AutismKB 2.0

Annotation Detail for TNFAIP3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TNFAIP3 ( A20,MGC104522,MGC138687,MGC138688,OTUD7C,TNFA1P2 )
Gene Full Name: tumor necrosis factor, alpha-induced protein 3
Band: 6q23.3
Quick LinksEntrez ID:7128; OMIM: 191163; Uniprot ID:TNAP3_HUMAN; ENSEMBL ID: ENSG00000118503; HGNC ID: 11896
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04621NOD-like receptor signaling pathway
No data
Pathway IDPathway Name
200031CD40/CD40L signaling
200086TNF receptor signaling pathway
200026Canonical NF-kappaB pathway
Pathway IDPathway Name
P00054Toll receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
rheumatoid arthritis
atherosclerosis, coronary
CARDIOVASCULAR
Wegener's granulomatosis
Celiac Disease
systemic lupus erythematosus
IMMUNE
psoriasis
Desease Name
Rheumatoid arthritis
Celiac disease
Psoriasis
Systemic lupus erythematosus
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TNFAIP3 mRNAincreases expression 17547211
C026114 2-xylene 2-xylene results in increased expression of TNFAIP3 mRNAincreases expression 20359517
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNFAIP3 mRNA]decreases reaction|increases expression 16137721
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TNFAIP3 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of TNFAIP3 mRNAincreases expression 19774075
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of TNFAIP3 mRNAdecreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of TNFAIP3 mRNA]decreases expression|decreases reaction 12205029
D000965 Antimony Antimony results in increased expression of TNFAIP3 mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of TNFAIP3 mRNAincreases expression 17547211
C058317 arsenic disulfide arsenic disulfide results in increased expression of TNFAIP3 mRNAincreases expression 16918137
C006632 arsenic trioxide arsenic trioxide results in increased expression of TNFAIP3 mRNAincreases expression 18231732
17547211
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of TNFAIP3 mRNAincreases expression 18687144
D001554 Benzene Benzene results in increased expression of TNFAIP3 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TNFAIP3 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TNFAIP3 mRNAincreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TNFAIP3 mRNAincreases expression 15336504
D002104 Cadmium Cadmium results in increased expression of TNFAIP3 mRNAincreases expression 17547211
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of TNFAIP3 mRNAincreases expression 17547211
D002794 Choline Choline affects the expression of TNFAIP3 mRNAaffects expression 17616785
D002857 Chromium Chromium results in increased expression of TNFAIP3 mRNAincreases expression 17547211
D016572 Cyclosporine Cyclosporine results in increased expression of TNFAIP3 mRNAincreases expression 20106945
D002945 Cisplatin Cisplatin results in decreased expression of TNFAIP3 proteindecreases expression 16803524
D004041 Dietary Fats Dietary Fats results in increased expression of TNFAIP3 mRNAincreases expression 18042831
D004391 Dust Dust results in increased expression of TNFAIP3 mRNAincreases expression 17805423
D004958 Estradiol Estradiol results in increased expression of TNFAIP3 mRNAincreases expression 19153601
C004912 ethylbenzene ethylbenzene results in increased expression of TNFAIP3 mRNAincreases expression 20359517
D005472 Fluorouracil Fluorouracil results in increased expression of TNFAIP3 mRNAincreases expression 16557594
C056507 gemcitabine gemcitabine results in increased expression of TNFAIP3 mRNAincreases expression 17039268
C475919 hydroxytamoxifen GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of TNFAIP3 mRNA]affects reaction|increases expression 19153601
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of TNFAIP3 mRNAincreases expression 19153601
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TNFAIP3 mRNAincreases expression 20423518
D008070 Lipopolysaccharides phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]decreases reaction|increases expression 20423518
D047311 Luteolin Luteolin inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]decreases reaction|increases expression 15334063
D008628 Mercury Mercury results in increased expression of TNFAIP3 mRNAincreases expression 17547211
D008752 Methylene Chloride Methylene Chloride results in increased expression of TNFAIP3 mRNAincreases expression 20359517
C008493 methylselenic acid methylselenic acid affects the expression of TNFAIP3 mRNAaffects expression 14617803
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of TNFAIP3 mRNAincreases expression 16809437
D009151 Mustard Gas Mustard Gas results in increased expression of TNFAIP3 mRNAincreases expression 15674843
18955075
C029938 nickel sulfate nickel sulfate results in increased expression of TNFAIP3 mRNAincreases expression 16780908
C041786 palm oil palm oil results in increased expression of TNFAIP3 mRNAincreases expression 18042831
C058305 phenethyl isothiocyanate phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]decreases reaction|increases expression 20423518
D019800 Phenol Phenol results in increased expression of TNFAIP3 mRNAincreases expression 17547211
