AutismKB 2.0

Annotation Detail for CRISP2


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Basic Information Top
Gene Symbol:CRISP2 ( CRISP-2,CT36,GAPDL5,MGC111136,TPX1,TSP1 )
Gene Full Name: cysteine-rich secretory protein 2
Band: 6p12.3
Quick LinksEntrez ID:7180; OMIM: 187430; Uniprot ID:CRIS2_HUMAN; ENSEMBL ID: ENSG00000124490; HGNC ID: 12024
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CRISP2 mRNAaffects expression 16483693
C014347 decitabine decitabine results in increased expression of CRISP2 mRNAincreases expression 19401350
D004317 Doxorubicin Doxorubicin results in decreased expression of CRISP2 mRNAdecreases expression 16404146
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D000230 Adenocarcinoma Doxorubicin 2.6517418594
MESH:D000419 Albuminuria Doxorubicin 5.1321441931
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.5714601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.2617150277
MESH:D001943 Breast Neoplasms decitabine 2.3919208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 2.3915994142 17426702 18382427 11325840 15692762 15668708 16826403 17983394 15993339 15634643 15136595 16595493 15939500 16322301 18695136 16935488 18628466 16115903 19526202 17369602 16264153 15567936 16096432 18234424
MESH:D002276 Carcinoid Tumor Doxorubicin 5.6816051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2618059187 16023760 16234567 17876044
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.3316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.2319215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.236189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.8018627295 15811867 16731534 16242529 15505089 16455267 17519947 17928571 17924179 15792986 17308081 16278810 15476868 16952015 17974986 16612575 16109756 17131338 17382496 17007740 16269455 16364871 17351982 17329180 16651473
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0616243910 17334414
MESH:D003110 Colonic Neoplasms decitabine 2.3917616700
MESH:D015179 Colorectal Neoplasms decitabine 2.7618981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7618259882 18802399
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5317416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9918602426
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.9819294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.7217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 6.0218037988
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.3319069698
MESH:D005909 Glioblastoma Doxorubicin 3.6117150277
MESH:D006258 Head and Neck Neoplasms decitabine 8.9019215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.9015692506
MESH:D006331 Heart Diseases Doxorubicin 3.7816495754 17888722 17875725 16144979 18006777 18674790 16244372 16244371 16707910 16330681 12587719 16879835 14766674
MESH:D006333 Heart Failure Doxorubicin 3.5917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.3815692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.8218501091 15147373 17606976
MESH:D007248 Infertility, Male decitabine 3.4817581917
MESH:D007674 Kidney Diseases Doxorubicin 3.2816775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.6416707910
MESH:D007938 Leukemia decitabine 3.2519235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 6.0216085563
MESH:D007951 Leukemia, Myeloid decitabine 4.4919117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4319387464 19010910 18460780 18206229 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.3318055864
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1616439617 16595196
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.2616842330 17085340
MESH:D008175 Lung Neoplasms Doxorubicin 2.156189445 17418594
MESH:D008223 Lymphoma decitabine 8.7719470736
MESH:D008223 Lymphoma Doxorubicin 8.7716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.1817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.2215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2915458769
MESH:D008545 Melanoma decitabine 3.7316505122 17785578
MESH:D008545 Melanoma Doxorubicin 3.7316827129
MESH:D008654 Mesothelioma Doxorubicin 3.2017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.9815792986
MESH:D052016 Mucositis Doxorubicin 5.5317415656
MESH:D009101 Multiple Myeloma decitabine 3.6518172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.6019157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Doxorubicin 3.0919429709 15857846
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0918259882
MESH:D009369 Neoplasms decitabine 2.8919116145 17925555 19470736
MESH:D009401 Nephrosis Doxorubicin 5.4216636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.4215640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.4515555623
MESH:D012516 Osteosarcoma Doxorubicin 4.4815930896
MESH:D010051 Ovarian Neoplasms decitabine 2.7519331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8919294695
MESH:D003557 Phyllodes Tumor Doxorubicin 6.0217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 6.0217638057
MESH:D055728 Primary Myelofibrosis decitabine 5.3817616702
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4915897917 16888761 16729912 15749863 16868541 18437689
MESH:D051437 Renal Insufficiency Doxorubicin 4.8717922066
MESH:D012208 Rhabdomyosarcoma decitabine 4.9319155313
MESH:D012509 Sarcoma Doxorubicin 4.4415625365 18313854 15675481 16767912 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.8314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.5317846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.1215692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.2215625365 16767912 17203757
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 8.5817967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.5817909728 16010429
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.8117616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.8117653716
MESH:D014604 Uveal Neoplasms decitabine 5.7817785578
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.8717334414 16364871 17678736 17638931
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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