AutismKB 2.0

Annotation Detail for TPM1


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Basic Information Top
Gene Symbol:TPM1 ( C15orf13,CMD1Y,HTM-alpha,TMSA )
Gene Full Name: tropomyosin 1 (alpha)
Band: 15q22.2
Quick LinksEntrez ID:7168; OMIM: 191010; Uniprot ID:TPM1_HUMAN; ENSEMBL ID: ENSG00000140416; HGNC ID: 12010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Muscle contraction
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Cardiac diseases
H00294Dilated cardiomyopathy (DCM)
H00292Hypertrophic cardiomyopathy (HCM)
Desease IDDesease Name
1944Breast cancer
2067Primary tumor
Desease Name
HEMATOLOGICAL
CARDIOVASCULAR
mean platelet volume
cardiovascular
nemaline myopathy
Desease Name
Mean platelet volume
Desease Name
Cardiomyopathy, familial hypertrophic, 3
Cardiomyopathy, dilated, 1Y
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016614 1-nitronaphthalene 1-nitronaphthalene metabolite binds to TPM1 proteinaffects binding 16453347
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TPM1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TPM1 mRNAaffects expression 21346803
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]decreases reaction|increases expression 15910882
D000499 Allylamine Acetylcysteine inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]decreases reaction|increases expression 15910882
D000499 Allylamine Allylamine results in increased expression of TPM1 mRNAincreases expression 15910882
D000499 Allylamine Allylamine results in increased expression of TPM1 proteinincreases expression 15910882
D000499 Allylamine Hydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]decreases reaction|increases expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPM1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of TPM1 proteindecreases expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of TPM1 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TPM1 mRNAdecreases expression 19150397
C095105 bexarotene bexarotene results in increased expression of TPM1 mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A affects the expression of TPM1 mRNAaffects expression 20170705
C032036 bromobenzene bromobenzene metabolite binds to TPM1 proteinaffects binding 17305373
D002104 Cadmium Cadmium results in decreased expression of TPM1 mRNAdecreases expression 17327700
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of TPM1 mRNAdecreases expression 17327700
C459604 candoxin candoxin results in increased expression of TPM1 mRNAincreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TPM1 mRNAaffects expression 17484886
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]affects binding|increases expression|increases reaction 16940432
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of TPM1 mRNAincreases expression 17654400
D003520 Cyclophosphamide TPM1 protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNAaffects cotreatment|decreases expression 16054899
D004041 Dietary Fats Dietary Fats results in increased expression of TPM1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TPM1 mRNAincreases expression 18597072
D004052 Diethylnitrosamine troglitazone promotes the reaction [Diethylnitrosamine results in increased expression of TPM1 mRNA]increases expression|increases reaction 18597072
D004317 Doxorubicin TPM1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004317 Doxorubicin [Doxorubicin co-treated with MT2A protein] results in decreased expression of TPM1 proteinaffects cotreatment|decreases expression 16144979
D004317 Doxorubicin Doxorubicin results in decreased expression of TPM1 proteindecreases expression 16144979
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TPM1 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TPM1 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TPM1 mRNAincreases expression 12655037
D005472 Fluorouracil TPM1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C056933 fumonisin B1 fumonisin B1 results in increased expression of TPM1 mRNAincreases expression 16221962
D006861 Hydrogen Peroxide Hydrogen Peroxide inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]decreases reaction|increases expression 15910882
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNAaffects cotreatment|decreases expression 16054899
C008493 methylselenic acid methylselenic acid results in increased expression of TPM1 mRNAincreases expression 18548127
D008942 Mitoxantrone TPM1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of TPM1 mRNAincreases expression 16809437
C031721 naphthalene naphthalene metabolite binds to TPM1 proteinaffects binding 16453347
C031721 naphthalene naphthalene metabolite binds to TPM1 proteinaffects binding 15892573
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]affects binding|increases expression|increases reaction 16940432
C041786 palm oil palm oil results in increased expression of TPM1 mRNAincreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in increased expression of TPM1 mRNAincreases expression 15728792
C006253 pirinixic acid pirinixic acid results in decreased expression of TPM1 mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in decreased expression of TPM1 mRNAdecreases expression 18037150
D011794 Quercetin Quercetin results in decreased expression of TPM1 mRNAdecreases expression 18095365
D020849 Raloxifene Raloxifene affects the expression of TPM1 mRNAaffects expression 14699072
D020849 Raloxifene Raloxifene affects the expression of TPM1 mRNAaffects expression 16079270
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNAaffects cotreatment|decreases expression 16054899
D013629 Tamoxifen Tamoxifen affects the expression of TPM1 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TPM1 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TPM1 mRNAincreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TPM1 mRNAdecreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TPM1 proteinincreases expression 19201780
D019772 Topotecan TPM1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin affects the expression of TPM1 proteinaffects expression 15789344
