AutismKB 2.0

Annotation Detail for TPR


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Basic Information Top
Gene Symbol:TPR ( - )
Gene Full Name: translocated promoter region (to activated MET oncogene)
Band: 1q31.1
Quick LinksEntrez ID:7175; OMIM: 189940; Uniprot ID:TPR_HUMAN; ENSEMBL ID: ENSG00000047410; HGNC ID: 12017
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05216Thyroid cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Metabolism of carbohydrates
Transmembrane transport of small molecules
HIV Infection
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00032Thyroid cancer
Cancers of endocrine organs
No data
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TPR mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TPR mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TPR mRNAdecreases expression 20018196
D001710 Biotin Biotin results in increased expression of TPR mRNAincreases expression 15219929
D004958 Estradiol Estradiol results in decreased expression of TPR mRNAdecreases expression 20068009
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of TPR mRNAdecreases expression 17616710
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TPR mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TPR mRNAincreases expression 19482888
D010758 Phosphorus Phosphorus results in increased expression of TPR mRNAincreases expression 17715259
C006253 pirinixic acid pirinixic acid results in decreased expression of TPR mRNAdecreases expression 17426115
C443641 poly(propyleneimine) poly(propyleneimine) analog results in increased expression of TPR mRNAincreases expression 16308212
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of TPR mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of TPR mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of TPR mRNAdecreases expression 12679051
C004648 testosterone enanthate testosterone enanthate affects the expression of TPR mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of TPR mRNAaffects expression 18691609
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of TPR mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of TPR mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4615322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.6016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.6016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9617306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Estradiol 1.9417289903 16675129 19861407 17261762 14630087 17018787 12948864 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.913084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.9116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.911701930 20007298 6705139 20935162 17173139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.9117306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3918572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3120889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.3118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.3119524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.118697196 12621046 16354765 15340226 15668235
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6520423518
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4919769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0211743745 12392966 12153990 12958197 19739265 16485898 17562736 15968718 16781746 16393943 19416960 17906064 11461765 11287661 11739529 19420014 11529661 18071297 18713872 11834606 10663392 19923254 12540782 10774834 14550746 19164858 14725611 19370779 16227642 10915739 15619225 11421492 16081117 2444490 14986274 16177239 12705907 12594235 19085960 17522070 16109766
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 16714409 15322242
MESH:D016889 Endometrial Neoplasms Estradiol 3.0018566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.933922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0820426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver pirinixic acid 2.7920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9920067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7316452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6210048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6216080930
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006333 Heart Failure Selenium 7.0117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Phenobarbital 14.6416109766
MESH:D006529 Hepatomegaly pirinixic acid 14.6418467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.6412621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D019584 Hot Flashes Estradiol 10.2617088409
MESH:D019584 Hot Flashes Vitamin E 10.2614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.0112646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712200463 12878042
MESH:D007251 Influenza, Human Selenium 11.1716624496
MESH:D007251 Influenza, Human Vitamin E 11.1716624496
MESH:D007333 Insulin Resistance Estradiol 7.2616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 14.5715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 14.5715618244
MESH:D007674 Kidney Diseases sodium arsenite 14.5720008137
MESH:D007674 Kidney Diseases Vitamin E 14.5712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.4416705839
MESH:D007680 Kidney Neoplasms Estradiol 7.4415610895
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9516169303
MESH:D008107 Liver Diseases Acetaminophen 3.9512587719 19784758 19014921 12969438 19460945 16611625 16610002 11587558
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 10.778742319 19073162 19482888 15975961 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 10.7716377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 10.7716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7716984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.851399818 6150874 17172636 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8512151625
MESH:D008171 Lung Diseases sodium arsenite 7.5019095001
MESH:D008171 Lung Diseases Vitamin E 7.5016863852
MESH:D008175 Lung Neoplasms sodium arsenite 3.4215276417 17306315 17077188 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.4211062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0816891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0815318939
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9118551238
MESH:D009369 Neoplasms pirinixic acid 4.9817405874
MESH:D009369 Neoplasms sodium arsenite 4.9811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 9.5911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4516049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.8619401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8617306315 15276417
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5016965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.652563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures Phenobarbital 5.993137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.6318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.9915864552
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1316049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1311723127 17306315 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7911813266
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
Pathway ID Pathway Name
REACT:6185 HIV Infection
REACT:474 Metabolism of carbohydrates
KEGG:05200 Pathways in cancer
KEGG:03013 RNA transport
KEGG:05216 Thyroid cancer
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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