D010656 Phenylephrine Phenylephrine results in increased expression of TNFAIP3 proteinincreases expression 12900338
D011192 Potassium Dichromate Potassium Dichromate results in increased expression of TNFAIP3 mRNAincreases expression 17547211
D020849 Raloxifene Raloxifene results in decreased expression of TNFAIP3 mRNAdecreases expression 19429434
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNFAIP3 mRNAincreases expression 16704738
D014028 Tobacco Smoke Pollution Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNFAIP3 mRNA]decreases reaction|increases expression 16137721
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of TNFAIP3 mRNAincreases expression 16137721
D014050 Toluene Toluene results in increased expression of TNFAIP3 mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of TNFAIP3 mRNAincreases expression 20359517
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of TNFAIP3 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3715322242 14514962 11752688
MESH:D058186 Acute Kidney Injury Cisplatin 3.5315814532 12690470 17670903
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.9918653653 11850527
MESH:D055371 Acute Lung Injury nickel sulfate 7.9912718980 16100012 11954676 19131640
MESH:D000230 Adenocarcinoma arsenic trioxide 11.9611798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.9620127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 11.9617638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 11.9611473722
MESH:D000230 Adenocarcinoma Fluorouracil 11.9617638652
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.0315814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.366695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.8916835633
MESH:D000419 Albuminuria Raloxifene 4.1317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4215800139
MESH:D000740 Anemia Fluorouracil 7.2816511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D000741 Anemia, Aplastic Benzene 3.9911369114 17661222 14761424
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 7.7418057881 18218290 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 7.7417460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.4215238619
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 20453842 18794853
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.0619898480
MESH:D001249 Asthma Mustard Gas 2.5510378619
MESH:D050197 Atherosclerosis Cadmium 3.3515687053
MESH:D001281 Atrial Fibrillation Amiodarone 3.5419698954 18651412
MESH:D001321 Autistic Disorder Choline 2.8516818868
MESH:D001321 Autistic Disorder Mercury 2.8517497416
MESH:D001327 Autoimmune Diseases Mercury 4.4016634805
MESH:D001768 Blister Mustard Gas 4.6719167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 12.8619483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.8616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.8612125929
MESH:D001836 Body Weight Changes 2-xylene 10.457457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 10.4515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7316183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.3914601052
MESH:D001859 Bone Neoplasms Phenol 4.7610556009
MESH:D001913 Bowen's Disease Phenol 5.2519293009
MESH:D001919 Bradycardia Phenylephrine 4.0615306635
MESH:D001930 Brain Injuries Raloxifene 4.0016580743
MESH:D001943 Breast Neoplasms Benzene 8.8317162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.8320146248 17474063
MESH:D001943 Breast Neoplasms Chromium 8.8315986119
MESH:D001943 Breast Neoplasms Cisplatin 8.8318382427 19526202
MESH:D001943 Breast Neoplasms Dietary Fats 8.8320435547
MESH:D001943 Breast Neoplasms Estradiol 8.8316675129 12948864 17018787 17261762 17289903 19861407 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 8.8318608205 15136595 19217205 18357371 16557594 16110121 16595493
MESH:D001943 Breast Neoplasms gemcitabine 8.8317039268 18382427
MESH:D001943 Breast Neoplasms Methylene Chloride 8.8315986119
MESH:D001943 Breast Neoplasms Raloxifene 8.8317049068 16837676 17893378 17242785 15775269 17595753 17440819 17952589 15572757 16912660 15758505 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.8320435547
MESH:D001943 Breast Neoplasms Trichloroethylene 8.8315986119
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6715286001
MESH:D001991 Bronchitis Antimony 5.648768112
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4810378619 17687719
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8811589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1716051944
MESH:D002277 Carcinoma Fluorouracil 6.9017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9016835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 7.8312619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 7.8311135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 7.8317982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 7.8316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 7.8317971768 17045692 16332177 17088986 18930000 16799960
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.3012023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 5.3011212258