C057693 troglitazone troglitazone promotes the reaction [Diethylnitrosamine results in increased expression of TPM1 mRNA]increases expression|increases reaction 18597072
D014520 Urethane Urethane results in decreased expression of TPM1 mRNAdecreases expression 16289808
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of TPM1 mRNAdecreases expression 16330358
C025643 vinclozolin vinclozolin affects the expression of TPM1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3611752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.0618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4317505938
MESH:D055371 Acute Lung Injury 1-nitronaphthalene 8.0415204773
MESH:D055371 Acute Lung Injury pirinixic acid 8.0418653653
MESH:D000230 Adenocarcinoma Doxorubicin 8.9817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.9814692618
MESH:D000230 Adenocarcinoma Fluorouracil 8.9817638652
MESH:D000230 Adenocarcinoma Urethane 8.9818316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.2015814487
MESH:D000236 Adenoma Diethylnitrosamine 6.1110737359 6695378
MESH:D000236 Adenoma Urethane 6.1117093202 16926031 17195641 6695378 11497255 10822126 10530776
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.4019061943 17620307 19052882 17162532 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.4016835633
MESH:D000419 Albuminuria Doxorubicin 9.8921441931
MESH:D000419 Albuminuria Raloxifene 9.8917308373 17451421
MESH:D000505 Alopecia Tretinoin 3.2215955085
MESH:D000544 Alzheimer Disease Raloxifene 4.0715800139
MESH:D000544 Alzheimer Disease rosiglitazone 4.0719621015
MESH:D000740 Anemia Fluorouracil 7.2517963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2511748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7917084956
MESH:D001008 Anxiety Disorders vinclozolin 3.2419015723
MESH:D001161 Arteriosclerosis Cyclophosphamide 14.2615014928
MESH:D001161 Arteriosclerosis Dietary Fats 14.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 14.2611256880
MESH:D001169 Arthritis, Experimental Dexamethasone 10.4217659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 10.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1316292516
MESH:D001249 Asthma Tretinoin 2.1816456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4815336622
MESH:D050197 Atherosclerosis Cadmium 3.3415687053
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.0220106747
MESH:D001327 Autoimmune Diseases Quercetin 3.9219761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9316935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.6919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.6912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.6916197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.1914601052
MESH:D001862 Bone Resorption bisphenol A 3.4211985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8317868700
MESH:D001930 Brain Injuries Progesterone 9.3515665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.3516580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.3817150277
MESH:D001943 Breast Neoplasms bexarotene 11.6416344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 11.6417123778
MESH:D001943 Breast Neoplasms Chromium 11.6415986119
MESH:D001943 Breast Neoplasms Cyclophosphamide 11.6412006526 17020986 18234424 15136595 11325840 16978400 17388661 15093573 18323546
MESH:D001943 Breast Neoplasms Dietary Fats 11.6420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.6417474063
MESH:D001943 Breast Neoplasms Doxorubicin 11.6416115903 15994142 16096432 15939500 19526202 15668708 18628466 15567936 17369602 18695136 11325840 16322301 17983394 15634643 15692762 16826403 18234424 15136595 17426702 15993339 16595493 18382427 16264153 16935488
MESH:D001943 Breast Neoplasms Fluorouracil 11.6416110121 16595493 18608205 19217205 15136595 18357371 16557594
MESH:D001943 Breast Neoplasms Progesterone 11.6417614352 16175315 15562024
MESH:D001943 Breast Neoplasms Quercetin 11.6418628248
MESH:D001943 Breast Neoplasms Raloxifene 11.6417952589 17893378 17261762 15775269 16837676 15572757 16912660 15758505 17440819 17595753 17242785 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 11.6419200415 16818667 19084267 18629630 19410462 15668708 21138602 19155303 19011961 20005174 17440819 17893378 17261762 19142967 20390343 18984771 19288272 18815881 16873071 19189210 21152245 16202921 20859285 19103187 17049068 15565566 19487384 16273361 18425577 20544844 19059307 18821012 11161223 18351453 17242785 18997820 19066611 18855134 19115204 20065188 19244106 20135344 19189212 19221464 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.6420435547
MESH:D001943 Breast Neoplasms Tretinoin 11.6416166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0916813970
MESH:D002105 Cadmium Poisoning Quercetin 5.0416962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.303786805 16097048 15700767 16011737 16227642 16124888 15673190 18705752 16192424 10355542 16050911 15721981
MESH:D002276 Carcinoid Tumor Doxorubicin 10.6616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.6616051944
MESH:D002277 Carcinoma Fluorouracil 6.8717121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 20.7016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 20.7016705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 20.7018788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 20.7019701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 20.7016681979 16540662 20727157 20084675 18788625 20524982 16935385 3581430 20214788 19822196 19208518 20512989 18691550 3084413 20432363 18210153 16878318 19701751 18056438 16830150 10737359 19418558 19919837 18494052 10672840 21159647 16569478 18978308 16328049 18506893 17055752 19335982 20514400 19519916 16502159 19052882 11831363 16807293 20935162 18971187 17978847 18393292 20101231 17173139 17428255 17162532 18785209 16779866 19107877 19383236 19171122 17138121 17761372 16698587 19539802 20007298 19394651 18665156 16288022
