1217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.1219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9517893378 19155303 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9516569247
MESH:D004715 Endometriosis Progesterone 8.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.883659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.356401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.793659116
MESH:D004890 Erythema Mustard Gas 4.939357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4220426865
MESH:D004938 Esophageal Neoplasms Ethanol 4.4216704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2816938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 22.4619224547
MESH:D005234 Fatty Liver Ethanol 22.4619236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.4615345470
MESH:D005234 Fatty Liver pirinixic acid 22.4619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 22.4614986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4317920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0715451040 10194807 16946407 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005355 Fibrosis Cyclosporine 13.4212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4220067830
MESH:D005355 Fibrosis Tretinoin 13.4217994277
MESH:D005756 Gastritis Acetaminophen 10.3616983495
MESH:D005756 Gastritis Ethanol 10.3615046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Tretinoin 2.8617312396
MESH:D018149 Glucose Intolerance sodium arsenate 4.8719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 10.5911294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.5914991402 9664655
MESH:D006333 Heart Failure pirinixic acid 6.4920558911
MESH:D006333 Heart Failure Selenium 6.4917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006529 Hepatomegaly Phenobarbital 13.0816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.0818467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0816120746 15340226 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.818697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 12.0416870215
MESH:D006930 Hyperalgesia Ethanol 12.0418783367
MESH:D006930 Hyperalgesia Tretinoin 12.0416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1417937319
MESH:D007248 Infertility, Male sodium arsenite 6.1415346721 12646999
MESH:D007249 Inflammation Mustard Gas 10.9911428620 9357497 16001271 17524151 11428631 8975870 11428647 11402378 9260866
MESH:D007249 Inflammation Progesterone 10.9915869954
MESH:D007249 Inflammation Tamoxifen 10.9919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.9912200463 12878042
MESH:D007251 Influenza, Human Selenium 3.9716624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4916306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007569 Jaw Abnormalities Ethanol 15.9915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.9916580747
MESH:D007569 Jaw Abnormalities Tretinoin 15.9917551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 13.3812587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 13.3816962696
MESH:D007674 Kidney Diseases Cyclosporine 13.388314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 13.3820008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.6816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6912371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.6918625569
MESH:D007859 Learning Disorders Ethanol 3.9915451040
MESH:D007938 Leukemia Tretinoin 2.6617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0416294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0116891316 17107899 19225113 19035177 12679006 9834237 19029980 16331271 16935935 19642359 19075265 16140955 17301526 17712046 17361223 16766008 17506722 17649720 16788101 17217047 17339181 16823087 17368321 17294898 15748426
MESH:D017880 Limb Deformities, Congenital Ethanol 7.7817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.789224671
MESH:D008064 Lipidoses Tamoxifen 2.9915342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 6.4315289165
MESH:D008103 Liver Cirrhosis Phenobarbital 6.4321047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8718295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.4118166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.7312587719 19784758 16610002 16611625 11587558 12969438 19460945 19014921
MESH:D008107 Liver Diseases Phenobarbital 3.7319363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4317207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 13.308742319 19812893 19073162 15975961 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 13.3016377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 13.3016712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 13.3016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.3016984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.3318308698 1399818 2563599 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3312151625
MESH:D008171 Lung Diseases Mustard Gas 7.0418161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.0419095001
MESH:D008175 Lung Neoplasms Mustard Gas 4.623148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 4.6217077188 16712894 15276417 19931552 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 4.6218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6211884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.1511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.1515318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.1514580682 11731420 16827153 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 13.1517927505
MESH:D020149 Manganese Poisoning Tamoxifen 4.3219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma sodium arsenite 4.8519082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.8519393235 12393984
MESH:D008545 Melanoma Tretinoin 4.8516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008569 Memory Disorders Ethanol 3.9715451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008654 Mesothelioma Selenium 6.3715107826
MESH:D008654 Mesothelioma Tocopherols 6.3715878867
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6518186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms pirinixic acid 7.5817405874
MESH:D009369 Neoplasms sodium arsenite 7.5811559025
MESH:D009369 Neoplasms Tretinoin 7.5816594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.789125849
MESH:D009436 Neural Tube Defects sodium arsenate 11.4211749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 11.4212854658
MESH:D009436 Neural Tube Defects Tretinoin 11.429142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D009503 Neutropenia Mustard Gas 3.7616761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D010051 Ovarian Neoplasms Progesterone 7.4916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.4915276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4916936753
MESH:D010146 Pain Acetaminophen 5.9816870215
MESH:D010146 Pain Tretinoin 5.9816870215
MESH:D010190 Pancreatic Neoplasms Ethanol 8.2012384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.2016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.2015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2711550810
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D011041 Poisoning Mustard Gas 3.5915727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3312371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.332563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9611896295 11222880 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5515572423
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9216644109 15754350 16289102 18247401 12479363
MESH:D011471 Prostatic Neoplasms Cholecalciferol 1.9217024972
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9215067354
MESH:D011471 Prostatic Neoplasms Tocopherols 1.9212504091
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.7615861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.7618058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2612752131
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8417720292 17894541 17266442 17620002 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures Ethanol 5.659754883
MESH:D012640 Seizures Phenobarbital 5.653137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D012871 Skin Diseases Mustard Gas 2.6616961503 15451306 12880345
MESH:D012878 Skin Neoplasms sodium arsenite 8.8118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7916709447
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.1116503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.1119457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D013274 Stomach Neoplasms Ethanol 2.5618456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.5617261132
MESH:D013276 Stomach Ulcer Ethanol 3.3311906479 9211565 17189318 9562338 17918041 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.069754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.631399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.8217306315 11723127 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.8216712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.7511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36592
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444818Lung Neoplasms
    Releated drug ID Related drug Name
    PA449383docetaxel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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