AutismKB 2.0

Annotation Detail for TPO


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Basic Information Top
Gene Symbol:TPO ( MSA,TDH2A,TPX )
Gene Full Name: thyroid peroxidase
Band: 2p25.3
Quick LinksEntrez ID:7173; OMIM: 606765; Uniprot ID:PERT_HUMAN; ENSEMBL ID: ENSG00000115705; HGNC ID: 12015
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6241thyroid hormone biosynthesis
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa05320Autoimmune thyroid disease
hsa04630Jak-STAT signaling pathway
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1946Thyroid gland disease
2032Kidney disease
2051Leukemia
2052Infection
2136Hypothyroidism
2226Thrombocytosis
2237Neoplasm metastasis
Desease Name
METABOLIC
hypothyroidism
No data
Desease Name
Thyroid dyshormonogenesis 2A
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in decreased expression of TPO mRNAdecreases expression 18020914
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPO mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine results in increased expression of TPO mRNAincreases expression 17679169
D005031 Ethylenethiourea Ethylenethiourea results in decreased activity of TPO proteindecreases activity 7626075
C015320 leucomalachite green leucomalachite green results in decreased activity of TPO proteindecreases activity 9760285
C013099 mancozeb mancozeb results in decreased activity of TPO proteindecreases activity 9418944
D008713 Methimazole Methimazole results in decreased activity of TPO proteindecreases activity 7626075
D008713 Methimazole Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein]decreases activity|decreases reaction 7626075
D009151 Mustard Gas Mustard Gas results in increased expression of TPO mRNAincreases expression 15674843
C510603 Org 41841 Org 41841 analog inhibits the reaction [TSHB protein results in increased expression of TPO mRNA]decreases reaction|increases expression 18669595
D012974 Sodium Iodide Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein]decreases activity|decreases reaction 7626075
D014212 Tretinoin Tretinoin results in increased expression of TPO mRNAincreases expression 17679169
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced mancozeb 5.47982313
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Ethylenethiourea 3.927955072
MESH:D000236 Adenoma leucomalachite green 5.8712351145
MESH:D000382 Agricultural Workers' Diseases mancozeb 5.4716132792 8807224 15864902
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9318057881 20041841 18218290
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Mustard Gas 5.1110378619
MESH:D001249 Asthma Tretinoin 5.1116456186
MESH:D001281 Atrial Fibrillation Amiodarone 4.0118651412 19698954
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.7219483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.7216197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2616166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1910378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9315710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D003409 Congenital Hypothyroidism marker/mechanism 12564727 14751036 16187919 17381485
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8216925845 8800419 9224671 10589399 9211117 9664655 14991402 9142499 9125849 17551590
MESH:D017449 Dermatitis, Allergic Contact mancozeb 4.988807224
MESH:D009783 Dermatitis, Occupational mancozeb 6.098807224
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4215265979 18218290
MESH:D004487 Edema Mustard Gas 3.4511428647 9260866 11428631 11402378
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 8.377955072
MESH:D016889 Endometrial Neoplasms Tretinoin 8.3716569247
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D005124 Eye Abnormalities Tretinoin 3.6816938888 9664655
MESH:D005234 Fatty Liver Amiodarone 3.6614986274
MESH:D005355 Fibrosis Tretinoin 3.6917994277
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D005910 Glioma Sodium Iodide 5.1312489024
MESH:D006042 Goiter marker/mechanism 12564727 14751036 17547680
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9614991402 9664655
MESH:D006529 Hepatomegaly Amiodarone 3.9215265979
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.018137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006980 Hyperthyroidism Methimazole 5.7814678291
MESH:D007037 Hypothyroidism Amiodarone 12.4117991464 18020914
MESH:D007037 Hypothyroidism Methimazole 12.4118031379
MESH:D007249 Inflammation Mustard Gas 2.8517524151 9260866 9357497 16001271 11428631 11402378 8975870 11428647 11428620