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 20.7018059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 20.7016799960 17045692 18930000 16332177 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Quercetin 20.7019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 20.7016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 20.701917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4917123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.3916152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0416247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4717234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 9.4216201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.421485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.4218695887
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 9.4417015178
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 9.446189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.4418986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.4416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.0617572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.0617572228
MESH:D006332 Cardiomegaly Quercetin 5.8319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.8318850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.1915792986 17308081 17974986 17007740 17382496 16364871 17924179 16651473 16269455 18627295 16278810 17329180 15811867 16109756 16731534 15505089 16952015 17131338 17928571 17519947 16455267 17351982 15476868 16612575 16242529
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7617334414 16243910
OMIM:115196 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 marker/mechanism
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.4116936243
MESH:D002318 Cardiovascular Diseases Raloxifene 6.4115775269
MESH:D002386 Cataract Tretinoin 2.7917460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.406135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.4020889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 17.4018226522
MESH:D002471 Cell Transformation, Neoplastic Cadmium 17.4017332340
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.4021159647 7505956 17174075 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.5011677210 16919318 16105132 15861022 17681005 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 6.5019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.588697196 15340226 16354765 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 8.589407595
MESH:D002972 Cleft Palate Urethane 8.5812810352
MESH:D003072 Cognition Disorders Raloxifene 4.1315800139
MESH:D003092 Colitis Tretinoin 3.2217035595
MESH:D003110 Colonic Neoplasms Dexamethasone 5.2315824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.2317018589 17725105 17287894 15001691 16340194 18772588 17172411 16510598 17169374 17016597
MESH:D003110 Colonic Neoplasms Quercetin 5.2319056647 19440933 17191121 16640504 15741050 17148506 11134977
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.2018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.2017094418 18802399 14970324 16524972 18383874 20501625 18448328 17695437 18509181 16282729 17401013 16391804 17255274 17016601 16331619 17594712 18949393 16303861 18288408 15289873 15148649 17454858
MESH:D015179 Colorectal Neoplasms Quercetin 3.2018095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6414669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.4317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.438800419 9211117 17551590 9125849 10589399 9664655 14991402 9142499 9224671 16925845
MESH:D003456 Cryptorchidism vinclozolin 3.8714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.2818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.2818551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.9519747007
MESH:D003556 Cystitis Cyclophosphamide 4.4818372110 12913760 16614059 18295254 11948286 10700343 16989017 16413132 15276878 12388444 10498854 12161096 18483878 17979934 18710439 15643279 16651033 18433785 17010015 18093676
MESH:D007644 Darier Disease Fluorouracil 4.2916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7417474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9512438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.8817446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 11.7915331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 11.7919496084
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 11.7916684804
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0518772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.0820387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 9.0812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.0817107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 9.0816023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.1512601628
MESH:D003928 Diabetic Nephropathies Raloxifene 7.6417451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.6419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0117187935
MESH:D003967 Diarrhea Dexamethasone 3.247237001
MESH:D056486 Drug-Induced Liver Injury 1-nitronaphthalene 33.028212003
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 33.0221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 33.0218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 33.0211287661
MESH:D056486 Drug-Induced Liver Injury bromobenzene 33.0210092053 12628495
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 33.0215998439 6884620 3732212 7440962 6623471 10915739 11566570 21278145 9327722 16227642 3786805 10092053 19336974 2869522 7120509 15027814 4309450 16177239 15968718 7179309 17522070 19085960
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 33.0217654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 33.0219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 33.0217416283
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 33.0216221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 33.0220420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 33.0214986274
MESH:D004362 Drug Toxicity Doxorubicin 6.8718602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.8711462148
