AutismKB 2.0

Annotation Detail for TPM2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TPM2 ( AMCD1,DA1,DA2B,NEM4,TMSB )
Gene Full Name: tropomyosin 2 (beta)
Band: 9p13.3
Quick LinksEntrez ID:7169; OMIM: 190990; Uniprot ID:TPM2_HUMAN; ENSEMBL ID: ENSG00000198467; HGNC ID: 12011
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Muscle contraction
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1775Muscular atrophy
1832Congenital abnormality
1849Myopathies, Nemaline
No data
No data
Desease Name
Nemaline myopathy
Arthrogryposis multiplex congenita, distal, type 1
Arthrogryposis, distal, type 2B
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPM2 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TPM2 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TPM2 mRNAaffects expression 17484886
C014347 decitabine decitabine affects the expression of TPM2 mRNAaffects expression 17145863
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPM2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TPM2 mRNAincreases expression 12075121
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TPM2 mRNAaffects cotreatment|increases expression 17183730
D008628 Mercury Mercury results in increased expression of TPM2 mRNAincreases expression 16823088
D010656 Phenylephrine Phenylephrine results in increased expression of TPM2 mRNAincreases expression 18158353
D012643 Selenium Selenium results in increased expression of TPM2 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPM2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TPM2 proteinincreases expression 19201780
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TPM2 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of TPM2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of TPM2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001008 Anxiety Disorders Valproic Acid 9.0717497229
MESH:D001008 Anxiety Disorders vinclozolin 9.0719015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1917460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
OMIM:108120 ARTHROGRYPOSIS, DISTAL, TYPE 1 marker/mechanism
MESH:D001321 Autistic Disorder Mercury 2.3617497416
MESH:D001321 Autistic Disorder Valproic Acid 2.3618985861 18316065 20603192 16609825 15238991 18775368 18558336 18177632 18396377 17157402 18940202 17507914 19232924 17688650 19460635
MESH:D001327 Autoimmune Diseases Mercury 4.9816634805
MESH:D001714 Bipolar Disorder Valproic Acid 3.1117594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D001919 Bradycardia Phenylephrine 4.6615306635
MESH:D001943 Breast Neoplasms decitabine 2.0919208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.2916097048 16227642 16050911 10355542 3786805 15673190 16192424 15700767 16124888 15721981 16011737 18705752
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.2916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8418788625
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6119215824
MESH:D006332 Cardiomegaly Phenylephrine 7.0215728586 16170337 11754973 17124262 11179087 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0218670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4810334427
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9311677210 15861022 16919318 17110522 17681005 17333356 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 8697196 15668235 16354765 12621046
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8220055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8217688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8219769572
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.9016823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:C538400 Distal arthrogryposis type 2B marker/mechanism
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.1716177239 19336974 16227642 7179309 7120509 15027814 19085960 6884620 17522070 10915739 15968718 15998439 3732212 2869522 7440962 21278145 3786805 10092053 4309450 6623471 9327722 11566570
MESH:D056486 Drug-Induced Liver Injury Selenium 9.1715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.1719641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.053922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.6017595544 12631006 16239168 12795759 15959796 61145 16045604 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6015345470
MESH:D005234 Fatty Liver Valproic Acid 13.6014986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2318558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16354765 18606429 16959395 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006973 Hypertension Phenylephrine 5.4012717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D006984 Hypertrophy Phenylephrine 4.6312791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male decitabine 11.5517581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.5517937319
MESH:D007248 Infertility, Male vinclozolin 11.5516467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Mercury 6.6217934191
MESH:D007674 Kidney Diseases Vitamin E 6.6212488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007938 Leukemia decitabine 3.1119235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0817236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0419387464 19010910 17679729 18206229 18460780 18704418
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0416294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8511408273 16239168 16221502 21278145 17174718 11903743 16943688 17157831 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5117525996 17922224 15818738 16638106 18251166 15959796 18279442 16097048 10355542 11481614 18418968 17944888 15362042 18317297 16027843 18472332 12632512 17869086 13678700 18472094 12445421 12649538 17714472 17698563 18412020 18166357 17631135 15052691 18339082 17708605 12958196 17481882 18187930 14748882 17640975 16136751 17766677 18210741 15123356 17565644 18205269 12632514 18156304 12898905 16192424 18263696 12741479 15057751 12586293 20821823 18429990 17761835 15996030 18277467 18395914 15370692 17557913 15925388 18376398 14724832 15876570 18420326 12667390 14716833 17721639 12666154 17976157 15673190 14512876 18395095 18006644 16116963 17900296 16015684 12609069 12546737 17805973 15338365 12445418 18705752 14620537 14716496 15931870 18054572 16248980 16033810 18481824 16011737 15893842 17823541 15730626 12389079 15650968
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5116169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016246199 17285989 15720792 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9212151625
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 2.3311062179
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008545 Melanoma decitabine 2.2516505122 17785578
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009101 Multiple Myeloma decitabine 3.4018172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6519157545 18608210 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.6517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D017696 Myopathies, Nemaline marker/mechanism
MESH:D009369 Neoplasms decitabine 2.7517925555 19470736 19116145
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1816359493 8888407
MESH:D010051 Ovarian Neoplasms decitabine 2.6719259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.7919294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.9511896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.9520603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.9518220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2915084515
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.6711422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.2719155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.2719155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.793137016 15475178 16876388 11738929 1511512 17978042 14763951 11044598
MESH:D012852 Sinusitis Phenylephrine 4.827327846
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.718532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms decitabine 3.3917967635
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7517616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved