AutismKB 2.0

Annotation Detail for TPTE


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Basic Information Top
Gene Symbol:TPTE ( CT44,PTEN2 )
Gene Full Name: transmembrane phosphatase with tensin homology
Band: 21p11.2
Quick LinksEntrez ID:7179; OMIM: 604336; Uniprot ID:TPTE_HUMAN; ENSEMBL ID: ENSG00000166157; HGNC ID: 12023
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P04398p53 pathway feedback loops 2
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00030Hypoxia response via HIF activation
P00059p53 pathway
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1983Down syndrome
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TPTE mRNAincreases expression 20406850
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.8016705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.126135515
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.9318551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0818551238 21346803
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.4616705839
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.307678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.846135515 2876784 2876786
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.9518551238 7678174
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 4.0016049721
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8818551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4516049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.4110091137
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Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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