MESH:D050171 Dyslipidemias Dietary Fats 3.0918367378
MESH:D004485 Eczema Dexamethasone 3.9912438553
MESH:D004487 Edema Dexamethasone 16.9919703484
MESH:D004487 Edema pirinixic acid 16.9912083418
MESH:D004487 Edema Raloxifene 16.9915860553
MESH:D004487 Edema rosiglitazone 16.9912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.9911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.2516714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.2518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.0617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 18.0615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.0619031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.5417359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.5416202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 10.5416569247
MESH:D004715 Endometriosis Progesterone 7.4916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.499294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6518037988
MESH:D004802 Eosinophilia Cyclophosphamide 3.7411006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6116302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.0020426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.0016481741 16785472 15173087 17638652 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.5911564622
MESH:D005124 Eye Abnormalities Tretinoin 7.599664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.5316239168 19224547 15959796 12631006 17595544 61145 12795759 16045604
MESH:D005234 Fatty Liver Dietary Fats 35.5318296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 35.5320387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.5315345470
MESH:D005234 Fatty Liver pirinixic acid 35.5320131406 19236843
MESH:D005234 Fatty Liver Raloxifene 35.5317473493
MESH:D005234 Fatty Liver rosiglitazone 35.5319196556
MESH:D005234 Fatty Liver Tamoxifen 35.5314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0314745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.7919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.7919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 22.6018705752
MESH:D005355 Fibrosis Dietary Fats 22.6018296743
MESH:D005355 Fibrosis Quercetin 22.6019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.6020067830
MESH:D005355 Fibrosis Tretinoin 22.6017994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7916417039
MESH:D005909 Glioblastoma Doxorubicin 10.0017150277
MESH:D005909 Glioblastoma Quercetin 10.0019804834
MESH:D005909 Glioblastoma Tretinoin 10.0017312396
MESH:D005910 Glioma Fluorouracil 5.4516145905
MESH:D005910 Glioma Quercetin 5.4517643826
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0211389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0910696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5515172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms Doxorubicin 10.9815692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 10.9818337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 10.9816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.6011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.609664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 15.2918006777 12587719 17875725 16244371 17888722 18674790 14766674 16707910 16144979 16495754 16330681 16879835 16244372
MESH:D006331 Heart Diseases Mitoxantrone 15.2916019553
MESH:D006331 Heart Diseases Raloxifene 15.2911110106
MESH:D006331 Heart Diseases Urethane 15.2916046796
MESH:D006333 Heart Failure Doxorubicin 5.9917481944
MESH:D006333 Heart Failure pirinixic acid 5.9920558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4615692506
MESH:D006467 Hemophilia A Cyclophosphamide 4.8011918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8911000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0314986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1319110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 11.6916221962
MESH:D006529 Hepatomegaly pirinixic acid 11.6919176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.6916120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.887520565
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.3417606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 6.3415147373 18501091 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5418606429 16354765 15340226 16959395 8697196
MESH:D006930 Hyperalgesia rosiglitazone 6.7612083418
MESH:D006930 Hyperalgesia Tretinoin 6.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0316899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1521332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0816778211
MESH:D006943 Hyperglycemia pirinixic acid 7.8120558911
MESH:D006943 Hyperglycemia Quercetin 7.8118262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 3.1621332399
MESH:D006973 Hypertension Dexamethasone 10.6517042910
MESH:D006973 Hypertension Quercetin 10.6518356687
MESH:D006973 Hypertension Raloxifene 10.6515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.6518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3216569931 16945680
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 4.9418306037
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8216076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0012013081
MESH:D007248 Infertility, Male Cyclophosphamide 9.3116517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.3117937319
MESH:D007248 Infertility, Male vinclozolin 9.3116467254
MESH:D007249 Inflammation Dexamethasone 19.9711099482 8960868
MESH:D007249 Inflammation Dietary Fats 19.9720412841
MESH:D007249 Inflammation Diethylnitrosamine 19.9718785209
MESH:D007249 Inflammation Progesterone 19.9715869954
MESH:D007249 Inflammation rosiglitazone 19.9712083418
MESH:D007249 Inflammation Tamoxifen 19.9719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.9712878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.0016624496
MESH:D007333 Insulin Resistance bisphenol A 14.9216393666
MESH:D007333 Insulin Resistance Dietary Fats 14.9211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 14.9216306350
