AutismKB 2.0

Annotation Detail for C1QB


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Basic Information Top
Gene Symbol:C1QB ( - )
Gene Full Name: complement component 1, q subcomponent, B chain
Band: 1p36.12
Quick LinksEntrez ID:713; OMIM: 120570; Uniprot ID:C1QB_HUMAN; ENSEMBL ID: ENSG00000173369; HGNC ID: 1242
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05142Chagas disease
hsa05322Systemic lupus erythematosus
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
Pathway IDPathway Name
Signaling in Immune system
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Immune system diseases
Primary immunodeficiency
H00102Classic complement pathway component defects
No data
No data
No data
Desease Name
C1q deficiency, type B
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of C1QB mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of C1QB mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of C1QB mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of C1QB mRNAdecreases expression 17103032
C006632 arsenic trioxide arsenic trioxide results in increased expression of C1QB mRNAincreases expression 19128835
C095105 bexarotene bexarotene results in increased expression of C1QB mRNAincreases expression 16648578
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA]decreases reaction|increases expression 18200517
D004041 Dietary Fats Dietary Fats results in decreased expression of C1QB mRNAdecreases expression 18042831
D004958 Estradiol Estradiol affects the expression of C1QB mRNAaffects expression 15598610
D000431 Ethanol Ethanol results in decreased expression of C1QB mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of C1QB mRNAaffects cotreatment|increases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of C1QB mRNAincreases expression 12072388
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C1QB mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of C1QB mRNAincreases expression 15834898
C056933 fumonisin B1 fumonisin B1 results in increased expression of C1QB mRNAincreases expression 16221962
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of C1QB mRNAincreases expression 15159207
C030589 methylmercury cysteine methylmercury cysteine results in decreased expression of C1QB mRNAdecreases expression 19465457
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of C1QB mRNAincreases expression 15120970
C029938 nickel sulfate nickel sulfate results in decreased expression of C1QB mRNAdecreases expression 16780908
C025589 ochratoxin A ochratoxin A results in increased expression of C1QB mRNAincreases expression 16251485
C041786 palm oil palm oil results in decreased expression of C1QB mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of C1QB mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of C1QB mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of C1QB mRNAdecreases expression 17426115
D020849 Raloxifene Raloxifene affects the expression of C1QB mRNAaffects expression 16079270
D012643 Selenium Selenium results in increased expression of C1QB mRNAincreases expression 19244175
D013311 Streptozocin Streptozocin results in increased expression of C1QB mRNAincreases expression 16684804
D013311 Streptozocin vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C1QB mRNA]decreases reaction|increases expression 16684804
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of C1QB mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of C1QB mRNAdecreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of C1QB mRNAincreases expression 16960034
C015559 trimellitic anhydride trimellitic anhydride results in increased expression of C1QB mRNAincreases expression 16141432
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNAincreases expression 17982090
18200517
C034028 vanadyl sulfate vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C1QB mRNA]decreases reaction|increases expression 16684804
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.9318926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.936195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.9315322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 9.7118287403
MESH:D000138 Acidosis Ethanol 9.7111192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury nickel sulfate 8.4416100012 11954676 19131640 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 8.4418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6911798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.6911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.623712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.9617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.9616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.9616835633
MESH:D000419 Albuminuria Raloxifene 4.3817308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0915451039 15451040
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8517887948
MESH:D000544 Alzheimer Disease Curcumin 4.2615590663
MESH:D000544 Alzheimer Disease Raloxifene 4.2615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D000853 Anophthalmos Ethanol 4.5915513904
MESH:D001008 Anxiety Disorders Ethanol 3.8311141031
MESH:D001161 Arteriosclerosis Dietary Fats 9.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6816807698
MESH:D001249 Asthma trimellitic anhydride 3.8616141432
MESH:D050197 Atherosclerosis Curcumin 3.1918704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Curcumin 4.2719761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7911289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.0916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D001930 Brain Injuries Raloxifene 4.2516580743
MESH:D002545 Brain Ischemia Curcumin 4.1016770732
MESH:D001932 Brain Neoplasms Curcumin 3.7417596214
MESH:D001943 Breast Neoplasms bexarotene 4.5516344269 16818667
MESH:D001943 Breast Neoplasms Curcumin 4.5519250217 18593918 16243823 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 4.5520435547
MESH:D001943 Breast Neoplasms Estradiol 4.5517261762 12948864 19861407 14630087 17018787 18497071 16675129 17289903
MESH:D001943 Breast Neoplasms Hexachlorobenzene 4.5512709520 15061365
MESH:D001943 Breast Neoplasms ochratoxin A 4.5511921183