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3819014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.7718695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6912490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 12.5817015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.5820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 12.586189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.5817066447 16280240 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 12.5811212258
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6517572228
MESH:D006332 Cardiomegaly Phenylephrine 5.9311754973 16170337 15728586 17287366 11179087 17124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9316120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 8.6719225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Antimony 8.6710334427
MESH:D002311 Cardiomyopathy, Dilated Mercury 8.6710334427
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1115775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6018974383
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 13.2918226522
MESH:D002471 Cell Transformation, Neoplastic Cadmium 13.2917332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.2912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.2918566989
MESH:D002547 Cerebral Palsy Toluene 5.369294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7516835633
MESH:D002779 Cholestasis Cyclosporine 2.5519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8915340226 15668235 12621046 8697196 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.1415800139
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.4720423518
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1518772588 17725105 17287894 15001691 17169374 16510598 17018589 17172411 17016597 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.1920501625
MESH:D015179 Colorectal Neoplasms Cisplatin 3.1915273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.1917094418 18509181 14970324 16282729 18288408 16331619 15289873 18383874 18949393 15148649 17255274 17454858 17016601 16391804 17594712 18802399 20501625 17695437 16524972 16303861 18448328 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6517141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.9110525206
MESH:D019465 Craniofacial Abnormalities Benzene 4.9115643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 4.919294310
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.9619747007
MESH:D007644 Darier Disease Fluorouracil 4.3016733453
MESH:D003643 Death Toluene 5.176431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6515213294
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7517474826
MESH:D003872 Dermatitis Benzene 4.2915902427
MESH:D017449 Dermatitis, Allergic Contact Mercury 9.2316823706
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 9.2316823706 16780908 11298694
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 9.2316823706
MESH:D002658 Developmental Disabilities Choline 4.3416818868
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 3.9816684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5417107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.6519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 7.6515920148 17308373 17451421
MESH:D004283 Dog Diseases Antimony 5.1712019027
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 7.6911287661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 7.6918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.6920420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 7.697120509
MESH:D004362 Drug Toxicity Cisplatin 6.9612649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1018367378
MESH:D004487 Edema Mustard Gas 9.0511402378 9260866 11428631 11428647
MESH:D004487 Edema Raloxifene 9.0515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.0511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.5415845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.6619148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.609294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9115328337 17637181 15821434
MESH:D004890 Erythema Mustard Gas 4.679357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.1712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.1716530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.1716481741 15173087 16785472 15464296 17638652
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.1716785472 15173087 16481741 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6511564622
MESH:D005234 Fatty Liver Amiodarone 20.0614986274
MESH:D005234 Fatty Liver arsenic trioxide 20.0615073043
MESH:D005234 Fatty Liver Cyclosporine 20.0619224547
MESH:D005234 Fatty Liver Dietary Fats 20.0617967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Raloxifene 20.0617473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D005334 Fever Lipopolysaccharides 3.5911852909 9205823
MESH:D005355 Fibrosis Cyclosporine 11.9812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 11.9818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.9820067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8016904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.738708960
MESH:D005910 Glioma Fluorouracil 2.6616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 6.8715102660 15464296
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.8715162350 18337622 15102660