MESH:D007333 Insulin Resistance rosiglitazone 14.9216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.4516580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.4515992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 4.9418306037
MESH:D007627 Keloid Quercetin 4.4717086741
MESH:D007674 Kidney Diseases Cadmium 15.9116226777 16322080 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 15.9116962696
MESH:D007674 Kidney Diseases Chromium 15.9117934191
MESH:D007674 Kidney Diseases Doxorubicin 15.9115699352 15369732 16775033
MESH:D007674 Kidney Diseases Quercetin 15.9116962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.6416707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.6416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.4516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.4516705839
MESH:D007680 Kidney Neoplasms Fluorouracil 14.4516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 14.4518625569
MESH:D007889 Leiomyoma Raloxifene 4.0416973256
MESH:D007938 Leukemia Cyclophosphamide 9.0510602166
MESH:D007938 Leukemia Quercetin 9.0517468513
MESH:D007938 Leukemia Tretinoin 9.0517143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 12.5416085563
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 12.5416085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 6.2017008537 17658394 17296974 17802794 18587576 18172266
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 6.2018172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7210373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9816294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8217506722 17361223 12679006 15748426 19075265 16331271 19029980 17217047 16891316 19642359 19225113 17339181 16935935 16140955 17301526 17368321 17294898 16766008 16823087 19035177 16788101 17107899 9834237 17649720 17712046
MESH:D007970 Leukopenia Cyclophosphamide 4.4710052129 11830472
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2316417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.959224671
MESH:D008064 Lipidoses Tamoxifen 2.8017567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.3217334410 11408273 17174718 11903743 16221502 17157831 16239168 16943688 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 9.3218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.3219638242 18522880 18407596 18665156 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.0815730626 12586293 16248980 18006644 12632512 18472332 15818738 18339082 18210741 16033810 13678700 18277467 17714472 20821823 17761835 17976157 17557913 12666154 15338365 16015684 18412020 15893842 17708605 15876570 16192424 16011737 18395914 17922224 12958196 18054572 17631135 12649538 15673190 16027843 12898905 18420326 12632514 15362042 17766677 15996030 18376398 12741479 18251166 18395095 18187930 15370692 17805973 18481824 12546737 12609069 12445421 15925388 17640975 15931870 17481882 17698563 17565644 14748882 17823541 18263696 16136751 16638106 18705752 11481614 16116963 18279442 18429990 17944888 18156304 10355542 17721639 15052691 18317297 12445418 14716833 15123356 18205269 18472094 15650968 17869086 14724832 14716496 14620537 15959796 18166357 16097048 17525996 17900296 15057751 14512876 12667390 12389079 18418968
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.0816718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 14.0816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.0815474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 14.0812741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 14.0817347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.0818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.0812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 14.0818397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.5716246199 15830285 16964402 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 3.5717034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.2616899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 25.887678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 25.8819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 25.8820434301 20118626 19499222 20101389 18644402 18648771 9163691 21071580 19256749 20501860 19690152 18978307 12771043 19254457 19551842 15175105 21047994 19294768 19996281 18977376 19255062 19642983 21278145 2862719 2422723 19426721 20405173 10737359 20492335 19073162 20583210 21167192 15885732 19090486 18754104 20137499 19833225 19812893 19427195 19638242 16942905 12112319 20452335 19850985
MESH:D008113 Liver Neoplasms Fluorouracil 25.8818383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 25.8820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 25.8818980244
MESH:D008113 Liver Neoplasms Tamoxifen 25.8816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.8816984957
MESH:D008113 Liver Neoplasms Urethane 25.8816391232 17093202 17559639
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.182876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.1815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.1816267830 17854601 19009564 18079962 9362446 16842330 19519916 2563599 19004024 3124819 17174075 18544905 19539802 17942915 18282651 18093689 18164116 18253720 18775883 21159647 18308698 19126423
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.1816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 19.1819519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.1812151625
MESH:D008171 Lung Diseases 1-nitronaphthalene 7.288212003
MESH:D008171 Lung Diseases Acetylcysteine 7.2812815614
MESH:D055370 Lung Injury 1-nitronaphthalene 12.802384072
MESH:D055370 Lung Injury Asbestos, Crocidolite 12.8017365036
MESH:D055370 Lung Injury naphthalene 12.806834280
MESH:D008175 Lung Neoplasms bexarotene 13.8117849452
MESH:D008175 Lung Neoplasms Dexamethasone 13.8111195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 13.8120512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 13.816189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 13.8115246190
MESH:D008175 Lung Neoplasms Quercetin 13.8116280456
