AutismKB 2.0

Annotation Detail for TPM4


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Basic Information Top
Gene Symbol:TPM4 ( - )
Gene Full Name: tropomyosin 4
Band: 19p13.12-p13.11
Quick LinksEntrez ID:7171; OMIM: 600317; Uniprot ID:TPM4_HUMAN; ENSEMBL ID: ENSG00000167460; HGNC ID: 12013
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Muscle contraction
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TPM4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TPM4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPM4 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of TPM4 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TPM4 mRNAdecreases expression 19150397
20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TPM4 mRNAincreases expression 20382639
C095105 bexarotene bexarotene results in increased expression of TPM4 mRNAincreases expression 16648578
D016572 Cyclosporine Cyclosporine results in increased expression of TPM4 mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased expression of TPM4 proteindecreases expression 19294695
D004041 Dietary Fats Dietary Fats results in increased expression of TPM4 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TPM4 mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in increased expression of TPM4 mRNAincreases expression 20106945
C041786 palm oil palm oil results in increased expression of TPM4 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TPM4 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TPM4 mRNAdecreases expression 17884332
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TPM4 mRNAincreases expression 18495758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TPM4 proteindecreases expression 16548065
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TPM4 proteinincreases expression 19201780
D014212 Tretinoin Tretinoin results in decreased expression of TPM4 mRNAdecreases expression 16140955
C012589 trichostatin A trichostatin A results in decreased expression of TPM4 proteindecreases expression 19294695
C025643 vinclozolin vinclozolin affects the expression of TPM4 mRNAaffects expression 19015723
D015032 Zinc Zinc results in decreased expression of TPM4 mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of TPM4 mRNAdecreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7911752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 10.4218287403
MESH:D000138 Acidosis Zinc Sulfate 10.427265320
MESH:D000169 Acrodermatitis Zinc 5.3417190629 16889938 17202136
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3411798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000236 Adenoma Diethylnitrosamine 2.816695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.9317162532 19052882 17620307 19061943 18056438 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.9316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.9316835633
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D000544 Alzheimer Disease Zinc 2.7417119284 16325427 16580781 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.8416916123
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D000860 Anoxia Zinc Sulfate 4.967265320
MESH:D001008 Anxiety Disorders vinclozolin 3.5819015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.8215238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 5.0016456186
MESH:D001249 Asthma Zinc 5.0017085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 21.4416206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 21.4419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 21.4412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 21.4416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001930 Brain Injuries Zinc 4.6317109824
MESH:D001943 Breast Neoplasms bexarotene 3.7316344269 16818667
MESH:D001943 Breast Neoplasms decitabine 3.7318320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 3.7320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.7317474063
MESH:D001943 Breast Neoplasms Estradiol 3.7318497071 12948864 17261762 16675129 14630087 17289903 17018787 19861407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7320435547
MESH:D001943 Breast Neoplasms Tretinoin 3.7316443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.2616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.263084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.2615073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.2619539802 20007298 18788625 19822196 18691550 18393292 19919837 3581430 19107877 3084413 20101231 18785209 18506893 20524982 10737359 19519916 20514400 20935162 20727157 19701751 19208518 19335982 16540662 16807293 10672840 20084675 16830150 17428255 17162532 19052882 16288022 19394651 16502159 21159647 18056438 16779866 17173139 11831363 16935385 18210153 19418558 17978847 20432363 16698587 17138121 19171122 16681979 19383236 18978308 17761372 16569478 16328049 20512989 16878318 18971187 17055752 18494052 20214788 18665156
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.2616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.261917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2016247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.5419215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.5416051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.5416543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.6116936243
MESH:D002386 Cataract Acetaminophen 7.1010977129
MESH:D002386 Cataract Tretinoin 7.1017460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.6320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.6312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.6317174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.6318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002779 Cholestasis Cyclosporine 7.5919486331
MESH:D002779 Cholestasis pirinixic acid 7.5919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6715340226 8697196 15668235 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 5.679407595
