AutismKB 2.0

Annotation Detail for TNNT2


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Basic Information Top
Gene Symbol:TNNT2 ( CMH2,CMPD2,LVNC6,MGC3889,RCM3,TnTC,cTnT )
Gene Full Name: troponin T type 2 (cardiac)
Band: 1q32.1
Quick LinksEntrez ID:7139; OMIM: 191045; Uniprot ID:TNNT2_HUMAN; ENSEMBL ID: ENSG00000118194; HGNC ID: 11949
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Muscle contraction
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Cardiac diseases
H00294Dilated cardiomyopathy (DCM)
H00292Hypertrophic cardiomyopathy (HCM)
No data
Desease Name
CARDIOVASCULAR
left ventricular hypertrophy
cardiomyopathy
No data
Desease Name
Cardiomyopathy, familial restrictive, 3
Cardiomyopathy, familial hypertrophic, 2
Cardiomyopathy, dilated, 1D
Left ventricular noncompaction 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of TNNT2 mRNAincreases expression 20713471
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TNNT2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TNNT2 mRNAincreases expression 14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TNNT2 mRNAaffects expression 17484886
C016299 chelerythrine chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein]decreases reaction|increases phosphorylation 12003851
D004317 Doxorubicin [Doxorubicin co-treated with MT2A protein] results in increased expression of TNNT2 proteinaffects cotreatment|increases expression 16144979
D004317 Doxorubicin Doxorubicin results in decreased expression of TNNT2 proteindecreases expression 16144979
D004317 Doxorubicin Doxorubicin results in increased secretion of TNNT2 proteinincreases secretion 17382496
D004317 Doxorubicin Zinc inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein]decreases reaction|increases secretion 17382496
D004317 Doxorubicin Doxorubicin results in decreased expression of TNNT2 proteindecreases expression 17924179
D004317 Doxorubicin EPO protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]decreases expression|decreases reaction 17924179
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TNNT2 mRNAincreases expression 17616710
D010795 Phthalic Acids Phthalic Acids affects the expression of TNNT2 mRNAaffects expression 15728792
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TNNT2 proteindecreases expression 20130022
D013755 Tetradecanoylphorbol Acetate chelerythrine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of TNNT2 protein]decreases reaction|increases phosphorylation 12003851
C025643 vinclozolin vinclozolin affects the expression of TNNT2 mRNAaffects expression 19015723
D015032 Zinc Zinc inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein]decreases reaction|increases secretion 17382496
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000169 Acrodermatitis Zinc 5.5617190629 16889938 17202136
MESH:D000230 Adenocarcinoma Doxorubicin 2.5917418594
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000419 Albuminuria Doxorubicin 4.6721441931
MESH:D000544 Alzheimer Disease Zinc 2.7717119284 16325427 16410023 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.0316916123
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001249 Asthma Zinc 2.9817085522
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4320106747
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8714601052
MESH:D001930 Brain Injuries Zinc 4.8317109824
MESH:D001932 Brain Neoplasms Doxorubicin 3.9117150277
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0011921183
MESH:D001943 Breast Neoplasms Doxorubicin 2.0017983394 15567936 16096432 17426702 17369602 16115903 18628466 15692762 19526202 18234424 16322301 15994142 18695136 18382427 11325840 15939500 15136595 16264153 16826403 15668708 15993339 16935488 15634643 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216192424 16227642 15721981 16124888 16050911 16011737 10355542 15673190 3786805 18705752 15700767 16097048
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2018788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.2017876044 16234567 18059187 16023760
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.201485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.926189445
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.9218922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.9216543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.6016269455 16455267 16278810 17007740 16109756 16242529 17974986 17329180 17382496 17131338 15505089 16612575 15792986 16731534 15811867 18627295 17924179 16651473 17928571 17308081 16952015 17351982 16364871 17519947 15476868
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism 19477965
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9817334414 16243910
OMIM:115195 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 2 marker/mechanism
OMIM:612422 CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 3 marker/mechanism
MESH:D002318 Cardiovascular Diseases Zinc 3.7316936243
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 12621046 8697196 15340226 15668235
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 2.7019302082
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003920 Diabetes Mellitus Zinc 4.3016479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.416884620 15968718 17522070 7120509 10092053 9327722 10915739 6623471 19085960 3786805 21278145 15998439 2869522 11566570 7179309 19336974 4309450 3732212 7440962 16227642 15027814 16177239
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.4117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4120420201
MESH:D004362 Drug Toxicity Doxorubicin 8.3818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3811462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3211000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.328273558 16716910 9599246 8113982 7812673 11698051 15177302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5217359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3318037988
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 5.0015264214 15623463 16510608 16805852 16704527 15878914 15547721 15547733 15150132