MESH:D008175 Lung Neoplasms Tamoxifen 13.8118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.8119555203 11884234
MESH:D008175 Lung Neoplasms Urethane 13.8111246140 6695378 10997738 11893704 11497255 12957351 11062179 15902970 11074608 10822126 10530776 12466968 12117781 11544531 16204055 16289808 16337739 16391232 7750092 15166089 17255336 11307925 11552296 14587096 17093202 16007126 10779650 11323394 17195641 16788158 11807781 16926031 11992545 15136453 12765245
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2915086387
MESH:D008223 Lymphoma Cyclophosphamide 6.6812854902
MESH:D008223 Lymphoma Doxorubicin 6.6816098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.1416675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 7.6411911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.6417654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0815621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6611161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2719428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 15.3419196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 15.3415458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.3411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 15.3416827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 15.3411731420 16827153 19196722 19196723 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.0419453300
MESH:D008527 Medulloblastoma Tretinoin 2.5717453147
MESH:D008545 Melanoma Doxorubicin 4.4916827129
MESH:D008545 Melanoma Tamoxifen 4.4919393235 12393984
MESH:D008545 Melanoma Tretinoin 4.4916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6815990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.3216388313
MESH:D008591 Meningomyelocele Tretinoin 3.9416940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 5.7016966607 16166281 18303189
MESH:D008654 Mesothelioma Doxorubicin 5.7017638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.9717261469
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0515792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0515863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.2516757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.2917415656
MESH:D009101 Multiple Myeloma Dexamethasone 6.3616118317 15867202 15744524
MESH:D009101 Multiple Myeloma Raloxifene 6.3616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.0216239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.549809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.5417596541
MESH:D009203 Myocardial Infarction Doxorubicin 8.1615857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 8.1619151258
MESH:D009203 Myocardial Infarction Quercetin 8.1619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.1616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.1619207477
MESH:D009232 Myxoma Raloxifene 5.0516343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.6918551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.6918551238 7678174
MESH:D009362 Neoplasm Metastasis Acetylcysteine 11.8014720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.809029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 11.8018259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 11.8019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3419410462
MESH:D009369 Neoplasms Cyclophosphamide 19.9518854779
MESH:D009369 Neoplasms Fluorouracil 19.9518239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 19.9516640825
MESH:D009369 Neoplasms pirinixic acid 19.9517405874
MESH:D009369 Neoplasms Quercetin 19.9515185748
MESH:D009369 Neoplasms Tretinoin 19.9516594593 16946489
MESH:D009369 Neoplasms Urethane 19.9515625555
MESH:D009374 Neoplasms, Experimental Urethane 4.2015582191
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.2519196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.2519189210 19196722 19200415
MESH:D009401 Nephrosis Doxorubicin 4.2816636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.5815640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 13.6411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.6414600291
MESH:D009421 Nervous System Malformations Tretinoin 13.649125849
MESH:D009436 Neural Tube Defects Acetylcysteine 6.5219446573
MESH:D009436 Neural Tube Defects Tretinoin 6.529142499
MESH:D009447 Neuroblastoma Cyclophosphamide 10.0116115947 8761367 15176712
MESH:D009447 Neuroblastoma Doxorubicin 10.0115555623
MESH:D009447 Neuroblastoma Topotecan 10.0115176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 2.9420387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.398761367 12837982
MESH:D020078 Neurogenic Inflammation Quercetin 3.9017929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6120387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0916436463
MESH:D009503 Neutropenia Cyclophosphamide 3.878291058
MESH:D009765 Obesity Dietary Fats 3.9420518802 17217161 11836018 19632207 18674790 21332399 20132043 16723640 18457598
MESH:D009765 Obesity pirinixic acid 3.9420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.4516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.4516049721
MESH:D009845 Oligospermia Cyclophosphamide 4.2216517039
MESH:D010024 Osteoporosis Raloxifene 3.0819059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.6719495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 8.6715579764 17893378 17823083 15758505
MESH:D012516 Osteosarcoma Doxorubicin 3.7215930896
MESH:D010049 Ovarian Diseases bisphenol A 4.4911985600
MESH:D010051 Ovarian Neoplasms Progesterone 9.8516525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 9.8519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 9.8516936753
MESH:D010051 Ovarian Neoplasms Urethane 9.8516391232
MESH:D010146 Pain Cyclophosphamide 5.7212161096 18093676
