AutismKB 2.0

Annotation Detail for TPH1


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Basic Information Top
Gene Symbol:TPH1 ( MGC119994,TPRH,TRPH )
Gene Full Name: tryptophan hydroxylase 1
Band: 11p15.1
Quick LinksEntrez ID:7166; OMIM: 191060; Uniprot ID:TPH1_HUMAN; ENSEMBL ID: ENSG00000129167; HGNC ID: 12008
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6030serotonin and melatonin biosynthesis
Pathway IDPathway Name
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P043715-Hydroxytryptamine biosynthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1907Depression
1909Migraine
1999Thalassemia
2091Hypertension
2045Bipolar disorder
2124Autistic disorder
2221Behavior disease
Desease Name
mood disorder
suicidal behavior
CHEMDEPENDENCY
nicotine dependence
Alzheimer's disease
PSYCH
Weight Gain
somatic anxiety
PHARMACOGENOMIC
alcoholism
anxiety disorder
aggressive behavior
smoking initiation
suicide
depressive disorder, major
alcohol abuse
nicotine
impulsive behavior
NEUROLOGICAL
attention deficit hyperactivity disorder
schizophrenia
impulsive inpatients
personality trait
METABOLIC
mood disorders
major and bipolar depressives
anger-related traits
psychosis schizophrenia
Borderline Personality Disorder
self-harm behavior
depression
bulimia harm avoidance personality traits
depressive episode, major
major depressive disorder
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029955 2-nitrotoluene 2-nitrotoluene results in increased expression of TPH1 mRNAincreases expression 15612046
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPH1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of TPH1 proteindecreases expression 16483693
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of TPH1 mRNAincreases expression 18835401
17452286
D003976 Diazinon Diazinon affects the expression of TPH1 mRNAaffects expression 18835401
D003976 Diazinon Diazinon results in increased expression of TPH1 mRNAincreases expression 17452286
D015946 Ethylene Dibromide Ethylene Dibromide results in increased expression of TPH1 mRNAincreases expression 15612046
D004026 Dieldrin Dieldrin results in increased expression of TPH1 mRNAincreases expression 18835401
D004041 Dietary Fats Dietary Fats results in decreased expression of TPH1 mRNAdecreases expression 18042831
C004312 glycidol glycidol results in increased expression of TPH1 mRNAincreases expression 15612046
D012701 Serotonin TPH1 gene polymorphism affects the abundance of Serotoninaffects abundance 17203304
D012701 Serotonin TPH1 gene polymorphism results in increased abundance of Serotoninincreases abundance 18405062
C036868 methyl carbamate methyl carbamate results in increased expression of TPH1 mRNAincreases expression 15612046
D009151 Mustard Gas Mustard Gas results in increased expression of TPH1 mRNAincreases expression 15674843
D009532 Nickel Nickel results in decreased expression of TPH1 mRNAdecreases expression 18835401
C041786 palm oil palm oil results in decreased expression of TPH1 mRNAdecreases expression 18042831
D028321 Plant Preparations Plant Preparations affects the expression of TPH1 mRNAaffects expression 16046712
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury Nickel 4.6416166738
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.4516611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.4516487989
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001249 Asthma Mustard Gas 2.7210378619
MESH:D001321 Autistic Disorder Serotonin 3.468570775 17157402 19221690 18062943 15132762 18361446 18405062
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001919 Bradycardia Serotonin 5.568112388
MESH:D001932 Brain Neoplasms glycidol 5.4710528639 12562636
MESH:D001943 Breast Neoplasms Dieldrin 3.0315770527 11859874
MESH:D001943 Breast Neoplasms Dietary Fats 3.0320435547
MESH:D001943 Breast Neoplasms Ethylene Dibromide 3.0311921183
MESH:D001943 Breast Neoplasms glycidol 3.0311921183
MESH:D001943 Breast Neoplasms Nickel 3.0315986119
MESH:D001943 Breast Neoplasms Plant Preparations 3.0317398067
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 3.6517418620
MESH:D002318 Cardiovascular Diseases Plant Preparations 4.4316862667
MESH:D016893 Carotid Stenosis Plant Preparations 6.2215158307
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.7314688030
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.1821254450
MESH:D021081 Chronobiology Disorders Serotonin 6.7917157402