MESH:D001943 Breast Neoplasms Raloxifene 4.5517049068 15775269 17242785 17893378 16837676 15572757 17595753 17261762 17440819 15758505 17952589 16912660
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1211589617
MESH:D002056 Burns Ethanol 4.4316374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002276 Carcinoid Tumor Streptozocin 5.3716051944
MESH:D002277 Carcinoma Curcumin 7.6918593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 10.887296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.883084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.8815553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.8816924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.8815763234 15289165 18788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.8817173139 6705139 20007298 20935162 1701930
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.5816247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.5818414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.577296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9212490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.7018462866
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8717572228
MESH:D006332 Cardiomegaly Ethanol 6.4319332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4316120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2915775269
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.447505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4418566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 10.442727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.419022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4117110522 17681005 17333356 16105132 11677210 15861022 16919318
MESH:D002779 Cholestasis pirinixic acid 12.4119176532
MESH:D002971 Cleft Lip Ethanol 3.4715513904
MESH:D002972 Cleft Palate Ethanol 5.6315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.638697196 15340226 16354765 12621046 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.3915800139
MESH:D003092 Colitis Curcumin 14.8616782535 18200517 16804969
MESH:D003092 Colitis Selenium 14.8617936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 14.8618023891 16804969 17936198 16782535 11698051 18200517 16867261 16474422 17991707
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3717276891
MESH:D003103 Coloboma Curcumin 4.3418809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4719359593 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.6718497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.2710525206
MESH:D019465 Craniofacial Abnormalities Ethanol 5.2711198716 15451040 10194807 19302082 15513904 15451039 11873399
MESH:D019465 Craniofacial Abnormalities ochratoxin A 5.2720036863
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2710048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8815213294
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9717474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.4111906362 8970840 2524372 18759878 12868966 14531868 8156756 11298694
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.4116780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.283621924 2952479
MESH:D003920 Diabetes Mellitus Streptozocin 4.5416285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.4415862027 19960420 2177838 17442507 16684804 1374869 12446591 12644472 11055810 12093613 12083368 7637645 15298345 18715473 16286809 19298542 17874149 18603373 11260395 8740154 6379147 15831366 19496084 19586609
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 8.4416684804
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5618603373
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.9518403477
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 6.9519647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9517107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.5016025228
MESH:D003928 Diabetic Nephropathies Curcumin 19.9218204486
MESH:D003928 Diabetic Nephropathies Estradiol 19.9219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 19.9217451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Streptozocin 19.9219960420 19682444
MESH:D003930 Diabetic Retinopathy Streptozocin 5.2117662242
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.351440618 9328219 16192314 18692083 9653073 18289764 6679447 11289319 8291058 9022650 7440962 6482804 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.3519370779 12705907 12392966 16781746 14986274 11421492 16393943 14725611 16109766 17522070 11834606 19416960 16227642 11461765 19085960 15968718 16177239 18071297 10774834 12958197 17562736 10663392 16081117 12540782 16485898 11529661 19420014 2444490 11287661 15619225 17906064 11739529 14550746 19923254 18713872 19164858 12153990 19739265 11743745 12594235 10915739
MESH:D056486 Drug-Induced Liver Injury Ethanol 14.3511566570
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 14.3516221962
MESH:D056486 Drug-Induced Liver Injury Selenium 14.3515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.3520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8317351913
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004421 Dystonia Phenobarbital 3.791851702
MESH:D004487 Edema pirinixic acid 10.2512083418
MESH:D004487 Edema Raloxifene 10.2515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.3915845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.8311473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.883659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.356401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.793659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.963581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9612903497
MESH:D004938 Esophageal Neoplasms Ethanol 6.9616704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver arsenic trioxide 33.8215073043
MESH:D005234 Fatty Liver Curcumin 33.8219297423
MESH:D005234 Fatty Liver Dietary Fats 33.8217967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Ethanol 33.8218620774 16409862 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.8215345470
MESH:D005234 Fatty Liver pirinixic acid 33.8219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 33.8217473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0716946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D005355 Fibrosis Curcumin 19.3718705752