MESH:D010146 Pain Tretinoin 5.7216870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 14.1511332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.1516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 14.1519003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 14.1516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.1515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2311578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.6112065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7412520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8815687053
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6517983394
MESH:D010911 Pituitary Neoplasms Urethane 4.9316391232
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.4110923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.832563599
MESH:D011230 Precancerous Conditions Quercetin 7.8319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 6.8321297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.8321297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.3810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.3811399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.3819015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.4418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.7620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.7316740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.7317075824
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.7317136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7316888761 15897917 15749863 18437689 16868541 16729912
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7319082440 18626508
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.7316205645
MESH:D011471 Prostatic Neoplasms Quercetin 2.7314715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7315067354
MESH:D011472 Prostatitis vinclozolin 4.4418629315
MESH:D011507 Proteinuria Tretinoin 3.1516636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8216919318 15861022
MESH:D011625 Pterygium Tretinoin 4.2916723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2910548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.2917975199 17322281 15814490 17365031
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 8.2916636934
MESH:D011658 Pulmonary Fibrosis troglitazone 8.2918162602
MESH:D011693 Purpura Raloxifene 5.0515770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5918722050 18286688 16160472 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 3.7417922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 7.9712210543
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.9711700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6416283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6618045962
MESH:D012509 Sarcoma Doxorubicin 3.5617710206 15675481 16767912 17203757 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.7714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2917846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.0416862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3616636934
MESH:D012640 Seizures 2,4-dinitrotoluene 4.7318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 4.7318551238
MESH:D012878 Skin Neoplasms Doxorubicin 15.2315692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.2312065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.2316192470
MESH:D012878 Skin Neoplasms Tretinoin 15.2316467112
MESH:D012878 Skin Neoplasms Urethane 15.2311807781
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0816767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 9.8716709447
MESH:D013088 Spermatocele Tamoxifen 9.8716709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0216517039
MESH:D013119 Spinal Cord Injuries Progesterone 9.2216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.2219457130
MESH:D013272 Stomach Diseases Dexamethasone 3.8315472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.2718456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.2718567086 16424979 18396642 16951190 17522103 15786421 17172411 19015929 19084572 17498489
MESH:D013274 Stomach Neoplasms Tretinoin 4.2717261132
MESH:D013274 Stomach Neoplasms troglitazone 4.2715930296
MESH:D013276 Stomach Ulcer Acetylcysteine 6.2717918041
MESH:D013276 Stomach Ulcer Dexamethasone 6.2715138204
MESH:D020521 Stroke Raloxifene 3.4316837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.4916045194 16684133
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5612837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.817505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.8116010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 9.8117045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 4.7019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.3916280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.3916051514
MESH:D014376 Tuberculosis Tretinoin 2.9116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 20.7716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 20.7716049721
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 20.7714692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 20.7717653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 20.7716720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 20.7717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 20.778653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.3310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.3310091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.0116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.0116129372
MESH:D014591 Uterine Diseases bisphenol A 4.5014652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1016752155
MESH:D014605 Uveitis Dexamethasone 4.311336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0912125929
MESH:D019043 Vascular Neoplasms Urethane 5.4010620525
MESH:D054556 Venous Thromboembolism Raloxifene 4.7016837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.7417638931 17334414 17678736 16364871
MESH:D014820 Vitiligo Tretinoin 3.5816761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7415886252
MESH:D015430 Weight Gain Dietary Fats 3.3216723640
MESH:D009396 Wilms Tumor Tretinoin 3.5516287080
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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