AutismKB 2.0

Annotation Detail for TOP1


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Basic Information Top
Gene Symbol:TOP1 ( TOPI )
Gene Full Name: topoisomerase (DNA) I
Band: 20q12
Quick LinksEntrez ID:7150; OMIM: 126420; Uniprot ID:TOP1_HUMAN; ENSEMBL ID: ENSG00000198900; HGNC ID: 11986
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200148Caspase cascade in apoptosis
Pathway IDPathway Name
P00017DNA replication
No data
Related Diseases/Disorders Top
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Desease Name
DNA topoisomerase I, camptothecin-resistant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C054649 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of TOP1 mRNAdecreases expression 12734338
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TOP1 mRNAdecreases expression 18648102
C013813 4-anisidine 4-anisidine results in decreased expression of TOP1 mRNAdecreases expression 12929121
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of TOP1 mRNAdecreases expression 12419474
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of TOP1 mRNAdecreases expression 16514628
C094432 acetyl-11-ketoboswellic acid acetyl-11-ketoboswellic acid results in decreased activity of TOP1 proteindecreases activity 10860928
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of TOP1 proteinincreases expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOP1 mRNAdecreases expression 19150397
C002070 betulinic acid betulinic acid results in decreased activity of TOP1 proteindecreases activity 10860928
C054625 boswellic acid boswellic acid analog binds to and results in decreased activity of TOP1 proteinaffects binding|decreases activity 10860928
D002166 Camptothecin Ciprofloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]decreases activity|increases reaction 18191106
D002166 Camptothecin moxifloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]decreases activity|increases reaction 18191106
D002166 Camptothecin Camptothecin results in decreased activity of TOP1 proteindecreases activity 19201781
D002166 Camptothecin decitabine inhibits the reaction [Camptothecin results in decreased activity of TOP1 protein]decreases activity|decreases reaction 19201781
D002166 Camptothecin [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 proteinaffects cotreatment|decreases activity 18191106
D002166 Camptothecin [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 proteinaffects cotreatment|decreases activity 18191106
D002166 Camptothecin Camptothecin results in decreased activity of TOP1 proteindecreases activity 9673414
C001614 captafol captafol results in decreased activity of TOP1 proteindecreases activity 12113771
D002392 Catechin Catechin results in decreased expression of TOP1 mRNAdecreases expression 15465739
D002392 Catechin Catechin results in decreased expression of TOP1 proteindecreases expression 15465739
D002939 Ciprofloxacin Ciprofloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]decreases activity|increases reaction 18191106
D002939 Ciprofloxacin [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 proteinaffects cotreatment|decreases activity 18191106
C014347 decitabine decitabine inhibits the reaction [Camptothecin results in decreased activity of TOP1 protein]decreases activity|decreases reaction 19201781
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNAaffects cotreatment|decreases expression 18253720
D004958 Estradiol Estradiol results in increased expression of TOP1 mRNAincreases expression 16514628
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP1 mRNAaffects cotreatment|increases expression 17942748
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNAaffects cotreatment|decreases expression 18253720
D005419 Flavonoids Flavonoids results in decreased expression of TOP1 mRNAdecreases expression 15465739
D005419 Flavonoids Flavonoids results in decreased expression of TOP1 proteindecreases expression 15465739
D005419 Flavonoids Flavonoids results in decreased expression of TOP1 mRNAdecreases expression 18035473
D005472 Fluorouracil Fluorouracil results in decreased expression of TOP1 mRNAdecreases expression 16709241
D005472 Fluorouracil TOP1 protein affects the susceptibility to Fluorouracilaffects response to substance 18509181
C070081 fulvestrant fulvestrant results in decreased expression of TOP1 mRNAdecreases expression 16514628
D006918 Hydroxyurea Hydroxyurea results in decreased expression of TOP1 mRNAdecreases expression 12929121
C027185 indirubin indirubin results in decreased expression of TOP1 mRNAdecreases expression 15056799
C051890 irinotecan irinotecan binds to TOP1 proteinaffects binding 15655543
C051890 irinotecan irinotecan results in decreased activity of TOP1 proteindecreases activity 11914913
C051890 irinotecan TOP1 protein affects the susceptibility to irinotecanaffects response to substance 18509181
15041737
C051890 irinotecan irinotecan results in decreased activity of TOP1 proteindecreases activity 15292932
D047311 Luteolin Luteolin binds to and results in decreased activity of TOP1 proteinaffects binding|decreases activity 12027807
D008610 Menthol Menthol results in decreased activity of TOP1 proteindecreases activity 16158947
C104727 moxifloxacin moxifloxacin promotes the reaction [Camptothecin results in decreased activity of TOP1 protein]decreases activity|increases reaction 18191106
C104727 moxifloxacin [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 proteinaffects cotreatment|decreases activity 18191106
D009828 Oleanolic Acid Oleanolic Acid results in decreased activity of TOP1 proteindecreases activity 10860928