MESH:D034381 Hearing Loss Cisplatin 3.8919898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0215464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.5411294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.1911110106
MESH:D006402 Hematologic Diseases Benzene 4.2016183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9315720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006529 Hepatomegaly 2-xylene 11.957457013 7457028
MESH:D006529 Hepatomegaly Amiodarone 11.9515265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.9512621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D006689 Hodgkin Disease Cisplatin 3.2016170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5516959395 16354765 8697196 18606429 15340226
MESH:D006937 Hypercholesterolemia Amiodarone 7.729751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 7.7221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.1721332399
MESH:D006973 Hypertension Benzene 14.1817940673
MESH:D006973 Hypertension Cyclosporine 14.1810903974
MESH:D006973 Hypertension Phenylephrine 14.1812717712 8949925
MESH:D006973 Hypertension Raloxifene 14.1815787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 14.1818850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.1218502941 12791704
MESH:D007037 Hypothyroidism Amiodarone 4.0417991464 18020914
MESH:D007249 Inflammation Dietary Fats 13.0020412841
MESH:D007249 Inflammation Lipopolysaccharides 13.0017237260 17255318 9205823 17963957 12878042
MESH:D007249 Inflammation Mustard Gas 13.0011428631 8975870 11428647 17524151 11402378 9260866 16001271 9357497 11428620
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.0012878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 13.0018590791
MESH:D007333 Insulin Resistance Dietary Fats 6.2811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.2816393666 16627594
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1817255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9415604871
MESH:D055623 Keratosis, Actinic Phenol 5.9519293009
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.6415464296
MESH:D007674 Kidney Diseases Cadmium 28.7816322080 16226777 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 28.7816962696
MESH:D007674 Kidney Diseases Chromium 28.7817934191
MESH:D007674 Kidney Diseases Cisplatin 28.7812231392 18289764 19839026 15190930 12649298
MESH:D007674 Kidney Diseases Cyclosporine 28.788314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 28.7815618244
MESH:D007674 Kidney Diseases Mercury 28.7817934191
MESH:D007674 Kidney Diseases Potassium Dichromate 28.7819665454
MESH:D007680 Kidney Neoplasms Cyclosporine 10.1212371664
MESH:D007680 Kidney Neoplasms Estradiol 10.1215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 10.1216985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3011231351
MESH:D007889 Leiomyoma Raloxifene 4.0516973256
MESH:D007896 Leishmaniasis Antimony 4.4010953559 15220340 21063981 12019027 21182181
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.278889330 11475954 19141829
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.0010651420 10881086 11370249 7854095 9643325
MESH:D007898 Leishmaniasis, Visceral Antimony 7.491899875 7554475 20495762 11105143 8142506 7875148 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 7.4912707265
MESH:D007938 Leukemia arsenic trioxide 5.7015070760
MESH:D007938 Leukemia Benzene 5.7017119257 18335105 15935818 14694614
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.3612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 7.7012421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.7014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.2519077051
MESH:D007951 Leukemia, Myeloid Benzene 8.2517506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7516467208 20471514 19850784 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.7519478238
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 7.049834237
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0417217047 15336539 16823087 17107899 12679006 17712046 11161223 9834237 16966277 15748426 16891316 12018890 19225113 16112521 17649720 12712474 16330433 19642359 17869043 11468182 19075265 16331271 15622746 19035177 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8916882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.2115821434
MESH:D008064 Lipidoses Amiodarone 3.1617567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.6018296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.1114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.1112878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.1112878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 12.0218177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 12.0214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 12.0221137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 12.0215113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.0216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.338603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.3320377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 15.3312562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.3312151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 15.337955063
MESH:D008133 Long QT Syndrome Amiodarone 6.9517391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 6.9515213294
