AutismKB 2.0

Annotation Detail for TPBG


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Basic Information Top
Gene Symbol:TPBG ( 5T4,5T4AG,M6P1 )
Gene Full Name: trophoblast glycoprotein
Band: 6q14.1
Quick LinksEntrez ID:7162; OMIM: 190920; Uniprot ID:TPBG_HUMAN; ENSEMBL ID: ENSG00000146242; HGNC ID: 12004
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2044Pre-Eclampsia
No data
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TPBG mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TPBG mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TPBG proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPBG mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TPBG mRNAincreases expression 20106945
D003345 Corticosterone Corticosterone results in decreased expression of TPBG mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in increased expression of TPBG mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of TPBG mRNAincreases expression 16002434
D005419 Flavonoids Flavonoids results in decreased expression of TPBG mRNAdecreases expression 18035473
C025299 polyphenols polyphenols results in decreased expression of TPBG mRNAdecreases expression 16293270
D011374 Progesterone Progesterone results in increased expression of TPBG mRNAincreases expression 18037150
C079198 S 1 (combination) TPBG protein results in decreased susceptibility to S 1 (combination)decreases response to substance 16734730
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TPBG mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.753712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.756695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9611237771
MESH:D001943 Breast Neoplasms Progesterone 1.9617614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.657296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6512907637 12619106 21507988
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 4.0918212800 18347146
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8820419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.8811237771
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 7.8815984520
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.757505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7512371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.0819486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.0819486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1312621046 8697196 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms polyphenols 2.6816293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9014531868 18759878 11906362 8156756 2524372 8970840 12868966 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.1921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.1911289319 9022650 6482804 6679447 18289764 7440962 18692083 8291058 18648102 9328219 9653073 1440618 16192314
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.1919370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.6315138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.6317692515
MESH:D004715 Endometriosis Progesterone 9.1916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.1910568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.433581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 2.9419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.8619093184
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 4.8018607998 15984520
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0012621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 15340226 8697196 18606429 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007249 Inflammation Flavonoids 12.3417296493
MESH:D007249 Inflammation polyphenols 12.3416366677
MESH:D007249 Inflammation Progesterone 12.3415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.3412200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.388314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.7716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.776582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.7712371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases polyphenols 2.8016698588
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.552125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5521137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.093712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.098603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4120869020 17053015 6695378 18520028 20064080 20464547 18569708 20135361 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4119555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.6212807724
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.6211408345 17203775
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2011141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1412819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.146482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010051 Ovarian Neoplasms Progesterone 2.5516525653 17393432
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11896295 11399792 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2617292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2616289102 15754350 12479363 16644109 18247401
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.4016503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.942093021 20155912
MESH:D013274 Stomach Neoplasms S 1 (combination) 2.9416557585 18506536 18553229
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.3917997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.956587162 7505956 1399818 3712494 6582329
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.448074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36685
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA450196letrozole
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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