C030110 oxaliplatin TOP1 protein affects the susceptibility to oxaliplatinaffects response to substance 18509181
D017239 Paclitaxel Paclitaxel results in decreased expression of TOP1 mRNAdecreases expression 12929121
D010936 Plant Extracts Plant Extracts results in decreased expression of TOP1 mRNAdecreases expression 15465739
D010936 Plant Extracts Plant Extracts results in decreased expression of TOP1 proteindecreases expression 15465739
C025299 polyphenols polyphenols results in decreased expression of TOP1 mRNAdecreases expression 15465739
C025299 polyphenols polyphenols results in decreased expression of TOP1 proteindecreases expression 15465739
D020849 Raloxifene Raloxifene results in decreased expression of TOP1 mRNAdecreases expression 16514628
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of TOP1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of TOP1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TOP1 proteinincreases expression 16548065
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of TOP1 mRNAincreases expression 15289447
D019772 Topotecan Topotecan results in decreased activity of TOP1 proteindecreases activity 15292932
D014415 Tunicamycin Tunicamycin results in increased expression of TOP1 mRNAincreases expression 17127020
C005466 ursolic acid ursolic acid results in decreased activity of TOP1 proteindecreases activity 10860928
D014635 Valproic Acid Valproic Acid results in decreased expression of TOP1 mRNAdecreases expression 19101580
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of TOP1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of TOP1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.8515322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 6.858875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5319490988
MESH:D000138 Acidosis Ammonium Chloride 3.1218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4917505938
MESH:D000230 Adenocarcinoma Estradiol 6.2911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.2914692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.2917638652
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.0815814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.783712494
MESH:D000236 Adenoma Diethylnitrosamine 5.786695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.5817162532 18056438 17620307 19052882 19061943 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.5816835633
MESH:D000419 Albuminuria Raloxifene 4.1717308373 17451421
MESH:D000544 Alzheimer Disease Plant Extracts 4.1916962711
MESH:D000544 Alzheimer Disease Raloxifene 4.1915800139
MESH:D000550 Amblyopia Valproic Acid 4.7817688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8210965797
MESH:D000740 Anemia Fluorouracil 7.4117963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.4111748828
MESH:D000881 Anthrax Ciprofloxacin 6.2620385868
MESH:D016736 Antiphospholipid Syndrome Ciprofloxacin 6.269485080
MESH:D001008 Anxiety Disorders Valproic Acid 3.2217497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5915885639
MESH:D001169 Arthritis, Experimental Plant Extracts 6.5914686799
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.0719898480
MESH:D001284 Atrophy fulvestrant 4.4311514358
MESH:D001321 Autistic Disorder Valproic Acid 2.0617688650 16609825 17157402 19232924 18940202 15238991 18316065 18775368 18985861 18396377 17507914 18558336 20603192 18177632 19460635
MESH:D001424 Bacterial Infections Ciprofloxacin 5.4511505790
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5711289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.8420046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.6512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.0515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.058888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.1615867366
MESH:D001930 Brain Injuries Raloxifene 4.0416580743
MESH:D002545 Brain Ischemia Plant Extracts 4.2916041641
MESH:D001943 Breast Neoplasms captafol 5.308441825
MESH:D001943 Breast Neoplasms decitabine 5.3018320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.3017474063
MESH:D001943 Breast Neoplasms Estradiol 5.3012948864 17018787 17289903 18497071 17261762 14630087 16675129 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 5.3019217205 16110121 15136595 18357371 16595493 18608205 16557594
MESH:D001943 Breast Neoplasms fulvestrant 5.3018984771
MESH:D001943 Breast Neoplasms Paclitaxel 5.3016115903 16244791 15136595 16273361 11325840 18323546 18223236 18234424
MESH:D001943 Breast Neoplasms Raloxifene 5.3016912660 17893378 15572757 17049068 15775269 17242785 17440819 17952589 16837676 17595753 17261762 15758505
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.3020435547
MESH:D002057 Burns, Chemical Plant Extracts 4.889625245
MESH:D002177 Candidiasis moxifloxacin 6.1616352735
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0216111702
MESH:D002252 Carbon Tetrachloride Poisoning Oleanolic Acid 9.1410355542
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.1416050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2216051944
MESH:D002277 Carcinoma Fluorouracil 7.0217121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.0216835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 10.267296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.2617173139 20084675 19335982 16830150 18393292 17428255 19701751 20512989 19539802 18056438 18506893 20432363 17761372 16328049 19822196 16935385 20007298 19107877 3084413 18494052 17978847 19208518 16779866 10737359 21159647 18788625 16288022 19383236 19052882 16540662 19171122 18691550 17138121 17055752 3581430 18665156 18210153 20101231 19919837 20214788 19394651 20727157 20524982 11831363 19519916 19418558 16807293 18978308 16698587 16569478 10672840 16502159 16681979 17162532 16878318 18785209 20935162 18971187 20514400