MESH:D004938 Esophageal Neoplasms Zinc 5.0016543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.2816239168 12631006 15959796 61145 17595544 12795759 16045604 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.0618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0620067830
MESH:D005756 Gastritis Zinc 4.9717241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005909 Glioblastoma Doxorubicin 3.4217150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006130 Growth Disorders Zinc 4.0317217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6015692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.5617875725 14766674 18006777 16495754 16330681 16244372 16879835 17888722 16707910 12587719 16144979 16244371 18674790
MESH:D006333 Heart Failure Doxorubicin 7.6617481944
MESH:D006333 Heart Failure Zinc 7.6617162251
MESH:D006335 Heart Injuries Zinc 5.9417074742
MESH:D016481 Helicobacter Infections Zinc 4.6517241300
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0115692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8317276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.5017606976 15147373 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 8697196 15340226 16959395 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.3415177302 7562506 8273558 11698051 7812673
MESH:D007511 Ischemia Zinc 4.7716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Doxorubicin 6.6715699352 15369732 16775033
MESH:D007674 Kidney Diseases Zinc 6.6716960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.5516707910
MESH:D007676 Kidney Failure, Chronic Zinc 10.5516518626
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3316085563
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8617157831 21278145 11408273 16239168 11903743 16221502 16943688 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5618420326 15370692 17565644 12546737 15925388 18418968 16027843 15730626 16033810 15818738 15650968 14512876 12389079 12898905 15893842 17525996 18395095 17557913 12649538 12667390 14748882 17766677 10355542 17714472 15931870 15673190 14724832 12445421 18263696 16192424 16097048 18412020 17922224 17761835 18429990 13678700 14716496 17631135 12666154 17805973 16011737 17640975 17900296 18210741 12586293 18395914 17976157 18187930 15123356 18156304 18054572 12632512 15052691 16248980 17721639 15876570 18472332 17708605 16015684 12958196 12741479 15338365 15362042 18251166 15959796 18376398 11481614 17823541 18481824 12632514 18339082 18166357 17869086 12445418 18472094 14716833 18205269 16136751 18277467 20821823 17481882 18279442 18006644 17944888 18317297 15996030 18705752 15057751 16116963 16638106 17698563 12609069 14620537
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.5616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016246199 15830285 16964402 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5219294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.2412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.2416842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2412151625
MESH:D008175 Lung Neoplasms Doxorubicin 3.5817418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5819555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.5811807781
MESH:D008223 Lymphoma Doxorubicin 3.5416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7015621674
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 14.9711921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 14.9715458769
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 14.978985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 14.9712773700
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008654 Mesothelioma Doxorubicin 3.1017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6115792986
MESH:D052016 Mucositis Doxorubicin 4.9417415656
MESH:D009203 Myocardial Infarction Doxorubicin 2.9919429709 15857846
MESH:D017202 Myocardial Ischemia marker/mechanism 10789933
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9918259882
MESH:D009401 Nephrosis Doxorubicin 4.9116636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1016889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009447 Neuroblastoma Doxorubicin 3.3115555623
MESH:D012516 Osteosarcoma Doxorubicin 4.2015930896
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1715976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.4312065085 8330346 18404319 18922899
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011225 Pre-Eclampsia Zinc 4.2617114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0111118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.0119015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5716729912 15897917 15749863 18437689 16888761 16868541
MESH:D011471 Prostatic Neoplasms Zinc 3.5716517595 12429649 16606632 16700911
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D051437 Renal Insufficiency Doxorubicin 4.3617922066
MESH:D012127 Respiratory Distress Syndrome, Newborn marker/mechanism 10789933
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration Zinc 4.2116584753
MESH:D012509 Sarcoma Doxorubicin 4.0916767912 17203757 17710206 15675481 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9417846226
MESH:D012878 Skin Neoplasms Doxorubicin 14.0115692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.018532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.0116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 14.018985016 18404319 8330346 11807781 12065085
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7016767912 17203757 15625365
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3212958204 17575124
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4516010429 17909728
MESH:D014062 Tongue Neoplasms Zinc 4.5016543248
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8017653716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3617638931 16364871 17678736 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36638
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    PA443632Cardiomyopathy, Dilated
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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