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D003110 Colonic Neoplasms decitabine 2.3217616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5720501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5718981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3720055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.379211117 17551590 9142499 9125849 9224671 8800419 16925845 9664655 10589399 14991402
MESH:D019465 Craniofacial Abnormalities Zinc 5.3719302082
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003920 Diabetes Mellitus Zinc 4.1516479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.7818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.782444490 10663392 14986274 18071297 19085960 14550746 17562736 11739529 16081117 11743745 16109766 11287661 11421492 18713872 11834606 19739265 16177239 16781746 12958197 19164858 15968718 17906064 16227642 19420014 16485898 10915739 16393943 11529661 19370779 12153990 19923254 11461765 17522070 15619225 14725611 12594235 10774834 19416960 12392966 12705907 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.7819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4018367378
MESH:D004487 Edema pirinixic acid 6.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.7618230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.8419294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.8419294695
MESH:D016889 Endometrial Neoplasms Estradiol 7.2711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.2716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.969294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2312903497
MESH:D004938 Esophageal Neoplasms Zinc 7.2316543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.679664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 23.9915073043
MESH:D005234 Fatty Liver Cyclosporine 23.9919224547
MESH:D005234 Fatty Liver Dietary Fats 23.9917967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 23.9920387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 23.9919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005355 Fibrosis Cyclosporine 20.6212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.6220067830
MESH:D005355 Fibrosis Tretinoin 20.6217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005756 Gastritis Acetaminophen 10.9816983495
MESH:D005756 Gastritis Zinc 10.9817241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Tretinoin 7.2717312396
MESH:D005909 Glioblastoma trichostatin A 7.2718801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006130 Growth Disorders Zinc 3.9217217573
MESH:D006258 Head and Neck Neoplasms decitabine 7.6819215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.429664655 14991402
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006333 Heart Failure Zinc 7.0117162251
MESH:D006335 Heart Injuries Zinc 5.7117074742
MESH:D016481 Helicobacter Infections Zinc 4.4717241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006527 Hepatolenticular Degeneration Zinc 11.1117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.1117063115
MESH:D006529 Hepatomegaly pirinixic acid 8.0516221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0512621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.998697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.4416870215
MESH:D006930 Hyperalgesia Tretinoin 7.4416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5321332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5521332399
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618670907 18850075
MESH:D007022 Hypotension Zinc Sulfate 4.417265320
MESH:D007248 Infertility, Male decitabine 6.7817581917
MESH:D007248 Infertility, Male vinclozolin 6.7816467254
MESH:D007249 Inflammation Dietary Fats 8.0820412841
MESH:D007249 Inflammation Diethylnitrosamine 8.0818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0812878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 12.0411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.0416627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.0416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007511 Ischemia Zinc 4.5716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.7315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Acetaminophen 14.1315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 14.138314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 14.1315618244
MESH:D007674 Kidney Diseases Zinc 14.1316960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.3616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.0416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.0412371664
MESH:D007680 Kidney Neoplasms Estradiol 12.0415610895
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.2115237267
MESH:D007938 Leukemia arsenic trioxide 10.3215070760
MESH:D007938 Leukemia decitabine 10.3218980019 19235587
MESH:D007938 Leukemia Tretinoin 10.3217143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 15.6419077051
MESH:D007951 Leukemia, Myeloid decitabine 15.6417236224 18454857 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 15.6416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.7119850784 16968895 16467208 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.7117679729 19010910 18704418 18206229 18460780 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.7119850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.7118206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4118055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.4919035177 16330433 12712474 17649720 12018890 19225113 15748426 19075265 17107899 16966277 16331271 17217047 15336539 15213294 17712046 16823087 11468182 11161223 19642359 16891316 9834237 12679006 16112521 17869043 15622746
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.4917649720 16140955 17368321 16891316 19035177 19029980 17712046 15748426 9834237 17301526 17217047 16331271 17107899 16935935 17339181 17506722 19642359 12679006 19225113 17361223 17294898 16788101 16823087 19075265 16766008
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2916882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5118665156 19638242 18522880 20032147 18407596