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.2616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 10.2617971768 18930000 17088986 17045692 16332177 16799960
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 10.2616313753
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 10.2618834353
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.2611212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.767296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.7618695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 6.8619215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.8616757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 6.8611212258
MESH:D002295 Carcinoma, Transitional Cell Ciprofloxacin 8.8210741713 15028437
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.8217572228
MESH:D006332 Cardiomegaly Plant Extracts 6.1317645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1415775269
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 13.487505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.4820889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.4821159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.4818566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5420734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.0919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.0916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 6.779022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.7717110522 16105132 15861022 17681005 11677210 16919318 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9116354765 15668235 15340226 12621046 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.1915800139
MESH:D003092 Colitis Selenium 3.3517936198
MESH:D003110 Colonic Neoplasms decitabine 10.0417616700
MESH:D003110 Colonic Neoplasms Fluorouracil 10.0417018589 18772588 17287894 17725105 17016597 15001691 17169374 16510598 17172411 16340194
MESH:D003110 Colonic Neoplasms irinotecan 10.0417725105 17287894
MESH:D003110 Colonic Neoplasms oxaliplatin 10.0416024531 16004971 16510598
MESH:D003110 Colonic Neoplasms polyphenols 10.0416293270
MESH:D015179 Colorectal Neoplasms decitabine 5.9418981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.9417454858 17094418 16331619 15289873 17401013 17255274 14970324 17594712 16303861 18802399 18509181 16282729 18383874 18288408 15148649 20501625 17016601 16524972 16391804 18448328 17695437 18949393
MESH:D015179 Colorectal Neoplasms irinotecan 5.9418259882 18509181 17159606 16391804 17454858 15273666 16303861
MESH:D015179 Colorectal Neoplasms oxaliplatin 5.9418448328 17594712 17695437 18509181 17255274 17401013
MESH:D015179 Colorectal Neoplasms Paclitaxel 5.9418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6917141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.4516575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.4519769572
MESH:D003550 Cystic Fibrosis Ciprofloxacin 4.5819747007
MESH:D007644 Darier Disease Fluorouracil 4.3516733453
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7917474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.402524372 18759878 11906362 11298694 12868966 8156756 14531868 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.092952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.8020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.8017107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.0019279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 13.0019706694
MESH:D003928 Diabetic Nephropathies Raloxifene 13.0015920148 17308373 17451421
MESH:D003967 Diarrhea 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 4.4810611417
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 16.3511289319 7440962 18692083 6679447 6482804 16192314 18289764 8291058 9022650 1440618 9653073 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury captafol 16.351765226
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.3519107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 16.3519370779
MESH:D056486 Drug-Induced Liver Injury Selenium 16.3515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.3520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 16.351733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4311462148
MESH:D050171 Dyslipidemias Fenofibrate 4.1016707586
MESH:D004421 Dystonia Valproic Acid 3.641851702
MESH:C538011 Eales disease Vitamin E 4.259068938
MESH:D004487 Edema captafol 13.381765226
MESH:D004487 Edema Plant Extracts 13.3812787963
MESH:D004487 Edema Raloxifene 13.3815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.3811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 7.7215845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.6619294695
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 10.9919148513
MESH:D016889 Endometrial Neoplasms Estradiol 10.9919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Fenofibrate 10.9916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.2315268973
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.723659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.473922381 16628512
MESH:D004827 Epilepsy Plant Extracts 6.1819700373 19439326
