AutismKB 2.0

Annotation Detail for TPP2


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Basic Information Top
Gene Symbol:TPP2 ( FLJ40359,TPP-2 )
Gene Full Name: tripeptidyl peptidase II
Band: 13q33.1
Quick LinksEntrez ID:7174; OMIM: 190470; Uniprot ID:TPP2_HUMAN; ENSEMBL ID: ENSG00000134900; HGNC ID: 12016
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TPP2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TPP2 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of TPP2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TPP2 mRNAaffects expression 17562736
D006710 Homocysteine Homocysteine results in decreased expression of TPP2 mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPP2 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of TPP2 mRNAaffects cotreatment|decreases expression 18636392
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TPP2 mRNAincreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TPP2 mRNAincreases expression 17942748
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of TPP2 mRNAaffects cotreatment|decreases expression 18636392
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of TPP2 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.147525203
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury Chlorine 4.4720601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.923712494
MESH:D000236 Adenoma Diethylnitrosamine 6.926695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0917620307 19052882 18056438 16434500 17162532 19061943
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6717854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder Homocysteine 2.2420468076 16297937
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7916777450 14754758 17626835 15516495 18417511 19059883 18315731
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.713581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7120935162 17162532 20524982 10672840 11831363 20727157 19335982 16878318 18210153 18788625 19822196 20214788 20512989 16328049 17428255 20514400 18785209 17055752 3581430 16935385 17761372 16698587 20432363 19383236 19418558 19208518 21159647 18978308 3084413 16540662 19171122 19919837 18393292 16830150 16288022 16569478 19394651 18494052 19701751 16502159 16807293 20101231 20084675 19107877 19539802 18971187 16681979 18691550 18506893 18056438 17173139 17978847 10737359 20007298 19052882 16779866 19519916 18665156 17138121
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.6814694615
MESH:D002386 Cataract Acetaminophen 7.6810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.746135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.747505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.747505956 2727394 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.219022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2116919318 16105132 11677210 17333356 17110522 15861022 17681005
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2815095906
MESH:D003324 Coronary Artery Disease Homocysteine 3.8016379339
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9718759878 14531868 11298694 8156756 8970840 2524372 12868966 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.4916684804
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.4318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.437440962 9328219 9022650 1440618 6482804 11289319 8291058 18692083 9653073 16192314 6679447 18289764 18648102
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.4321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4311287661 11421492 17906064 19085960 18713872 16177239 11739529 16393943 12705907 19420014 11743745 11461765 12540782 18071297 12153990 16081117 14550746 19416960 11529661 11834606 10663392 16485898 10915739 16227642 12594235 12392966 14986274 17562736 19739265 15968718 19164858 14725611 10774834 16781746 12958197 16109766 19923254 2444490 15619225 19370779 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.4319107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004417 Dyspnea Chlorine 4.8420016425
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D017889 Exfoliation Syndrome Homocysteine 5.8916504073
MESH:D005234 Fatty Liver Diethylnitrosamine 8.1721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1715345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005739 Gas Poisoning Chlorine 5.2320016425
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005901 Glaucoma Homocysteine 5.4416504073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Homocysteine 4.0719638421
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.8317292331 18234410 17369066
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.756582329
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8920032147 18407596 18522880 18665156 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 4.0119784758 12969438 12587719 19014921 11587558 19460945 16610002 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.727678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7221167192 21071580 15175105 19833225 18977376 20434301 19996281 18754104 15885732 19690152 19255062 20137499 18648771 19551842 19294768 19499222 20583210 12771043 19254457 2422723 20101389 19256749 20452335 19812893 21278145 20405173 10737359 19642983 2862719 19090486 9163691 19073162 19427195 19638242 12112319 20501860 20118626 18644402 19426721 18978307 20492335 16942905 21047994 19850985
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.342876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.341399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.3421159647 17854601 18282651 2563599 16842330 9362446 16267830 18775883 19009564 18079962 19539802 17942915 18308698 3124819 19004024 18164116 18253720 18544905 17174075 18093689 19519916 19126423
MESH:D008171 Lung Diseases Ozone 3.4719066396 8266340
MESH:D055370 Lung Injury Ozone 4.0220417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6120970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Ozone 2.618597069 7614698
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Homocysteine 5.7116602021
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D009203 Myocardial Infarction Homocysteine 3.7617412321
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.057678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.873581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.873581430 9029167
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.9416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.944026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.9414694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010300 Parkinson Disease Homocysteine 3.6216275827
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011014 Pneumonia Ozone 4.5918929643 18381685 18007984
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D012120 Respiration Disorders Chlorine 5.4318579056
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012559 Schizophrenia Homocysteine 3.1216641680
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.483712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.487505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.178074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36695
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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