MESH:D008171 Lung Diseases Acetylcysteine 10.5712815614
MESH:D008171 Lung Diseases Amiodarone 10.5712587719
MESH:D008171 Lung Diseases Mustard Gas 10.5718161513 18702808
MESH:D017563 Lung Diseases, Interstitial Amiodarone 9.8118516814
MESH:D017563 Lung Diseases, Interstitial Benzene 9.8114698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 7.7317365036
MESH:D055370 Lung Injury Lipopolysaccharides 7.7321114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 16.2114755239
MESH:D008175 Lung Neoplasms arsenic trioxide 16.2119825857 11798837
MESH:D008175 Lung Neoplasms Benzene 16.2112562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 16.2120064080 20464547 18816296 17053015 20869020 20135361 18569708 18520028 6695378
MESH:D008175 Lung Neoplasms Cisplatin 16.2117225452 11798837 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 16.2115246190
MESH:D008175 Lung Neoplasms Methylene Chloride 16.2115172992
MESH:D008175 Lung Neoplasms Mustard Gas 16.218781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.2119555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 16.2112111688 16288123 11091918 3440675
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3015086387
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 18677310 19165918 21336280 19838193
MESH:D008223 Lymphoma Benzene 3.3917584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 3.9612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 5.1611921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.1611807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 3.9919453300
MESH:D008545 Melanoma Cisplatin 2.4017761969 18332650 16248763 18505091 17023156 16809738 15577323 12374674 18176117 16432458 11135225 12393984 12883367
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.2915990972
MESH:D008607 Mental Retardation Toluene 3.479294310
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.7816966607 16166281 18303189
MESH:D008654 Mesothelioma Cisplatin 5.7817638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2916801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0615863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.021613127
MESH:D019957 Motor Skills Disorders Toluene 4.789294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.2916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.2918986760 16757204
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 12.2915006635
MESH:D009101 Multiple Myeloma arsenic trioxide 10.1719417148 15949261 11468182 19549372 14977855
MESH:D009101 Multiple Myeloma Benzene 10.1717119195
MESH:D009101 Multiple Myeloma Raloxifene 10.1716497877
MESH:D009181 Mycoses Amiodarone 4.4017974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.8516882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9116810080
MESH:D009232 Myxoma Raloxifene 5.0616343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5016624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 3.3714720322
MESH:D009369 Neoplasms Benzo(a)pyrene 9.8111141357
MESH:D009369 Neoplasms Cisplatin 9.8116773208
MESH:D009369 Neoplasms Fluorouracil 9.8118239605 16928823 18600527
MESH:D009369 Neoplasms Trichloroethylene 9.8111911487
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0015464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 7.9311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.9314600291
MESH:D009436 Neural Tube Defects Acetylcysteine 10.4619446573
MESH:D009436 Neural Tube Defects arsenic trioxide 10.4610525206
MESH:D009436 Neural Tube Defects Benzene 10.4615643154
MESH:D009447 Neuroblastoma Cisplatin 3.188761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.218761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1016436463
MESH:D009503 Neutropenia Mustard Gas 3.537688884 16761898
MESH:D009765 Obesity Dietary Fats 2.1518674790 20132043 19632207 20518802 18457598 16723640 11836018 17217161 21332399
MESH:D009784 Occupational Diseases Benzene 3.7615913788 15727169 17178637 15612468 15576619 17119257 16737584 15935809 17479406
MESH:D010024 Osteoporosis Raloxifene 3.0915775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.7817893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.1112452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Benzene 13.1112562636
MESH:D010051 Ovarian Neoplasms Cisplatin 13.116897625 17225452 19769630 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 13.1119401270
MESH:D010051 Ovarian Neoplasms Luteolin 13.1119005980
MESH:D010146 Pain Phenol 3.8117610455
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 10.7715580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 10.7719003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.7716929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 10.7716929163 11504793 18992248 17440100 18383843
MESH:D010235 Paraganglioma arsenic trioxide 3.7119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D010392 Pemphigus Phenol 5.9517163923 16522979
MESH:D010409 Penile Diseases Antimony 5.269643325
MESH:D010493 Pericarditis Antimony 5.6220465667
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.8515464296
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8915687053
MESH:D010864 Pilonidal Sinus Phenol 5.9515622588 19655223