MESH:D004827 Epilepsy Valproic Acid 6.1820417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.227562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.623659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6616302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.323581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.3220426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.3216337965 16481741 17638652 16785472 15173087
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.3216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6811564622
MESH:D005234 Fatty Liver Diethylnitrosamine 20.4921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.4915345470
MESH:D005234 Fatty Liver Plant Extracts 20.4915975614
MESH:D005234 Fatty Liver Raloxifene 20.4917473493
MESH:D005234 Fatty Liver Valproic Acid 20.4919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.718888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.576705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.5220067830
MESH:D005770 Gastrointestinal Neoplasms captafol 5.898441825
MESH:D005910 Glioma Fluorouracil 2.6816145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.637505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1410696789
MESH:D006258 Head and Neck Neoplasms decitabine 6.8919215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.8918337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 5.7516080930
MESH:D006331 Heart Diseases Ciprofloxacin 7.2511505790
MESH:D006331 Heart Diseases Raloxifene 7.2511110106
MESH:D006333 Heart Failure Plant Extracts 6.5118097624
MESH:D006333 Heart Failure Selenium 6.5117162251
MESH:D016481 Helicobacter Infections Ciprofloxacin 5.0717643012
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.106705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.4716120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5416863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5815709030
MESH:D006561 Herpes Simplex Plant Extracts 4.1910715843
MESH:D015658 HIV Infections Plant Extracts 3.4412878215
MESH:D019584 Hot Flashes Estradiol 14.5317088409
MESH:D019584 Hot Flashes Plant Extracts 14.5314716179 16566672 17454163
MESH:D019584 Hot Flashes Vitamin E 14.5314716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5915340226 16959395 18606429 16354765 8697196
MESH:D006930 Hyperalgesia oxaliplatin 4.0117418472
MESH:D020138 Hyperhomocysteinemia Catechin 8.6917292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 8.6916484555
MESH:D006949 Hyperlipidemias Oleanolic Acid 13.688847885
MESH:D006949 Hyperlipidemias Plant Extracts 13.6815268973 15975614
MESH:D006949 Hyperlipidemias ursolic acid 13.688847885
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5115034207
MESH:D006968 Hypersensitivity, Delayed indirubin 5.4811275354
MESH:D006973 Hypertension Raloxifene 4.6115787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0512013081
MESH:D007248 Infertility, Male decitabine 9.5917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.5917937319
MESH:D007248 Infertility, Male fulvestrant 9.5911514358
MESH:D007249 Inflammation Diethylnitrosamine 24.3818785209
MESH:D007249 Inflammation Flavonoids 24.3817296493
MESH:D007249 Inflammation Oleanolic Acid 24.388847885
MESH:D007249 Inflammation Plant Extracts 24.3812787963 15997105 16366677 19332304
MESH:D007249 Inflammation polyphenols 24.3816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 24.3812200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 24.3818590791
MESH:D007249 Inflammation ursolic acid 24.388847885
MESH:D007251 Influenza, Human Selenium 9.4616624496
MESH:D007251 Influenza, Human Vitamin E 9.4616624496
MESH:D007333 Insulin Resistance Estradiol 2.6716627594 16393666
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.2312351151 12584176 12628509
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.579022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9416580747
MESH:D007674 Kidney Diseases captafol 8.851765226
MESH:D007674 Kidney Diseases Estradiol 8.8515618244
MESH:D007674 Kidney Diseases Vitamin E 8.8512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.4916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.936582329
MESH:D007680 Kidney Neoplasms captafol 14.938441825
MESH:D007680 Kidney Neoplasms Estradiol 14.9315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 14.9316985049
MESH:D007889 Leiomyoma Raloxifene 4.0916973256
MESH:D007938 Leukemia decitabine 2.8419235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 8.7317236224 18454857 19117987
MESH:D007951 Leukemia, Myeloid Hydroxyurea 8.7316532439
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.6819010910 18704418 18206229 17679729 18460780 19387464
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6817596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0118055864
MESH:D007970 Leukopenia Ciprofloxacin 5.3617846019
MESH:D008080 Liposarcoma Paclitaxel 4.4117353645
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.1018407596 18665156 19638242 18522880 20032147
MESH:D008103 Liver Cirrhosis Plant Extracts 6.1017157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.919327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.8714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 7.8715474484
MESH:D008106 Liver Cirrhosis, Experimental Oleanolic Acid 7.8710355542
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 7.8715479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.8712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 7.8716169303
MESH:D008107 Liver Diseases Diethylnitrosamine 8.4417034775
MESH:D008107 Liver Diseases Oleanolic Acid 8.448847885 15720792
MESH:D008107 Liver Diseases Plant Extracts 8.4417034775