MESH:D003324 Coronary Artery Disease Plant Preparations 4.0115158307
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.0217244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.692952479
MESH:D003967 Diarrhea Serotonin 4.838112388 11488427 10446763
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 4.052862719
MESH:D004362 Drug Toxicity Plant Preparations 4.7111033412
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004417 Dyspnea Diazinon 4.9016487989
MESH:D004487 Edema Mustard Gas 7.7911428647 11402378 9260866 11428631
MESH:D004487 Edema Serotonin 7.7918841975
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D004938 Esophageal Neoplasms Plant Preparations 3.6016510608
MESH:D005234 Fatty Liver Dietary Fats 3.2917967931 18296743 19004024 19551842
MESH:D005355 Fibrosis Dietary Fats 3.6018296743
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 5.1313678655
MESH:D006505 Hepatitis Diazinon 4.6416487989
MESH:D015658 HIV Infections Nickel 3.8417263646
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D007247 Infertility, Female Dieldrin 5.0010630421
MESH:D007248 Infertility, Male Diazinon 3.8512948887 16466525
MESH:D007249 Inflammation Dietary Fats 8.7020412841
MESH:D007249 Inflammation Mustard Gas 8.7011428620 17524151 9260866 11402378 11428631 9357497 16001271 11428647 8975870
MESH:D007249 Inflammation Nickel 8.7016166738
MESH:D007333 Insulin Resistance Dietary Fats 3.1411836018 18457598
MESH:D007674 Kidney Diseases Ethylene Dibromide 4.6812628311
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 3.1517724770
MESH:D008107 Liver Diseases Chlorpyrifos 3.0815991261
MESH:D008113 Liver Neoplasms Dieldrin 3.368742319 9539021
MESH:D008114 Liver Neoplasms, Experimental glycidol 4.6612562636 12692647
MESH:D008171 Lung Diseases Mustard Gas 3.4818161513 18702808
MESH:D008175 Lung Neoplasms glycidol 3.3512562636 12692647
MESH:D008175 Lung Neoplasms Mustard Gas 3.353148597 8781369
MESH:D015674 Mammary Neoplasms, Animal glycidol 5.868818859 12692647 12562636
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 7.5911921183
MESH:D008325 Mammary Neoplasms, Experimental glycidol 7.5911921183
MESH:D009062 Mouth Neoplasms glycidol 9.9012562636
MESH:D009062 Mouth Neoplasms Plant Preparations 9.9017418620
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.7813678655
MESH:D009369 Neoplasms Dieldrin 3.498820588
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2015081274
MESH:D009503 Neutropenia Mustard Gas 4.0316761898 7688884
MESH:D009669 Nose Neoplasms Ethylene Dibromide 5.609385384
MESH:D009765 Obesity Dietary Fats 2.3021332399 20132043 18674790 11836018 17217161 20518802 18457598 19632207 16723640
MESH:D010300 Parkinson Disease Dieldrin 3.5416112328 17291500 11181820 11445065 16809432
MESH:D011041 Poisoning Diazinon 9.2217603234
MESH:D011041 Poisoning Mustard Gas 9.2215727166
MESH:D011537 Pruritus Mustard Gas 4.1718058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9410334151 17894541 17620002 17720292 17266442
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.7117119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.9916611668 17119214
MESH:D012559 Schizophrenia marker/mechanism 18583979
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.196418539
MESH:D012871 Skin Diseases Mustard Gas 2.7315451306 16961503 12880345
MESH:D012878 Skin Neoplasms glycidol 4.5912562636 12692647
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 3.883768853
MESH:D013274 Stomach Neoplasms glycidol 3.8812562636 11397402 8818859 12692647
MESH:D013964 Thyroid Neoplasms glycidol 5.0212562636
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 3.7811251952
MESH:D014570 Urologic Diseases Diazinon 5.3716487989
MESH:D014594 Uterine Neoplasms glycidol 5.7312562636 12692647
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00380 Tryptophan metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA355
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    PA447278Depression
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA450801paroxetine
    PA449690fluvoxamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00150 - L-Tryptophan Dietary supplement;Micronutrient;Essential Amino Acids;Antidepressive Agents, Second-Generation
    DB00360 cofactor Tetrahydrobiopterin Dietary supplement;Cofactor
    DB03271 - 7,8-Dihydro-L-Biopterin
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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