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.4210923243
MESH:D010997 Pleural Neoplasms Cisplatin 4.8517638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.0711605937 12224865
MESH:D011041 Poisoning Mustard Gas 7.6715727166
MESH:D011041 Poisoning Phenol 7.678825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.8112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7111896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0117292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.0117075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.0116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0118626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0116205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0116536755 16220300 15731164
MESH:D011537 Pruritus Mustard Gas 3.6118058305
MESH:D011565 Psoriasis marker/mechanism 20953190 19169254
MESH:D011565 Psoriasis Cyclosporine 2.0416882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 8.1312832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.1317975199 17322281 15814490 17365031
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.1317620002 17266442 17720292 17894541 10334151
MESH:D011693 Purpura Raloxifene 5.0615770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6016160472 18722050 18286688 15538739
MESH:D051437 Renal Insufficiency Cisplatin 3.9315464296
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.0812210543
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4010835634
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.1518410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.8116646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 8.8114601052
MESH:D012640 Seizures Toluene 3.406431079 9294310
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6018724381
MESH:D012852 Sinusitis Phenylephrine 4.227327846
MESH:D012871 Skin Diseases Mustard Gas 2.5715451306 16961503 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.5310029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 11.538532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.5316192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 11.5318590791
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.8515464296
MESH:D013088 Spermatocele Phenol 5.1418646496
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.7317007042
MESH:D013274 Stomach Neoplasms Benzene 5.7312562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.732093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 5.7317522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Fluorouracil 5.7317522103 19084572 18396642 15786421 19015929 17498489 16951190 17172411 18567086 16424979
MESH:D013276 Stomach Ulcer Acetylcysteine 6.2417918041
MESH:D013276 Stomach Ulcer Amiodarone 6.2418087811
MESH:D020521 Stroke Raloxifene 3.4416837676
MESH:D013610 Tachycardia Amiodarone 3.8311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7319225199
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 9.2915864552
MESH:D013733 Testicular Diseases Toluene 9.2910048760 10514026
MESH:D013736 Testicular Neoplasms Cisplatin 4.1815464296 17225452
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7415821434
MESH:D013953 Thymus Neoplasms Benzene 4.4710850423
MESH:D013959 Thyroid Diseases Amiodarone 10.4019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.4012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.7219014326
MESH:D013971 Thyrotoxicosis Amiodarone 4.3818020914 19584973
MESH:D013978 Tibial Fractures Estradiol 12.0619048282
MESH:D013978 Tibial Fractures Raloxifene 12.0619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.5716280240
MESH:D016171 Torsades de Pointes Amiodarone 8.6411989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 8.6415213294
MESH:D014277 Trigeminal Neuralgia Phenol 5.9516527771 10223447
MESH:D014352 Trypanosomiasis Antimony 5.4315220340
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.5511780464 12845720 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.5517053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 13.5512973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 13.5517572228
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 13.5512846360
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.2416803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.2416803524
MESH:D014594 Uterine Neoplasms Benzene 3.8712562636
MESH:D014605 Uveitis Cyclosporine 3.491336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.1315577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7116837676
MESH:D014839 Vomiting Cisplatin 4.2211897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0616343187
MESH:D014860 Warts Phenol 5.6019122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D015430 Weight Gain Dietary Fats 3.3316723640
MESH:D014985 Xerophthalmia Cyclosporine 3.9417120751
Pathway ID Pathway Name
KEGG:05162 Measles
KEGG:04621 NOD-like receptor signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36593
    • No data
    Releated disease ID Related disease Name
    PA445451Psoriasis
    PA444822Lupus Erythematosus, Systemic
    PA444822Lupus Erythematosus, Systemic
    PA445451Psoriasis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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