MESH:D008107 Liver Diseases polyphenols 8.4416698588
MESH:D008113 Liver Neoplasms Diethylnitrosamine 12.2921167192 19690152 19256749 19638242 21071580 12771043 19996281 19426721 9163691 20452335 19294768 19073162 19255062 21047994 19833225 19812893 19254457 19427195 2422723 12112319 18977376 20137499 18978307 18754104 20501860 18644402 15885732 21278145 20405173 16942905 20583210 19499222 19850985 20492335 10737359 2862719 19090486 15175105 20434301 20118626 18648771 20101389 19551842 19642983
MESH:D008113 Liver Neoplasms Fenofibrate 12.2918978307
MESH:D008113 Liver Neoplasms Fluorouracil 12.2916603448 18383874 15113037 17045692
MESH:D008113 Liver Neoplasms Plant Extracts 12.2919168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.2916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.683712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental captafol 15.688441825
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.6818308698 19126423 19539802 18079962 18253720 18775883 21159647 18544905 18164116 3124819 17854601 2563599 19519916 18093689 16842330 9362446 18282651 16267830 17174075 19009564 17942915 19004024
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 15.6818253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.6812151625
MESH:D008171 Lung Diseases Vitamin E 2.8816863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8117228818
MESH:D055370 Lung Injury Ciprofloxacin 4.6818197910
MESH:D008175 Lung Neoplasms Ciprofloxacin 9.6720211752
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.6721163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 9.6715246190
MESH:D008175 Lung Neoplasms Plant Extracts 9.6720869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.6711884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 9.6716288123 12111688 11091918 3440675
MESH:D008175 Lung Neoplasms Vitamin E 9.6711062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3515086387
MESH:D008223 Lymphoma decitabine 3.1019470736
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.7314749477
MESH:D008325 Mammary Neoplasms, Experimental captafol 8.578441825
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.5717203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.5715318939
MESH:D020149 Manganese Poisoning Estradiol 4.0319453300
MESH:D008545 Melanoma betulinic acid 5.0016077934
MESH:D008545 Melanoma decitabine 5.0017785578 16505122
MESH:D008545 Melanoma Paclitaxel 5.0016342250 12040289 12025231
MESH:D008654 Mesothelioma Selenium 2.6015107826
MESH:D008881 Migraine Disorders Valproic Acid 2.8718765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1015863610
MESH:D009062 Mouth Neoplasms Fluorouracil 7.8216757204 18986760
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 7.8215006635
MESH:D052016 Mucositis irinotecan 4.5717159606
MESH:D009101 Multiple Myeloma decitabine 10.4118172295
MESH:D009101 Multiple Myeloma Paclitaxel 10.4114749477
MESH:D009101 Multiple Myeloma Raloxifene 10.4116497877
MESH:D009128 Muscle Spasticity 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 5.6617220914
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.638888407
MESH:D009164 Mycobacterium Infections Ciprofloxacin 5.1110063276
MESH:D009190 Myelodysplastic Syndromes Ciprofloxacin 11.039809623
MESH:D009190 Myelodysplastic Syndromes decitabine 11.0318608210 16882708 19010910 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.0317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9416810080
MESH:D009232 Myxoma Raloxifene 5.1016343187
MESH:D016870 Neisseriaceae Infections Ciprofloxacin 5.9220378725
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 12.033581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.039029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 12.0318259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 12.0315867366
MESH:D009369 Neoplasms decitabine 10.1719470736 19116145 17925555
MESH:D009369 Neoplasms Fluorouracil 10.1716928823 18600527 18239605
MESH:D009369 Neoplasms Oleanolic Acid 10.178847885
MESH:D009369 Neoplasms ursolic acid 10.178847885
MESH:D009374 Neoplasms, Experimental captafol 5.258441825
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2917289903
MESH:D009421 Nervous System Malformations Estradiol 8.0711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.0714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.276679447
MESH:D009436 Neural Tube Defects Valproic Acid 6.278888407 16359493
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.7517168769
MESH:D009447 Neuroblastoma irinotecan 6.578761367
MESH:D009447 Neuroblastoma Topotecan 6.5715176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 2.9820387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.298761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6620387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1316436463
MESH:D009503 Neutropenia Ciprofloxacin 4.7517846019
MESH:D009765 Obesity Plant Extracts 3.0320132043 19056576
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.044026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.573988306
MESH:D010014 Osteolysis Paclitaxel 4.5415867366
MESH:D010024 Osteoporosis Raloxifene 3.1219059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8217823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms decitabine 10.0919331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 10.0919401270
MESH:D010051 Ovarian Neoplasms Luteolin 10.0919005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.0911161223
