AutismKB 2.0

Annotation Detail for TPM3


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Basic Information Top
Gene Symbol:TPM3 ( FLJ41118,MGC14582,MGC3261,MGC72094,NEM1,OK/SW-cl.5,TM-5,TM3,TM30,TM30nm,TPMsk3,TRK,hscp30 )
Gene Full Name: tropomyosin 3
Band: 1q21.3
Quick LinksEntrez ID:7170; OMIM: 191030; Uniprot ID:TPM3_HUMAN; ENSEMBL ID: ENSG00000143549; HGNC ID: 12012
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa05216Thyroid cancer
hsa05200Pathways in cancer
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Muscle contraction
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00032Thyroid cancer
Cancers of endocrine organs
Desease IDDesease Name
1887Carcinoma
1849Myopathies, Nemaline
Desease Name
nemaline myopathy
No data
Desease Name
Nemaline myopathy 1, autosomal dominant
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TPM3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TPM3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TPM3 mRNAaffects expression 17562736
D000171 Acrolein Acrolein results in increased metabolism of TPM3 proteinincreases metabolic processing 17570602
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPM3 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TPM3 proteindecreases expression 19364129
C095105 bexarotene bexarotene results in increased expression of TPM3 mRNAincreases expression 16648578
C110172 BHTOH-QM BHTOH-QM binds to TPM3 proteinaffects binding 16533022
C006780 bisphenol A bisphenol A results in increased expression of TPM3 mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of TPM3 mRNAdecreases expression 16644059
C014347 decitabine decitabine results in decreased expression of TPM3 proteindecreases expression 19294695
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TPM3 mRNAincreases expression 20360939
19638242
D004958 Estradiol Estradiol results in increased expression of TPM3 mRNAincreases expression 16474171
D004958 Estradiol Estradiol results in increased expression of TPM3 mRNAincreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TPM3 mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPM3 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of TPM3 mRNAincreases expression 16474171
C029424 hydrazine hydrazine results in increased expression of TPM3 proteinincreases expression 15370871
D001556 Lindane Lindane affects the expression of TPM3 mRNAaffects expression 17785943
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TPM3 mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in decreased expression of TPM3 mRNAdecreases expression 18445702
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of TPM3 mRNAincreases expression 16474171
C025299 polyphenols polyphenols results in decreased expression of TPM3 mRNAdecreases expression 16293270
D013629 Tamoxifen Tamoxifen affects the expression of TPM3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPM3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TPM3 mRNAincreases expression 16054898
C012589 trichostatin A trichostatin A results in decreased expression of TPM3 proteindecreases expression 19294695
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury Acrolein 8.7520525806 21297076
MESH:D055371 Acute Lung Injury pirinixic acid 8.7518653653
MESH:D000230 Adenocarcinoma marker/mechanism 15378696
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8119825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 9.8111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8114692618
MESH:D000230 Adenocarcinoma Genistein 9.8111473722
MESH:D000236 Adenoma Diethylnitrosamine 2.756695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.2818056438 16434500 17162532 19061943 17620307 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.2816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.2816835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.2012661182
MESH:D000544 Alzheimer Disease Acrolein 3.2415207723 17570602 14715435
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D001161 Arteriosclerosis Acrolein 9.7515014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D050197 Atherosclerosis Acrolein 3.8816126721 16037261 17363696
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.3716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001862 Bone Resorption bisphenol A 3.7111985600
MESH:D001943 Breast Neoplasms bexarotene 5.6716818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 5.6717123778
MESH:D001943 Breast Neoplasms decitabine 5.6718320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6717474063
MESH:D001943 Breast Neoplasms Estradiol 5.6714630087 16675129 18497071 17261762 12948864 17018787 17289903 19861407
MESH:D001943 Breast Neoplasms Genistein 5.6716873071 16541309 17200150
MESH:D001943 Breast Neoplasms Lindane 5.6714688026
MESH:D001943 Breast Neoplasms Tamoxifen 5.6719011961 18984771 16273361 18997820 20544844 19155303 18815881 11161223 19189210 20065188 19289846 20135344 19288272 19142967 20859285 20005174 18425577 18351453 19084267 16818667 19410462 18821012 15565566 17242785 17049068 18629630 19189212 19066611 19221464 16202921 19115204 18855134 19244106 19487384 20390343 17440819 17893378 21138602 16873071 19103187 19200415 17261762 21152245 15668708 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1711589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6115673190 16124888 16050911 16227642 16011737 16097048 15700767 16192424 15721981 10355542 18705752 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.3716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.3716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.373084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.3715553829 16217749 11135700 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.3718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.3711831363 19052882 16288022 18971187 16807293 19539802 19394651 16569478 19171122 16540662 17138121 20727157 17173139 18210153 19519916 16698587 18785209 19919837 18506893 20512989 20524982 18691550 20007298 17162532 19335982 16935385 20935162 20514400 3581430 10672840 21159647 18494052 17978847 18665156 16779866 16681979 19822196 19418558 20084675 3084413 17761372 20101231 17428255 17055752 19107877 20432363 16830150 19208518 20214788 16328049 18393292 18056438 16502159 18788625 16878318 18978308 19383236 19701751 10737359
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.3716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.3716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.3716924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1716247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9712490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5519215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2718850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.1916332659
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.516135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.512727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.5118566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3216919318 15861022 17110522 16105132 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 7.3219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 15668235 8697196 15340226 16354765
MESH:D003110 Colonic Neoplasms decitabine 5.7517616700
MESH:D003110 Colonic Neoplasms Genistein 5.7517182828
MESH:D003110 Colonic Neoplasms polyphenols 5.7516293270