MESH:D005355 Fibrosis Dietary Fats 19.3718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.3720067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 19.3717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0416904648
MESH:D005756 Gastritis Acetaminophen 10.3616983495
MESH:D005756 Gastritis Ethanol 10.3615046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4718462866
MESH:D005909 Glioblastoma Curcumin 3.3317596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.5018462866 18829502
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2111294989 10048152
MESH:D006331 Heart Diseases Raloxifene 7.6111110106
MESH:D006331 Heart Diseases Streptozocin 7.6112093613
MESH:D006333 Heart Failure pirinixic acid 6.4920558911
MESH:D006333 Heart Failure Selenium 6.4917162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.306705139
MESH:D006529 Hepatomegaly fumonisin B1 18.8516221962
MESH:D006529 Hepatomegaly Phenobarbital 18.8516109766
MESH:D006529 Hepatomegaly pirinixic acid 18.8516221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.8515340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8117701891
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116354765 18606429 8697196 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.2216870215
MESH:D006930 Hyperalgesia Ethanol 7.2218783367
MESH:D006937 Hypercholesterolemia Curcumin 8.5518704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.5521332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Raloxifene 4.9415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D007105 Immune Complex Diseases marker/mechanism
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3417937319
MESH:D007249 Inflammation Curcumin 7.6617151092 16956363 18403477
MESH:D007249 Inflammation Dietary Fats 7.6620412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6612878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.3818596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.3818200517
MESH:D007251 Influenza, Human Selenium 3.9716624496
MESH:D007333 Insulin Resistance Dietary Fats 11.4411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.4416627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.4416306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.3817994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.0210783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.799022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 9.4415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 13.4812587719 15629191
MESH:D007674 Kidney Diseases Estradiol 13.4815618244
MESH:D007674 Kidney Diseases ochratoxin A 13.4811409539
MESH:D007674 Kidney Diseases Streptozocin 13.4812093613
MESH:D007676 Kidney Failure, Chronic Selenium 3.6816518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.546582329
MESH:D007680 Kidney Neoplasms Estradiol 11.5415610895
MESH:D007680 Kidney Neoplasms ochratoxin A 11.5416251485
MESH:D007859 Learning Disorders Ethanol 3.9915451040
MESH:D007889 Leiomyoma Curcumin 10.4518555241
MESH:D007889 Leiomyoma Raloxifene 10.4516973256
MESH:D007938 Leukemia arsenic trioxide 6.1415070760
MESH:D007938 Leukemia Curcumin 6.1418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.0817077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.0816106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1016467208 16968895 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0719035177 19225113 9834237 15213294 15336539 15622746 16330433 11161223 15748426 17649720 17217047 12679006 16331271 16891316 17712046 17869043 17107899 16823087 11468182 12018890 19075265 16966277 16112521 19642359 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.9816882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.9816106398
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6517676605
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3818296743
MESH:D008103 Liver Cirrhosis Ethanol 10.3815289165
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3821047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8718295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.069327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.4217355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.4218166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4212878042
MESH:D008107 Liver Diseases Acetaminophen 6.1919460945 19784758 19014921 16610002 12969438 11587558 12587719 16611625
MESH:D008107 Liver Diseases Curcumin 6.1916956363
MESH:D008107 Liver Diseases Phenobarbital 6.1919363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4317347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0417185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 9.9514682389
MESH:D008113 Liver Neoplasms Phenobarbital 9.9519073162 19812893 21047994 8742319 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 9.9520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.9516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.166587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.1620377131
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 17.161423854
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.1618308698 2563599 1399818 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.1612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.6611798837 19825857
MESH:D008175 Lung Neoplasms bexarotene 4.6617849452
MESH:D008175 Lung Neoplasms Curcumin 4.6619359593 16243823 18462866
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6611884234 19555203
MESH:D008223 Lymphoma Curcumin 3.4318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4716173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 13.1719196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.1717203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 13.1711921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.1715318939
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008545 Melanoma Curcumin 2.3817885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008569 Memory Disorders Curcumin 9.0317263510
MESH:D008569 Memory Disorders Ethanol 9.0318411066 15451040
MESH:D008654 Mesothelioma Selenium 2.7015107826
MESH:D008850 Microphthalmos ochratoxin A 5.5720036863