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0415992940 17551590
MESH:D007680 Kidney Neoplasms Sodium Iodide 5.6412489024
MESH:D007938 Leukemia Azacitidine 6.8719148494
MESH:D007938 Leukemia Tretinoin 6.8717143497
MESH:D007945 Leukemia, Lymphoid mancozeb 6.5116132792
MESH:D007951 Leukemia, Myeloid Azacitidine 10.2619077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.2616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.2718720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.2719850784 17596541 16294345
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.3419299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2417368321 19029980 16766008 16788101 15748426 17301526 17712046 16823087 16331271 19225113 17217047 19075265 19642359 16891316 16140955 17339181 16935935 12679006 17107899 9834237 19035177 17506722 17361223 17294898 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008064 Lipidoses Amiodarone 3.6115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms Ethylenethiourea 3.9911940454
MESH:D008133 Long QT Syndrome Amiodarone 3.6917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 7.9212587719
MESH:D008171 Lung Diseases Mustard Gas 7.9218702808 18161513
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7018516814
MESH:D008175 Lung Neoplasms Azacitidine 4.1021224363
MESH:D008175 Lung Neoplasms leucomalachite green 4.1012351145
MESH:D008175 Lung Neoplasms Mustard Gas 4.103148597 8781369
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Sodium Iodide 4.2612489024
MESH:D008545 Melanoma Tretinoin 4.2616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D009006 Monosomy Azacitidine 6.3019299654
MESH:D009101 Multiple Myeloma Azacitidine 4.0619549372 18443271
MESH:D009181 Mycoses Amiodarone 5.1217974566 12754197
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.9618720364 19805378 17596541 17611569
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9617596541
MESH:D009369 Neoplasms Tretinoin 2.4716594593 16946489
MESH:D009410 Nerve Degeneration mancozeb 5.3415350641
MESH:D009421 Nervous System Malformations Tretinoin 3.949125849
MESH:D009436 Neural Tube Defects mancozeb 8.2615864902
MESH:D009436 Neural Tube Defects Tretinoin 8.269142499
MESH:D009503 Neutropenia Mustard Gas 4.127688884 16761898
MESH:D010051 Ovarian Neoplasms Sodium Iodide 5.8712489024
MESH:D010051 Ovarian Neoplasms Tretinoin 5.8716936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms mancozeb 6.108603375 16965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 6.1015976015
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D011471 Prostatic Neoplasms Azacitidine 4.4418324645
MESH:D011471 Prostatic Neoplasms Sodium Iodide 4.4412489024
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011537 Pruritus Mustard Gas 4.2918058305
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.0112832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Mustard Gas 6.0117266442 17720292 17894541 17620002 10334151
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D012871 Skin Diseases Mustard Gas 2.7415451306 16961503 12880345
MESH:D012878 Skin Neoplasms mancozeb 6.661733566
MESH:D012878 Skin Neoplasms Tretinoin 6.6616467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.4518087811
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3519225199
MESH:D013959 Thyroid Diseases Amiodarone 4.9819731979
OMIM:274500 THYROID DYSHORMONOGENESIS 2A marker/mechanism
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 8.1511940454
MESH:D013964 Thyroid Neoplasms Tretinoin 8.1517045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 5.0419584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D016171 Torsades de Pointes Amiodarone 4.3811989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
KEGG:05320 Autoimmune thyroid disease
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04640 Hematopoietic cell lineage
REACT:15314 Hormone biosynthesis
KEGG:04630 Jak-STAT signaling pathway
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36694
    • No data
    Releated disease ID Related disease Name
    PA445218Pancreatic Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00389 antagonist Carbimazole Antithyroid Agents
    DB00509 - Dextrothyroxine Antihyperlipidemics
    DB00550 inhibitor Propylthiouracil Antimetabolites;Antithyroid Agents
    DB00763 inhibitor Methimazole Antithyroid Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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