MESH:D015179 Colorectal Neoplasms Acrolein 4.7517597105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.7520501625
MESH:D015179 Colorectal Neoplasms decitabine 4.7518981723
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.7515531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4215322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3318551238
MESH:D003556 Cystitis Acrolein 5.2212161096
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9315213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5416140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8520387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.8911421492 14725611 12958197 19164858 17522070 11287661 12392966 10774834 11834606 14550746 16081117 11743745 19420014 19923254 14986274 12594235 15619225 19739265 16109766 18713872 16177239 11461765 15968718 12153990 16227642 2444490 19085960 12705907 11529661 16393943 17562736 10915739 19370779 19416960 16485898 11739529 18071297 10663392 16781746 12540782 17906064
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.892869522 3732212 10092053 6884620 15027814 19336974 10915739 4309450 21278145 7120509 7440962 6623471 17522070 16227642 11566570 3786805 15998439 16177239 9327722 7179309 19085960 15968718
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.8919107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 17.8919370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.8920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004487 Edema pirinixic acid 6.0312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7316714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3919031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.4519294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.4519294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.4216402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.8211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 11.8211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.8216202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.879294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9416302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5712903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.5715547733 15878914 16510608 15150132 15264214 16805852 15623463 15547721 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver arsenic trioxide 28.6815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.6819224547 17595544 12631006 16239168 12795759 16045604 61145 15959796
MESH:D005234 Fatty Liver Diethylnitrosamine 28.6821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.6815345470
MESH:D005234 Fatty Liver pirinixic acid 28.6819236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 28.6819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.0318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.0320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1016904648
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005909 Glioblastoma Genistein 7.1416598420
MESH:D005909 Glioblastoma trichostatin A 7.1418801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3719215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.7019176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 16959395 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male decitabine 6.3417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3417937319
MESH:D007249 Inflammation Diethylnitrosamine 11.2418785209
MESH:D007249 Inflammation polyphenols 11.2416366677
MESH:D007249 Inflammation Tamoxifen 11.2419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2412200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.6716393666
MESH:D007333 Insulin Resistance Estradiol 11.6716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.6716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007674 Kidney Diseases Acetaminophen 9.6115629191 12587719
MESH:D007674 Kidney Diseases Acrolein 9.6112488133
MESH:D007674 Kidney Diseases Estradiol 9.6115618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.6016705839
MESH:D007680 Kidney Neoplasms Estradiol 16.6015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.6018625569
MESH:D007938 Leukemia arsenic trioxide 10.0515070760
MESH:D007938 Leukemia decitabine 10.0518980019 19235587
MESH:D007938 Leukemia Genistein 10.0518980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.0719077051
MESH:D007951 Leukemia, Myeloid decitabine 9.0718454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0716467208 19850784 16968895 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.0717679729 19387464 18460780 18704418 18206229 19010910
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.0718206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2918055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1019642359 15622746 16112521 16823087 12712474 16966277 16330433 12018890 11468182 19225113 17712046 15213294 9834237 12679006 17107899 19075265 19035177 15336539 17649720 17217047 17869043 16331271 11161223 16891316 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1916882451
MESH:D008064 Lipidoses Tamoxifen 3.0315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3021278145 16943688 11903743 17334410 17157831 11408273 17174718 16221502 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3018522880 20032147 18407596 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.4515876570 15052691 18418968 18166357 18395914 17900296 18412020 16116963 16248980 14724832 16027843 17944888 17631135 18054572 18472332 16638106 12546737 18705752 17823541 17976157 12445421 20821823 12741479 15893842 12632512 15650968 16192424 18395095 17805973 18006644 12958196 15925388 12586293 15959796 17721639 18481824 15362042 15057751 12445418 14620537 18376398 15370692 16015684 16097048 18251166 18472094 15338365 17869086 18205269 14716833 17525996 16011737 14716496 12389079 18429990 12609069 17708605 14512876 12632514 18420326 12666154 17922224 15996030 11481614 18277467 12649538 17557913 15123356 18187930 18263696 15730626 17565644 17714472 17481882 17640975 17698563 10355542 15931870 18210741 18317297 12898905 16136751 18279442 16033810 12667390 15673190 14748882 18156304 13678700 15818738 18339082 17766677 17761835
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4512878042
MESH:D008107 Liver Diseases Acetaminophen 12.0619784758 12969438 19014921 12587719 11587558 16610002 19460945 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.0616964402 17285989 15830285 15720792 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 12.0617034775
MESH:D008107 Liver Diseases Lindane 12.061715830
MESH:D008107 Liver Diseases polyphenols 12.0616698588
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.917678174
MESH:D008113 Liver Neoplasms arsenic trioxide 20.9114682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.9119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.9120405173 18648771 20137499 18754104 19499222 19996281 19427195 19255062 20452335 18977376 19642983 19690152 12771043 21167192 21047994 19294768 19833225 2422723 21278145 20501860 19812893 15885732 20492335 21071580 16942905 19850985 19256749 19426721 9163691 19090486 12112319 15175105 10737359 2862719 19073162 20434301 19638242 19254457 20583210 18644402 20101389 19551842 20118626 18978307