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.6617671175
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3215863610
MESH:D009101 Multiple Myeloma arsenic trioxide 11.2719417148 11468182 15949261 14977855 19549372
MESH:D009101 Multiple Myeloma Curcumin 11.2719372569
MESH:D009101 Multiple Myeloma Raloxifene 11.2716497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6917962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0116105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:D009232 Myxoma Raloxifene 5.3216343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.6016624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.6018495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.383581430
MESH:D009369 Neoplasms pirinixic acid 1.8417405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.3619196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.3612497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009421 Nervous System Malformations Estradiol 8.7411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7414600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4018462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.466679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.4610525206
MESH:D009436 Neural Tube Defects ochratoxin A 11.4620036863
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D009765 Obesity Curcumin 7.0919297423
MESH:D009765 Obesity Dietary Fats 7.0921332399 20132043 18674790 11836018 17217161 19632207 20518802 18457598 16723640
MESH:D009765 Obesity pirinixic acid 7.0920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.224026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D010024 Osteoporosis Curcumin 6.9518719352
MESH:D010024 Osteoporosis Raloxifene 6.9515775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0217823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5116624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 7.5118462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 7.5119401270
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.6915580305
MESH:D010190 Pancreatic Neoplasms Curcumin 11.6917440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Ethanol 11.6912384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.6916965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9917698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010235 Paraganglioma arsenic trioxide 3.9519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 10.379918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.3718163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.432563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9611399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1519131511
MESH:D011471 Prostatic Neoplasms Curcumin 2.1510851300 18226269 18769126 11398177 15129424 18156803 12497104
MESH:D011471 Prostatic Neoplasms Estradiol 2.1516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1516536755 15731164 16220300
MESH:D011537 Pruritus Ethinyl Estradiol 3.0916919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.2612752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.3319168576
MESH:D011693 Purpura Raloxifene 5.3215770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8218379247 10666014
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 4.7220219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012509 Sarcoma Curcumin 3.9218462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7416646077
MESH:D012640 Seizures Ethanol 5.659754883
MESH:D012640 Seizures Phenobarbital 5.6511442880 4039156 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D018805 Sepsis Curcumin 3.8918389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5917007042
MESH:D013274 Stomach Neoplasms Ethanol 2.5918456281
MESH:D013276 Stomach Ulcer Curcumin 6.8816631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 6.8817918041 16755016 11906479 9211565 17189318 9562338
MESH:D020521 Stroke Raloxifene 3.6416837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.069754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.976582329 3712494 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.9719014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.971399818
MESH:D013978 Tibial Fractures Estradiol 12.9419048282
MESH:D013978 Tibial Fractures Raloxifene 12.9419048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7315213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.238074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.2320435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.2318593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.2317572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.0318462866
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
Pathway ID Pathway Name
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:04610 Complement and coagulation cascades
KEGG:05020 Prion diseases
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25623
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA450287magnesium
    PA137179528nimesulide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00002 - Cetuximab Antineoplastic Agents
    DB00005 - Etanercept Antirheumatic Agents;Immunomodulatory Agents
    DB00051 - Adalimumab Antirheumatic Agents;Immunomodulatory Agents
    DB00054 - Abciximab Anticoagulants;Antiplatelet Agents
    DB00056 - Gemtuzumab ozogamicin Antineoplastic Agents
    DB00072 - Trastuzumab Antineoplastic Agents
    DB00073 - Rituximab Antineoplastic Agents
    DB00074 - Basiliximab Immunomodulatory Agents;Immunosuppressive Agents
    DB00075 - Muromonab Immunomodulatory Agents;Immunosuppressive Agents
    DB00078 - Ibritumomab Antineoplastic Agents
    DB00081 - Tositumomab Antineoplastic Agents
    DB00087 - Alemtuzumab Antineoplastic Agents
    DB00092 - Alefacept Immunomodulatory Agents;Immunosuppressive Agents
    DB00095 - Efalizumab Immunomodulatory Agents;Immunosuppressive Agents
    DB00108 - Natalizumab Immunomodulatory Agents
    DB00110 - Palivizumab Antiviral Agents
    DB00111 - Daclizumab Immunomodulatory Agents;Immunosuppressive Agents
    DB00112 - Bevacizumab Antineoplastic Agents;Antiangiogenesis Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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