AutismKB 2.0

Annotation Detail for TPSAB1


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Basic Information Top
Gene Symbol:TPSAB1 ( MGC104064,TPS1,TPS2,TPSB1 )
Gene Full Name: tryptase alpha/beta 1
Band: 16p13.3
Quick LinksEntrez ID:7177; OMIM: 191080; Uniprot ID:TRYB1_HUMAN; ENSEMBL ID: ENSG00000172236; HGNC ID: 12019
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1724Vascular disease
1781Rheumatoid arthritis
1877Multiple sclerosis
1949Fibrosarcoma
2025Polyarthritis
2074Asthma
2080Mastocytosis
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C459179 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased expression of TPSAB1 mRNA]decreases reaction|increases expression 16872693
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPSAB1 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TPSAB1 mRNAincreases expression 15003993
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TPSAB1 mRNAaffects cotreatment|increases expression 17183730
C025299 polyphenols polyphenols results in decreased expression of TPSAB1 mRNAdecreases expression 16293270
C017947 sodium arsenite sodium arsenite affects the expression of TPSAB1 mRNAaffects expression 17450228
D014212 Tretinoin Tretinoin results in increased expression of TPSAB1 mRNAincreases expression 16054129
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TPSAB1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2817306315 16712894
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001321 Autistic Disorder Valproic Acid 1.9918316065 18177632 17507914 20603192 17157402 18396377 18558336 19232924 18940202 19460635 16609825 17688650 15238991 18775368 18985861
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8516197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Tretinoin 2.2516443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1816507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.181917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8816051514 16096774
MESH:D002386 Cataract Tretinoin 3.2217460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.749224671 14991402 9211117 9664655 9142499 16925845 9125849 17551590 10589399 8800419
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.748888407 17688650 16575769
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.4119370779
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.411733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005124 Eye Abnormalities Tretinoin 3.7516938888 9664655
MESH:D005234 Fatty Liver Valproic Acid 3.5414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D005355 Fibrosis Tretinoin 3.8217994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.019664655 14991402
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006930 Hyperalgesia Tretinoin 3.4016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007248 Infertility, Male sodium arsenite 3.1415346721 12646999
MESH:D007249 Inflammation polyphenols 3.1716366677
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1417551590 15992940
MESH:D007674 Kidney Diseases sodium arsenite 2.9220008137
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0119850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3017217047 19642359 19225113 19035177 17506722 17339181 12679006 9834237 16935935 16331271 17649720 17368321 16788101 17712046 19075265 16766008 16823087 15748426 19029980 17107899 16891316 17294898 17361223 17301526 16140955
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases polyphenols 2.8316698588
MESH:D008113 Liver Neoplasms sodium arsenite 2.4416712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms sodium arsenite 1.8916712894 17306315 19931552 17077188 15276417
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma sodium arsenite 3.4516487513 19082730
MESH:D008545 Melanoma Tretinoin 3.4516752155
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8117596541
MESH:D009369 Neoplasms sodium arsenite 5.4611559025
MESH:D009369 Neoplasms Tretinoin 5.4616946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9720056578
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects sodium arsenite 13.0312854658
MESH:D009436 Neural Tube Defects Tretinoin 13.039142499
MESH:D009436 Neural Tube Defects Valproic Acid 13.038888407 16359493
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1017306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1016936753
MESH:D010146 Pain Tretinoin 3.1016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2616039940
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.7516283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.7519155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8914763951 11044598 16876388 15475178 17978042 11738929 1511512 3137016
MESH:D012878 Skin Neoplasms sodium arsenite 10.1019524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 10.108532709
MESH:D012878 Skin Neoplasms Tretinoin 10.1016467112
MESH:D016135 Spinal Dysraphism sodium arsenite 10.1612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 10.1619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6317997062
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5817306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.1811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.1816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB06848 - 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine
DB06849 - 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine
No data
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No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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