MESH:D008113 Liver Neoplasms pirinixic acid 20.9115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 20.9116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.9116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.002876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.0020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.0012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.0018282651 18093689 19004024 3124819 16842330 18253720 18308698 18079962 18775883 17942915 19539802 18544905 2563599 18164116 19519916 19126423 17854601 21159647 16267830 19009564 17174075 9362446
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 22.001423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.0012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2215213294
MESH:D008171 Lung Diseases Acrolein 4.1011504702
MESH:D008175 Lung Neoplasms arsenic trioxide 6.3719825857 11798837
MESH:D008175 Lung Neoplasms bexarotene 6.3717849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.3720970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Tamoxifen 6.3718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3719555203 11884234
MESH:D008223 Lymphoma decitabine 3.3019470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9811161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 13.4115591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.4111807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.4112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.4119196722 11731420 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0719453300
MESH:D008545 Melanoma decitabine 5.0516505122 17785578
MESH:D008545 Melanoma Tamoxifen 5.0512393984 19393235
MESH:D008545 Melanoma trichostatin A 5.0516505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.4119513568
MESH:D008546 Melanoma, Experimental Acrolein 10.4110803710
MESH:D009101 Multiple Myeloma arsenic trioxide 11.5319549372 14977855 11468182 15949261 19417148
MESH:D009101 Multiple Myeloma decitabine 11.5318172295
MESH:D009101 Multiple Myeloma trichostatin A 11.5318172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1816882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.1818608210 16882708 19157545 19010910
MESH:D009203 Myocardial Infarction Genistein 5.4417141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.4116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.4117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.4116411023
MESH:D017696 Myopathies, Nemaline marker/mechanism
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.7718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.7718551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7916624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.503581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Acrolein 11.2717329238
MESH:D009369 Neoplasms decitabine 11.2719116145 17925555 19470736
MESH:D009369 Neoplasms Lindane 11.2716818664 12807735
MESH:D009369 Neoplasms pirinixic acid 11.2717405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.3619196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.3619189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009393 Nephritis Acrolein 6.1112653641
MESH:D009421 Nervous System Malformations bisphenol A 22.0811399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 22.0811399458 16427766
MESH:D009421 Nervous System Malformations Genistein 22.0816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.0814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.3418514411
MESH:D019636 Neurodegenerative Diseases Acrolein 13.3411342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.3420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9420387270
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.3816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.3816049721
MESH:D010024 Osteoporosis Genistein 3.1519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9216169203
MESH:D010049 Ovarian Diseases bisphenol A 4.8211985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.4216624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms decitabine 14.4219331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 14.4219401270
MESH:D010051 Ovarian Neoplasms Genistein 14.4219005980
MESH:D010051 Ovarian Neoplasms trichostatin A 14.4219331143
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.8815580305
MESH:D010190 Pancreatic Neoplasms decitabine 11.8819294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.8816540662
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.8819294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0019927285
MESH:D010300 Parkinson Disease Acrolein 5.8117690948
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.8116702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010787 Photosensitivity Disorders Acrolein 5.5711550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.412563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.9310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9311118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 11.8617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.8617616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.0320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4319131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4316740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.4316740699
MESH:D011471 Prostatic Neoplasms Genistein 2.4316925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Lindane 2.4314688026 12661182
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4315721890
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4315067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.4319789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.6110548101
MESH:D051437 Renal Insufficiency Acrolein 4.8412732208
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.2419155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 9.2618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.2618551238
MESH:D012640 Seizures Lindane 9.2615475178 12842176 7539098
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D013274 Stomach Neoplasms marker/mechanism 15378696
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6217007042
MESH:D013274 Stomach Neoplasms decitabine 4.6219037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6218456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.6217575124 12958204
MESH:D020521 Stroke Acrolein 4.4216269634
MESH:D019966 Substance-Related Disorders bisphenol A 3.8116684133 16045194
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0817997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.2619014326
MESH:D013964 Thyroid Neoplasms decitabine 11.2617967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.267505956
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7915213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.0916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.0916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.0912973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.0917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.0916712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4110091137
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D014591 Uterine Diseases bisphenol A 4.8414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014604 Uveal Neoplasms decitabine 4.7417785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
KEGG:05200 Pathways in cancer
KEGG:05216 Thyroid cancer
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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