MESH:D010190 Pancreatic Neoplasms decitabine 7.6419294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.6416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.6415113037 16500647 19003803 16929163
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.037296757
MESH:D010212 Papilloma Plant Extracts 8.0315173996 16517061
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 11.496228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 11.4911550810
MESH:D010954 Plasmacytoma Selenium 4.4415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.182563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.9911118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 7.9920603192
MESH:D055728 Primary Myelofibrosis decitabine 4.2917616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4920887781
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8816729912 16356831 17136230 17172428
MESH:D011471 Prostatic Neoplasms Plant Extracts 1.8817804756 14666653
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8816220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.8716919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.0911422049 12752131
MESH:D011693 Purpura Raloxifene 5.1015770314
MESH:D012003 Rectal Fistula Ciprofloxacin 5.9218371140
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6418722050 15538739 18286688 16160472
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.1918410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.043692021
MESH:D012208 Rhabdomyosarcoma decitabine 9.6219155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.6219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0115737665 19110320
MESH:D012640 Seizures Valproic Acid 2.4514763951 1511512 17978042 16876388 15475178 11738929 11044598 3137016
MESH:D012871 Skin Diseases Vitamin E 2.3218709164
MESH:D012878 Skin Neoplasms Plant Extracts 8.3615173996 16517061
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3616192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 8.3618590791
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4916709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0912833885
MESH:D013272 Stomach Diseases captafol 5.521765226
MESH:D013274 Stomach Neoplasms decitabine 5.8319037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.8318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 5.8318396642 17522103 15786421 16424979 16951190 18567086 19084572 17172411 19015929 17498489
MESH:D013274 Stomach Neoplasms irinotecan 5.8315723263
MESH:D013274 Stomach Neoplasms Paclitaxel 5.8318396642 18506536
MESH:D013276 Stomach Ulcer Plant Extracts 3.5218237397 17135157 15255614 18193104 12787963
MESH:D020521 Stroke Raloxifene 7.5516837676
MESH:D020521 Stroke Vitamin E 7.5516517955
MESH:D024801 Tauopathies Camptothecin 10.3616930453
MESH:D024801 Tauopathies Paclitaxel 10.3616930453
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 11.7717997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 11.7717997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.041399818 7505956 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms decitabine 10.0417967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.047505956
MESH:D013978 Tibial Fractures Estradiol 12.2119048282
MESH:D013978 Tibial Fractures Raloxifene 12.2119048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6116280240
MESH:D014123 Toxoplasmosis Ciprofloxacin 5.5720186551
MESH:D014178 Translocation, Genetic Valproic Acid 4.7817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.083119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 13.828074119
MESH:D001749 Urinary Bladder Neoplasms Ciprofloxacin 13.8215028437 10741713
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.8217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 13.8217572228
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 13.8212846360
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.218888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.5016803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8814692618
MESH:D014604 Uveal Neoplasms decitabine 4.4617785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1412125929
MESH:D019043 Vascular Neoplasms captafol 6.468441825
MESH:D054556 Venous Thromboembolism Raloxifene 4.7616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.3218097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.8718097624
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8015886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.8920213670 19894650
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA353
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA445113Neutropenia
    PA443265Adenocarcinoma
    PA443557Brain Neoplasms
    PA443756Colonic Neoplasms
    PA444840Lymphoma
    PA444903Melanoma
    PA445204Ovarian Neoplasms
    PA445425Prostatic Neoplasms
    Releated drug ID Related drug Name
    PA165110775SN-38
    PA153590860camptothecin
    PA449014cisplatin
    PA450085irinotecan
    PA452621antineoplastic agents
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00762 antagonist Irinotecan Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic
    DB01030 antagonist Topotecan Antineoplastic Agents;Enzyme Inhibitors
    DB04690 - Camptothecin Enzyme Inhibitors;Antineoplastic Agents, Phytogenic
    DB04967 antagonist Lucanthone Radiation-Sensitizing Agents;Anticancer Agents;Schistosomicides
    DB05630 antagonist Sodium stibogluconate Antiparasitic Agents;Anticancer Agents
    DB07354 - 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
    DB08159 - 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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