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.8516611625 19784758 19460945 19014921 12969438 16610002 11587558 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1816871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 10.4714682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.4720405173 20452335 18754104 19254457 19256749 20137499 19427195 12771043 9163691 18978307 19426721 2862719 18644402 19996281 19073162 12112319 20492335 19294768 21047994 15885732 10737359 21278145 19833225 19255062 16942905 21167192 19090486 19812893 2422723 19690152 20583210 18977376 20501860 19638242 19642983 15175105 19499222 18648771 20118626 19551842 19850985 20101389 21071580 20434301
MESH:D008113 Liver Neoplasms pirinixic acid 10.4715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.5720377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.5717942915 17174075 18093689 19004024 18164116 17854601 3124819 18079962 18253720 19519916 19126423 18544905 16842330 19009564 9362446 18282651 18308698 2563599 21159647 19539802 18775883 16267830
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8119825857 11798837
MESH:D008175 Lung Neoplasms bexarotene 4.8117849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8120970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8111884234 19555203
MESH:D008223 Lymphoma decitabine 3.3719470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0811161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.8915591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.8916891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Zinc 9.8912773700
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma decitabine 5.1816505122 17785578
MESH:D008545 Melanoma Tretinoin 5.1816752155
MESH:D008545 Melanoma trichostatin A 5.1816505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009101 Multiple Myeloma arsenic trioxide 11.9615949261 14977855 11468182 19417148 19549372
MESH:D009101 Multiple Myeloma decitabine 11.9618172295
MESH:D009101 Multiple Myeloma trichostatin A 11.9618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.1216105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 12.1219010910 19157545 18608210 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.1217596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8018551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9016624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.543581430 9029167
MESH:D009369 Neoplasms decitabine 8.0719470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 8.0717405874
MESH:D009369 Neoplasms Tretinoin 8.0716946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.7319196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.9616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.969125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1610525206
MESH:D009436 Neural Tube Defects Tretinoin 7.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D009765 Obesity Dietary Fats 4.3818674790 18457598 19632207 21332399 20518802 17217161 20132043 11836018 16723640
MESH:D009765 Obesity pirinixic acid 4.3820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3716049721 12819281
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.7716624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms decitabine 14.7719331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 14.7719401270
MESH:D010051 Ovarian Neoplasms Tretinoin 14.7716936753
MESH:D010051 Ovarian Neoplasms trichostatin A 14.7719331143
MESH:D010146 Pain Acetaminophen 6.4016870215
MESH:D010146 Pain Tretinoin 6.4016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 16.0815580305
MESH:D010190 Pancreatic Neoplasms decitabine 16.0819294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 16.0816540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 16.0815976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 16.0819294695
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.7512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.752563599
MESH:D011225 Pre-Eclampsia Zinc 4.1217114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2811399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.2819015723 18042343 18220299
MESH:D055728 Primary Myelofibrosis decitabine 12.2117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.2117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1519131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1516740699
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1518798265 19789329
MESH:D011471 Prostatic Neoplasms Zinc 2.1516517595 16700911 12429649 16606632
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration Zinc 4.0716584753
MESH:D012208 Rhabdomyosarcoma decitabine 10.7419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.7416116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.4616467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6817007042
MESH:D013274 Stomach Neoplasms decitabine 4.6819037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6818456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.6817261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 16.6919014326
MESH:D013964 Thyroid Neoplasms decitabine 16.6917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.697505956
MESH:D013964 Thyroid Neoplasms Tretinoin 16.6916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014062 Tongue Neoplasms Tretinoin 9.7816051514
MESH:D014062 Tongue Neoplasms Zinc 9.7816543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.2120435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.2117616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2510091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6216129372
MESH:D014604 Uveal Neoplasms decitabine 12.6417785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.6416752155
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Dietary Fats 3.6816723640
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:17044 Muscle contraction
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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